Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_J06
(672 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Z319|CORIN_MOUSE Atrial natriuteric peptide-converting... 46 1e-04
sp|Q9Y5Q5|CORIN_HUMAN Atrial natriuteric peptide-converting... 44 5e-04
sp|P98158|LRP2_RAT Low-density lipoprotein receptor-related... 42 0.001
sp|Q8IU80|TMPS6_HUMAN Transmembrane protease, serine 6 (Mat... 36 0.011
sp|P98074|ENTK_PIG Enteropeptidase precursor (Enterokinase)... 39 0.016
sp|P98164|LRP2_HUMAN Low-density lipoprotein receptor-relat... 39 0.016
sp|Q04833|LRP_CAEEL Low-density lipoprotein receptor-relate... 37 0.036
sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contai... 37 0.036
sp|Q9JI18|LRP1B_MOUSE Low-density lipoprotein receptor-rela... 36 0.080
sp|P35950|LDLR_CRIGR Low-density lipoprotein receptor precu... 36 0.10
>sp|Q9Z319|CORIN_MOUSE Atrial natriuteric peptide-converting enzyme (pro-ANP-converting
enzyme) (Corin) (Low density lipoprotein
receptor-related protein 4)
Length = 1113
Score = 45.8 bits (107), Expect = 1e-04
Identities = 18/34 (52%), Positives = 20/34 (58%)
Frame = +1
Query: 103 GCPERAPWPCKTPGKCLSFDFICDGEPDCPEKYD 204
GC ERA W C +CL ICDG PDCP+ D
Sbjct: 683 GCKERALWECPFNKQCLKHTLICDGFPDCPDSMD 716
Score = 31.2 bits (69), Expect = 2.6
Identities = 9/21 (42%), Positives = 17/21 (80%)
Frame = +1
Query: 142 GKCLSFDFICDGEPDCPEKYD 204
G+C++ +++CDG+ DC +K D
Sbjct: 421 GRCIAAEWVCDGDHDCVDKSD 441
Score = 29.3 bits (64), Expect = 9.7
Identities = 10/21 (47%), Positives = 13/21 (61%)
Frame = +1
Query: 142 GKCLSFDFICDGEPDCPEKYD 204
GKCL + +CDG DC + D
Sbjct: 384 GKCLHYSLLCDGYDDCGDPSD 404
>sp|Q9Y5Q5|CORIN_HUMAN Atrial natriuteric peptide-converting enzyme (pro-ANP-converting
enzyme) (Corin) (Heart-specific serine proteinase ATC2)
(Transmembrane protease, serine 10)
Length = 1042
Score = 43.5 bits (101), Expect = 5e-04
Identities = 17/34 (50%), Positives = 20/34 (58%)
Frame = +1
Query: 103 GCPERAPWPCKTPGKCLSFDFICDGEPDCPEKYD 204
GC ER W C + +CL ICDG PDCP+ D
Sbjct: 615 GCKERDLWECPSNKQCLKHTVICDGFPDCPDYMD 648
Score = 32.0 bits (71), Expect = 1.5
Identities = 9/21 (42%), Positives = 17/21 (80%)
Frame = +1
Query: 142 GKCLSFDFICDGEPDCPEKYD 204
G+C++ +++CDG+ DC +K D
Sbjct: 353 GRCIAMEWVCDGDHDCVDKSD 373
Score = 30.8 bits (68), Expect = 3.3
Identities = 16/47 (34%), Positives = 24/47 (51%)
Frame = +1
Query: 64 FNIFEKRESKAGNGCPERAPWPCKTPGKCLSFDFICDGEPDCPEKYD 204
+N + +A C E + C T GKCL++ +CDG DC + D
Sbjct: 292 YNDCDDWSDEAHCNCSENL-FHCHT-GKCLNYSLVCDGYDDCGDLSD 336
>sp|P98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 precursor
(Megalin) (Glycoprotein 330) (gp330)
Length = 4660
Score = 42.4 bits (98), Expect = 0.001
Identities = 15/27 (55%), Positives = 18/27 (66%)
Frame = +1
Query: 124 WPCKTPGKCLSFDFICDGEPDCPEKYD 204
W C G+C+S D +CDG PDCPE D
Sbjct: 270 WACPGSGRCISIDKVCDGVPDCPEGDD 296
Score = 40.0 bits (92), Expect = 0.006
Identities = 21/72 (29%), Positives = 33/72 (45%), Gaps = 7/72 (9%)
Frame = +1
Query: 61 CFNIFEKRESKAGNGCPERAP-------WPCKTPGKCLSFDFICDGEPDCPEKYD*DAAL 219
C +++ R++ GCP R P + C+ G C+ + CDG PDC D +
Sbjct: 1208 CDGVYDCRDNSDEAGCPTRPPGMCHPDEFQCQGDGTCIPNTWECDGHPDCIHGSD-EHTG 1266
Query: 220 CIAKDRPPAVFM 255
C+ K P F+
Sbjct: 1267 CVPKTCSPTHFL 1278
Score = 31.2 bits (69), Expect = 2.6
Identities = 14/39 (35%), Positives = 19/39 (48%)
Frame = +1
Query: 106 CPERAPWPCKTPGKCLSFDFICDGEPDCPEKYD*DAALC 222
CP W C C++ +CDG DCP D ++ LC
Sbjct: 1313 CPS-TQWQCPGYSTCINLSALCDGVFDCPNGTD-ESPLC 1349
Score = 30.0 bits (66), Expect = 5.7
Identities = 10/23 (43%), Positives = 17/23 (73%)
Frame = +1
Query: 142 GKCLSFDFICDGEPDCPEKYD*D 210
G+C+S +++CDG+ DC + D D
Sbjct: 2918 GRCISGNWVCDGDNDCGDMSDED 2940
Score = 30.0 bits (66), Expect = 5.7
Identities = 17/42 (40%), Positives = 22/42 (52%)
Frame = +1
Query: 97 GNGCPERAPWPCKTPGKCLSFDFICDGEPDCPEKYD*DAALC 222
G CP A + CK C+ +ICDGE DC + D + LC
Sbjct: 3841 GTYCPA-AMFECKNH-VCIQSFWICDGENDCVDGSDEEIHLC 3880
Score = 29.3 bits (64), Expect = 9.7
Identities = 9/23 (39%), Positives = 17/23 (73%)
Frame = +1
Query: 142 GKCLSFDFICDGEPDCPEKYD*D 210
G+C++ +++CDG+ DC + D D
Sbjct: 232 GQCINQNWVCDGDDDCQDSGDED 254
Score = 29.3 bits (64), Expect = 9.7
Identities = 17/51 (33%), Positives = 22/51 (43%), Gaps = 9/51 (17%)
Frame = +1
Query: 79 KRESKAGNGCPERAP---------WPCKTPGKCLSFDFICDGEPDCPEKYD 204
+R+ G P R P +PC GKC+ F CDG DC + D
Sbjct: 1006 QRDQMTCEGDPAREPPTQQCGSLSFPCNN-GKCVPSFFRCDGVDDCHDNSD 1055
Score = 29.3 bits (64), Expect = 9.7
Identities = 11/31 (35%), Positives = 17/31 (54%)
Frame = +1
Query: 130 CKTPGKCLSFDFICDGEPDCPEKYD*DAALC 222
C+T C+ F+CDG+ DC + D + C
Sbjct: 2830 CQTTNICVPRAFLCDGDNDCGDGSDENPIYC 2860
Score = 29.3 bits (64), Expect = 9.7
Identities = 10/25 (40%), Positives = 15/25 (60%)
Frame = +1
Query: 130 CKTPGKCLSFDFICDGEPDCPEKYD 204
C +P +C+ + CDGE DC + D
Sbjct: 2872 CLSPQRCIPSYWFCDGEADCADGSD 2896
>sp|Q8IU80|TMPS6_HUMAN Transmembrane protease, serine 6 (Matriptase-2)
Length = 802
Score = 35.8 bits (81), Expect(2) = 0.011
Identities = 13/28 (46%), Positives = 17/28 (60%)
Frame = +1
Query: 106 CPERAPWPCKTPGKCLSFDFICDGEPDC 189
C RA + CK C+S +CDG+PDC
Sbjct: 480 CVCRATFQCKEDSTCISLPKVCDGQPDC 507
Score = 22.3 bits (46), Expect(2) = 0.011
Identities = 8/18 (44%), Positives = 10/18 (55%)
Frame = +1
Query: 169 CDGEPDCPEKYD*DAALC 222
CDG PDC + D + C
Sbjct: 542 CDGRPDCRDGSDEEHCDC 559
>sp|P98074|ENTK_PIG Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic mini chain; Enteropeptidase non-catalytic
heavy chain; Enteropeptidase catalytic light chain]
Length = 1034
Score = 38.5 bits (88), Expect = 0.016
Identities = 14/32 (43%), Positives = 20/32 (62%)
Frame = +1
Query: 127 PCKTPGKCLSFDFICDGEPDCPEKYD*DAALC 222
PC KC++ D CDGE +CP+ D D+ +C
Sbjct: 205 PCADALKCIAVDLFCDGELNCPDGSDEDSKIC 236
>sp|P98164|LRP2_HUMAN Low-density lipoprotein receptor-related protein 2 precursor
(Megalin) (Glycoprotein 330) (gp330)
Length = 4655
Score = 38.5 bits (88), Expect = 0.016
Identities = 21/74 (28%), Positives = 34/74 (45%), Gaps = 7/74 (9%)
Frame = +1
Query: 52 SSECFNIFEKRESKAGNGCPERAP-------WPCKTPGKCLSFDFICDGEPDCPEKYD*D 210
++ C +F+ ++ GCP R P + C+ G C+ + CDG PDC D +
Sbjct: 1204 TNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSD-E 1262
Query: 211 AALCIAKDRPPAVF 252
C+ K P + F
Sbjct: 1263 HNACVPKTCPSSYF 1276
Score = 34.3 bits (77), Expect = 0.30
Identities = 12/27 (44%), Positives = 16/27 (59%)
Frame = +1
Query: 124 WPCKTPGKCLSFDFICDGEPDCPEKYD 204
W C G+C+S +CDG DCP + D
Sbjct: 271 WSCPESGRCISIYKVCDGILDCPGRED 297
Score = 30.4 bits (67), Expect = 4.4
Identities = 16/47 (34%), Positives = 23/47 (48%), Gaps = 13/47 (27%)
Frame = +1
Query: 142 GKCLSFDFICDGEPDCPEKYD*DAA-------------LCIAKDRPP 243
G+C+ ++ICDG+ DC + D D LC+ DRPP
Sbjct: 2916 GRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCV-NDRPP 2961
Score = 30.0 bits (66), Expect = 5.7
Identities = 15/41 (36%), Positives = 20/41 (48%), Gaps = 3/41 (7%)
Frame = +1
Query: 109 PERAP---WPCKTPGKCLSFDFICDGEPDCPEKYD*DAALC 222
P R P W C C++ +CDG DCP D ++ LC
Sbjct: 1309 PFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTD-ESPLC 1348
Score = 29.6 bits (65), Expect = 7.5
Identities = 10/23 (43%), Positives = 16/23 (69%)
Frame = +1
Query: 142 GKCLSFDFICDGEPDCPEKYD*D 210
G+C+ +++CDGE DC + D D
Sbjct: 232 GRCIYQNWVCDGEDDCKDNGDED 254
Score = 29.3 bits (64), Expect = 9.7
Identities = 16/53 (30%), Positives = 24/53 (45%), Gaps = 5/53 (9%)
Frame = +1
Query: 61 CFNIFEKRESKAGNGCPERAPWP-----CKTPGKCLSFDFICDGEPDCPEKYD 204
C + + R++ GC ER P CK C+ + CDG+ DC + D
Sbjct: 3699 CNGVDDCRDNSDEQGCEERTCHPVGDFRCKNH-HCIPLRWQCDGQNDCGDNSD 3750
>sp|Q04833|LRP_CAEEL Low-density lipoprotein receptor-related protein precursor (LRP)
Length = 4753
Score = 37.4 bits (85), Expect = 0.036
Identities = 15/41 (36%), Positives = 23/41 (56%), Gaps = 2/41 (4%)
Frame = +1
Query: 121 PW--PCKTPGKCLSFDFICDGEPDCPEKYD*DAALCIAKDR 237
PW C G+C+ F CDG+ DC ++ D LC++ +R
Sbjct: 3711 PWMFKCAATGRCIPRRFTCDGDDDCGDRSDEADTLCMSAER 3751
Score = 34.3 bits (77), Expect = 0.30
Identities = 16/45 (35%), Positives = 22/45 (48%)
Frame = +1
Query: 106 CPERAPWPCKTPGKCLSFDFICDGEPDCPEKYD*DAALCIAKDRP 240
C + + C T GKC+ ++CD E DC + D A C RP
Sbjct: 3833 CDDVGEFRCATSGKCIPRRWMCDTENDCGDNSDELDASCGGTTRP 3877
Score = 31.2 bits (69), Expect = 2.6
Identities = 12/37 (32%), Positives = 18/37 (48%)
Frame = +1
Query: 130 CKTPGKCLSFDFICDGEPDCPEKYD*DAALCIAKDRP 240
C+ KC+ + CDG+ DC + D D C +P
Sbjct: 1108 CRNTKKCIPAQYGCDGDNDCGDYSDEDVKYCKDGQKP 1144
Score = 30.4 bits (67), Expect = 4.4
Identities = 12/20 (60%), Positives = 14/20 (70%)
Frame = +1
Query: 145 KCLSFDFICDGEPDCPEKYD 204
KC+S FICDGE DC + D
Sbjct: 3018 KCISRAFICDGEDDCGDGSD 3037
Score = 30.0 bits (66), Expect = 5.7
Identities = 14/56 (25%), Positives = 27/56 (48%)
Frame = +1
Query: 55 SECFNIFEKRESKAGNGCPERAPWPCKTPGKCLSFDFICDGEPDCPEKYD*DAALC 222
++C + +++ GN + C G+C+ ++CDG+ DC + D D C
Sbjct: 1169 NDCGDGSDEKLEMCGNATCAANQFSCAN-GRCIPIYWLCDGDNDCYDGTDEDKERC 1223
>sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1069
Score = 37.4 bits (85), Expect = 0.036
Identities = 14/32 (43%), Positives = 18/32 (56%)
Frame = +1
Query: 127 PCKTPGKCLSFDFICDGEPDCPEKYD*DAALC 222
PC C++ D CDGE +CP+ D D LC
Sbjct: 235 PCAHAWNCVATDLFCDGEVNCPDGSDEDTGLC 266
>sp|Q9JI18|LRP1B_MOUSE Low-density lipoprotein receptor-related protein 1B precursor
(Low-density lipoprotein receptor-related protein-deleted
in tumor) (LRP-DIT)
Length = 4599
Score = 36.2 bits (82), Expect = 0.080
Identities = 13/44 (29%), Positives = 26/44 (59%), Gaps = 4/44 (9%)
Frame = +1
Query: 85 ESKAGNG----CPERAPWPCKTPGKCLSFDFICDGEPDCPEKYD 204
+ K NG C + + C++ G+C++ ++CDG+ DC ++ D
Sbjct: 1084 DEKGCNGTIRLCDHKTKFSCRSTGRCINNAWVCDGDVDCEDQSD 1127
Score = 33.9 bits (76), Expect = 0.40
Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 4/37 (10%)
Frame = +1
Query: 106 CPERAPWP----CKTPGKCLSFDFICDGEPDCPEKYD 204
CPE + P CKT C+S ++CD +PDC + D
Sbjct: 3431 CPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASD 3467
Score = 33.5 bits (75), Expect = 0.52
Identities = 12/31 (38%), Positives = 18/31 (58%)
Frame = +1
Query: 130 CKTPGKCLSFDFICDGEPDCPEKYD*DAALC 222
C C+S ++CDG+PDCP++ D C
Sbjct: 39 CHDHVTCVSQSWLCDGDPDCPDQSDESLDTC 69
Score = 32.3 bits (72), Expect = 1.1
Identities = 12/26 (46%), Positives = 17/26 (65%)
Frame = +1
Query: 145 KCLSFDFICDGEPDCPEKYD*DAALC 222
KC+S +ICDGE DC + D ++C
Sbjct: 2731 KCISKHWICDGEDDCGDSLDESDSIC 2756
Score = 32.0 bits (71), Expect = 1.5
Identities = 12/33 (36%), Positives = 17/33 (51%)
Frame = +1
Query: 106 CPERAPWPCKTPGKCLSFDFICDGEPDCPEKYD 204
CP P+ C+ CL + IC+G DC + D
Sbjct: 3715 CPPTRPYRCRNDRICLQLEKICNGINDCGDNSD 3747
Score = 30.4 bits (67), Expect = 4.4
Identities = 16/52 (30%), Positives = 25/52 (48%)
Frame = +1
Query: 49 YSSECFNIFEKRESKAGNGCPERAPWPCKTPGKCLSFDFICDGEPDCPEKYD 204
+S E K E+++ GC + C+ G C+ + CDGE DC + D
Sbjct: 1034 FSDETHINCTKEEARSPAGCIGNE-FQCRPDGNCIPDLWRCDGEKDCEDGSD 1084
Score = 29.6 bits (65), Expect = 7.5
Identities = 13/49 (26%), Positives = 24/49 (48%)
Frame = +1
Query: 58 ECFNIFEKRESKAGNGCPERAPWPCKTPGKCLSFDFICDGEPDCPEKYD 204
+C + ++ +S G + C+ C+ ++CDGE DCP+ D
Sbjct: 2744 DCGDSLDESDSICGAVTCAADMFSCQGSHACVPQHWLCDGERDCPDGSD 2792
>sp|P35950|LDLR_CRIGR Low-density lipoprotein receptor precursor (LDL receptor)
Length = 854
Score = 35.8 bits (81), Expect = 0.10
Identities = 13/39 (33%), Positives = 25/39 (64%)
Frame = +1
Query: 112 ERAPWPCKTPGKCLSFDFICDGEPDCPEKYD*DAALCIA 228
+R + C+ GKC++ ++CDG P+CP+ D + C++
Sbjct: 28 DRNEFRCRD-GKCIASKWVCDGSPECPDGSDESSETCMS 65
Score = 30.0 bits (66), Expect = 5.7
Identities = 16/37 (43%), Positives = 20/37 (54%)
Frame = +1
Query: 142 GKCLSFDFICDGEPDCPEKYD*DAALCIAKDRPPAVF 252
GKC+S F+CD + DC + D A C A PA F
Sbjct: 119 GKCISQKFVCDQDQDCVDGS--DEAHCQAATCGPAHF 153
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,283,057
Number of Sequences: 369166
Number of extensions: 1574675
Number of successful extensions: 5515
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4943
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5510
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5636246860
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)