Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_L10
(800 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q13409|DYI2_HUMAN Dynein intermediate chain 2, cytosolic... 250 4e-66
sp|O88487|DYI2_MOUSE Dynein intermediate chain 2, cytosolic... 250 4e-66
sp|Q62871|DYI2_RAT Dynein intermediate chain 2, cytosolic (... 247 2e-65
sp|O14576|DYI1_HUMAN Dynein intermediate chain 1, cytosolic... 243 3e-64
sp|Q63100|DYI1_RAT Dynein intermediate chain 1, cytosolic (... 243 4e-64
sp|O88485|DYI1_MOUSE Dynein intermediate chain 1, cytosolic... 240 4e-63
sp|Q24246|DYIN_DROME Dynein intermediate chain, cytosolic (... 238 2e-62
sp|P54703|DYIN_DICDI Dynein intermediate chain, cytosolic (... 159 8e-39
sp|P27766|DYI3_CHLRE Dynein, 70 kDa intermediate chain, fla... 74 4e-13
sp|Q16959|DYI2_ANTCR Dynein intermediate chain 2, ciliary 70 7e-12
>sp|Q13409|DYI2_HUMAN Dynein intermediate chain 2, cytosolic (DH IC-2) (Cytoplasmic dynein
intermediate chain 2)
Length = 638
Score = 250 bits (638), Expect = 4e-66
Identities = 121/221 (54%), Positives = 151/221 (68%)
Frame = +1
Query: 1 LRMLNAPSETREFSVKQAKSIAVTCMDFLSNDVNNFLVGSEDGMVYPGIRHGGKAGLSEG 180
L ML+ P ++ E KQ+K++AVT M F DVNNF+VGSE+G VY RHG KAG+SE
Sbjct: 412 LDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEM 471
Query: 181 FEGHLGPISGLSSHKVPGAVDFSHLFLTSSFDWTVKLWSGRDSGSRPLHSFEDNGDYVYD 360
FEGH GPI+G+ H GAVDFSHLF+TSSFDWTVKLW+ ++ ++PL+SFEDN DYVYD
Sbjct: 472 FEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKN--NKPLYSFEDNADYVYD 529
Query: 361 VAWSPVHPAVFASVDGQGLLDIWKLTADTEVPISRTQVNPMTALNKCSWHKTGAHVAVGD 540
V WSP HPA+FA VDG G LD+W L DTEVP + V ALN+ W +G +AVGD
Sbjct: 530 VMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGD 589
Query: 541 DSGRISIMDVNEQLYQPSSSAWSDLSHTLTELQLASADIKE 663
G+I I DV EQ+ P + W+ TL E+ AD +E
Sbjct: 590 SEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINANRADAEE 630
>sp|O88487|DYI2_MOUSE Dynein intermediate chain 2, cytosolic (DH IC-2) (Cytoplasmic dynein
intermediate chain 2)
Length = 612
Score = 250 bits (638), Expect = 4e-66
Identities = 121/221 (54%), Positives = 151/221 (68%)
Frame = +1
Query: 1 LRMLNAPSETREFSVKQAKSIAVTCMDFLSNDVNNFLVGSEDGMVYPGIRHGGKAGLSEG 180
L ML+ P ++ E KQ+K++AVT M F DVNNF+VGSE+G VY RHG KAG+SE
Sbjct: 386 LDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEM 445
Query: 181 FEGHLGPISGLSSHKVPGAVDFSHLFLTSSFDWTVKLWSGRDSGSRPLHSFEDNGDYVYD 360
FEGH GPI+G+ H GAVDFSHLF+TSSFDWTVKLW+ ++ ++PL+SFEDN DYVYD
Sbjct: 446 FEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKN--NKPLYSFEDNSDYVYD 503
Query: 361 VAWSPVHPAVFASVDGQGLLDIWKLTADTEVPISRTQVNPMTALNKCSWHKTGAHVAVGD 540
V WSP HPA+FA VDG G LD+W L DTEVP + V ALN+ W +G +AVGD
Sbjct: 504 VMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGD 563
Query: 541 DSGRISIMDVNEQLYQPSSSAWSDLSHTLTELQLASADIKE 663
G+I I DV EQ+ P + W+ TL E+ AD +E
Sbjct: 564 SEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINANRADAEE 604
>sp|Q62871|DYI2_RAT Dynein intermediate chain 2, cytosolic (DH IC-2) (Cytoplasmic dynein
intermediate chain 2)
Length = 638
Score = 247 bits (631), Expect = 2e-65
Identities = 121/221 (54%), Positives = 151/221 (68%)
Frame = +1
Query: 1 LRMLNAPSETREFSVKQAKSIAVTCMDFLSNDVNNFLVGSEDGMVYPGIRHGGKAGLSEG 180
L ML+ P ++ E KQ+K++AVT M F DVNNF+VGSE+G VY RHG KAG+SE
Sbjct: 412 LDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEM 471
Query: 181 FEGHLGPISGLSSHKVPGAVDFSHLFLTSSFDWTVKLWSGRDSGSRPLHSFEDNGDYVYD 360
FEGH GPI+G+ H GAVDFSHLF+TSSFDWTVKLWS ++ ++PL+SFEDN DYVYD
Sbjct: 472 FEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKN--NKPLYSFEDNSDYVYD 529
Query: 361 VAWSPVHPAVFASVDGQGLLDIWKLTADTEVPISRTQVNPMTALNKCSWHKTGAHVAVGD 540
V SP HPA+FA VDG G LD+W L DTEVP + V ALN+ W +G +AVGD
Sbjct: 530 VIGSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGD 589
Query: 541 DSGRISIMDVNEQLYQPSSSAWSDLSHTLTELQLASADIKE 663
G+I I DV EQ+ P + W+ TL E+ + AD +E
Sbjct: 590 SEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINASRADAEE 630
>sp|O14576|DYI1_HUMAN Dynein intermediate chain 1, cytosolic (DH IC-1) (Cytoplasmic dynein
intermediate chain 1)
Length = 645
Score = 243 bits (621), Expect = 3e-64
Identities = 118/223 (52%), Positives = 152/223 (68%)
Frame = +1
Query: 1 LRMLNAPSETREFSVKQAKSIAVTCMDFLSNDVNNFLVGSEDGMVYPGIRHGGKAGLSEG 180
L ML+ P E+ E ++K +AVT M F + DVNNF+VGSE+G VY RHG KAG+ E
Sbjct: 420 LDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEV 479
Query: 181 FEGHLGPISGLSSHKVPGAVDFSHLFLTSSFDWTVKLWSGRDSGSRPLHSFEDNGDYVYD 360
FEGH GP++G++ H G +DFSHLF+TSSFDWTVKLW+ + ++PL+SFEDN DYVYD
Sbjct: 480 FEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKH--NKPLYSFEDNADYVYD 537
Query: 361 VAWSPVHPAVFASVDGQGLLDIWKLTADTEVPISRTQVNPMTALNKCSWHKTGAHVAVGD 540
V WSPVHPA+FA VDG G LD+W L DTEVP + + +ALN+ W + G VAVGD
Sbjct: 538 VMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEGASALNRVRWAQAGKEVAVGD 597
Query: 541 DSGRISIMDVNEQLYQPSSSAWSDLSHTLTELQLASADIKELG 669
GRI + DV E L P + W+ + TL E++ AD +E G
Sbjct: 598 SEGRIWVYDVGE-LAVPHNDEWTRFARTLVEIRANRADSEEEG 639
>sp|Q63100|DYI1_RAT Dynein intermediate chain 1, cytosolic (DH IC-1) (Cytoplasmic dynein
intermediate chain 1)
Length = 643
Score = 243 bits (620), Expect = 4e-64
Identities = 119/223 (53%), Positives = 152/223 (68%)
Frame = +1
Query: 1 LRMLNAPSETREFSVKQAKSIAVTCMDFLSNDVNNFLVGSEDGMVYPGIRHGGKAGLSEG 180
L ML+ P E+ E ++K +AVT M F + DVNNF+VGSE+G VY RHG KAG+ E
Sbjct: 418 LDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEV 477
Query: 181 FEGHLGPISGLSSHKVPGAVDFSHLFLTSSFDWTVKLWSGRDSGSRPLHSFEDNGDYVYD 360
FEGH GP++G++ H G +DFSHLF+TSSFDWTVKLW+ + ++PL+SFEDN DYVYD
Sbjct: 478 FEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKH--NKPLYSFEDNADYVYD 535
Query: 361 VAWSPVHPAVFASVDGQGLLDIWKLTADTEVPISRTQVNPMTALNKCSWHKTGAHVAVGD 540
V WSPVHPA+FA VDG G LD+W L +DTEVP + + ALN+ W + G VAVGD
Sbjct: 536 VMWSPVHPALFACVDGMGRLDLWNLNSDTEVPTASVAIEGAYALNRVRWAQGGKEVAVGD 595
Query: 541 DSGRISIMDVNEQLYQPSSSAWSDLSHTLTELQLASADIKELG 669
GRI I DV E L P + W+ + TL E++ AD +E G
Sbjct: 596 SEGRIWIYDVGE-LAVPHNDEWTRFARTLVEIRANRADSEEEG 637
>sp|O88485|DYI1_MOUSE Dynein intermediate chain 1, cytosolic (DH IC-1) (Cytoplasmic dynein
intermediate chain 1)
Length = 628
Score = 240 bits (612), Expect = 4e-63
Identities = 117/223 (52%), Positives = 152/223 (68%)
Frame = +1
Query: 1 LRMLNAPSETREFSVKQAKSIAVTCMDFLSNDVNNFLVGSEDGMVYPGIRHGGKAGLSEG 180
L ML+ P E+ E ++K +AVT M F + DVNNF+VGSE+G VY RHG KAG+ E
Sbjct: 403 LDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEV 462
Query: 181 FEGHLGPISGLSSHKVPGAVDFSHLFLTSSFDWTVKLWSGRDSGSRPLHSFEDNGDYVYD 360
FEGH GP++G++ H G +DFSHLF+TSSFDWTVKLW+ + ++P++S EDN DYVYD
Sbjct: 463 FEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKH--NKPVYSSEDNADYVYD 520
Query: 361 VAWSPVHPAVFASVDGQGLLDIWKLTADTEVPISRTQVNPMTALNKCSWHKTGAHVAVGD 540
V WSPVHPA+FA VDG G LD+W L +DTEVP + + +ALN+ W + G VAVGD
Sbjct: 521 VMWSPVHPALFACVDGMGRLDLWNLNSDTEVPTASVAIEGASALNRVRWAQGGKEVAVGD 580
Query: 541 DSGRISIMDVNEQLYQPSSSAWSDLSHTLTELQLASADIKELG 669
GRI I DV E L P + W+ + TL E++ AD +E G
Sbjct: 581 SEGRIWIYDVGE-LAVPHNDEWTRFARTLVEIRANRADSEEEG 622
>sp|Q24246|DYIN_DROME Dynein intermediate chain, cytosolic (DH IC) (Cytoplasmic dynein
intermediate chain) (Short wing protein)
Length = 663
Score = 238 bits (606), Expect = 2e-62
Identities = 112/218 (51%), Positives = 156/218 (71%)
Frame = +1
Query: 1 LRMLNAPSETREFSVKQAKSIAVTCMDFLSNDVNNFLVGSEDGMVYPGIRHGGKAGLSEG 180
L ML+ P +T E +Q+K+IA+T M F +N++N+ ++GSEDG VY RHG ++G++E
Sbjct: 446 LDMLSQPQDTLELQQRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEV 505
Query: 181 FEGHLGPISGLSSHKVPGAVDFSHLFLTSSFDWTVKLWSGRDSGSRPLHSFEDNGDYVYD 360
+E HLGPI+G+S+H + DF HLFLTSS DWT+KLWS +D+ +PL+SFEDN DYV D
Sbjct: 506 YERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKDT--KPLYSFEDNSDYVMD 563
Query: 361 VAWSPVHPAVFASVDGQGLLDIWKLTADTEVPISRTQVNPMTALNKCSWHKTGAHVAVGD 540
VAWSPVHPA+FA+VDG G LD+W L DTEVP + V ALN+ SW +G HV +GD
Sbjct: 564 VAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGD 623
Query: 541 DSGRISIMDVNEQLYQPSSSAWSDLSHTLTELQLASAD 654
++G++ + DV E L QPS WS + L+E+++ +D
Sbjct: 624 EAGKLYVYDVAENLAQPSRDEWSRFNTHLSEIKMNQSD 661
>sp|P54703|DYIN_DICDI Dynein intermediate chain, cytosolic (DH IC) (Cytoplasmic dynein
intermediate chain)
Length = 652
Score = 159 bits (402), Expect = 8e-39
Identities = 79/193 (40%), Positives = 119/193 (61%)
Frame = +1
Query: 58 SIAVTCMDFLSNDVNNFLVGSEDGMVYPGIRHGGKAGLSEGFEGHLGPISGLSSHKVPGA 237
SIAVT + F N++N+F +G+E+G++ RHG + ++E ++ LGPI+ + H G
Sbjct: 446 SIAVTSLVFPENELNHFYIGTEEGVICQAGRHGNRIVMNERYK-ELGPITSVDLHPSKGG 504
Query: 238 VDFSHLFLTSSFDWTVKLWSGRDSGSRPLHSFEDNGDYVYDVAWSPVHPAVFASVDGQGL 417
DFS FL+SS DWT KLWS + PL+SFED DYVYD WSPVHP++F++ DG G
Sbjct: 505 ADFSQYFLSSSTDWTCKLWSSKKE--TPLYSFEDYVDYVYDARWSPVHPSIFSTGDGSGT 562
Query: 418 LDIWKLTADTEVPISRTQVNPMTALNKCSWHKTGAHVAVGDDSGRISIMDVNEQLYQPSS 597
L +W L D E PI R +++ ++N+ +W G + VGD G +S+ D +E P+S
Sbjct: 563 LSLWDLNQDLEGPIFRHKIS-NRSVNRLAWSHDGKRILVGDSGGSLSLFDSSE-FSSPTS 620
Query: 598 SAWSDLSHTLTEL 636
+S +T++
Sbjct: 621 EEYSQFEDVMTKM 633
>sp|P27766|DYI3_CHLRE Dynein, 70 kDa intermediate chain, flagellar outer arm (IC69)
(IC70)
Length = 567
Score = 74.3 bits (181), Expect = 4e-13
Identities = 53/210 (25%), Positives = 97/210 (46%), Gaps = 4/210 (1%)
Frame = +1
Query: 1 LRMLNAPSETREFSVKQAKS-IAVTCMDFLSN-DVNNFLVGSEDGMVYPGIRHGGKA--G 168
LR +N E K +++ + C+++ +N NF+VG+E G ++ R
Sbjct: 294 LRKMNECVENMPLKEKNSETTVGGVCLEYDTNAGPTNFMVGTEQGQIFSCNRKAKNPVDR 353
Query: 169 LSEGFEGHLGPISGLSSHKVPGAVDFSHLFLTSSFDWTVKLWSGRDSGSRPLHSFEDNGD 348
+ GH GPI GL + F+ + S DWT ++W + P+ + + +
Sbjct: 354 VKYVLSGHHGPIYGLRRNP------FNSKYFLSIGDWTARVWVEDTAVKTPILTTKYHPT 407
Query: 349 YVYDVAWSPVHPAVFASVDGQGLLDIWKLTADTEVPISRTQVNPMTALNKCSWHKTGAHV 528
Y+ WSP P VF ++ G +D+W L P QV+ + AL + ++G V
Sbjct: 408 YLTGGTWSPSRPGVFFTIKMDGAMDVWDLYYKHNEPTLTVQVSDL-ALTAFAVQESGGTV 466
Query: 529 AVGDDSGRISIMDVNEQLYQPSSSAWSDLS 618
AVG G S++ ++ L + S + ++++
Sbjct: 467 AVGTSDGCTSVLQLSTGLSEASPAEKANIN 496
>sp|Q16959|DYI2_ANTCR Dynein intermediate chain 2, ciliary
Length = 702
Score = 70.1 bits (170), Expect = 7e-12
Identities = 58/198 (29%), Positives = 93/198 (46%), Gaps = 3/198 (1%)
Frame = +1
Query: 70 TCMDFLSNDVNNFLVGSEDGMVYPGIRHGGKAGLSEGFEGHLGPISGLSSHKVPGAVDFS 249
TC DF FLVG+E+G ++ + L + FE H ++ +KV
Sbjct: 499 TCFDFHKQTDYLFLVGTEEGKIHKCSKAYSSQFL-DTFEAH-----HMAVYKVMWNHFHP 552
Query: 250 HLFLTSSFDWTVKLWSGRDSGSRPLHSFEDNGDYVYDVAWSPVHPAVFASVDGQGLLDIW 429
+F++ S DW+VK+W + P+ +F D G V DVAW+P VFA+V G + ++
Sbjct: 553 KIFISCSADWSVKIWD-HTYRNGPMFTF-DLGSAVGDVAWAPYSSTVFAAVTADGKVHVF 610
Query: 430 KLTADTEVPISRTQV--NPMTALNKCSWHKTGAHVAVGDDSGRISIMDVNEQLYQ-PSSS 600
L + PI V T L +++ V VGDD G +S + ++ L + P
Sbjct: 611 DLNLNKYEPICEQAVVQKKKTKLTHITFNPNFPIVLVGDDRGYVSSLKLSPNLRKVPKDK 670
Query: 601 AWSDLSHTLTELQLASAD 654
+ L+H E ++A D
Sbjct: 671 KGAALNHG-PEAEIAKMD 687
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,973,638
Number of Sequences: 369166
Number of extensions: 2230716
Number of successful extensions: 6582
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6102
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6536
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7570361805
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)