Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_I11
(869 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P16086|SPTA2_RAT Spectrin alpha chain, brain (Spectrin, ... 355 7e-98
sp|Q13813|SPTA2_HUMAN Spectrin alpha chain, brain (Spectrin... 355 1e-97
sp|P07751|SPTA2_CHICK Spectrin alpha chain, brain (Spectrin... 353 4e-97
sp|P13395|SPTCA_DROME Spectrin alpha chain 323 4e-88
sp|P08032|SPTA1_MOUSE Spectrin alpha chain, erythrocyte (Er... 244 2e-64
sp|P16546|SPTA2_MOUSE Spectrin alpha chain, brain (Spectrin... 242 1e-63
sp|P02549|SPTA1_HUMAN Spectrin alpha chain, erythrocyte (Er... 234 2e-61
sp|Q01082|SPTB2_HUMAN Spectrin beta chain, brain 1 (Spectri... 192 8e-49
sp|Q00963|SPTCB_DROME Spectrin beta chain 175 2e-43
sp|Q9QWN8|SPTN2_RAT Spectrin beta chain, brain 2 (Spectrin,... 167 5e-41
>sp|P16086|SPTA2_RAT Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Alpha-II spectrin) (Fodrin alpha chain)
Length = 2472
Score = 355 bits (912), Expect = 7e-98
Identities = 173/288 (60%), Positives = 219/288 (76%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ A+++K L +A+ QQQF RNVED+E+WL EVE L SDD GKDL +V NLQKKH L
Sbjct: 663 LLEATELKGVKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHAL 722
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
LE+D+++HQDRID QA QF HFDA+ IKKKQ + RY L+EP+ RK KL D
Sbjct: 723 LEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
+ +L Q +RD +DEE WI EKEPIA STN G+DLIGVQNL+KKHQA+QAE+ GHEPRI
Sbjct: 783 SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
V +G M++ H+A D++ K+ ++ W LK KA +RRQ L+DSL+AQQY ADA+EA
Sbjct: 843 VTQKGNAMVEEGHFAAEDVKAKLSELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
ESWMREKEP+VGST++GKDEDS EALLKKH+ALM+D+ AY S+I +LR
Sbjct: 903 ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALR 950
Score = 242 bits (617), Expect = 1e-63
Identities = 118/287 (41%), Positives = 179/287 (62%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
LV S K L +A+ QQ F ++D + WL+EVE+ L S+D GKDL SV NL KKH L
Sbjct: 1643 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQL 1702
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
LE+DIS+H+DR+ QAD + + FD +K+K+ + R+ K++ R+ KL++
Sbjct: 1703 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSE 1762
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
+++LHQF+RD DDEE WI EK+ + S + GRDL GVQNL KKH+ ++AE+ HEP I
Sbjct: 1763 SHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1822
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
V + G+K+ D N +I++++ W +LK A R Q L++SLE QQ++A+ E
Sbjct: 1823 VLDTGKKLSDDNTIGQEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1882
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E+W+ EK LV S ++G + + LLKKH+A D ++ ++ +
Sbjct: 1883 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDV 1929
Score = 169 bits (427), Expect = 1e-41
Identities = 91/280 (32%), Positives = 155/280 (55%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
+ L + QQF R+ ++++ W+ E + + +D+ KD +++ +KH E+++S+
Sbjct: 565 RRAQLADSFHLQQFFRDSDELKSWVNE-KMKTATDEAYKDPSNLQGKVQKHQAFEAELSA 623
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
+Q RID+ + + + NH+ + + + EV + + KL E E + KL +A + QF
Sbjct: 624 NQSRIDALEKAGQKLIDVNHYAKEEVAARMNEVISLWKKLLEATELKGVKLREANQQQQF 683
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
R+ +D E W++E E S + G+DL VQNL KKH ++A+V H+ RI + + ++
Sbjct: 684 NRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQ 743
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
D H+ +I+KK + + + LK R+Q L DSL QQ D + E+W+REK
Sbjct: 744 FQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREK 803
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
EP+ ST GKD + LLKKH AL A+I + I ++
Sbjct: 804 EPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAV 843
Score = 166 bits (420), Expect = 8e-41
Identities = 82/279 (29%), Positives = 154/279 (55%)
Frame = +2
Query: 11 SASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLE 190
S + + L+++ QF R+++D E W+ E + + S+D G+DL V NL+KKH LE
Sbjct: 1751 SMATSRRAKLSESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLE 1810
Query: 191 SDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAY 370
+++++H+ I L + DN + I+++ + + +L++ R +L ++
Sbjct: 1811 AELAAHEPAIQGVLDTGKKLSDDNTIGQEEIQQRLAQFVEHWKELKQLAAARGQRLEESL 1870
Query: 371 KLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVC 550
+ QF + ++EE WI+EK + S + G L +Q L+KKH+A + + T H+ R+ +VC
Sbjct: 1871 EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVC 1930
Query: 551 NEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAES 730
GQ +I N++ +I K+ + SDL+ A +R+ LD++ Q+ A ES
Sbjct: 1931 TNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVES 1990
Query: 731 WMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYR 847
W+ EKE + + ++G+D S + LL K + A ++A++
Sbjct: 1991 WIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQ 2029
Score = 165 bits (417), Expect = 2e-40
Identities = 86/286 (30%), Positives = 156/286 (54%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ + K L QA Q++R ED+ W+ + E+ + S++ G+DL V LQKK
Sbjct: 134 LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
++D+++H++R++ Q A + + + H + + IK KQ EV + +L+ +R+ KL
Sbjct: 194 FQTDLAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQEEVNAAWQRLKGLALQRQGKLFG 253
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
A ++ +F RD D+ WI EKE + S + GRDL VQ L++KH+ ++ ++ E ++
Sbjct: 254 AAEVQRFNRDVDETIGWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
+C E ++ + + I+ K +++ W ++ A +R LDDS Q++LAD +
Sbjct: 314 LCAEADRLQQSHPLSANQIQVKREELITNWEQIRTLAAERHARLDDSYRLQRFLADFRDL 373
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDS 862
SW+ E + L+ + E D EALL +H +I+A+ + S
Sbjct: 374 TSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFKS 419
Score = 161 bits (407), Expect = 3e-39
Identities = 83/287 (28%), Positives = 163/287 (56%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ +++ Q Q F R+ E ++ W+++ E+ L ++D G L+SV L KKH
Sbjct: 452 LLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
E +S+ +++I + + A + + +NH+ + + ++ + +R + L E R+ +L D
Sbjct: 512 FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMHRRAQLAD 571
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
++ L QF+RD+D+ + W++EK A + +D +Q ++KHQA +AE++ ++ RI
Sbjct: 572 SFHLQQFFRDSDELKSWVNEKMKTA-TDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDA 630
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
+ GQK+ID NHYA ++ +++++ +LW L + + L ++ + QQ+ + +
Sbjct: 631 LEKAGQKLIDVNHYAKEEVAARMNEVISLWKKLLEATELKGVKLREANQQQQFNRNVEDI 690
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E W+ E E + S ++GKD + + L KKH L AD+ A++ ID +
Sbjct: 691 ELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGI 737
Score = 153 bits (386), Expect = 7e-37
Identities = 86/283 (30%), Positives = 152/283 (53%)
Frame = +2
Query: 17 SKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESD 196
S ++ L + Q F R+ E++E W+ E + Q+ SD+ KD ++ +KH E++
Sbjct: 33 STLRRQKLEDSYRFQFFQRDAEELEKWIQE-KLQVASDENYKDPTNLQGKLQKHQAFEAE 91
Query: 197 ISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKL 376
+ ++ I + + + + HF ++ I+ + +E+ ++ L E + ++ KL A KL
Sbjct: 92 VQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKL 151
Query: 377 HQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNE 556
Q+ R+ +D DWI++KE I S +G+DL V+ L KK + Q ++ HE R+ EV
Sbjct: 152 VQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQF 211
Query: 557 GQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWM 736
K+I H I+ K +++ W LK A +R+ L + E Q++ D E W+
Sbjct: 212 AAKLIQEQHPEEELIKTKQEEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIGWI 271
Query: 737 REKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
+EKE L+ S +FG+D S +ALL+KH+ L D+ A + +L
Sbjct: 272 KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKAL 314
Score = 151 bits (381), Expect = 3e-36
Identities = 77/282 (27%), Positives = 151/282 (53%), Gaps = 2/282 (0%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
K + L ++ QQF R+V+++E W++E + Q SD+ KD ++ + +KH E+++ +
Sbjct: 1543 KRSKLGESQTLQQFSRDVDEIEAWISE-KLQTASDESYKDPTNIQSKHQKHQAFEAELHA 1601
Query: 206 HQDRIDSFLQQADQFVHDNHF--DADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLH 379
+ DRI + + + DA+K + + +++ L + ++ KL +A K
Sbjct: 1602 NADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQ 1661
Query: 380 QFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEG 559
F D + W+ E E + S + G+DL V NL+KKHQ ++A+++ HE R+ ++ ++
Sbjct: 1662 NFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQA 1721
Query: 560 QKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMR 739
++ + + +++K D + + +K+ A RR L +S Q+ D + ESW++
Sbjct: 1722 DSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSESHRLHQFFRDMDDEESWIK 1781
Query: 740 EKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
EK+ LV S ++G+D + L KKH L A++ A+ I +
Sbjct: 1782 EKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGV 1823
Score = 149 bits (375), Expect = 1e-35
Identities = 76/280 (27%), Positives = 147/280 (52%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ L A+ Q+F R+V++ W+ E E + SDD G+DL SV L +KH LE D+++
Sbjct: 247 RQGKLFGAAEVQRFNRDVDETIGWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAA 306
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
+D++ + +AD+ + A+ I+ K+ E+ + +++ +R +L+D+Y+L +F
Sbjct: 307 LEDKVKALCAEADRLQQSHPLSANQIQVKREELITNWEQIRTLAAERHARLDDSYRLQRF 366
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
D D W+ E + + + + D+ G + L+ +HQ + E+ HE GQ
Sbjct: 367 LADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQA 426
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
++ HYA+ ++ +K+ + + L + RRQ + ++ Q + D + ++WM ++
Sbjct: 427 LLAAGHYASDEVREKLSILSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQ 486
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E + + + G DS EALLKKH+ + A I +L
Sbjct: 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITAL 526
Score = 146 bits (369), Expect = 6e-35
Identities = 81/277 (29%), Positives = 147/277 (53%)
Frame = +2
Query: 38 LTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDR 217
L A Q+F R+ ++ + W+ E L +D+ G DL SV LQ+KH E D+++ D+
Sbjct: 1229 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 1288
Query: 218 IDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDA 397
++S + A + + + A+ +K+K E+ ++ L + ++RK KL D++ L +F D
Sbjct: 1289 VNSLGETAQRLIQSHPESAEDLKEKCTELNQAWTSLGKRADQRKAKLGDSHDLQRFLSDF 1348
Query: 398 DDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDG 577
D WI+ + S + +D+ G + L+++HQ + E+ GQ+++
Sbjct: 1349 RDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH 1408
Query: 578 NHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLV 757
HYA+ +I++K+D + +DL+ +RR +LD LE Q + D +AE+WM +E +
Sbjct: 1409 GHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDHCLELQLFHRDCEQAENWMAAREAFL 1468
Query: 758 GSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
+ + G DS EAL+KKH+ I I +L+
Sbjct: 1469 NTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQ 1505
Score = 132 bits (333), Expect = 1e-30
Identities = 77/322 (23%), Positives = 153/322 (47%), Gaps = 36/322 (11%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ + ++ L ++ + R +++ W+ E E+ L S++ G DL V LQKK +
Sbjct: 1076 LLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDD 1135
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHF--DADAIKKKQI-------------------- 298
+ D+ +++ R+ + A+ + + A++++++
Sbjct: 1136 FQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDEADSKTASPWKSA 1195
Query: 299 --------------EVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPI 436
E+ R+ LQ+ E+R L A+++ +F+RDAD+ ++WI EK
Sbjct: 1196 RLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQA 1255
Query: 437 AGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKID 616
+ N G DL VQ L +KH+ + ++ ++ + Q++I + + D+++K
Sbjct: 1256 LNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAQRLIQSHPESAEDLKEKCT 1315
Query: 617 DMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTE 796
++ W+ L +AD+R+ L DS + Q++L+D + SW+ LV S E KD E
Sbjct: 1316 ELNQAWTSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAE 1375
Query: 797 ALLKKHDALMADIEAYRSTIDS 862
ALL++H +I+A T +
Sbjct: 1376 ALLERHQEHRTEIDARAGTFQA 1397
Score = 132 bits (332), Expect = 1e-30
Identities = 71/269 (26%), Positives = 136/269 (50%)
Frame = +2
Query: 59 QQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQ 238
Q+F+ + D+ W+ E+++ + +D+ D+ L +H + +I +H+D S +
Sbjct: 364 QRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFKSADES 423
Query: 239 ADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWI 418
+ H+ +D +++K + + L E E R+ + L FYRD + ++W+
Sbjct: 424 GQALLAAGHYASDEVREKLSILSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWM 483
Query: 419 HEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD 598
++E + ++G L V+ L+KKH+ + ++ E +I + K+I NHYA D
Sbjct: 484 SKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMED 543
Query: 599 IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGK 778
+ + D + + + L +A RR L DS QQ+ D+ E +SW+ EK + E K
Sbjct: 544 VATRRDALLSRRNALHERAMHRRAQLADSFHLQQFFRDSDELKSWVNEKMK-TATDEAYK 602
Query: 779 DEDSTEALLKKHDALMADIEAYRSTIDSL 865
D + + ++KH A A++ A +S ID+L
Sbjct: 603 DPSNLQGKVQKHQAFEAELSANQSRIDAL 631
Score = 126 bits (316), Expect = 9e-29
Identities = 61/179 (34%), Positives = 104/179 (58%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ L + QQ R+VED E W+ E E S + GKDL V NL KKH L+++I+
Sbjct: 776 RKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAG 835
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
H+ RI + Q+ + V + HF A+ +K K E+ ++ L+ +R+ L D+ + Q+
Sbjct: 836 HEPRIKAVTQKGNAMVEEGHFAAEDVKAKLSELNQKWEALKAKASQRRQDLEDSLQAQQY 895
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQ 562
+ DA++ E W+ EKEPI GST+ G+D + L+KKH+A+ ++++ + I + + Q
Sbjct: 896 FADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQ 954
Score = 115 bits (289), Expect = 1e-25
Identities = 68/272 (25%), Positives = 131/272 (48%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ L + Q+F+ + D+ W+ + + SD+ KD+ L ++H ++I +
Sbjct: 1331 RKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDA 1390
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
+F Q Q + H+ + IK+K + + L++ +R+ L+ +L F
Sbjct: 1391 RAGTFQAFEQFGQQLLAHGHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDHCLELQLF 1450
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
+RD + E+W+ +E + + G L V+ LIKKH+ + E +I + +
Sbjct: 1451 HRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQ 1510
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
+I +HYA DI + +++ + W LK + ++R L +S QQ+ D E E+W+ EK
Sbjct: 1511 LIAVDHYAKGDIANRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEK 1570
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEA 841
S E KD + ++ +KH A A++ A
Sbjct: 1571 LQ-TASDESYKDPTNIQSKHQKHQAFEAELHA 1601
Score = 112 bits (281), Expect = 1e-24
Identities = 59/198 (29%), Positives = 106/198 (53%)
Frame = +2
Query: 272 ADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTN 451
A+ I++++ +V +RY + +E R+ KL D+Y+ F RDA++ E WI EK +A N
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQVASDEN 71
Query: 452 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNL 631
+D +Q ++KHQA +AEV + I+++ G MI H+A+ I ++ ++
Sbjct: 72 Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 632 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 811
W L K ++ L + + QYL + + W+ +KE +V S E G+D + E L KK
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 812 HDALMADIEAYRSTIDSL 865
+ D+ A+ ++ +
Sbjct: 191 FEEFQTDLAAHEERVNEV 208
Score = 110 bits (274), Expect = 7e-24
Identities = 77/293 (26%), Positives = 136/293 (46%), Gaps = 6/293 (2%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
+L + + L ++ QQF+ NVE+ E W+ E + + S+D G L ++ L KKH
Sbjct: 1854 ELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHE 1913
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
E+D + H+DR++ + N+ + I K + + S L++ +RK KL+
Sbjct: 1914 AFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLD 1973
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPR-I 538
+ QF AD E WI EKE + + GRDL VQ L+ K + A + + I
Sbjct: 1974 ENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGI 2033
Query: 539 LEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSD-LKNKADKRRQLLDDSLEAQQYLADA 715
+ +++ H ++ IE + + W+ L N A ++++L LEAQ +
Sbjct: 2034 ANITALKDQLLAAKHIQSKAIEARHASLMKRWTQLLANSATRKKKL----LEAQSHFRKV 2089
Query: 716 SEAESWMREKEPLVGSTEFGKDEDSTEAL----LKKHDALMADIEAYRSTIDS 862
+ +K S +ED T+ + L++ AL +A+RS++ S
Sbjct: 2090 EDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSS 2142
Score = 89.7 bits (221), Expect = 9e-18
Identities = 77/317 (24%), Positives = 134/317 (42%), Gaps = 41/317 (12%)
Frame = +2
Query: 38 LTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCG--KDLNSVTNLQKKHNLLESD--ISS 205
+T G + N + + W EV + G K L+ + ++ NLLE I+
Sbjct: 986 VTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRE-NLLEEQGSIAL 1044
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
Q +ID+ Q + +++ KQ+E Y L E EKRK L + K
Sbjct: 1045 RQGQIDN------QTRITKEAGSVSLRMKQVE--ELYQSLLELGEKRKGMLEKSCKKFML 1096
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
+R+A++ + WI+EKE S VG DL V+ L KK Q ++ +E R+ ++ N+ +
Sbjct: 1097 FREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDI-NKVAE 1155
Query: 566 MIDGNHYANRDIE-------------------------------------KKIDDMKNLW 634
++ +++ I ++ W
Sbjct: 1156 DLESEGLMAEEVQAVQQQEVYGMMPRDEADSKTASPWKSARLMVHTVATFNSIKELNERW 1215
Query: 635 SDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKH 814
L+ A++R QLL + E Q++ DA E + W+ EK + + +G D S +AL +KH
Sbjct: 1216 RSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKH 1275
Query: 815 DALMADIEAYRSTIDSL 865
+ D+ A ++SL
Sbjct: 1276 EGFERDLAALGDKVNSL 1292
>sp|Q13813|SPTA2_HUMAN Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Alpha-II spectrin) (Fodrin alpha chain)
Length = 2472
Score = 355 bits (910), Expect = 1e-97
Identities = 173/288 (60%), Positives = 219/288 (76%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ A+++K L +A+ QQQF RNVED+E+WL EVE L SDD GKDL +V NLQKKH L
Sbjct: 663 LLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHAL 722
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
LE+D+++HQDRID QA QF HFDA+ IKKKQ + RY L+EP+ RK KL D
Sbjct: 723 LEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
+ +L Q +RD +DEE WI EKEPIA STN G+DLIGVQNL+KKHQA+QAE+ GHEPRI
Sbjct: 783 SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
V +G M++ H+A D++ K+ ++ W LK KA +RRQ L+DSL+AQQY ADA+EA
Sbjct: 843 VTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
ESWMREKEP+VGST++GKDEDS EALLKKH+ALM+D+ AY S+I +LR
Sbjct: 903 ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALR 950
Score = 245 bits (626), Expect = 1e-64
Identities = 120/287 (41%), Positives = 179/287 (62%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
LV S K L +A+ QQ F ++D + WL+EVE+ L S+D GKDL SV NL KKH L
Sbjct: 1643 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQL 1702
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
LE+DIS+H+DR+ QAD + + FD +K K+ + R+ K++ R+ KLN+
Sbjct: 1703 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNE 1762
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
+++LHQF+RD DDEE WI EK+ + GS + GRDL GVQNL KKH+ ++AE+ HEP I
Sbjct: 1763 SHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1822
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
V + G+K+ D N +I++++ W +LK A R Q L++SLE QQ++A+ E
Sbjct: 1823 VLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1882
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E+W+ EK LV S ++G + + LLKKH+A D ++ ++ +
Sbjct: 1883 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDV 1929
Score = 170 bits (431), Expect = 4e-42
Identities = 92/280 (32%), Positives = 155/280 (55%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
+ L + QQF R+ ++++ W+ E + + +D+ KD +++ +KH E+++S+
Sbjct: 565 RRAQLADSFHLQQFFRDSDELKSWVNE-KMKTATDEAYKDPSNLQGKVQKHQAFEAELSA 623
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
+Q RID+ + + + NH+ D + + EV + + KL E E + KL +A + QF
Sbjct: 624 NQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQF 683
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
R+ +D E W++E E S + G+DL VQNL KKH ++A+V H+ RI + + ++
Sbjct: 684 NRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQ 743
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
D H+ +I+KK + + + LK R+Q L DSL QQ D + E+W+REK
Sbjct: 744 FQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREK 803
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
EP+ ST GKD + LLKKH AL A+I + I ++
Sbjct: 804 EPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAV 843
Score = 168 bits (425), Expect = 2e-41
Identities = 83/279 (29%), Positives = 154/279 (55%)
Frame = +2
Query: 11 SASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLE 190
S + + L ++ QF R+++D E W+ E + +GS+D G+DL V NL+KKH LE
Sbjct: 1751 SMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLE 1810
Query: 191 SDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAY 370
+++++H+ I L + DN + I+++ + + +L++ R +L ++
Sbjct: 1811 AELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESL 1870
Query: 371 KLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVC 550
+ QF + ++EE WI+EK + S + G L +Q L+KKH+A + + T H+ R+ +VC
Sbjct: 1871 EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVC 1930
Query: 551 NEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAES 730
GQ +I N++ +I K+ + SDL+ A +R+ LD++ Q+ A ES
Sbjct: 1931 TNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVES 1990
Query: 731 WMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYR 847
W+ EKE + + ++G+D S + LL K + A ++A++
Sbjct: 1991 WIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQ 2029
Score = 162 bits (411), Expect = 9e-40
Identities = 85/286 (29%), Positives = 156/286 (54%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ + K L QA Q++R ED+ W+ + E+ + S++ G+DL V LQKK
Sbjct: 134 LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
++D+++H++R++ Q A + + + H + + IK KQ EV + +L+ +R+ KL
Sbjct: 194 FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
A ++ +F RD D+ WI EKE + S + GRDL VQ L++KH+ ++ ++ E ++
Sbjct: 254 AAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
+C E ++ + + I+ K +++ W ++ A +R L+DS Q++LAD +
Sbjct: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDL 373
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDS 862
SW+ E + L+ + E D EALL +H +I+A+ + S
Sbjct: 374 TSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKS 419
Score = 161 bits (407), Expect = 3e-39
Identities = 83/287 (28%), Positives = 164/287 (57%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ +++ Q Q F R+ E ++ W+++ E+ L ++D G L+SV L KKH
Sbjct: 452 LLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
E +S+ +++I + + A + + +NH+ + + ++ + +R + L E +R+ +L D
Sbjct: 512 FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLAD 571
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
++ L QF+RD+D+ + W++EK A + +D +Q ++KHQA +AE++ ++ RI
Sbjct: 572 SFHLQQFFRDSDELKSWVNEKMKTA-TDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDA 630
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
+ GQK+ID NHYA ++ +++++ +LW L + + L ++ + QQ+ + +
Sbjct: 631 LEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDI 690
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E W+ E E + S ++GKD + + L KKH L AD+ A++ ID +
Sbjct: 691 ELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGI 737
Score = 156 bits (395), Expect = 6e-38
Identities = 88/283 (31%), Positives = 153/283 (54%)
Frame = +2
Query: 17 SKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESD 196
S ++ L + Q F R+ E++E W+ E + Q+ SD+ KD ++ +KH E++
Sbjct: 33 STLRRQKLEDSYRFQFFQRDAEELEKWIQE-KLQIASDENYKDPTNLQGKLQKHQAFEAE 91
Query: 197 ISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKL 376
+ ++ I + + + + HF ++ I+ + +E+ ++ L E + ++ KL A KL
Sbjct: 92 VQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKL 151
Query: 377 HQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNE 556
Q+ R+ +D DWI++KE I S +G+DL V+ L KK + Q ++ HE R+ EV
Sbjct: 152 VQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
Query: 557 GQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWM 736
K+I H I+ K D++ W LK A +R+ L + E Q++ D E SW+
Sbjct: 212 AAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWI 271
Query: 737 REKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
+EKE L+ S +FG+D S +ALL+KH+ L D+ A + +L
Sbjct: 272 KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKAL 314
Score = 152 bits (385), Expect = 9e-37
Identities = 78/282 (27%), Positives = 152/282 (53%), Gaps = 2/282 (0%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
K + L ++ QQF R+V+++E W++E + Q SD+ KD ++ + +KH E+++ +
Sbjct: 1543 KRSKLGESQTLQQFSRDVDEIEAWISE-KLQTASDESYKDPTNIQSKHQKHQAFEAELHA 1601
Query: 206 HQDRIDSFLQQADQFVHDNHF--DADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLH 379
+ DRI + + + DA+K + + +++ L + ++ KL +A K
Sbjct: 1602 NADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQ 1661
Query: 380 QFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEG 559
F D + W+ E E + S + G+DL V NL+KKHQ ++A+++ HE R+ ++ ++
Sbjct: 1662 NFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQA 1721
Query: 560 QKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMR 739
++ + + ++ K D + + +K+ A RR L++S Q+ D + ESW++
Sbjct: 1722 DSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIK 1781
Query: 740 EKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
EK+ LVGS ++G+D + L KKH L A++ A+ I +
Sbjct: 1782 EKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGV 1823
Score = 150 bits (378), Expect = 6e-36
Identities = 77/280 (27%), Positives = 146/280 (52%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ L A+ Q+F R+V++ W+ E E + SDD G+DL SV L +KH LE D+++
Sbjct: 247 RQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAA 306
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
+D++ + +AD+ + A I+ K+ E+ + +++ +R +LND+Y+L +F
Sbjct: 307 LEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRF 366
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
D D W+ E + + + + D+ G + L+ +HQ + E+ HE GQ
Sbjct: 367 LADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQA 426
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
++ HYA+ ++ +K+ + + L + RRQ + ++ Q + D + ++WM ++
Sbjct: 427 LLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQ 486
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E + + + G DS EALLKKH+ + A I +L
Sbjct: 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITAL 526
Score = 146 bits (368), Expect = 8e-35
Identities = 81/277 (29%), Positives = 147/277 (53%)
Frame = +2
Query: 38 LTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDR 217
L A Q+F R+ ++ + W+ E L +D+ G DL SV LQ+KH E D+++ D+
Sbjct: 1229 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 1288
Query: 218 IDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDA 397
++S + A++ + A+ +++K E+ +S L + ++RK KL D++ L +F D
Sbjct: 1289 VNSLGETAERLTQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDF 1348
Query: 398 DDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDG 577
D WI+ + S + +D+ G + L+++HQ + E+ GQ+++
Sbjct: 1349 RDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH 1408
Query: 578 NHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLV 757
HYA+ +I++K+D + +DL+ +RR +LD LE Q + D +AE+WM +E +
Sbjct: 1409 GHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFL 1468
Query: 758 GSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
+ + G DS EAL+KKH+ I I +L+
Sbjct: 1469 NTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQ 1505
Score = 141 bits (356), Expect = 2e-33
Identities = 88/290 (30%), Positives = 150/290 (51%), Gaps = 2/290 (0%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
DL A + L Q Q F R+ E E W+A E+ L ++D G L+SV L KKH
Sbjct: 1429 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE 1488
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
+ I+ +++I + ADQ + H+ I ++ EV +R+ +L+ + ++++KL
Sbjct: 1489 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG 1548
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRIL 541
++ L QF RD D+ E WI EK A + +D +Q+ +KHQA +AE+ + RI
Sbjct: 1549 ESQTLQQFSRDVDEIEAWISEKLQTASDESY-KDPTNIQSKHQKHQAFEAELHANADRIR 1607
Query: 542 EVCNEGQKMIDGNHYANRD--IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADA 715
V + G +I+ A + ++ ++ + + W L K+ ++ Q L ++ + Q +
Sbjct: 1608 GVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGI 1667
Query: 716 SEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
+ + W+ E E L+ S ++GKD S LLKKH L ADI A+ + L
Sbjct: 1668 KDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDL 1717
Score = 134 bits (338), Expect = 3e-31
Identities = 72/280 (25%), Positives = 140/280 (50%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
+ L + Q+F+ + D+ W+ E+++ + +D+ D+ L +H + +I +
Sbjct: 353 RHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDA 412
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
H+D S + + H+ +D +++K + + L E E R+ + L F
Sbjct: 413 HEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLF 472
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
YRD + ++W+ ++E + ++G L V+ L+KKH+ + ++ E +I + K
Sbjct: 473 YRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATK 532
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
+I NHYA D+ + D + + + L +A +RR L DS QQ+ D+ E +SW+ EK
Sbjct: 533 LIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEK 592
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
+ E KD + + ++KH A A++ A +S ID+L
Sbjct: 593 MK-TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDAL 631
Score = 131 bits (329), Expect = 3e-30
Identities = 76/322 (23%), Positives = 152/322 (47%), Gaps = 36/322 (11%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ + ++ L ++ + R +++ W+ E E+ L S++ G DL V LQKK +
Sbjct: 1076 LLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDD 1135
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHF--DADAIKKKQI-------------------- 298
+ D+ +++ R+ + A+ + + A++++++
Sbjct: 1136 FQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSA 1195
Query: 299 --------------EVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPI 436
E+ R+ LQ+ E+R L A+++ +F+RDAD+ ++WI EK
Sbjct: 1196 RLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQA 1255
Query: 437 AGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKID 616
+ N G DL VQ L +KH+ + ++ ++ + +++ + + D+++K
Sbjct: 1256 LNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLTQSHPESAEDLQEKCT 1315
Query: 617 DMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTE 796
++ WS L +AD+R+ L DS + Q++L+D + SW+ LV S E KD E
Sbjct: 1316 ELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAE 1375
Query: 797 ALLKKHDALMADIEAYRSTIDS 862
ALL++H +I+A T +
Sbjct: 1376 ALLERHQEHRTEIDARAGTFQA 1397
Score = 125 bits (315), Expect = 1e-28
Identities = 61/179 (34%), Positives = 104/179 (58%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ L + QQ R+VED E W+ E E S + GKDL V NL KKH L+++I+
Sbjct: 776 RKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAG 835
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
H+ RI + Q+ + V + HF A+ +K K E+ ++ L+ +R+ L D+ + Q+
Sbjct: 836 HEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQY 895
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQ 562
+ DA++ E W+ EKEPI GST+ G+D + L+KKH+A+ ++++ + I + + Q
Sbjct: 896 FADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQ 954
Score = 117 bits (293), Expect = 4e-26
Identities = 68/272 (25%), Positives = 130/272 (47%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ L + Q+F+ + D+ W+ + + SD+ KD+ L ++H ++I +
Sbjct: 1331 RKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDA 1390
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
+F Q Q + H+ + IK+K + + L++ +R+ L+ +L F
Sbjct: 1391 RAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF 1450
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
+RD + E+W+ +E + + G L V+ LIKKH+ + E +I + +
Sbjct: 1451 HRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQ 1510
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
+I HYA DI + +++ + W LK + ++R L +S QQ+ D E E+W+ EK
Sbjct: 1511 LIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEK 1570
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEA 841
S E KD + ++ +KH A A++ A
Sbjct: 1571 LQ-TASDESYKDPTNIQSKHQKHQAFEAELHA 1601
Score = 112 bits (281), Expect = 1e-24
Identities = 60/198 (30%), Positives = 106/198 (53%)
Frame = +2
Query: 272 ADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTN 451
A+ I++++ +V +RY + +E R+ KL D+Y+ F RDA++ E WI EK IA N
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
Query: 452 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNL 631
+D +Q ++KHQA +AEV + I+++ G MI H+A+ I ++ ++
Sbjct: 72 Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 632 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 811
W L K ++ L + + QYL + + W+ +KE +V S E G+D + E L KK
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 812 HDALMADIEAYRSTIDSL 865
+ D+ A+ ++ +
Sbjct: 191 FEEFQTDMAAHEERVNEV 208
Score = 110 bits (276), Expect = 4e-24
Identities = 78/293 (26%), Positives = 136/293 (46%), Gaps = 6/293 (2%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
+L + + L ++ QQF+ NVE+ E W+ E + + S+D G L ++ L KKH
Sbjct: 1854 ELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHE 1913
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
E+D + H+DR++ + N+ + I K + + S L++ +RK KL+
Sbjct: 1914 AFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLD 1973
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPR-I 538
+ QF AD E WI EKE + + GRDL VQ L+ K + A + + I
Sbjct: 1974 ENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGI 2033
Query: 539 LEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSD-LKNKADKRRQLLDDSLEAQQYLADA 715
+ +++ H ++ IE + + WS L N A ++++L LEAQ +
Sbjct: 2034 ANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKL----LEAQSHFRKV 2089
Query: 716 SEAESWMREKEPLVGSTEFGKDEDSTEAL----LKKHDALMADIEAYRSTIDS 862
+ +K S +ED T+ + L++ AL +A+RS++ S
Sbjct: 2090 EDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSS 2142
Score = 90.5 bits (223), Expect = 5e-18
Identities = 77/317 (24%), Positives = 135/317 (42%), Gaps = 41/317 (12%)
Frame = +2
Query: 38 LTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCG--KDLNSVTNLQKKHNLLESD--ISS 205
+T G + N + + W EV + G K L+ + ++ NLLE I+
Sbjct: 986 VTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRE-NLLEEQGSIAL 1044
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
Q++ID+ Q + +++ KQ+E Y L E EKRK L + K
Sbjct: 1045 RQEQIDN------QTRITKEAGSVSLRMKQVE--ELYHSLLELGEKRKGMLEKSCKKFML 1096
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
+R+A++ + WI+EKE S VG DL V+ L KK Q ++ +E R+ ++ N+ +
Sbjct: 1097 FREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDI-NKVAE 1155
Query: 566 MIDGNHYANRDIE-------------------------------------KKIDDMKNLW 634
++ +++ I ++ W
Sbjct: 1156 DLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERW 1215
Query: 635 SDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKH 814
L+ A++R QLL + E Q++ DA E + W+ EK + + +G D S +AL +KH
Sbjct: 1216 RSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKH 1275
Query: 815 DALMADIEAYRSTIDSL 865
+ D+ A ++SL
Sbjct: 1276 EGFERDLAALGDKVNSL 1292
>sp|P07751|SPTA2_CHICK Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Fodrin alpha chain)
Length = 2477
Score = 353 bits (905), Expect = 4e-97
Identities = 172/288 (59%), Positives = 219/288 (76%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ A+++K L +A+ QQQF RNVED+E+WL EVE L SDD GKDL SV NLQKKH L
Sbjct: 663 LLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTSVQNLQKKHAL 722
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
LE+D+++HQD ID QA QF HFDAD IKKKQ + RY L++P+ RK KL D
Sbjct: 723 LEADVAAHQDPIDGITIQARQFQDAGHFDADNIKKKQEALVARYEALKDPMVARKQKLAD 782
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
+ +L Q +RD +DEE WI EKEPIA STN G+DLIGVQNL+KKHQA+QAE+ GHEPRI
Sbjct: 783 SLRLQQLFRDIEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
V +G M++ H+A D++ K++++ W LK KA +RRQ L+DSL+AQQY ADA+EA
Sbjct: 843 VTQKGNAMVEEGHFAAEDVKIKLNELNQKWDSLKAKASQRRQDLEDSLQAQQYFADANEA 902
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
+SWMREKEP+VGST++GKDEDS EALLKKH+ALM+D+ AY S+I +LR
Sbjct: 903 QSWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALR 950
Score = 242 bits (618), Expect = 9e-64
Identities = 118/287 (41%), Positives = 179/287 (62%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
LV S K L +A+ QQ F ++D + WL+EVE+ L S+D GKDL SV NL KKH L
Sbjct: 1648 LVQKSSEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQL 1707
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
LE+DIS+H+DR+ QAD + + FD +K K+ + R+ +++ R+ KLN+
Sbjct: 1708 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRETINGRFQRIKSMAAARRAKLNE 1767
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
+++LHQF+RD DDEE WI EK+ + S + GRDL GVQNL KKH+ ++AE+ HEP I
Sbjct: 1768 SHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1827
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
V + G+K+ D N +I++++ + W +LK A R Q L++SLE QQ++A+ E
Sbjct: 1828 VLDTGKKLSDDNTIGKEEIQQRLAQFVDHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E+W+ EK LV S ++G + + LLKKH+A D ++ ++ +
Sbjct: 1888 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDV 1934
Score = 167 bits (424), Expect = 3e-41
Identities = 91/280 (32%), Positives = 156/280 (55%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
+ L + QQF R+ ++++ W+ E + + +D+ KD +++ +KH E+++S+
Sbjct: 565 RRAQLADSFHLQQFFRDSDELKSWVNE-KMKTATDEAYKDPSNLQGKVQKHQAFEAELSA 623
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
+Q RID+ + + + NH+ +D + + EV + + KL E E + KL +A + QF
Sbjct: 624 NQSRIDALEKAGQKLIDVNHYASDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQF 683
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
R+ +D E W++E E S + G+DL VQNL KKH ++A+V H+ I + + ++
Sbjct: 684 NRNVEDIELWLYEVEGHLASDDYGKDLTSVQNLQKKHALLEADVAAHQDPIDGITIQARQ 743
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
D H+ +I+KK + + + LK+ R+Q L DSL QQ D + E+W+REK
Sbjct: 744 FQDAGHFDADNIKKKQEALVARYEALKDPMVARKQKLADSLRLQQLFRDIEDEETWIREK 803
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
EP+ ST GKD + LLKKH AL A+I + I ++
Sbjct: 804 EPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAV 843
Score = 165 bits (418), Expect = 1e-40
Identities = 86/287 (29%), Positives = 165/287 (57%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ +++ Q Q F R+ E ++ W+++ E+ L ++D G L+SV L KKH
Sbjct: 452 LLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
E +S+ +++I + + A + + +NH+ D + ++ + +R + L E KR+ +L D
Sbjct: 512 FEKSLSAQEEKITALDEFATKLIQNNHYAMDDVATRRDALLSRRNALHERAMKRRAQLAD 571
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
++ L QF+RD+D+ + W++EK A + +D +Q ++KHQA +AE++ ++ RI
Sbjct: 572 SFHLQQFFRDSDELKSWVNEKMKTA-TDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDA 630
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
+ GQK+ID NHYA+ ++ +++++ +LW L + + L ++ + QQ+ + +
Sbjct: 631 LEKAGQKLIDVNHYASDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDI 690
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E W+ E E + S ++GKD S + L KKH L AD+ A++ ID +
Sbjct: 691 ELWLYEVEGHLASDDYGKDLTSVQNLQKKHALLEADVAAHQDPIDGI 737
Score = 164 bits (416), Expect = 2e-40
Identities = 82/279 (29%), Positives = 155/279 (55%)
Frame = +2
Query: 11 SASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLE 190
S + + L ++ QF R+++D E W+ E + + S+D G+DL V NL+KKH LE
Sbjct: 1756 SMAAARRAKLNESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLE 1815
Query: 191 SDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAY 370
+++++H+ I L + DN + I+++ + + + +L++ R +L ++
Sbjct: 1816 AELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVDHWKELKQLAAARGQRLEESL 1875
Query: 371 KLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVC 550
+ QF + ++EE WI+EK + S + G L +Q L+KKH+A + + T H+ R+ +VC
Sbjct: 1876 EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVC 1935
Query: 551 NEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAES 730
G+ +I N++ +I K+ +K SDL+ A +R+ LD++ Q+ A ES
Sbjct: 1936 ANGEDLIKKNNHHVENITAKMKGLKGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVES 1995
Query: 731 WMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYR 847
W+ EKE + + ++G+D S + LL K + A ++A++
Sbjct: 1996 WIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQ 2034
Score = 160 bits (406), Expect = 3e-39
Identities = 84/286 (29%), Positives = 154/286 (53%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ + K L QA QF+R ED+ W+ + E+ + S++ G+DL V LQKK
Sbjct: 134 LLEKMREKGVKLLQAQKLVQFLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
++D+++H++R++ Q A + + + H + + IK KQ EV + +L+ ++R+ KL
Sbjct: 194 FQTDLAAHEERVNEVNQFAGKLIQEQHPEEELIKSKQDEVNASWQRLKGLAQQRQGKLFG 253
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
A ++ +F RD D+ WI EK + S + GRDL VQ L++KH+ ++ ++ ++
Sbjct: 254 AAEVQRFNRDVDETISWIKEKGQLMASDDFGRDLASVQALLRKHEGLERDLAAFHHKVKA 313
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
+C E ++ + I+ K +++ W ++ A +R L+DS Q++LAD +
Sbjct: 314 LCAEADRLQQSHPINASQIQVKREELIANWEQIRTLAAERHARLNDSYRLQRFLADFRDL 373
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDS 862
SW+ E + L+ + E D EALL +H +I+A+ + S
Sbjct: 374 TSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFRS 419
Score = 155 bits (391), Expect = 2e-37
Identities = 87/283 (30%), Positives = 153/283 (54%)
Frame = +2
Query: 17 SKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESD 196
S ++ L + Q F R+ +++ W+ E + Q+ SD+ KD +++ +KH E++
Sbjct: 33 SSLRRQKLEDSYRFQFFQRDADELGKWIQE-KLQIASDENYKDPSNLQGKLQKHQAFEAE 91
Query: 197 ISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKL 376
+ ++ I + +Q +++ HF ++ I+ + E+ + L E + ++ KL A KL
Sbjct: 92 VQANSGAIVKLDETGNQMINEGHFASETIRTRLQELHRLWELLLEKMREKGVKLLQAQKL 151
Query: 377 HQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNE 556
QF R+ +D DWI++KE I S +G+DL V+ L KK + Q ++ HE R+ EV
Sbjct: 152 VQFLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQF 211
Query: 557 GQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWM 736
K+I H I+ K D++ W LK A +R+ L + E Q++ D E SW+
Sbjct: 212 AGKLIQEQHPEEELIKSKQDEVNASWQRLKGLAQQRQGKLFGAAEVQRFNRDVDETISWI 271
Query: 737 REKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
+EK L+ S +FG+D S +ALL+KH+ L D+ A+ + +L
Sbjct: 272 KEKGQLMASDDFGRDLASVQALLRKHEGLERDLAAFHHKVKAL 314
Score = 147 bits (370), Expect = 5e-35
Identities = 76/280 (27%), Positives = 146/280 (52%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ L A+ Q+F R+V++ W+ E + SDD G+DL SV L +KH LE D+++
Sbjct: 247 RQGKLFGAAEVQRFNRDVDETISWIKEKGQLMASDDFGRDLASVQALLRKHEGLERDLAA 306
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
++ + +AD+ + +A I+ K+ E+ + +++ +R +LND+Y+L +F
Sbjct: 307 FHHKVKALCAEADRLQQSHPINASQIQVKREELIANWEQIRTLAAERHARLNDSYRLQRF 366
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
D D W+ E + + + + D+ G + L+ +HQ + E+ HE GQ
Sbjct: 367 LADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFRSADESGQA 426
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
++ HYA+ ++++K+ + + S L + RRQ + ++ Q + D + ++WM ++
Sbjct: 427 LLAAGHYASDEVKEKLTILSDERSALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQ 486
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E + + + G DS EALLKKH+ + A I +L
Sbjct: 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITAL 526
Score = 144 bits (364), Expect = 2e-34
Identities = 77/287 (26%), Positives = 153/287 (53%), Gaps = 7/287 (2%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKD-----LNSVTNLQKKHNLLE 190
K + L ++ QQF R+V+++E W++E + Q SD+ KD L+ + + +KH E
Sbjct: 1543 KRSKLGESQTLQQFSRDVDEIEAWISE-KLQTASDESYKDPTNIQLSKLLSKHQKHQAFE 1601
Query: 191 SDISSHQDRIDSFLQQADQFVHDNHF--DADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
+++ ++ DRI ++ + + DA+K + + +++ L + ++ KL +
Sbjct: 1602 AELHANADRIRGVIEMGNPLIERGACAGSEDAVKARLAALADQWEFLVQKSSEKSQKLKE 1661
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
A K F D + W+ E E + S + G+DL V NL+KKHQ ++A+++ HE R+ +
Sbjct: 1662 ANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKD 1721
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
+ ++ ++ + + ++ K + + + +K+ A RR L++S Q+ D +
Sbjct: 1722 LNSQADSLMTSSAFDTSQVKDKRETINGRFQRIKSMAAARRAKLNESHRLHQFFRDMDDE 1781
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
ESW++EK+ LV S ++G+D + L KKH L A++ A+ I +
Sbjct: 1782 ESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGV 1828
Score = 137 bits (344), Expect = 5e-32
Identities = 75/280 (26%), Positives = 141/280 (50%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
+ L + Q+F+ + D+ W+ E+++ + +D+ D+ L +H + +I +
Sbjct: 353 RHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDA 412
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
H+D S + + H+ +D +K+K + + S L E E R+ + L F
Sbjct: 413 HEDSFRSADESGQALLAAGHYASDEVKEKLTILSDERSALLELWELRRQQYEQCMDLQLF 472
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
YRD + ++W+ ++E + ++G L V+ L+KKH+ + ++ E +I + K
Sbjct: 473 YRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATK 532
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
+I NHYA D+ + D + + + L +A KRR L DS QQ+ D+ E +SW+ EK
Sbjct: 533 LIQNNHYAMDDVATRRDALLSRRNALHERAMKRRAQLADSFHLQQFFRDSDELKSWVNEK 592
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
+ E KD + + ++KH A A++ A +S ID+L
Sbjct: 593 MK-TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDAL 631
Score = 135 bits (341), Expect = 1e-31
Identities = 89/296 (30%), Positives = 149/296 (50%), Gaps = 8/296 (2%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
DL A + L Q Q F R+ E E W+A E+ L ++D G L+SV L KKH
Sbjct: 1429 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE 1488
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
+ I+ +++I ADQ + +H+ I ++ EV +R+ +L+ + ++++KL
Sbjct: 1489 DFDKAINVQEEKIAVLQSFADQLIAADHYAKGVIANRRNEVLDRWRRLKAQMIEKRSKLG 1548
Query: 362 DAYKLHQFYRDADDEEDWIHEK------EPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTG 523
++ L QF RD D+ E WI EK E TN+ L + + +KHQA +AE+
Sbjct: 1549 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNI--QLSKLLSKHQKHQAFEAELHA 1606
Query: 524 HEPRILEVCNEGQKMIDGNHYANRD--IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQ 697
+ RI V G +I+ A + ++ ++ + + W L K+ ++ Q L ++ + Q
Sbjct: 1607 NADRIRGVIEMGNPLIERGACAGSEDAVKARLAALADQWEFLVQKSSEKSQKLKEANKQQ 1666
Query: 698 QYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
+ + + W+ E E L+ S ++GKD S LLKKH L ADI A+ + L
Sbjct: 1667 NFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDL 1722
Score = 125 bits (313), Expect = 2e-28
Identities = 75/322 (23%), Positives = 149/322 (46%), Gaps = 36/322 (11%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ + ++ L ++ + R +++ W+ E E+ L +++ G DL V LQKK +
Sbjct: 1076 LLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTNEEVGADLEQVEVLQKKFDD 1135
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHF--DADAIKKKQI-------------------- 298
+ D+ +++ R+ + A+ + + A++ +++
Sbjct: 1136 FQKDLKANESRLKDINKVANDLESEGLMAEEVQAVEHQEVYGMMPRDETDSKTVSPWKSA 1195
Query: 299 --------------EVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPI 436
E+ R+ LQ+ E+R L A ++ +F+RDAD+ ++WI EK
Sbjct: 1196 RMMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSADEVQRFHRDADETKEWIEEKNQA 1255
Query: 437 AGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKID 616
+ N G DL VQ L + + + ++ ++ + Q++I + D+++K
Sbjct: 1256 LNTDNYGHDLASVQALQRNDEGFERDLAALGDKVNSLGETAQRLIQSHPELAEDLQEKCT 1315
Query: 617 DMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTE 796
++ WS L +AD+R++ L DS + Q++L+D + SW+ LV S E KD E
Sbjct: 1316 ELNQAWSSLGKRADQRKEKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAE 1375
Query: 797 ALLKKHDALMADIEAYRSTIDS 862
ALL++H +I+A T +
Sbjct: 1376 ALLERHQEHRTEIDARAGTFQA 1397
Score = 124 bits (310), Expect = 4e-28
Identities = 59/179 (32%), Positives = 104/179 (58%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ L + QQ R++ED E W+ E E S + GKDL V NL KKH L+++I+
Sbjct: 776 RKQKLADSLRLQQLFRDIEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAG 835
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
H+ RI + Q+ + V + HF A+ +K K E+ ++ L+ +R+ L D+ + Q+
Sbjct: 836 HEPRIKAVTQKGNAMVEEGHFAAEDVKIKLNELNQKWDSLKAKASQRRQDLEDSLQAQQY 895
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQ 562
+ DA++ + W+ EKEPI GST+ G+D + L+KKH+A+ ++++ + I + + Q
Sbjct: 896 FADANEAQSWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQ 954
Score = 115 bits (289), Expect = 1e-25
Identities = 60/198 (30%), Positives = 108/198 (54%)
Frame = +2
Query: 272 ADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTN 451
A+ I++++ +V +RY + +E R+ KL D+Y+ F RDAD+ WI EK IA N
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSSLRRQKLEDSYRFQFFQRDADELGKWIQEKLQIASDEN 71
Query: 452 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNL 631
+D +Q ++KHQA +AEV + I+++ G +MI+ H+A+ I ++ ++ L
Sbjct: 72 Y-KDPSNLQGKLQKHQAFEAEVQANSGAIVKLDETGNQMINEGHFASETIRTRLQELHRL 130
Query: 632 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 811
W L K ++ L + + Q+L + + W+ +KE +V S E G+D + E L KK
Sbjct: 131 WELLLEKMREKGVKLLQAQKLVQFLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 812 HDALMADIEAYRSTIDSL 865
+ D+ A+ ++ +
Sbjct: 191 FEEFQTDLAAHEERVNEV 208
Score = 110 bits (275), Expect = 5e-24
Identities = 77/293 (26%), Positives = 138/293 (47%), Gaps = 6/293 (2%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
+L + + L ++ QQF+ NVE+ E W+ E + + S+D G L ++ L KKH
Sbjct: 1859 ELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHE 1918
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
E+D + H+DR++ + + N+ + I K + + S L++ +RK KL+
Sbjct: 1919 AFETDFTVHKDRVNDVCANGEDLIKKNNHHVENITAKMKGLKGKVSDLEKAAAQRKAKLD 1978
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPR-I 538
+ QF AD E WI EKE + + GRDL VQ L+ K + A + + I
Sbjct: 1979 ENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGI 2038
Query: 539 LEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSD-LKNKADKRRQLLDDSLEAQQYLADA 715
+ +++ H ++ IE + + W+ L N A ++++L LEAQ++
Sbjct: 2039 ANITALKDQLLAAKHIQSKAIEVRHASLMKRWNQLLANSAARKKKL----LEAQEHFRKV 2094
Query: 716 SEAESWMREKEPLVGSTEFGKDEDSTEAL----LKKHDALMADIEAYRSTIDS 862
+ +K S +ED T+ + L++ AL +A+RS++ S
Sbjct: 2095 EDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSS 2147
Score = 108 bits (270), Expect = 2e-23
Identities = 69/283 (24%), Positives = 131/283 (46%), Gaps = 2/283 (0%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ L + Q+F+ + D+ W+ + + SD+ KD+ L ++H ++I +
Sbjct: 1331 RKEKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDA 1390
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
+F Q Q + H+ + IK+K + + L++ +R+ L+ +L F
Sbjct: 1391 RAGTFQAFEQFGQQLLARGHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDQCLELQLF 1450
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
+RD + E+W+ +E + + G L V+ LIKKH+ + E +I + + +
Sbjct: 1451 HRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAVLQSFADQ 1510
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
+I +HYA I + +++ + W LK + ++R L +S QQ+ D E E+W+ EK
Sbjct: 1511 LIAADHYAKGVIANRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEK 1570
Query: 746 EPLVGSTEFGKDEDSTE--ALLKKHDALMADIEAYRSTIDSLR 868
S E KD + + LL KH A + D +R
Sbjct: 1571 LQ-TASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIR 1612
Score = 85.1 bits (209), Expect = 2e-16
Identities = 74/317 (23%), Positives = 133/317 (41%), Gaps = 41/317 (12%)
Frame = +2
Query: 38 LTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCG--KDLNSVTNLQKKHNLLESD--ISS 205
+T G + N + + W EV + G K L+ + ++ NLLE I+
Sbjct: 986 VTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRE-NLLEEQGSIAL 1044
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
Q++ID+ Q + + +++ KQ+E Y L E EKRK L + K
Sbjct: 1045 RQEQIDN------QTLITKEVGSVSLRMKQVE--ELYHSLLELGEKRKGMLEKSCKKFML 1096
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
+R+A++ + WI+EKE + VG DL V+ L KK Q ++ +E R+ ++ N+
Sbjct: 1097 FREANELQQWINEKEAALTNEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDI-NKVAN 1155
Query: 566 MIDGNHYANRDIE-------------------------------------KKIDDMKNLW 634
++ +++ I ++ W
Sbjct: 1156 DLESEGLMAEEVQAVEHQEVYGMMPRDETDSKTVSPWKSARMMVHTVATFNSIKELNERW 1215
Query: 635 SDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKH 814
L+ A++R QLL + E Q++ DA E + W+ EK + + +G D S +AL +
Sbjct: 1216 RSLQQLAEERSQLLGSADEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRND 1275
Query: 815 DALMADIEAYRSTIDSL 865
+ D+ A ++SL
Sbjct: 1276 EGFERDLAALGDKVNSL 1292
>sp|P13395|SPTCA_DROME Spectrin alpha chain
Length = 2415
Score = 323 bits (828), Expect = 4e-88
Identities = 156/288 (54%), Positives = 214/288 (74%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
LV AS K T L +A QQQF R +ED+E+WL+E+E QL S+D GKDL SV NLQKKH L
Sbjct: 666 LVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHAL 725
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
LE+D+ +HQDRI+S A++F+ HFDAD I+ K+ + RY+ L P+ +RK L D
Sbjct: 726 LEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAPMGERKQHLLD 785
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
+ ++ Q +RD +DE WI EKEPIA STN GRDLIGVQNLIKKHQA+ AE+ HE R+L
Sbjct: 786 SLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLN 845
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
V + G+ M+ +A+ DI ++++ ++ W+ LK K+ +R+Q LDDSL+A QY ADA+EA
Sbjct: 846 VISSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEA 905
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
ESWMREKEP+ +++GKDEDS+EALLKKH+AL++D+EA+ +TI +L+
Sbjct: 906 ESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQ 953
Score = 236 bits (603), Expect = 5e-62
Identities = 118/274 (43%), Positives = 172/274 (62%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
K L +A+ Q+ +I V+D++ WL EVES L ++D GKDL SV NL KKH L+E+DI +
Sbjct: 1598 KSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKKHQLVEADIVA 1657
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
H+DRI QAD V FD I++K+ + RY ++ R+ +LN+A LHQF
Sbjct: 1658 HEDRIKDMNNQADSLVESGQFDTAGIQEKRQSINERYERICNLAAHRQARLNEALTLHQF 1717
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
+RD DEE WI EK+ + GS + GRDL GVQNL KKH+ ++AE+ HEP I V G+K
Sbjct: 1718 FRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGSHEPAIQAVQEAGEK 1777
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
++D ++ +IE+++ + W++LKN A R Q LD+SL QQ+LA E E+W+ EK
Sbjct: 1778 LMDVSNLGVPEIEQRLKALNQAWAELKNLAATRGQKLDESLTYQQFLAQVEEEEAWITEK 1837
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEAYR 847
+ L+ ++G + + LLKKHDA D A++
Sbjct: 1838 QQLLSVEDYGDSMAAVQGLLKKHDAFETDFTAHK 1871
Score = 164 bits (416), Expect = 2e-40
Identities = 86/283 (30%), Positives = 157/283 (55%), Gaps = 2/283 (0%)
Frame = +2
Query: 23 IKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDIS 202
+++ L A Q+F R+ ++ W+AE + L SDD G+DL SV LQ+KH +E D++
Sbjct: 249 VRQEKLFGAHEIQRFNRDADETVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLA 308
Query: 203 SHQDRIDSFLQQADQF--VHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKL 376
+ +D++ + +A + +H +H +D I+ KQ E+ N + L +RK KL+++Y L
Sbjct: 309 ALEDKVSTLGAEAQRLCSIHADH--SDQIRDKQAEIANYWQSLTTKARERKQKLDESYYL 366
Query: 377 HQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNE 556
H+F D D WI+ + I + + +D+ G + L+++HQ + E+ E
Sbjct: 367 HRFLADFRDLVSWINGMKAIISADELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTES 426
Query: 557 GQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWM 736
GQK+++ HYA +I++K+ ++N S L + + RR L + ++ Q + D +A++WM
Sbjct: 427 GQKLLEREHYAAAEIQEKLAALENDKSSLLSLWEDRRILYEQCMDLQLFYRDTEQADTWM 486
Query: 737 REKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
++E + + + G DS EAL+KKH+ + A I +L
Sbjct: 487 AKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIKAL 529
Score = 158 bits (400), Expect = 2e-38
Identities = 87/279 (31%), Positives = 153/279 (54%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+S K L QA QF+R E++ W+ + E+ + +D+ G+DL V LQ+K +
Sbjct: 137 LLSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDE 196
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
+ D++S + R+ Q AD+ V D H + D I K++ E+ + +L++ R+ KL
Sbjct: 197 FQKDMASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFG 256
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
A+++ +F RDAD+ WI EK+ + S + GRDL VQ L +KH+ ++ ++ E ++
Sbjct: 257 AHEIQRFNRDADETVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVST 316
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
+ E Q++ + + I K ++ N W L KA +R+Q LD+S ++LAD +
Sbjct: 317 LGAEAQRLCSIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDL 376
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEA 841
SW+ + ++ + E KD EALL++H +I+A
Sbjct: 377 VSWINGMKAIISADELAKDVAGAEALLERHQEHKGEIDA 415
Score = 154 bits (388), Expect = 4e-37
Identities = 77/273 (28%), Positives = 146/273 (53%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ L +A QF R++ D E W+ E + +GSDD G+DL V NL+KKH LE+++ S
Sbjct: 1704 RQARLNEALTLHQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGS 1763
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
H+ I + + ++ + ++ I+++ + +++L+ R KL+++ QF
Sbjct: 1764 HEPAIQAVQEAGEKLMDVSNLGVPEIEQRLKALNQAWAELKNLAATRGQKLDESLTYQQF 1823
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
++EE WI EK+ + + G + VQ L+KKH A + + T H+ R +C++G +
Sbjct: 1824 LAQVEEEEAWITEKQQLLSVEDYGDSMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSE 1883
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
+++ ++ I ++ ++ +L A +R+ L D+ Q++ A ESW+ +K
Sbjct: 1884 LVEAKNHHGESIAQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFMWKADVVESWIDDK 1943
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEAY 844
E V S EFG+D + + LL K + A + A+
Sbjct: 1944 ENYVRSDEFGRDLSTVQTLLTKQETFDAGLNAF 1976
Score = 153 bits (387), Expect = 5e-37
Identities = 78/283 (27%), Positives = 155/283 (54%), Gaps = 2/283 (0%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
K + L QQF R+ +++E W+AE + QL +++ KD ++ + +KH E+++++
Sbjct: 1491 KRSRLGDEQTLQQFSRDADEIENWIAE-KLQLATEESYKDPANIQSKHQKHQAFEAELAA 1549
Query: 206 HQDRIDSFLQQADQFVHDNHFDA--DAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLH 379
+ DRI S L + DA++K+ ++ +++ L ++ KL +A K
Sbjct: 1550 NADRIQSVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQR 1609
Query: 380 QFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEG 559
+ D + W+ E E + + + G+DL VQNL+KKHQ ++A++ HE RI ++ N+
Sbjct: 1610 TYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKKHQLVEADIVAHEDRIKDMNNQA 1669
Query: 560 QKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMR 739
+++ + I++K + + + N A R+ L+++L Q+ D ++ ESW++
Sbjct: 1670 DSLVESGQFDTAGIQEKRQSINERYERICNLAAHRQARLNEALTLHQFFRDIADEESWIK 1729
Query: 740 EKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
EK+ LVGS ++G+D + L KKH L A++ ++ I +++
Sbjct: 1730 EKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGSHEPAIQAVQ 1772
Score = 150 bits (380), Expect = 3e-36
Identities = 84/281 (29%), Positives = 147/281 (52%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
K + L A Q+F R++++ + W+AE + L +DD GKDL SV LQ+KH +E D+++
Sbjct: 1173 KASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVERDLAA 1232
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
+D+I + A++ + + A+ KQ E+ + ++ RK KL D+Y L +F
Sbjct: 1233 LRDKIRQLDETANRLMQSHPDTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRF 1292
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
D D WI+ + S + D+ G + LI++HQ + E+ G +
Sbjct: 1293 LSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQEHRTEIDARAGTFGAFEQFGNE 1352
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
++ NHYA+ +I++KI+D+ DL+ +RR L+ +L+ Q Y+ D AESWM +
Sbjct: 1353 LLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLYMRDCELAESWMSAR 1412
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
E + + + + EAL+KKH+ I + I +L+
Sbjct: 1413 EAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQ 1453
Score = 150 bits (379), Expect = 4e-36
Identities = 82/273 (30%), Positives = 146/273 (53%)
Frame = +2
Query: 38 LTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDR 217
L ++ QQF R+ ++ + W++E + + +DD D ++ +KH E ++++++ R
Sbjct: 572 LEDSNRYQQFERDCDETKGWISE-KLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSR 630
Query: 218 IDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDA 397
I+ + + H+ AD I + E+ + L + +K+ KLN+A + QF R
Sbjct: 631 IEDITNVGTELIEKQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTI 690
Query: 398 DDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDG 577
+D E W+ E E S + G+DL VQNL KKH ++A+V H+ RI + K I+
Sbjct: 691 EDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVAANKFIES 750
Query: 578 NHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLV 757
H+ +I K ++ ++ L +R+Q L DSL+ QQ D + +W+REKEP+
Sbjct: 751 GHFDADNIRNKEGNLSARYAALAAPMGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIA 810
Query: 758 GSTEFGKDEDSTEALLKKHDALMADIEAYRSTI 856
ST G+D + L+KKH A++A+I + + +
Sbjct: 811 ASTNRGRDLIGVQNLIKKHQAVLAEINNHEARL 843
Score = 149 bits (376), Expect = 1e-35
Identities = 83/275 (30%), Positives = 147/275 (53%)
Frame = +2
Query: 44 QASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRID 223
Q Q F R+ E + W+A+ E+ L ++D G L+SV L KKH E +++ +++I
Sbjct: 468 QCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIK 527
Query: 224 SFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADD 403
+ A + + H+ AD + +++ + R + LQE KR+ L D+ + QF RD D+
Sbjct: 528 ALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFERDCDE 587
Query: 404 EEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNH 583
+ WI EK A + D + ++KHQ + E+ ++ RI ++ N G ++I+ H
Sbjct: 588 TKGWISEKLKFATDDSY-LDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQH 646
Query: 584 YANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGS 763
YA I ++ ++ LW L +DK+ L+++ + QQ+ + E W+ E E + S
Sbjct: 647 YAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLS 706
Query: 764 TEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
+ GKD S + L KKH L AD+ A++ I+S++
Sbjct: 707 EDHGKDLTSVQNLQKKHALLEADVMAHQDRIESIK 741
Score = 145 bits (367), Expect = 1e-34
Identities = 86/290 (29%), Positives = 154/290 (53%), Gaps = 2/290 (0%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
DL A + L Q Q ++R+ E E W++ E+ L +DD +V L KKH
Sbjct: 1377 DLEKAWTERRLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHE 1436
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
+ I+ H+ +I + ADQ + NH+ ++ + +K+ +V R+ L+E L +++++L
Sbjct: 1437 DFDKAINGHEQKIAALQTVADQLIAQNHYASNLVDEKRKQVLERWRHLKEGLIEKRSRLG 1496
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRIL 541
D L QF RDAD+ E+WI EK +A + +D +Q+ +KHQA +AE+ + RI
Sbjct: 1497 DEQTLQQFSRDADEIENWIAEKLQLATEESY-KDPANIQSKHQKHQAFEAELAANADRIQ 1555
Query: 542 EVCNEGQKMIDGNHYANRD--IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADA 715
V G +ID + + ++K++ + + W L +K ++ L ++ + + Y+A
Sbjct: 1556 SVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAV 1615
Query: 716 SEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
+ + W+ E E L+ + + GKD S + L+KKH + ADI A+ I +
Sbjct: 1616 KDLDFWLGEVESLLTTEDSGKDLASVQNLMKKHQLVEADIVAHEDRIKDM 1665
Score = 131 bits (329), Expect = 3e-30
Identities = 76/288 (26%), Positives = 144/288 (50%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
D ++ K L + Q F R+ +++E W+ E + Q S++ +D ++ +KH
Sbjct: 31 DFKIETRQKREKLEDSRRFQYFKRDADELESWIHE-KLQAASEESYRDPTNLQAKIQKHQ 89
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
E+++S+H + I S + ++ HF +++I+ + E+ + L L ++ KL
Sbjct: 90 AFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWELLLSRLAEKGLKLQ 149
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRIL 541
A L QF R ++ WI +KE + G+DL V+ L +K Q ++ E R+
Sbjct: 150 QALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQKDMASQEYRVT 209
Query: 542 EVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASE 721
EV K++ H I K+ +++ W LK A R++ L + E Q++ DA E
Sbjct: 210 EVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNRDADE 269
Query: 722 AESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
+W+ EK+ ++ S ++G+D S +AL +KH+ + D+ A + +L
Sbjct: 270 TVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTL 317
Score = 123 bits (308), Expect = 8e-28
Identities = 66/193 (34%), Positives = 110/193 (56%), Gaps = 2/193 (1%)
Frame = +2
Query: 281 IKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGR 460
I++++ +V +RY+ + +++ KL D+ + F RDAD+ E WIHEK A S R
Sbjct: 18 IQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQ-AASEESYR 76
Query: 461 DLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSD 640
D +Q I+KHQA +AEV+ H I+ + N GQ+MI+ H+A+ I+ ++D++ LW
Sbjct: 77 DPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWEL 136
Query: 641 LKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDA 820
L ++ ++ L +L Q+L E W+++KE V + EFG+D + E L +K D
Sbjct: 137 LLSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDE 196
Query: 821 LMADI--EAYRST 853
D+ + YR T
Sbjct: 197 FQKDMASQEYRVT 209
Score = 119 bits (298), Expect = 1e-26
Identities = 71/287 (24%), Positives = 136/287 (47%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
+++ S ++ L + Q+F+ + D+ W+ + S + SD+ D+ L ++H
Sbjct: 1272 IITKSTARKEKLLDSYDLQRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQE 1331
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
++I + +F Q ++ + NH+ + IK+K ++ L++ +R+ +L
Sbjct: 1332 HRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLEQ 1391
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
L + RD + E W+ +E + + V+ LIKKH+ + GHE +I
Sbjct: 1392 NLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAA 1451
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
+ ++I NHYA+ +++K + W LK ++R L D QQ+ DA E
Sbjct: 1452 LQTVADQLIAQNHYASNLVDEKRKQVLERWRHLKEGLIEKRSRLGDEQTLQQFSRDADEI 1511
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E+W+ EK L + E KD + ++ +KH A A++ A I S+
Sbjct: 1512 ENWIAEKLQL-ATEESYKDPANIQSKHQKHQAFEAELAANADRIQSV 1557
Score = 119 bits (297), Expect = 1e-26
Identities = 69/287 (24%), Positives = 137/287 (47%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L + ++ ++ L ++ +F+ + D+ W+ +++ + +D+ KD+ L ++H
Sbjct: 349 LTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELAKDVAGAEALLERHQE 408
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
+ +I + +D + + + H+ A I++K + N S L E R+
Sbjct: 409 HKGEIDAREDSFKLTTESGQKLLEREHYAAAEIQEKLAALENDKSSLLSLWEDRRILYEQ 468
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
L FYRD + + W+ ++E + ++G L V+ LIKKH+ + + E +I
Sbjct: 469 CMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIKA 528
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
+ K+IDG HYA D+ ++ + + L+ K+ KRRQLL+DS QQ+ D E
Sbjct: 529 LDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFERDCDET 588
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
+ W+ EK + D + ++KH ++ A +S I+ +
Sbjct: 589 KGWISEKLKFATDDSY-LDPTNLNGKMQKHQNFEHELNANKSRIEDI 634
Score = 118 bits (295), Expect = 2e-26
Identities = 67/286 (23%), Positives = 144/286 (50%), Gaps = 2/286 (0%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLG-SDDCGKDLNSVTNLQKKH 178
+L++ ++ ++ L + +R D+ W+ + E+ +D G+DL V LQKK
Sbjct: 1057 NLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQIADVVGEDLEEVEVLQKKF 1116
Query: 179 NLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCN-RYSKLQEPLEKRKNK 355
+ D+ +++ R+ + + A Q +A + Q++ N +++ LQ ++ ++
Sbjct: 1117 DDFNDDLKANEVRLANMNEIAVQLTSLGQTEAALKIQTQMQDLNEKWNNLQTLTAEKASQ 1176
Query: 356 LNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPR 535
L A+++ +F+RD D+ +DWI EK + ++G+DL VQ L +KH+ ++ ++ +
Sbjct: 1177 LGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDK 1236
Query: 536 ILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADA 715
I ++ +++ + K ++ +W + K+ R++ L DS + Q++L+D
Sbjct: 1237 IRQLDETANRLMQSHPDTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRFLSDY 1296
Query: 716 SEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRST 853
+ +W+ LV S E D EAL+++H +I+A T
Sbjct: 1297 RDLLAWINSMMSLVTSDELANDVTGAEALIERHQEHRTEIDARAGT 1342
Score = 98.6 bits (244), Expect = 2e-20
Identities = 69/266 (25%), Positives = 118/266 (44%), Gaps = 1/266 (0%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
+L + + + L ++ QQF+ VE+ E W+ E + L +D G + +V L KKH+
Sbjct: 1802 ELKNLAATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLLSVEDYGDSMAAVQGLLKKHD 1861
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
E+D ++H+DR Q + V + ++I ++ ++ + L +RK L
Sbjct: 1862 AFETDFTAHKDRCSLICDQGSELVEAKNHHGESIAQRCQQLRLKLDNLSALAARRKGALL 1921
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPR-I 538
D QF AD E WI +KE S GRDL VQ L+ K + A + E I
Sbjct: 1922 DNSAYLQFMWKADVVESWIDDKENYVRSDEFGRDLSTVQTLLTKQETFDAGLNAFEQEGI 1981
Query: 539 LEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADAS 718
+ ++I+ +H + I K+ D+ W L++ ++ R+ D L Q+
Sbjct: 1982 HNITALKDQLINASHAQSPAILKRHGDVIARWQKLRDASNTRK---DRLLAMQEQFRQIE 2038
Query: 719 EAESWMREKEPLVGSTEFGKDEDSTE 796
E +K S +ED T+
Sbjct: 2039 ELYLTFAKKASAFNSWFENAEEDLTD 2064
Score = 96.3 bits (238), Expect = 1e-19
Identities = 62/219 (28%), Positives = 109/219 (49%), Gaps = 2/219 (0%)
Frame = +2
Query: 215 RIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRD 394
+ID+ L + Q + DNH +I K+Q ++ ++Y L +R+NKLN+ K + R+
Sbjct: 1026 KIDAGLSASQQNLVDNH----SIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVRE 1081
Query: 395 ADDEEDWIHEKEPIAGSTNV-GRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMI 571
A D WI +KE A +V G DL V+ L KK ++ +E R+ + ++
Sbjct: 1082 AADLAQWIRDKENHAQIADVVGEDLEEVEVLQKKFDDFNDDLKANEVRLANMNEIAVQLT 1141
Query: 572 D-GNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKE 748
G A I+ ++ D+ W++L+ ++ L + E Q++ D E + W+ EK
Sbjct: 1142 SLGQTEAALKIQTQMQDLNEKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKA 1201
Query: 749 PLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
+ + + GKD S + L +KH+ + D+ A R I L
Sbjct: 1202 NALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDKIRQL 1240
Score = 55.1 bits (131), Expect = 3e-07
Identities = 63/280 (22%), Positives = 117/280 (41%), Gaps = 1/280 (0%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L S ++ +L + Q+ + + E W+ E E D GKD +S L KKH
Sbjct: 878 LKEKSSQRKQDLDDSLQAHQYFADANEAESWMREKEPIATGSDYGKDEDSSEALLKKHEA 937
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
L SD+ + + I + +QA D K+ + Y++ + P E K D
Sbjct: 938 LVSDLEAFGNTIQALQEQAKNCRQQETPVVDITGKECVVALYDYTE-KSpreVSMKK-GD 995
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
L ++++++ W E G IKK I A ++ +
Sbjct: 996 VLTL----LNSNNKDWWKVEVNDRQGFVPAA--------YIKK---IDAGLSASQ----- 1035
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
Q ++D N I K+ + + + + +L A +R+ L+++++A + +A++
Sbjct: 1036 -----QNLVD-----NHSIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADL 1085
Query: 725 ESWMREKEPLVGSTE-FGKDEDSTEALLKKHDALMADIEA 841
W+R+KE + G+D + E L KK D D++A
Sbjct: 1086 AQWIRDKENHAQIADVVGEDLEEVEVLQKKFDDFNDDLKA 1125
Score = 54.7 bits (130), Expect = 3e-07
Identities = 29/90 (32%), Positives = 53/90 (58%)
Frame = +2
Query: 596 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 775
DI+++ + + + ++D K + ++R+ L+DS Q + DA E ESW+ EK S E
Sbjct: 17 DIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQ-AASEESY 75
Query: 776 KDEDSTEALLKKHDALMADIEAYRSTIDSL 865
+D + +A ++KH A A++ A+ + I SL
Sbjct: 76 RDPTNLQAKIQKHQAFEAEVSAHSNAIVSL 105
>sp|P08032|SPTA1_MOUSE Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin)
Length = 2415
Score = 244 bits (624), Expect = 2e-64
Identities = 120/289 (41%), Positives = 184/289 (63%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
+L+ A+ K T L +A+ QF N ED++ WL EVE Q+ S+D GK L V NL +KH
Sbjct: 669 ELLEATAQKGTQLYEANQLLQFENNAEDLKRWLEEVEWQVTSEDYGKVLADVQNLLRKHG 728
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
LLESD+++ Q+++D+ A F H D+ I+ +Q + +R+ L+EPL RK KL
Sbjct: 729 LLESDVTARQNQMDTLTDMAAHFEEIGHPDSGDIRARQESLLSRFEALKEPLAIRKKKLI 788
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRIL 541
D KL Q RD++DEE WI E EP A ST++G+DL+ +NL+ +H+ I A++ HEPRI
Sbjct: 789 DLLKLQQICRDSEDEEAWIQETEPSAASTHLGKDLVAAKNLLNRHEVILADIASHEPRIQ 848
Query: 542 EVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASE 721
+ G KM++ H+A DI +++ + L +A +R L +++ QQYLAD E
Sbjct: 849 VITERGNKMVEEGHFAAEDIASRVESLNKNMESLHARAIRRENDLKANVQLQQYLADLHE 908
Query: 722 AESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
AE+W++EKEP+V + +G DE++ ALLKKH+A + D+ A+ ++I +LR
Sbjct: 909 AEAWIKEKEPIVDNKNYGADEEAAGALLKKHEAFLVDLNAFENSIKALR 957
Score = 184 bits (468), Expect = 2e-46
Identities = 98/287 (34%), Positives = 154/287 (53%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ + K L +AS QQ+F ++ D E WL+E E L D +DL S NL KKH L
Sbjct: 1590 LLERTTDKGQKLNEASRQQRFNTSIRDFEFWLSEAEGLLAMKDQARDLTSAGNLLKKHQL 1649
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
LE+++ + +D + A + + F+ D I++K V R+ +Q KL +
Sbjct: 1650 LEAEMLAREDPLKDLNDLAQELISSGTFNIDQIEEKMNGVNERFENVQSLAAAHHEKLKE 1709
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
Y L QF++D DDEE WI EK S + GRDL VQNL+KKH+ ++ E+ HEP +
Sbjct: 1710 TYALFQFFQDLDDEEAWIEEKLLRVSSQDYGRDLQSVQNLLKKHKRLEGELVAHEPAVQN 1769
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
V + + + D +I++++ W LK A R L++SLE Q++ +A E
Sbjct: 1770 VLDTAESLRDKAAVGKEEIQERLAQFVQHWEKLKELAKTRGVNLEESLEYLQFMENAEEE 1829
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E+W+ EK LV + G +T++LLKKH+AL D +++ + +
Sbjct: 1830 EAWLGEKCALVSRGDSGDTLAATQSLLKKHEALENDFAVHKNRVQDV 1876
Score = 139 bits (350), Expect = 1e-32
Identities = 74/264 (28%), Positives = 138/264 (52%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
+ +L+ A+ Q+F R+V + W+ E E QL S+D GKDL S L H LE +++
Sbjct: 254 RRESLSNAADLQRFKRDVNEAIQWMEEKEPQLTSEDYGKDLVSSEALFHNHKRLERNLAV 313
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
D++ +AD+ + + DA I++ ++++ + + +++ R KL +Y H+F
Sbjct: 314 MDDKVKELCAKADKLMISHSADALQIQQMKLDLVSNWERIRALATNRYAKLKASYGYHRF 373
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
D D+ W+ EK + + + D+ + L+ +HQ + E+ ++ R GQ+
Sbjct: 374 LSDYDELSGWMKEKTALINADELPTDVASGEALLARHQQHKHEIDSYDDRFQSADATGQE 433
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
++DGNH A+ +I +K+ + N W+ L DK + L+ + D+ + +SWM +
Sbjct: 434 LLDGNHEASEEIREKMTILANDWAALLELWDKCQHQYRQCLDFHLFYRDSEQVDSWMSRQ 493
Query: 746 EPLVGSTEFGKDEDSTEALLKKHD 817
E + + + G S EALL+KHD
Sbjct: 494 EAFLENEDLGNSVGSVEALLQKHD 517
Score = 136 bits (343), Expect = 7e-32
Identities = 77/263 (29%), Positives = 137/263 (52%), Gaps = 1/263 (0%)
Frame = +2
Query: 62 QFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQA 241
QF ++++D E W+ E ++ S D G+DL SV NL KKH LE ++ +H+ + + L A
Sbjct: 1715 QFFQDLDDEEAWIEEKLLRVSSQDYGRDLQSVQNLLKKHKRLEGELVAHEPAVQNVLDTA 1774
Query: 242 DQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIH 421
+ + I+++ + + KL+E + R L ++ + QF +A++EE W+
Sbjct: 1775 ESLRDKAAVGKEEIQERLAQFVQHWEKLKELAKTRGVNLEESLEYLQFMENAEEEEAWLG 1834
Query: 422 EKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD- 598
EK + + G L Q+L+KKH+A++ + H+ R+ +VC +G+ +++ N+D
Sbjct: 1835 EKCALVSRGDSGDTLAATQSLLKKHEALENDFAVHKNRVQDVCAQGEDILNKEETQNKDK 1894
Query: 599 IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGK 778
I KI + + L + LDD QQ+ A ESW+ EKE + + G
Sbjct: 1895 ISTKIQVLNEKTASLAKALAAWKSQLDDVHAFQQFNWKADVVESWIGEKEASLKTKSNGA 1954
Query: 779 DEDSTEALLKKHDALMADIEAYR 847
D + LL KHD L A +++++
Sbjct: 1955 DLTAFLTLLAKHDTLDASLQSFQ 1977
Score = 131 bits (329), Expect = 3e-30
Identities = 70/267 (26%), Positives = 149/267 (55%)
Frame = +2
Query: 65 FIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQAD 244
F R+ E ++ W++ E+ L ++D G + SV L +KH+ E ++ +++I + + A
Sbjct: 479 FYRDSEQVDSWMSRQEAFLENEDLGNSVGSVEALLQKHDDFEEAFTAQEEKIITLDETAT 538
Query: 245 QFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHE 424
+ + ++H+D++ I + + R L+E R+ L D+ L Q Y+D+DD + WI++
Sbjct: 539 KLIDNDHYDSENIAAIRDGLLARRDALRERAATRRKLLVDSQLLQQLYQDSDDLKTWINK 598
Query: 425 KEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIE 604
K+ +A + +D+ +++ ++K Q + E+ +E + + GQ+MI+ HYA+ +
Sbjct: 599 KKKLADDDDY-KDVQNLKSRVQKQQDFEEELAVNEIMLNNLEKTGQEMIEDGHYASEAVA 657
Query: 605 KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDE 784
++ ++ NLW +L ++ L ++ + Q+ +A + + W+ E E V S ++GK
Sbjct: 658 ARLSEVANLWKELLEATAQKGTQLYEANQLLQFENNAEDLKRWLEEVEWQVTSEDYGKVL 717
Query: 785 DSTEALLKKHDALMADIEAYRSTIDSL 865
+ LL+KH L +D+ A ++ +D+L
Sbjct: 718 ADVQNLLRKHGLLESDVTARQNQMDTL 744
Score = 128 bits (322), Expect = 2e-29
Identities = 69/266 (25%), Positives = 146/266 (54%)
Frame = +2
Query: 59 QQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQ 238
QQ ++ +D++ W+ + + +L DD KD+ ++ + +K E +++ ++ +++ +
Sbjct: 583 QQLYQDSDDLKTWINK-KKKLADDDDYKDVQNLKSRVQKQQDFEEELAVNEIMLNNLEKT 641
Query: 239 ADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWI 418
+ + D H+ ++A+ + EV N + +L E ++ +L +A +L QF +A+D + W+
Sbjct: 642 GQEMIEDGHYASEAVAARLSEVANLWKELLEATAQKGTQLYEANQLLQFENNAEDLKRWL 701
Query: 419 HEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD 598
E E S + G+ L VQNL++KH ++++VT + ++ + + + H + D
Sbjct: 702 EEVEWQVTSEDYGKVLADVQNLLRKHGLLESDVTARQNQMDTLTDMAAHFEEIGHPDSGD 761
Query: 599 IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGK 778
I + + + + + LK R++ L D L+ QQ D+ + E+W++E EP ST GK
Sbjct: 762 IRARQESLLSRFEALKEPLAIRKKKLIDLLKLQQICRDSEDEEAWIQETEPSAASTHLGK 821
Query: 779 DEDSTEALLKKHDALMADIEAYRSTI 856
D + + LL +H+ ++ADI ++ I
Sbjct: 822 DLVAAKNLLNRHEVILADIASHEPRI 847
Score = 121 bits (304), Expect = 2e-27
Identities = 74/286 (25%), Positives = 137/286 (47%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ ++ K L +A Q+ + ED+ W+ E E+ + + G D L KK
Sbjct: 141 LLELTQEKSDVLLRALKFYQYSQECEDILEWVKEKEAIVTLVELGDDWERTEVLHKKFEE 200
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
+ ++++ + ++D Q A++ + H IK KQ EV + +L KR+ L++
Sbjct: 201 FQEELTARKGKVDRVNQYANECAQEKHPKLPEIKAKQDEVNAAWDRLWSLALKRRESLSN 260
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
A L +F RD ++ W+ EKEP S + G+DL+ + L H+ ++ + + ++ E
Sbjct: 261 AADLQRFKRDVNEAIQWMEEKEPQLTSEDYGKDLVSSEALFHNHKRLERNLAVMDDKVKE 320
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
+C + K++ + I++ D+ + W ++ A R L S ++L+D E
Sbjct: 321 LCAKADKLMISHSADALQIQQMKLDLVSNWERIRALATNRYAKLKASYGYHRFLSDYDEL 380
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDS 862
WM+EK L+ + E D S EALL +H +I++Y S
Sbjct: 381 SGWMKEKTALINADELPTDVASGEALLARHQQHKHEIDSYDDRFQS 426
Score = 121 bits (303), Expect = 3e-27
Identities = 82/281 (29%), Positives = 137/281 (48%), Gaps = 5/281 (1%)
Frame = +2
Query: 38 LTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDR 217
L Q Q F + +E W+ E+ L SDD L+S+ L KK + L+ I++ + +
Sbjct: 1389 LDQCLELQLFRGKCDQVESWMVARENSLRSDD-RDHLDSLQALMKKRDDLDKAITAQEGK 1447
Query: 218 IDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDA 397
I A + + ++H+ + I + V +R+ L+E L KL D L QFYRD
Sbjct: 1448 ISDLENVATRLIDNDHYAKEEIAARLQRVLDRWKALKEQLLTELGKLGDYADLKQFYRDL 1507
Query: 398 DDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMI-- 571
+D E+WI+E PIA + +D +Q KHQA + EV G ++ V N G +I
Sbjct: 1508 EDLEEWINEMLPIACDESY-KDPTNIQRKYLKHQAFENEVNGRAEQVDGVINLGNSLIER 1566
Query: 572 ---DGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMRE 742
DG+ ++++++D +K W L + + Q L+++ Q++ + E W+ E
Sbjct: 1567 RVCDGD---EENMQEQLDMLKENWDYLLERTTDKGQKLNEASRQQRFNTSIRDFEFWLSE 1623
Query: 743 KEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E L+ + +D S LLKKH L A++ A + L
Sbjct: 1624 AEGLLAMKDQARDLTSAGNLLKKHQLLEAEMLAREDPLKDL 1664
Score = 120 bits (301), Expect = 5e-27
Identities = 75/277 (27%), Positives = 137/277 (49%), Gaps = 1/277 (0%)
Frame = +2
Query: 38 LTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDR 217
L+ A + F R +D++ + + L + D G DL SV LQ++H E DI ++
Sbjct: 1177 LSSAHAVEMFHREADDVKEQIDKKCRALNAADPGSDLLSVQALQRQHECFERDIIPLGEK 1236
Query: 218 IDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDA 397
+++ + A++ + + ++K++ E+ + LQ RK LN+A+K F A
Sbjct: 1237 VNTLGETAERLCESHPDATEDLQKQRTELNEAWDTLQGLTSDRKESLNEAHKFFLFLSKA 1296
Query: 398 DDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDG 577
D E+WI + S + DL G + L+++HQ ++ +P + + G ++ID
Sbjct: 1297 SDLENWIKTIGGVISSPELAEDLTGTEILLERHQEHHDDIKREDPTFQALEDFGTELIDS 1356
Query: 578 NHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLV 757
H R+I+ + ++ + +L+ + R+++LD LE Q + + ESWM +E +
Sbjct: 1357 GHRNRREIDNTLQNINSKRDNLEKSWENRKKMLDQCLELQLFRGKCDQVESWMVARENSL 1416
Query: 758 GSTEFGKDE-DSTEALLKKHDALMADIEAYRSTIDSL 865
S + +D DS +AL+KK D L I A I L
Sbjct: 1417 RSDD--RDHLDSLQALMKKRDDLDKAITAQEGKISDL 1451
Score = 113 bits (282), Expect = 8e-25
Identities = 63/276 (22%), Positives = 136/276 (49%)
Frame = +2
Query: 38 LTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDR 217
L + G +F+ + +++ W+ E + + +D+ D+ S L +H + +I S+ DR
Sbjct: 364 LKASYGYHRFLSDYDELSGWMKEKTALINADELPTDVASGEALLARHQQHKHEIDSYDDR 423
Query: 218 IDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDA 397
S + + NH ++ I++K + N ++ L E +K +++ H FYRD+
Sbjct: 424 FQSADATGQELLDGNHEASEEIREKMTILANDWAALLELWDKCQHQYRQCLDFHLFYRDS 483
Query: 398 DDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDG 577
+ + W+ +E + ++G + V+ L++KH + T E +I+ + K+ID
Sbjct: 484 EQVDSWMSRQEAFLENEDLGNSVGSVEALLQKHDDFEEAFTAQEEKIITLDETATKLIDN 543
Query: 578 NHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLV 757
+HY + +I D + L+ +A RR+LL DS QQ D+ + ++W+ +K+ L
Sbjct: 544 DHYDSENIAAIRDGLLARRDALRERAATRRKLLVDSQLLQQLYQDSDDLKTWINKKKKLA 603
Query: 758 GSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
++ KD + ++ ++K ++ +++L
Sbjct: 604 DDDDY-KDVQNLKSRVQKQQDFEEELAVNEIMLNNL 638
Score = 107 bits (267), Expect = 4e-23
Identities = 70/276 (25%), Positives = 132/276 (47%)
Frame = +2
Query: 38 LTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDR 217
L ++ Q F R+ +D+E W+ E + ++ D + N + +KH S++ +
Sbjct: 48 LEESYHYQVFRRDADDLEKWIME-KLEIAKDKTYEPTN-IQGKYQKHESFVSEVQAKSRV 105
Query: 218 IDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDA 397
+ + + ++HF +A K ++ + L E +++ + L A K +Q+ ++
Sbjct: 106 LPELEEIREARFAEDHFAHEATKTHLKQLRLLWDLLLELTQEKSDVLLRALKFYQYSQEC 165
Query: 398 DDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDG 577
+D +W+ EKE I +G D + L KK + Q E+T + ++ V +
Sbjct: 166 EDILEWVKEKEAIVTLVELGDDWERTEVLHKKFEEFQEELTARKGKVDRVNQYANECAQE 225
Query: 578 NHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLV 757
H +I+ K D++ W L + A KRR+ L ++ + Q++ D +EA WM EKEP +
Sbjct: 226 KHPKLPEIKAKQDEVNAAWDRLWSLALKRRESLSNAADLQRFKRDVNEAIQWMEEKEPQL 285
Query: 758 GSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
S ++GKD S+EAL H L ++ + L
Sbjct: 286 TSEDYGKDLVSSEALFHNHKRLERNLAVMDDKVKEL 321
Score = 105 bits (262), Expect = 2e-22
Identities = 63/287 (21%), Positives = 144/287 (50%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ ++ + L Q + DM W+ E +++ + G +L+ V LQKK +
Sbjct: 1065 LLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKTE----NTGVELDDVWELQKKFDE 1120
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
+ D+ S++ R+ + AD+ + + + +Q E+ R++ L+ +++ L+
Sbjct: 1121 FQRDLKSNEPRLKDINKVADELLFEELLTPEGAHIRQ-ELNTRWNSLKRLADEQYQLLSS 1179
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
A+ + F+R+ADD ++ I +K + + G DL+ VQ L ++H+ + ++ ++
Sbjct: 1180 AHAVEMFHREADDVKEQIDKKCRALNAADPGSDLLSVQALQRQHECFERDIIPLGEKVNT 1239
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
+ +++ + + A D++K+ ++ W L+ R++ L+++ + +L+ AS+
Sbjct: 1240 LGETAERLCESHPDATEDLQKQRTELNEAWDTLQGLTSDRKESLNEAHKFFLFLSKASDL 1299
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E+W++ ++ S E +D TE LL++H DI+ T +L
Sbjct: 1300 ENWIKTIGGVISSPELAEDLTGTEILLERHQEHHDDIKREDPTFQAL 1346
Score = 101 bits (251), Expect = 3e-21
Identities = 73/287 (25%), Positives = 126/287 (43%), Gaps = 10/287 (3%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L +K + NL ++ QF+ N E+ E WL E + + D G L + +L KKH
Sbjct: 1802 LKELAKTRGVNLEESLEYLQFMENAEEEEAWLGEKCALVSRGDSGDTLAATQSLLKKHEA 1861
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCN-RYSKLQEPLEKRKNKLN 361
LE+D + H++R+ Q + ++ +I+V N + + L + L K++L+
Sbjct: 1862 LENDFAVHKNRVQDVCAQGEDILNKEETQNKDKISTKIQVLNEKTASLAKALAAWKSQLD 1921
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTG-HEPRI 538
D + QF AD E WI EKE + + G DL L+ KH + A + + R+
Sbjct: 1922 DVHAFQQFNWKADVVESWIGEKEASLKTKSNGADLTAFLTLLAKHDTLDASLQSFQQERL 1981
Query: 539 LEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQ-LLDDSLEAQ------ 697
E+ +++ G H + IE++ + W L + RQ LL+ L Q
Sbjct: 1982 SEIAELKDQLVAGEHSQAKAIEEQHAALLRHWEQLLEASRVHRQKLLEKQLPLQKAEELF 2041
Query: 698 -QYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADI 835
++ AS +W E + + L K+H+A +A +
Sbjct: 2042 MEFAHKASAFNNWCENAEEDMSEPVHCVSLNEIRQLQKEHEAFLASL 2088
Score = 93.2 bits (230), Expect = 8e-19
Identities = 62/281 (22%), Positives = 117/281 (41%), Gaps = 1/281 (0%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ +L +A F+ D+E W+ + + S + +DL L ++H DI
Sbjct: 1279 RKESLNEAHKFFLFLSKASDLENWIKTIGGVISSPELAEDLTGTEILLERHQEHHDDIKR 1338
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
+ + + H + I + ++ L++ E RK L+ +L F
Sbjct: 1339 EDPTFQALEDFGTELIDSGHRNRREIDNTLQNINSKRDNLEKSWENRKKMLDQCLELQLF 1398
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRD-LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQ 562
D E W+ +E S + RD L +Q L+KK + +T E +I ++ N
Sbjct: 1399 RGKCDQVESWMVARENSLRSDD--RDHLDSLQALMKKRDDLDKAITAQEGKISDLENVAT 1456
Query: 563 KMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMRE 742
++ID +HYA +I ++ + + W LK + L D + +Q+ D + E W+ E
Sbjct: 1457 RLIDNDHYAKEEIAARLQRVLDRWKALKEQLLTELGKLGDYADLKQFYRDLEDLEEWINE 1516
Query: 743 KEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
P + E KD + + KH A ++ +D +
Sbjct: 1517 MLP-IACDESYKDPTNIQRKYLKHQAFENEVNGRAEQVDGV 1556
Score = 92.4 bits (228), Expect = 1e-18
Identities = 53/196 (27%), Positives = 97/196 (49%)
Frame = +2
Query: 272 ADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTN 451
A+ I+ ++ EV N+Y + ++ + +R KL ++Y F RDADD E WI EK IA
Sbjct: 20 AEEIQHRRAEVLNQYQRFKDRVAERGQKLEESYHYQVFRRDADDLEKWIMEKLEIAKDKT 79
Query: 452 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNL 631
+ +Q +KH++ +EV + E+ + +H+A+ + + ++ L
Sbjct: 80 Y--EPTNIQGKYQKHESFVSEVQAKSRVLPELEEIREARFAEDHFAHEATKTHLKQLRLL 137
Query: 632 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 811
W L ++ +L +L+ QY + + W++EKE +V E G D + TE L KK
Sbjct: 138 WDLLLELTQEKSDVLLRALKFYQYSQECEDILEWVKEKEAIVTLVELGDDWERTEVLHKK 197
Query: 812 HDALMADIEAYRSTID 859
+ ++ A + +D
Sbjct: 198 FEEFQEELTARKGKVD 213
Score = 36.6 bits (83), Expect = 0.093
Identities = 21/78 (26%), Positives = 41/78 (52%), Gaps = 1/78 (1%)
Frame = +2
Query: 14 ASKIKETNLTQASGQ-QQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLE 190
A I+ N +A+ Q QQ++ ++ + E W+ E E + + + G D + L KKH
Sbjct: 884 ARAIRRENDLKANVQLQQYLADLHEAEAWIKEKEPIVDNKNYGADEEAAGALLKKHEAFL 943
Query: 191 SDISSHQDRIDSFLQQAD 244
D+++ ++ I + QA+
Sbjct: 944 VDLNAFENSIKALRDQAE 961
>sp|P16546|SPTA2_MOUSE Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Alpha-II spectrin) (Fodrin alpha chain)
Length = 1458
Score = 242 bits (617), Expect = 1e-63
Identities = 118/287 (41%), Positives = 179/287 (62%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
LV S K L +A+ QQ F ++D + WL+EVE+ L S+D GKDL SV NL KKH L
Sbjct: 629 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQL 688
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
LE+DIS+H+DR+ QAD + + FD +K+K+ + R+ K++ R+ KL++
Sbjct: 689 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSE 748
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
+++LHQF+RD DDEE WI EK+ + S + GRDL GVQNL KKH+ ++AE+ HEP I
Sbjct: 749 SHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 808
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
V + G+K+ D N +I++++ W +LK A R Q L++SLE QQ++A+ E
Sbjct: 809 VLDTGKKLSDDNTIGQEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 868
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E+W+ EK LV S ++G + + LLKKH+A D ++ ++ +
Sbjct: 869 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDV 915
Score = 166 bits (420), Expect = 8e-41
Identities = 82/279 (29%), Positives = 154/279 (55%)
Frame = +2
Query: 11 SASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLE 190
S + + L+++ QF R+++D E W+ E + + S+D G+DL V NL+KKH LE
Sbjct: 737 SMATSRRAKLSESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLE 796
Query: 191 SDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAY 370
+++++H+ I L + DN + I+++ + + +L++ R +L ++
Sbjct: 797 AELAAHEPAIQGVLDTGKKLSDDNTIGQEEIQQRLAQFVEHWKELKQLAAARGQRLEESL 856
Query: 371 KLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVC 550
+ QF + ++EE WI+EK + S + G L +Q L+KKH+A + + T H+ R+ +VC
Sbjct: 857 EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVC 916
Query: 551 NEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAES 730
GQ +I N++ +I K+ + SDL+ A +R+ LD++ Q+ A ES
Sbjct: 917 TNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVES 976
Query: 731 WMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYR 847
W+ EKE + + ++G+D S + LL K + A ++A++
Sbjct: 977 WIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQ 1015
Score = 151 bits (381), Expect = 3e-36
Identities = 77/282 (27%), Positives = 151/282 (53%), Gaps = 2/282 (0%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
K + L ++ QQF R+V+++E W++E + Q SD+ KD ++ + +KH E+++ +
Sbjct: 529 KRSKLGESQTLQQFSRDVDEIEAWISE-KLQTASDESYKDPTNIQSKHQKHQAFEAELHA 587
Query: 206 HQDRIDSFLQQADQFVHDNHF--DADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLH 379
+ DRI + + + DA+K + + +++ L + ++ KL +A K
Sbjct: 588 NADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQ 647
Query: 380 QFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEG 559
F D + W+ E E + S + G+DL V NL+KKHQ ++A+++ HE R+ ++ ++
Sbjct: 648 NFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQA 707
Query: 560 QKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMR 739
++ + + +++K D + + +K+ A RR L +S Q+ D + ESW++
Sbjct: 708 DSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSESHRLHQFFRDMDDEESWIK 767
Query: 740 EKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
EK+ LV S ++G+D + L KKH L A++ A+ I +
Sbjct: 768 EKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGV 809
Score = 146 bits (369), Expect = 6e-35
Identities = 81/277 (29%), Positives = 147/277 (53%)
Frame = +2
Query: 38 LTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDR 217
L A Q+F R+ ++ + W+ E L +D+ G DL SV LQ+KH E D+++ D+
Sbjct: 215 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 274
Query: 218 IDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDA 397
++S + A + + + A+ +K+K E+ ++ L + ++RK KL D++ L +F D
Sbjct: 275 VNSLGETAQRLIQSHPESAEDLKEKCTELNQAWTSLGKRADQRKAKLGDSHDLQRFLSDF 334
Query: 398 DDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDG 577
D WI+ + S + +D+ G + L+++HQ + E+ GQ+++
Sbjct: 335 RDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH 394
Query: 578 NHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLV 757
HYA+ +I++K+D + +DL+ +RR +LD LE Q + D +AE+WM +E +
Sbjct: 395 GHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDHCLELQLFHRDCEQAENWMAAREAFL 454
Query: 758 GSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
+ + G DS EAL+KKH+ I I +L+
Sbjct: 455 NTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQ 491
Score = 132 bits (332), Expect = 1e-30
Identities = 76/322 (23%), Positives = 153/322 (47%), Gaps = 36/322 (11%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ + ++ L ++ + R +++ W+ E E+ L +++ G DL V LQKK +
Sbjct: 62 LLELGEKRKGMLEKSCKKFMLFREANELQQWITEKEAALTNEEVGADLEQVEVLQKKFDD 121
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHF--DADAIKKKQI-------------------- 298
+ D+ +++ R+ + A+ + + A++++++
Sbjct: 122 FQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGAMPRDEADSKTASPWKSA 181
Query: 299 --------------EVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPI 436
E+ R+ LQ+ E+R L A+++ +F+RDAD+ ++WI EK
Sbjct: 182 RLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQA 241
Query: 437 AGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKID 616
+ N G DL VQ L +KH+ + ++ ++ + Q++I + + D+++K
Sbjct: 242 LNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAQRLIQSHPESAEDLKEKCT 301
Query: 617 DMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTE 796
++ W+ L +AD+R+ L DS + Q++L+D + SW+ LV S E KD E
Sbjct: 302 ELNQAWTSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAE 361
Query: 797 ALLKKHDALMADIEAYRSTIDS 862
ALL++H +I+A T +
Sbjct: 362 ALLERHQEHRTEIDARAGTFQA 383
Score = 115 bits (289), Expect = 1e-25
Identities = 68/272 (25%), Positives = 131/272 (48%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ L + Q+F+ + D+ W+ + + SD+ KD+ L ++H ++I +
Sbjct: 317 RKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDA 376
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
+F Q Q + H+ + IK+K + + L++ +R+ L+ +L F
Sbjct: 377 RAGTFQAFEQFGQQLLAHGHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDHCLELQLF 436
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
+RD + E+W+ +E + + G L V+ LIKKH+ + E +I + +
Sbjct: 437 HRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQ 496
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
+I +HYA DI + +++ + W LK + ++R L +S QQ+ D E E+W+ EK
Sbjct: 497 LIAVDHYAKGDIANRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEK 556
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEA 841
S E KD + ++ +KH A A++ A
Sbjct: 557 LQ-TASDESYKDPTNIQSKHQKHQAFEAELHA 587
Score = 110 bits (274), Expect = 7e-24
Identities = 77/293 (26%), Positives = 136/293 (46%), Gaps = 6/293 (2%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
+L + + L ++ QQF+ NVE+ E W+ E + + S+D G L ++ L KKH
Sbjct: 840 ELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHE 899
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
E+D + H+DR++ + N+ + I K + + S L++ +RK KL+
Sbjct: 900 AFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLD 959
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPR-I 538
+ QF AD E WI EKE + + GRDL VQ L+ K + A + + I
Sbjct: 960 ENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGI 1019
Query: 539 LEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSD-LKNKADKRRQLLDDSLEAQQYLADA 715
+ +++ H ++ IE + + W+ L N A ++++L LEAQ +
Sbjct: 1020 ANITALKDQLLAAKHIQSKAIEARHASLMKRWTQLLANSATRKKKL----LEAQSHFRKV 1075
Query: 716 SEAESWMREKEPLVGSTEFGKDEDSTEAL----LKKHDALMADIEAYRSTIDS 862
+ +K S +ED T+ + L++ AL +A+RS++ S
Sbjct: 1076 EDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSS 1128
Score = 87.4 bits (215), Expect = 5e-17
Identities = 58/233 (24%), Positives = 103/233 (44%), Gaps = 37/233 (15%)
Frame = +2
Query: 278 AIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVG 457
+I +Q ++ N+Y L E EKRK L + K +R+A++ + WI EKE + VG
Sbjct: 47 SIALRQGQIDNQYQSLLELGEKRKGMLEKSCKKFMLFREANELQQWITEKEAALTNEEVG 106
Query: 458 RDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIE----------- 604
DL V+ L KK Q ++ +E R+ ++ N+ + ++ +++
Sbjct: 107 ADLEQVEVLQKKFDDFQKDLKANESRLKDI-NKVAEDLESEGLMAEEVQAVQQQEVYGAM 165
Query: 605 --------------------------KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYL 706
I ++ W L+ A++R QLL + E Q++
Sbjct: 166 PRDEADSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFH 225
Query: 707 ADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
DA E + W+ EK + + +G D S +AL +KH+ D+ A ++SL
Sbjct: 226 RDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSL 278
>sp|P02549|SPTA1_HUMAN Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin)
Length = 2418
Score = 234 bits (597), Expect = 2e-61
Identities = 117/289 (40%), Positives = 178/289 (61%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
+L+ A+K K T L +A+ Q QF N ED++ WL +VE Q+ S+D GK L V N +KH
Sbjct: 671 ELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHG 730
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
LLES +++ QD++D A F H D+ I+ +Q + R+ L+EPL RK KL
Sbjct: 731 LLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLL 790
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRIL 541
D L RD +DEE WI E EP A ST +G+DLI + L+ +H+ I + HEPRI
Sbjct: 791 DLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQ 850
Query: 542 EVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASE 721
E+ G KM++ H+A D+ ++ + L+ +A +R+ L+ +++ QQYLAD E
Sbjct: 851 EITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHE 910
Query: 722 AESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
AE+W+REKEP+V +T +G DE++ ALLKKH+A + D+ ++ ++ +LR
Sbjct: 911 AETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALR 959
Score = 188 bits (478), Expect = 1e-47
Identities = 102/287 (35%), Positives = 155/287 (54%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ + K L +AS QQ+F ++ D E WL+E E+ L D +DL S NL KKH L
Sbjct: 1591 LLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQL 1650
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
LE ++ + +D + A+ + F+ D I KK+ V R+ +QE KL +
Sbjct: 1651 LEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKE 1710
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
AY L QF++D DDEE WI EK S + GRDL GVQNL+KKH+ ++ E+ HEP I
Sbjct: 1711 AYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQN 1770
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
V + +K+ D +I+ ++ W LK A R L++SLE Q++ +A E
Sbjct: 1771 VLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEE 1830
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E+W+ EK L + G +T++LL KH+AL D + + + ++
Sbjct: 1831 EAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNV 1877
Score = 132 bits (331), Expect = 2e-30
Identities = 76/273 (27%), Positives = 139/273 (50%), Gaps = 3/273 (1%)
Frame = +2
Query: 38 LTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDR 217
L +A QF ++++D E W+ E ++ S D G+DL V NL KKH LE ++ +H+
Sbjct: 1708 LKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPA 1767
Query: 218 IDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDA 397
I + L A++ + I+ + + + KL+E + R KL ++ + QF ++A
Sbjct: 1768 IQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNA 1827
Query: 398 DDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMID- 574
++EE WI+EK +A + G L Q+L+ KH+A++ + HE R+ VC +G+ +++
Sbjct: 1828 EEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNK 1887
Query: 575 --GNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKE 748
N++I KI+ + L + L+D Q++ A E+W+ +KE
Sbjct: 1888 VLHEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKE 1947
Query: 749 PLVGSTEFGKDEDSTEALLKKHDALMADIEAYR 847
+ + G D LL K D L A +++++
Sbjct: 1948 TSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQ 1980
Score = 130 bits (328), Expect = 4e-30
Identities = 66/267 (24%), Positives = 147/267 (55%)
Frame = +2
Query: 65 FIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQAD 244
F R+ E ++ W++ E+ L ++D G L S L +KH E ++ +++I + + A
Sbjct: 481 FYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTAT 540
Query: 245 QFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHE 424
+ + D+H+D++ IK + + R L+E R+ L ++ L + Y D+DD ++WI++
Sbjct: 541 KLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINK 600
Query: 425 KEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIE 604
K+ +A + +D+ +++ ++K Q + E+ ++ ++ + GQ+MI+G HYA+ ++
Sbjct: 601 KKKLADDEDY-KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVT 659
Query: 605 KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDE 784
++ ++ +LW +L ++ L ++ + Q+ +A + + W+ + E V S ++GK
Sbjct: 660 TRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGL 719
Query: 785 DSTEALLKKHDALMADIEAYRSTIDSL 865
+ L+KH L + + A + +D L
Sbjct: 720 AEVQNRLRKHGLLESAVAARQDQVDIL 746
Score = 129 bits (324), Expect = 1e-29
Identities = 68/264 (25%), Positives = 135/264 (51%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ L+ A+ Q+F R+V + W+ E E L S+D GKDL + L H LE +++
Sbjct: 256 RQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAV 315
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
D++ +A++ + DA I++ + ++ + + ++ R KL Y H+F
Sbjct: 316 MSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRF 375
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
D D+ W++EK + + D+ G + L+ +HQ + E+ ++ R GQ
Sbjct: 376 SSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQD 435
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
+++ NH A+ ++ +K++ + N W+ L D+R + + L+ + D+ + +SWM +
Sbjct: 436 LVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQ 495
Query: 746 EPLVGSTEFGKDEDSTEALLKKHD 817
E + + + G S EALL+KH+
Sbjct: 496 EAFLENEDLGNSLGSAEALLQKHE 519
Score = 122 bits (305), Expect = 2e-27
Identities = 81/277 (29%), Positives = 143/277 (51%), Gaps = 1/277 (0%)
Frame = +2
Query: 38 LTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDR 217
L A + F R +D + + + L + D G DL SV LQ++H E D+ D+
Sbjct: 1179 LGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDK 1238
Query: 218 IDSFLQQADQFVHDNHFDA-DAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRD 394
+ + L + + + ++H DA + ++++++E+ + LQ + RK LN+A K + F
Sbjct: 1239 V-TILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSK 1297
Query: 395 ADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMID 574
A D ++WI + S + DL G++ L+++HQ +A++ P + + ++ID
Sbjct: 1298 ARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELID 1357
Query: 575 GNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPL 754
H+A+ +IEKK+ +K DL+ +KR+++LD LE Q + + + ES M +E
Sbjct: 1358 SGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESRMVARENS 1417
Query: 755 VGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
+ S + DS EAL+KK D L I A I L
Sbjct: 1418 LRSDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDL 1453
Score = 119 bits (299), Expect = 8e-27
Identities = 69/279 (24%), Positives = 132/279 (47%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
K L +A QQ+++ D+ W+ + E+ S + G+D L KK + ++ +
Sbjct: 150 KGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVA 209
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
+ R+ Q A++ +NH D I+ KQ EV + +L+ +R+ L++A L +F
Sbjct: 210 KEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRF 269
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
RD + WI EKEP+ S + G+DL+ + L H+ ++ + ++ E+C + +K
Sbjct: 270 KRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEK 329
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
+ + I++ +D+ + W ++ A R + L + ++ +D E WM EK
Sbjct: 330 LTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEK 389
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDS 862
+ + E D E LL +H +I++Y S
Sbjct: 390 TAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQS 428
Score = 117 bits (293), Expect = 4e-26
Identities = 81/292 (27%), Positives = 138/292 (47%), Gaps = 4/292 (1%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
DL A + ++ L Q Q F N + +E + E+ L SDD L+S+ L KK +
Sbjct: 1379 DLEKAWEKRKKILDQCLELQMFQGNCDQVESRMVARENSLRSDD-KSSLDSLEALMKKRD 1437
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
L+ I++ + +I A+ + D H+ + I + V +R+ L+ L + KL
Sbjct: 1438 DLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLG 1497
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRIL 541
D L QFYRD ++ E+WI E P A + +D +Q KHQ EV G ++
Sbjct: 1498 DYANLKQFYRDLEELEEWISEMLPTACDESY-KDATNIQRKYLKHQTFAHEVDGRSEQVH 1556
Query: 542 EVCNEGQKMI----DGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLA 709
V N G +I DGN A ++++++ +K W L + + + + L+++ Q++
Sbjct: 1557 GVINLGNSLIERSCDGNEEA---MKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNT 1613
Query: 710 DASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
+ E W+ E E L+ + +D S LLKKH L ++ A + L
Sbjct: 1614 SIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDL 1665
Score = 112 bits (280), Expect = 1e-24
Identities = 60/269 (22%), Positives = 135/269 (50%)
Frame = +2
Query: 62 QFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQA 241
+F + +++ W+ E + + +D+ D+ L +H + +I S+ DR S +
Sbjct: 374 RFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETG 433
Query: 242 DQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIH 421
V+ NH +D +++K + N ++ L E ++R + H FYRD++ + W+
Sbjct: 434 QDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMS 493
Query: 422 EKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDI 601
+E + ++G L + L++KH+ + T E +I+ V K+I +HY + +I
Sbjct: 494 RQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENI 553
Query: 602 EKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKD 781
+ D + L+ KA RR+LL +SL Q+ D+ + ++W+ +K+ L ++ KD
Sbjct: 554 KAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDY-KD 612
Query: 782 EDSTEALLKKHDALMADIEAYRSTIDSLR 868
+ ++ ++K ++ ++ +++++
Sbjct: 613 IQNLKSRVQKQQVFEKELAVNKTQLENIQ 641
Score = 112 bits (279), Expect = 2e-24
Identities = 65/281 (23%), Positives = 131/281 (46%), Gaps = 1/281 (0%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
+ T L + +QF R++E++E W++E+ D+ KD ++ KH ++
Sbjct: 1492 ERTKLGDYANLKQFYRDLEELEEWISEM-LPTACDESYKDATNIQRKYLKHQTFAHEVDG 1550
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIE-VCNRYSKLQEPLEKRKNKLNDAYKLHQ 382
+++ + + + + + K+Q+E + + L E + KLN+A + +
Sbjct: 1551 RSEQVHGVINLGNSLIERSCDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQR 1610
Query: 383 FYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQ 562
F D E W+ E E + + RDL NL+KKHQ ++ E+ E + ++ +
Sbjct: 1611 FNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAE 1670
Query: 563 KMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMRE 742
++ + I KK D++ + +++ A + L ++ Q+ D + ESW+ E
Sbjct: 1671 DLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEE 1730
Query: 743 KEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
K V S ++G+D + LLKKH L ++ A+ I ++
Sbjct: 1731 KLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNV 1771
Score = 108 bits (270), Expect = 2e-23
Identities = 63/287 (21%), Positives = 144/287 (50%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ ++ + L Q + DM W+ E +++ + G +L+ V LQKK +
Sbjct: 1067 LLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAE----NTGVELDDVWELQKKFDE 1122
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
+ D+++++ R+ + AD + + + + +Q E+ R+ LQ ++++ L
Sbjct: 1123 FQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQ-ELNARWGSLQRLADEQRQLLGS 1181
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
A+ + F+R+ADD ++ I +K + + G DL VQ L ++H+ + ++ ++
Sbjct: 1182 AHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTI 1241
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
+ +++ + + A D++++ ++ W DL+ + R++ L+++ + +L+ A +
Sbjct: 1242 LGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDL 1301
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
++W+ +V S E +D E LL++H AD+EA T +L
Sbjct: 1302 QNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQAL 1348
Score = 107 bits (266), Expect = 6e-23
Identities = 68/269 (25%), Positives = 131/269 (48%)
Frame = +2
Query: 59 QQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQ 238
Q F R+ +D+ W+ E + L +D +D ++ +KH LE+++ + + +
Sbjct: 56 QVFKRDADDLGKWIMEKVNIL-TDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKT 114
Query: 239 ADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWI 418
++ H + K E+ + + L E ++ ++L A K Q+ ++ D +WI
Sbjct: 115 REERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWI 174
Query: 419 HEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD 598
+KE IA S +G D + L KK + Q E+ E R++EV + + NH
Sbjct: 175 GDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPL 234
Query: 599 IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGK 778
I+ K +++ W L+ A +R++ L ++ Q++ D +EA W++EKEP++ S ++GK
Sbjct: 235 IQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGK 294
Query: 779 DEDSTEALLKKHDALMADIEAYRSTIDSL 865
D ++E L H L ++ + L
Sbjct: 295 DLVASEGLFHSHKGLERNLAVMSDKVKEL 323
Score = 98.6 bits (244), Expect = 2e-20
Identities = 57/190 (30%), Positives = 100/190 (52%)
Frame = +2
Query: 272 ADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTN 451
A+ I++++ EV RY +E + +R KL D+Y L F RDADD WI EK I +
Sbjct: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKS 80
Query: 452 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNL 631
D +Q +KHQ+++AEV + E+ ++ H A+ + + I+++++L
Sbjct: 81 Y-EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHL 139
Query: 632 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 811
W L ++ L +L+ QQY+ + ++ W+ +KE + S E G+D + TE L KK
Sbjct: 140 WDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKK 199
Query: 812 HDALMADIEA 841
+ ++ A
Sbjct: 200 FEDFQVELVA 209
Score = 88.6 bits (218), Expect = 2e-17
Identities = 69/289 (23%), Positives = 124/289 (42%), Gaps = 12/289 (4%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L +K + L ++ QF++N E+ E W+ E + DCG L + +L KH
Sbjct: 1803 LKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEA 1862
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK--KQIEVCN-RYSKLQEPLEKRKNK 355
LE+D + H+ R+ + Q + ++ + K+ +IE N + L + + K +
Sbjct: 1863 LENDFAVHETRVQNVCAQGEDILNKVLHEESQNKEISSKIEALNEKTPSLAKAIAAWKLQ 1922
Query: 356 LNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTG-HEP 532
L D Y +F AD E WI +KE + G DL L+ K + A + +
Sbjct: 1923 LEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQE 1982
Query: 533 RILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSD-LKNKADKRRQLLDDSLEAQ---- 697
R+ E+ + K+I H ++ IE++ + W L+ A R++LL+ L Q
Sbjct: 1983 RLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAED 2042
Query: 698 ---QYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADI 835
++ AS +W + E + + L K H+ +A +
Sbjct: 2043 LFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASL 2091
Score = 67.0 bits (162), Expect = 6e-11
Identities = 43/185 (23%), Positives = 88/185 (47%)
Frame = +2
Query: 281 IKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGR 460
I ++Q ++ N+Y L + E+R+ +L Y +A D +WI EK+ + N G
Sbjct: 1053 ITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----AENTGV 1108
Query: 461 DLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSD 640
+L V L KK Q ++ +EPR+ ++ ++ + + ++ W
Sbjct: 1109 ELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR-QELNARWGS 1167
Query: 641 LKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDA 820
L+ AD++RQLL + + + +A + + + +K + + + G D S +AL ++H+
Sbjct: 1168 LQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEG 1227
Query: 821 LMADI 835
D+
Sbjct: 1228 FERDL 1232
Score = 36.2 bits (82), Expect = 0.12
Identities = 50/259 (19%), Positives = 96/259 (37%)
Frame = +2
Query: 59 QQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQ 238
QQ++ ++ + E W+ E E + + + G D + L KKH D++S D + + Q
Sbjct: 902 QQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQ 961
Query: 239 ADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWI 418
A+ + + +Q + + + P E K + L +D W
Sbjct: 962 ANACQQQQAAPVEGVAGEQRVMALYDFQARSpreVTMKKGDVLTLLSSINKDW-----WK 1016
Query: 419 HEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD 598
E G + V+ L + + EP GN
Sbjct: 1017 VEAADHQGIV----PAVYVRRLAHDEFPMLPQRRREEP--------------GN------ 1052
Query: 599 IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGK 778
I ++ + ++N + L ++A++RR+ L +A + W++EK+ + G
Sbjct: 1053 ITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----AENTGV 1108
Query: 779 DEDSTEALLKKHDALMADI 835
+ D L KK D D+
Sbjct: 1109 ELDDVWELQKKFDEFQKDL 1127
>sp|Q01082|SPTB2_HUMAN Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1)
(Beta-II spectrin) (Fodrin beta chain)
Length = 2364
Score = 192 bits (489), Expect = 8e-49
Identities = 106/288 (36%), Positives = 167/288 (57%), Gaps = 1/288 (0%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L S ++ K L A+ + F ++ D++ WL +ESQ+ SDD GK L SV L KK +
Sbjct: 1365 LESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKHLTSVNILLKKQQM 1424
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
LE+ + + I+ QA + D + K++ V ++ +L EPL +RK+ L
Sbjct: 1425 LENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKRLTVQTKFMELLEPLNERKHNLLA 1483
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
+ ++HQF RD +DE W+ E+ P+A ST+ G +L VQ LIKK+Q +Q E+ GH+PRI +
Sbjct: 1484 SKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDD 1543
Query: 545 VCNEGQKMI-DGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASE 721
+ Q ++ D + + I +++ D+K LW L + +KR + L+++ AQQY DA+E
Sbjct: 1544 IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAE 1603
Query: 722 AESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
AE+WM E+E + S E KDE S ++LKKH L +E Y T+ L
Sbjct: 1604 AEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQL 1651
Score = 150 bits (379), Expect = 4e-36
Identities = 84/291 (28%), Positives = 156/291 (53%), Gaps = 4/291 (1%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ + + L G Q+ + + + W+ E++ + S D GK L V +L +KH L
Sbjct: 513 LLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTL 572
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNH----FDADAIKKKQIEVCNRYSKLQEPLEKRKN 352
+E+DI +R+ A +F D D I+ + + Y +L + +R+
Sbjct: 573 VEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRA 632
Query: 353 KLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEP 532
+L ++ +L +F+ + +EE WI EKE I S + G+DL V L+ KH+A + E++G
Sbjct: 633 RLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSG 692
Query: 533 RILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLAD 712
+ EG+ MI H+ + I ++I ++ W++L+ + R++ L+++ Q+ AD
Sbjct: 693 HFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQAD 752
Query: 713 ASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
A + ++WM + +V S++ G DE ST++L+KKH + +I YR T+D+L
Sbjct: 753 ADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTL 803
Score = 133 bits (335), Expect = 6e-31
Identities = 70/285 (24%), Positives = 142/285 (49%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
+L + + L ++ +F + + E W+ E E L SDD GKDL SV L KH
Sbjct: 622 ELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHR 681
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
E ++S + +++ + + + HF ++ I+++ I + +++ L++ RK +L
Sbjct: 682 AFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLE 741
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRIL 541
+A LHQF DADD + W+ + I S++VG D Q+L+KKH+ + E+ + P L
Sbjct: 742 EASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP-TL 800
Query: 542 EVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASE 721
+ +E + H + D+ ++ ++ + ++ R+Q L D+L + ++A
Sbjct: 801 DTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADA 860
Query: 722 AESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTI 856
E W+ EKE + + + + + E + + ++L ++ S +
Sbjct: 861 CELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRV 905
Score = 130 bits (328), Expect = 4e-30
Identities = 79/290 (27%), Positives = 150/290 (51%), Gaps = 2/290 (0%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ ++ + L +A QQ+ + + E W++E E + S++ KD S ++ KKH +
Sbjct: 1577 LIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQI 1636
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
LE + + + + + + V D+H +++ I +Q +V Y+ L++ E+R+ KL++
Sbjct: 1637 LEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDE 1696
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGH--EPRI 538
++L Q R+ DD E WI E+E +AGS +G+D V L ++ + A TG+ + R+
Sbjct: 1697 RHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREF-ARDTGNIGQERV 1755
Query: 539 LEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADAS 718
V + ++I+ H I + D + W+DL D R Q+L S E ++ DA
Sbjct: 1756 DTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAK 1815
Query: 719 EAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
E +++K + E G+D+++ E L + H DI+A + + L+
Sbjct: 1816 EIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQ 1864
Score = 127 bits (318), Expect = 5e-29
Identities = 74/271 (27%), Positives = 138/271 (50%), Gaps = 1/271 (0%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
+L+ ++ NL + QF R+VED +W+ E S D G +L +V L KK+
Sbjct: 1469 ELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQ 1528
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNH-FDADAIKKKQIEVCNRYSKLQEPLEKRKNKL 358
L+ +I HQ RID +++ V D+ A+AI+++ ++ + L E EKR +L
Sbjct: 1529 TLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRL 1588
Query: 359 NDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRI 538
+A++ Q+Y DA + E W+ E+E S +D +++KKHQ ++ V + +
Sbjct: 1589 EEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETV 1648
Query: 539 LEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADAS 718
++ + ++ +H + I + + L++ LK+ A++RR LD+ Q +
Sbjct: 1649 HQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVD 1708
Query: 719 EAESWMREKEPLVGSTEFGKDEDSTEALLKK 811
+ E W+ E+E + GS E G+D + L ++
Sbjct: 1709 DLEQWIAEREVVAGSHELGQDYEHVTMLQER 1739
Score = 124 bits (311), Expect = 3e-28
Identities = 77/270 (28%), Positives = 141/270 (52%), Gaps = 4/270 (1%)
Frame = +2
Query: 23 IKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDIS 202
I++ L Q + ++F R E WL+E + + D+ G DL +V KKH +E+DI+
Sbjct: 415 IRQEKLEQLA--RRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIA 472
Query: 203 SHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQ 382
++++R+ + + A + +N+ D I ++ V + L E L R+ +L L +
Sbjct: 473 AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQK 532
Query: 383 FYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQ 562
+++ DW+ E + + S + G+ L+GV++L++KH ++A++ R+ V Q
Sbjct: 533 IFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQ 592
Query: 563 KM-IDGNHYANRD---IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAES 730
K DG Y D I ++ M+ + +L A +RR L++S ++ + +E E
Sbjct: 593 KFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEG 652
Query: 731 WMREKEPLVGSTEFGKDEDSTEALLKKHDA 820
W+REKE ++ S ++GKD S LL KH A
Sbjct: 653 WIREKEKILSSDDYGKDLTSVMRLLSKHRA 682
Score = 123 bits (308), Expect = 8e-28
Identities = 70/290 (24%), Positives = 145/290 (50%), Gaps = 1/290 (0%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
+L S I++ L +AS QF + +D++ W+ ++ + S D G D S +L KKH
Sbjct: 728 NLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHK 787
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
+ +I++++ +D+ +QA + H ++ ++ + + RY ++ E RK L
Sbjct: 788 DVAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQALQ 846
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRIL 541
D L++ + +AD E WI EKE + + L ++ + + ++++ E+ R+
Sbjct: 847 DTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVA 906
Query: 542 EVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASE 721
V ++++ H + ++I+ + D + WS + D+++ L +L Q Y + +E
Sbjct: 907 VVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNE 966
Query: 722 AESWMREKEPLVGST-EFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
+SW+REK ++ ST + G D AL +K + D+ A + + L+
Sbjct: 967 TKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQ 1016
Score = 112 bits (280), Expect = 1e-24
Identities = 60/290 (20%), Positives = 140/290 (48%), Gaps = 1/290 (0%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
++ +++++ L + + E+W+ E E L + + L + +Q +
Sbjct: 833 EVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFE 892
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
LE ++++ R+ Q A Q +H H IK +Q ++ R+S+ +E ++++K+ L
Sbjct: 893 SLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALL 952
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGST-NVGRDLIGVQNLIKKHQAIQAEVTGHEPRI 538
A + ++ + ++ + WI EK + ST ++G DL GV L +K ++ ++ E ++
Sbjct: 953 SALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKL 1012
Query: 539 LEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADAS 718
++ E +K+ + + I ++ ++ ++W ++K R L ++ + QQ+L D
Sbjct: 1013 SDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLD 1072
Query: 719 EAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
+ +SW+ + + S + E LL +H+ + +I+ Y +R
Sbjct: 1073 DFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMR 1122
Score = 110 bits (276), Expect = 4e-24
Identities = 67/282 (23%), Positives = 138/282 (48%), Gaps = 2/282 (0%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGS-DDCGKDLNSVTNLQKKHNLLESDIS 202
K+ L A Q + + + W+ E + S D G DL V LQ+K +E D+
Sbjct: 947 KKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLV 1006
Query: 203 SHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQ 382
+ + ++ ++A++ ++ A AI + E+ + + +++ L+ R+ L +A KL Q
Sbjct: 1007 AIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQ 1066
Query: 383 FYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQ 562
F RD DD + W+ + S ++ L + L+ +H+ I+ E+ +E ++ + G+
Sbjct: 1067 FLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGE 1126
Query: 563 KMIDGNHYAN-RDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMR 739
+ G A + +++ + W++L + R+ LL S QQ+L D +AE+++
Sbjct: 1127 MVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLN 1186
Query: 740 EKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
+E ++ TE + EA +KK + M ++A I+++
Sbjct: 1187 NQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAV 1228
Score = 104 bits (259), Expect = 4e-22
Identities = 64/232 (27%), Positives = 114/232 (49%), Gaps = 1/232 (0%)
Frame = +2
Query: 128 DDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFD-ADAIKKKQIEV 304
++ G+D N+V LQ+ H E DI + ++ + A + D AD I+K++ EV
Sbjct: 1830 EELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEV 1889
Query: 305 CNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNL 484
+ L + E R+ +L D +F+ D W+ + + RD+ V+ L
Sbjct: 1890 LEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELL 1949
Query: 485 IKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKR 664
+ HQ I+AE+ G+ ++ HYA+ +I++K+ + ++ +K + R
Sbjct: 1950 MNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDR 2009
Query: 665 RQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDA 820
+ L LE Q+ DAS AE+W+ +EP + S E G+ D E L+K+H+A
Sbjct: 2010 WEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEA 2061
Score = 100 bits (248), Expect = 7e-21
Identities = 62/281 (22%), Positives = 134/281 (47%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ L+Q+ QQF+R+ + E +L E L + L KK + + +
Sbjct: 1161 RQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDA 1220
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
++++I++ ++ + V D + ++D I++K + +R+ K +E + +L D L +F
Sbjct: 1221 NEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKF 1280
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
+D + WI+EK A + + + + KHQA AE+ ++ + ++ EG +
Sbjct: 1281 LQDCQELSLWINEKMLTAQDMSYD-EARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ 1339
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
+I +++K+ + +W L++ + Q L D+ +A+ + ++ + W+
Sbjct: 1340 LISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGL 1399
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
E + S ++GK S LLKK L +E + I+ L+
Sbjct: 1400 ESQIQSDDYGKHLTSVNILLKKQQMLENQMEVRKKEIEELQ 1440
Score = 91.3 bits (225), Expect = 3e-18
Identities = 59/272 (21%), Positives = 130/272 (47%), Gaps = 3/272 (1%)
Frame = +2
Query: 59 QQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK---HNLLESDISSHQDRIDSF 229
Q+F+++ +++ +W+ E L + D D NL K H ++++S+++ +D
Sbjct: 1278 QKFLQDCQELSLWINE--KMLTAQDMSYD--EARNLHSKWLKHQAFMAELASNKEWLDKI 1333
Query: 230 LQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEE 409
++ Q + + +K+K + + L+ + + +L DA K F + D +
Sbjct: 1334 EKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLD 1393
Query: 410 DWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYA 589
W+H E S + G+ L V L+KK Q ++ ++ + I E+ ++ Q + +
Sbjct: 1394 KWLHGLESQIQSDDYGKHLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-S 1452
Query: 590 NRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTE 769
+++ K ++ + +L ++R+ L S E Q+ D + W+ E+ PL ST+
Sbjct: 1453 TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTD 1512
Query: 770 FGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
G + + + L+KK+ L +I+ ++ ID +
Sbjct: 1513 HGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDI 1544
Score = 83.2 bits (204), Expect = 9e-16
Identities = 42/177 (23%), Positives = 89/177 (50%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ A + + L + +F V D+ +W+ +V Q+ + + +D++SV L H
Sbjct: 1896 LLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQG 1955
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
++++I + D + ++ + H+ ++ IK+K +++ + ++ + E R L
Sbjct: 1956 IKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRL 2015
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPR 535
++HQF RDA E W+ +EP S +G+ + V+ LIK+H+A + + R
Sbjct: 2016 ILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDER 2072
Score = 79.3 bits (194), Expect = 1e-14
Identities = 52/167 (31%), Positives = 82/167 (49%), Gaps = 4/167 (2%)
Frame = +2
Query: 347 KNKLNDAYKLHQ----FYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAE 514
+N+L KL Q F R A E W+ E + + N G DL V+ KKH+AI+ +
Sbjct: 411 RNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETD 470
Query: 515 VTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEA 694
+ +E R+ V +++ N++ + I + D++ LW L RRQ L+ +L
Sbjct: 471 IAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGL 530
Query: 695 QQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADI 835
Q+ + WM E + LV S ++GK E LL+KH + ADI
Sbjct: 531 QKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADI 577
Score = 58.5 bits (140), Expect = 2e-08
Identities = 64/263 (24%), Positives = 104/263 (39%), Gaps = 21/263 (7%)
Frame = +2
Query: 140 KDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYS 319
K N+ NLQ NL E + + L D V +H D +I + + +S
Sbjct: 226 KKSNAHYNLQNAFNLAEQHLG-----LTKLLDPEDISV--DHPDEKSIITYVVTYYHYFS 278
Query: 320 KLQEPLEKRK-------NKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQ 478
K++ + K N + + ++ A D +WI + I + L+GVQ
Sbjct: 279 KMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQ 338
Query: 479 NLIKK---HQAIQAEVTGHEPRILEVC--NEGQKMIDGNHYANRDIEKK-IDDMKNLWSD 640
++ ++ ++ E LEV KM N E K I D+ W
Sbjct: 339 QQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMpreGKLISDINKAWER 398
Query: 641 LKNKADKRRQLLDDSLEAQQYLAD--------ASEAESWMREKEPLVGSTEFGKDEDSTE 796
L+ +R L + L Q+ L A+ E+W+ E + LV FG D + E
Sbjct: 399 LEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVE 458
Query: 797 ALLKKHDALMADIEAYRSTIDSL 865
A KKH+A+ DI AY + ++
Sbjct: 459 AATKKHEAIETDIAAYEERVQAV 481
Score = 33.1 bits (74), Expect = 1.0
Identities = 16/55 (29%), Positives = 26/55 (47%)
Frame = +2
Query: 62 QFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDS 226
QF R+ E WL E L S + G+ ++ V L K+H E ++ +R +
Sbjct: 2021 QFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSA 2075
>sp|Q00963|SPTCB_DROME Spectrin beta chain
Length = 2291
Score = 175 bits (443), Expect = 2e-43
Identities = 100/291 (34%), Positives = 158/291 (54%), Gaps = 3/291 (1%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
DL +K K L A+ + + +D++ ++ ++E Q+ S D DL SV L +K
Sbjct: 1364 DLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQ 1423
Query: 182 LLESDIS---SHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKN 352
++++ ++ + ID + + V + + +KK V R+ K++ PL +R+
Sbjct: 1424 VIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKTA--VLERFEKIKAPLLERQK 1481
Query: 353 KLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEP 532
L + QF RD +DE+ WI EK P+A S + G L V L KK+Q++ E+ HEP
Sbjct: 1482 ALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEP 1541
Query: 533 RILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLAD 712
RI +CN G+K+ID H + E I D+ W +LK+ + RR+ L +S + QQY D
Sbjct: 1542 RINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFD 1601
Query: 713 ASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
A EAESWM E+E + + GKDE S + L+KKH+ L +E Y +TI L
Sbjct: 1602 AQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQL 1652
Score = 168 bits (425), Expect = 2e-41
Identities = 92/294 (31%), Positives = 172/294 (58%), Gaps = 6/294 (2%)
Frame = +2
Query: 2 DLVSASKIK-ETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKH 178
+L+ A +++ E +L Q+ + +++ME E++ L +DD GK L V +L +KH
Sbjct: 511 ELLRARRMRLEISLQLQQNFQEMLYILDNME----EIKQLLMTDDYGKHLMGVEDLLQKH 566
Query: 179 NLLESDISSHQDRIDSFLQQADQFVHDNH-----FDADAIKKKQIEVCNRYSKLQEPLEK 343
+L+E+DI+ +R+ +Q + +F+ D+ D + I + ++ + Y++L +
Sbjct: 567 SLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVE 626
Query: 344 RKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTG 523
R+++L ++ KL QFY D DEE+WI EKE I + VG DL V ++ KH+A+++E+T
Sbjct: 627 RRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITS 686
Query: 524 HEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQY 703
H+P++ V G ++I H+ I+ ++ ++ N W L + RRQ L++++E Q
Sbjct: 687 HDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQL 746
Query: 704 LADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
ADA + ++WM + +V S + G+DE + ++LLKKH + +++ Y ID+L
Sbjct: 747 FADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAEVIDAL 800
Score = 129 bits (324), Expect = 1e-29
Identities = 72/261 (27%), Positives = 139/261 (53%), Gaps = 1/261 (0%)
Frame = +2
Query: 62 QFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQA 241
QF R+VED ++W+ E S D G L +V L+KK+ L ++I +H+ RI++
Sbjct: 1491 QFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNG 1550
Query: 242 DQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIH 421
+ + + H DA + ++ ++ +L++ +E R+ L ++ K+ Q++ DA + E W+
Sbjct: 1551 RKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMS 1610
Query: 422 EKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD- 598
E+E + G+D I QNL+KKH+ ++ V + I ++ E + G+ ++ D
Sbjct: 1611 EQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQL-GEVARQFSGDDISSGDA 1669
Query: 599 IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGK 778
+ K + L++ LK+ A +RR L+++L+ + + E W+ ++E + GS E G+
Sbjct: 1670 VAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQ 1729
Query: 779 DEDSTEALLKKHDALMADIEA 841
D D L ++ + D EA
Sbjct: 1730 DFDHVTLLSERFNEFARDTEA 1750
Score = 127 bits (318), Expect = 5e-29
Identities = 83/291 (28%), Positives = 142/291 (48%), Gaps = 2/291 (0%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
+L A + + +L ++ QQ+ + ++ E W++E E + +D GKD S NL KKH
Sbjct: 1577 ELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHE 1636
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
LE + + + I + A QF D+ DA+ KQ ++ Y+ L++ +R+ +LN
Sbjct: 1637 NLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLN 1696
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQ--AIQAEVTGHEPR 535
+A +L R+ DD E WI ++E +AGS +G+D V L ++ A E G E R
Sbjct: 1697 EALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEFARDTEAVGGE-R 1755
Query: 536 ILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADA 715
+ +V +I H + I + D++ W DL + R Q+L S E ++ D
Sbjct: 1756 VAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDC 1815
Query: 716 SEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
+ + EK+ V S E G+D S L +KH + D+ S + ++
Sbjct: 1816 KDVLGRILEKQHGV-SDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQ 1865
Score = 120 bits (301), Expect = 5e-27
Identities = 73/279 (26%), Positives = 148/279 (53%), Gaps = 5/279 (1%)
Frame = +2
Query: 23 IKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDIS 202
I++ L Q + + F R E WL+E + + D+ G DL +V KKH +E+DI
Sbjct: 411 IRQEKLEQLAAR--FDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIF 468
Query: 203 SHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQ 382
++++R+ + + D+ + + D I ++ V ++ L E L R+ +L + +L Q
Sbjct: 469 AYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQ 528
Query: 383 FYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQ 562
+++ D + E + + + + G+ L+GV++L++KH ++A++ R+ V Q
Sbjct: 529 NFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQ 588
Query: 563 KMI--DGNHYANRD---IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAE 727
K + D Y D I ++ +++ +++L A +RR L++S + Q+ D ++ E
Sbjct: 589 KFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEE 648
Query: 728 SWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAY 844
+W++EKE +V + E G D + +L KH AL ++I ++
Sbjct: 649 NWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSH 687
Score = 112 bits (281), Expect = 1e-24
Identities = 73/258 (28%), Positives = 129/258 (50%), Gaps = 5/258 (1%)
Frame = +2
Query: 107 VESQLG-SDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQA----DQFVHDNHFD 271
+E Q G SD+ G+D SV+ LQ+KH D+ + ++ +++ D + D
Sbjct: 1823 LEKQHGVSDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDK--- 1879
Query: 272 ADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTN 451
A I ++ EV + + LQ + RK KL D L +F+ W+ + ++
Sbjct: 1880 AKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSE 1939
Query: 452 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNL 631
RD+ GV+ L+ HQ+++AE+ E + G++++ NHYA+ DI+ ++ + N
Sbjct: 1940 KPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNS 1999
Query: 632 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 811
+ L + ++R + L LE Q+ DA+ AE+W+ +EP + S+E G D E L+KK
Sbjct: 2000 RNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKK 2059
Query: 812 HDALMADIEAYRSTIDSL 865
H+A A +L
Sbjct: 2060 HEAFEKSAAAQEERFSAL 2077
Score = 107 bits (266), Expect = 6e-23
Identities = 66/288 (22%), Positives = 140/288 (48%), Gaps = 1/288 (0%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L+ +K + L A Q + +D++ W+ + + S+D G+D +V +L KKH
Sbjct: 726 LLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKD 785
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
+ ++ ++ + ID+ +QA+ + N + + K+ + NRY +L E + RK +L D
Sbjct: 786 VADELKNYAEVIDALHKQAES-LKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLD 844
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
A L++ +AD E WI EK + + G+D+ V+ + + + E+ + R+
Sbjct: 845 ALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAV 904
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
V ++++ H + +I ++ + + WS L+ KA+ + L + Q + + E
Sbjct: 905 VNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRET 964
Query: 725 ESWMREKEPLVGSTE-FGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
SW+ +K+ ++ T+ D L ++ + D+ A ++ + SL
Sbjct: 965 ISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSL 1012
Score = 105 bits (263), Expect = 1e-22
Identities = 64/280 (22%), Positives = 129/280 (46%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ L+Q+ QQ F R+ E+ L++ E L DD +L N K+H + + +
Sbjct: 1161 RQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEA 1220
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
+ D+I++ LQ AD V +HFDAD I K+ + R ++ + KL + KLH+F
Sbjct: 1221 NDDKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEF 1280
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
+D ++ +W+ EK + + R + + +HQA +AE+ ++ R+ E Q+
Sbjct: 1281 LQDLEELAEWVQEKYATSQDESY-RSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQE 1339
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
+ IE K+ ++ + DL+ ++ +L D+ + +S++ +
Sbjct: 1340 LSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDL 1399
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E + S + D S L++K + + ++ +
Sbjct: 1400 EKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEI 1439
Score = 101 bits (251), Expect = 3e-21
Identities = 63/288 (21%), Positives = 144/288 (50%), Gaps = 5/288 (1%)
Frame = +2
Query: 17 SKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLG-SDDCGKDLNSVTNLQKKHNLLES 193
++ K +L A G Q F + W+ + + L +D DL V LQ++ + ++
Sbjct: 941 AEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDR 1000
Query: 194 DISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYK 373
D+++ Q ++ S ++A+ ++ +A I+++ ++ + +L + L++R +KL +A
Sbjct: 1001 DLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGD 1060
Query: 374 LHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCN 553
LH+F RD D + W+ + + S + L + L+ +HQ+I+ E+ + +
Sbjct: 1061 LHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMME 1120
Query: 554 EGQKMIDGNHYANRD----IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASE 721
G+++ ++ + ++++ +K+ W +L + R+ LL SL+ Q + DA +
Sbjct: 1121 YGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDARQ 1180
Query: 722 AESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
E + ++E + + + + E LK+H+A + +EA I++L
Sbjct: 1181 TEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTL 1228
Score = 99.0 bits (245), Expect = 2e-20
Identities = 58/282 (20%), Positives = 133/282 (47%), Gaps = 1/282 (0%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
+L +K+++ L A + + + +E W+ E L + GKD+ V ++ +
Sbjct: 830 ELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFE 889
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
+ +++++ R+ Q A Q +H H ++D I ++Q + +S L+E E + + L
Sbjct: 890 GFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLK 949
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGST-NVGRDLIGVQNLIKKHQAIQAEVTGHEPRI 538
A+ + FY + + WI +K+ I T ++ DL GV L ++ + ++ + ++
Sbjct: 950 SAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKL 1009
Query: 539 LEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADAS 718
+ E + D + + I ++I ++ +W L +R L+++ + ++L D
Sbjct: 1010 SSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLD 1069
Query: 719 EAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAY 844
++W+ + + V S + E LL +H ++ +I+ Y
Sbjct: 1070 HFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNY 1111
Score = 80.5 bits (197), Expect = 6e-15
Identities = 49/288 (17%), Positives = 129/288 (44%), Gaps = 4/288 (1%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L K +++ L +A +F+R+++ + WL + ++ + S+D L L +H
Sbjct: 1044 LTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQS 1103
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADA----IKKKQIEVCNRYSKLQEPLEKRKN 352
+ +I ++ + + ++ ++ + D ++++ + + + +L + E R+
Sbjct: 1104 IREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQV 1163
Query: 353 KLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEP 532
L+ + F RDA E + ++E + +L +N +K+H+A + ++
Sbjct: 1164 LLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDD 1223
Query: 533 RILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLAD 712
+I + +++ +H+ I K+ +++ D + +A + + L + ++ ++L D
Sbjct: 1224 KINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQD 1283
Query: 713 ASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTI 856
E W++EK E + + + +H A A+I A + +
Sbjct: 1284 LEELAEWVQEKY-ATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERL 1330
Score = 80.1 bits (196), Expect = 7e-15
Identities = 58/264 (21%), Positives = 120/264 (45%)
Frame = +2
Query: 62 QFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQA 241
+F V + IW+ ++ Q+ + + +D++ V L H L+++I + +D + +
Sbjct: 1916 RFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLG 1975
Query: 242 DQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIH 421
+ + NH+ + IK + + + N + L E+R L +++QF RDA E W+
Sbjct: 1976 KELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLI 2035
Query: 422 EKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDI 601
+EP S+ +G + V+NLIKKH+A + E R + R
Sbjct: 2036 AQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSAL--------------ERLT 2081
Query: 602 EKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKD 781
++ +MK +L +A+++R + +A A+ ++ E+ R+ + VG++ +
Sbjct: 2082 TFELKEMKRR-QELAEEAERQRIKEEQEAKAASEAAEQAKREAERRD-DVDVGASHDDSE 2139
Query: 782 EDSTEALLKKHDALMADIEAYRST 853
T + H+ + + ST
Sbjct: 2140 RGGTPGAGEGHEGYVTRKHEWDST 2163
Score = 56.6 bits (135), Expect = 9e-08
Identities = 63/252 (25%), Positives = 98/252 (38%), Gaps = 22/252 (8%)
Frame = +2
Query: 176 HNLLES-DISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKN 352
HNL + D++ + + L D FV H D +I + + +SKL++ + K
Sbjct: 228 HNLNNAFDVAEDKLGLAKLLDAEDVFVE--HPDEKSIITYVVTYYHYFSKLKQETVQGKR 285
Query: 353 -------KLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKK---HQA 502
+ + +H + D WI G L GVQ + + ++
Sbjct: 286 IGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRT 345
Query: 503 IQAEVTGHEPRILEVC--NEGQKMIDGNHYANRDIE-KKIDDMKNLWSDLKNKADKRRQL 673
I+ E LEV KM N E K I D+ W L+ +R
Sbjct: 346 IEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELA 405
Query: 674 LDDSLEAQQYLAD--------ASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMA 829
L + L Q+ L AS E+W+ E + LV FG D + EA KKH+A+
Sbjct: 406 LREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIET 465
Query: 830 DIEAYRSTIDSL 865
DI AY + ++
Sbjct: 466 DIFAYEERVQAV 477
>sp|Q9QWN8|SPTN2_RAT Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2)
(Beta-III spectrin) (SPNB-3) (Beta SpIII sigma 1)
(Spectrin-like protein GTRAP41)
Length = 2388
Score = 167 bits (422), Expect = 5e-41
Identities = 96/288 (33%), Positives = 165/288 (57%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
+L + ++ K +L A+ + F ++ +E WL +++QL SDD GKDL SV L KK
Sbjct: 1367 ELETTTQAKARSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQ 1426
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLN 361
+LE +++ + +++ QA ++ A +++ V ++ L +P++ R +L
Sbjct: 1427 MLEREMAVREKEVEAIQAQAKALAQEDQ-SAGEVERTSRAVEEKFRALCQPMKDRCRRLQ 1485
Query: 362 DAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRIL 541
+ + HQF+RD +DE W+ E+ P+A S G+DL VQ L+KK+Q +Q E+ GHEPRI
Sbjct: 1486 ASREQHQFHRDVEDEILWVTERLPMASSLEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIA 1545
Query: 542 EVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASE 721
++ E Q+ + G A ++ +++ +W L ++ + R + L+++L AQQ+ DA+E
Sbjct: 1546 DL-KERQRTL-GTAAAGPELA----ELQEMWKRLSHELELRGKRLEEALRAQQFYRDAAE 1599
Query: 722 AESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
AE+WM E+E + E KDE S +A +KKH L + Y TI L
Sbjct: 1600 AEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIKQL 1647
Score = 141 bits (356), Expect = 2e-33
Identities = 79/262 (30%), Positives = 139/262 (53%), Gaps = 4/262 (1%)
Frame = +2
Query: 95 WLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNH--- 265
W+AE++ +L S D GK L V +L + H L+E+DI+ +R+ + A +F
Sbjct: 546 WMAEMKGRLQSQDLGKHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYR 605
Query: 266 -FDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAG 442
D + ++ + Y L E R+ +L ++ +L +F + + E W+ E++ +
Sbjct: 606 PCDPQLVSERVATLEQSYEALCELAATRRARLEESRRLWRFLWEVGEAEAWVREQQHLLA 665
Query: 443 STNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDM 622
S GRDL GV L+ KH A++ E++G + +GQ+++ H + ++
Sbjct: 666 SAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGANQASTRAAEL 725
Query: 623 KNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEAL 802
+ W L+ A++R Q L + Q+ ADA++ E+W+ + LV S E G DE ST+AL
Sbjct: 726 QAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPEVGHDEFSTQAL 785
Query: 803 LKKHDALMADIEAYRSTIDSLR 868
++H AL +I A+R T+D+LR
Sbjct: 786 ARQHRALEEEIRAHRPTLDALR 807
Score = 119 bits (298), Expect = 1e-26
Identities = 78/257 (30%), Positives = 123/257 (47%), Gaps = 1/257 (0%)
Frame = +2
Query: 44 QASGQQ-QFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRI 220
QAS +Q QF R+VED +W+ E S + GKDL SV L KK+ L+ +I H+ RI
Sbjct: 1485 QASREQHQFHRDVEDEILWVTERLPMASSLEHGKDLPSVQLLMKKNQTLQKEIQGHEPRI 1544
Query: 221 DSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDAD 400
AD A + E+ + +L LE R +L +A + QFYRDA
Sbjct: 1545 ------ADLKERQRTLGTAAAGPELAELQEMWKRLSHELELRGKRLEEALRAQQFYRDAA 1598
Query: 401 DEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGN 580
+ E W+ E+E +D + Q +KKHQ ++ + + I ++ Q MID
Sbjct: 1599 EAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIKQLAASSQDMIDHE 1658
Query: 581 HYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVG 760
H + + + + L++ LK A +RR+ L + L Q + + E W++E+E +
Sbjct: 1659 HPESTRLTIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAA 1718
Query: 761 STEFGKDEDSTEALLKK 811
S E G+D + L K
Sbjct: 1719 SHELGQDYEHVTMLRDK 1735
Score = 113 bits (282), Expect = 8e-25
Identities = 74/284 (26%), Positives = 135/284 (47%), Gaps = 1/284 (0%)
Frame = +2
Query: 20 KIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDI 199
+++ L +A QQF R+ + E W+ E E + + KD S KKH +LE +
Sbjct: 1578 ELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQAL 1637
Query: 200 SSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLH 379
+ + I + + H ++ + +Q +V Y+ L+E +R+ +L + +L
Sbjct: 1638 ADYAQTIKQLAASSQDMIDHEHPESTRLTIRQAQVDKLYAGLKELAGERRERLQEHLRLC 1697
Query: 380 QFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEV-TGHEPRILEVCNE 556
Q R+ DD E WI E+E +A S +G+D V L K + + T + R+
Sbjct: 1698 QLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANAL 1757
Query: 557 GQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWM 736
+I G H A + + D + W+DL D R Q+L + E Q++L A +A + +
Sbjct: 1758 ANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARV 1817
Query: 737 REKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
+ K+ + G+D ++ EAL ++H A DI+A + + ++
Sbjct: 1818 QHKQQQLPDGT-GRDLNAAEALQRRHCAYEHDIQALSTQVQQVQ 1860
Score = 111 bits (277), Expect = 3e-24
Identities = 71/275 (25%), Positives = 138/275 (50%), Gaps = 4/275 (1%)
Frame = +2
Query: 23 IKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDIS 202
I++ L Q + + F R E WL+E + + D+ G +L +V +KH +E+DI
Sbjct: 418 IRQEKLEQLAAR--FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIV 475
Query: 203 SHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQ 382
++ R+ + A + +++ D I +Q V + L+E + R+ +L +L +
Sbjct: 476 AYSGRVQAVDAVAAELAAEHYHDIKRIAARQNNVARLWDFLREMVAARRERLLLNLELQK 535
Query: 383 FYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQ 562
++D DW+ E + S ++G+ L GV++L++ H+ ++A++ R+ V
Sbjct: 536 VFQDLLYLMDWMAEMKGRLQSQDLGKHLAGVEDLLQLHELVEADIAVQAERVRAVSASAL 595
Query: 563 KMID-GNHYANRD---IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAES 730
+ D G Y D + +++ ++ + L A RR L++S ++L + EAE+
Sbjct: 596 RFCDPGKEYRPCDPQLVSERVATLEQSYEALCELAATRRARLEESRRLWRFLWEVGEAEA 655
Query: 731 WMREKEPLVGSTEFGKDEDSTEALLKKHDALMADI 835
W+RE++ L+ S E G+D LL KH AL ++
Sbjct: 656 WVREQQHLLASAETGRDLTGVLRLLNKHTALRGEM 690
Score = 110 bits (275), Expect = 5e-24
Identities = 65/287 (22%), Positives = 134/287 (46%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L + + L ++ +F+ V + E W+ E + L S + G+DL V L KH
Sbjct: 626 LCELAATRRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTA 685
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
L ++S + L+Q Q V + H A+ + E+ ++ +L+ E+R +L
Sbjct: 686 LRGEMSGRLGPLKLTLEQGQQLVAEGHPGANQASTRAAELQAQWERLEALAEERAQRLAQ 745
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
A L+QF DA+D E W+ + + S VG D Q L ++H+A++ E+ H P L+
Sbjct: 746 AASLYQFQADANDMEAWLVDALRLVSSPEVGHDEFSTQALARQHRALEEEIRAHRP-TLD 804
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
E + +++ ++ ++ + +L+ +A +R + L+ +L L++A
Sbjct: 805 ALREQAAALPPALSHTPEVQGRVPTLEQHYEELQARAGERARALEAALAFYTMLSEAGAC 864
Query: 725 ESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
W+ EKE + + + E + ++ + L ++ A + + ++
Sbjct: 865 GLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARVTAV 911
Score = 98.2 bits (243), Expect = 3e-20
Identities = 73/292 (25%), Positives = 127/292 (43%), Gaps = 4/292 (1%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
DL+ + L A Q+F+ + + QL D G+DLN+ LQ++H
Sbjct: 1785 DLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQL-PDGTGRDLNAAEALQRRHC 1843
Query: 182 LLESDISSHQDRI----DSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRK 349
E DI + ++ D L+ + D A+ I + V +++LQ R+
Sbjct: 1844 AYEHDIQALSTQVQQVQDDGLRLQKAYAGDK---AEEIGRHMQAVAEAWAQLQGSSAARR 1900
Query: 350 NKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHE 529
L D +F++ + W+ + RD+ +IK Q I+AE+
Sbjct: 1901 QLLLDTTDKFRFFKAVRELMLWMDGINLQMDAQERPRDVSSADLVIKNQQGIKAEIEARA 1960
Query: 530 PRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLA 709
R + GQ+++ NHYA +I +K+ +++ + K ++ L LE +
Sbjct: 1961 DRFSACIDMGQELLARNHYAAEEISEKLSQLQSRRQETAEKWQEKMDWLQLVLEVLVFGR 2020
Query: 710 DASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
DA AE+W+ +EPLV S E G D E+L+K+H+A A+ +L
Sbjct: 2021 DAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSAL 2072
Score = 96.7 bits (239), Expect = 8e-20
Identities = 66/281 (23%), Positives = 128/281 (45%)
Frame = +2
Query: 26 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS 205
++ L QA G Q F+R+ E L+ E L + L + KK S + +
Sbjct: 1164 RQGRLAQAHGFQGFLRDARQAEGVLSSQEYFLSHTEMPGTLQAADAAIKKLEDFMSTMDA 1223
Query: 206 HQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQF 385
+ +RI L+ Q V + A+ I++K + R+ K QE +++ +L D + F
Sbjct: 1224 NGERIRGLLEAGRQLVSKGNIHAEKIQEKADSIEKRHRKNQEAVQQLLGRLRDNREQQHF 1283
Query: 386 YRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQK 565
+D + + WI EK A + + + +KHQA AE+ ++ + +V EG++
Sbjct: 1284 LQDCQELKLWIDEKMLTAQDVSYD-EARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRE 1342
Query: 566 MIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREK 745
+ + +K++D+ W +L+ + + L D+ A+ + S ESW+
Sbjct: 1343 LTLEKPELKVLVSEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSALESWLESL 1402
Query: 746 EPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
+ + S ++GKD S LLKK L ++ +++++
Sbjct: 1403 QAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQ 1443
Score = 90.5 bits (223), Expect = 5e-18
Identities = 64/288 (22%), Positives = 126/288 (43%), Gaps = 1/288 (0%)
Frame = +2
Query: 5 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHNL 184
L + ++ + L QA+ QF + DME WL + + S + G D S L ++H
Sbjct: 732 LEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPEVGHDEFSTQALARQHRA 791
Query: 185 LESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLND 364
LE +I +H+ +D+ +QA + ++ + + Y +LQ +R L
Sbjct: 792 LEEEIRAHRPTLDALREQAAALPPALSHTPE-VQGRVPTLEQHYEELQARAGERARALEA 850
Query: 365 AYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILE 544
A + +A W+ EKE + L ++ + ++ + ++ E+ R+
Sbjct: 851 ALAFYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARVTA 910
Query: 545 VCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEA 724
V + ++++ + I + + W ++ AD ++ L +L Q Y + +E
Sbjct: 911 VSDIAEQLLKASPPGKDRIIGTQEQLNQRWQQFRSLADGKKAALTSALSIQNYHLECTET 970
Query: 725 ESWMREKEPLVGST-EFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
++WMREK ++ ST + G D AL +K D+EA + + L
Sbjct: 971 QAWMREKTKVIESTQDLGNDLAGVLALQRKLAGTERDLEAISARVGEL 1018
Score = 87.8 bits (216), Expect = 4e-17
Identities = 57/272 (20%), Positives = 126/272 (46%), Gaps = 1/272 (0%)
Frame = +2
Query: 56 QQQFIRNVEDMEIWLAEVESQLGSDDCGKD-LNSVTNLQKKHNLLESDISSHQDRIDSFL 232
QQ F+++ +++++W+ E L + D D ++ +KH +++++++D +D
Sbjct: 1280 QQHFLQDCQELKLWIDE--KMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVD 1337
Query: 233 QQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEED 412
++ + + + +K ++ R+ +L+ + + L DA + F + E
Sbjct: 1338 KEGRELTLEKPELKVLVSEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSALES 1397
Query: 413 WIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYAN 592
W+ + S + G+DL V L+KK Q ++ E+ E + + + + + + A
Sbjct: 1398 WLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALAQEDQSAG 1457
Query: 593 RDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEF 772
++E+ ++ + L R + L S E Q+ D + W+ E+ P+ S E
Sbjct: 1458 -EVERTSRAVEEKFRALCQPMKDRCRRLQASREQHQFHRDVEDEILWVTERLPMASSLEH 1516
Query: 773 GKDEDSTEALLKKHDALMADIEAYRSTIDSLR 868
GKD S + L+KK+ L +I+ + I L+
Sbjct: 1517 GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLK 1548
Score = 87.4 bits (215), Expect = 5e-17
Identities = 57/260 (21%), Positives = 118/260 (45%), Gaps = 1/260 (0%)
Frame = +2
Query: 92 IWLAEVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFD 271
+W+ E E L + L + +Q++ LE ++++ R+ + A+Q + +
Sbjct: 866 LWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARVTAVSDIAEQLLKASPPG 925
Query: 272 ADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGST- 448
D I Q ++ R+ + + + +K L A + ++ + + + W+ EK + ST
Sbjct: 926 KDRIIGTQEQLNQRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQ 985
Query: 449 NVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKN 628
++G DL GV L +K + ++ R+ E+ E + G+ I ++ +++
Sbjct: 986 DLGNDLAGVLALQRKLAGTERDLEAISARVGELTQEANALAAGHPAQAPAINTRLGEVQT 1045
Query: 629 LWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLK 808
W DL+ +R + L ++ Q +L + ++W+ + V S E EALL
Sbjct: 1046 GWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLA 1105
Query: 809 KHDALMADIEAYRSTIDSLR 868
+H AL ++E +S LR
Sbjct: 1106 QHAALRGEVERAQSEYSRLR 1125
Score = 80.9 bits (198), Expect = 4e-15
Identities = 60/290 (20%), Positives = 123/290 (42%), Gaps = 2/290 (0%)
Frame = +2
Query: 2 DLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 181
DL + + +E +L +A Q F+R+++D + WL ++ + S++ L L +H
Sbjct: 1049 DLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHA 1108
Query: 182 LLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNR-YSKLQEPLEKRKNKL 358
L ++ Q ++ D ++++E + +L E R+ +L
Sbjct: 1109 ALRGEVERAQSEYSRLRTLGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
Query: 359 NDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRI 538
A+ F RDA E + +E T + L IKK + + + + RI
Sbjct: 1169 AQAHGFQGFLRDARQAEGVLSSQEYFLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERI 1228
Query: 539 LEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADAS 718
+ G++++ + I++K D ++ + + L D+ E Q +L D
Sbjct: 1229 RGLLEAGRQLVSKGNIHAEKIQEKADSIEKRHRKNQEAVQQLLGRLRDNREQQHFLQDCQ 1288
Query: 719 EAESWMREKEPLVGSTEFGKDE-DSTEALLKKHDALMADIEAYRSTIDSL 865
E + W+ EK ++ + + DE + +KH A MA++ A + +D +
Sbjct: 1289 ELKLWIDEK--MLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKV 1336
Score = 47.8 bits (112), Expect = 4e-05
Identities = 60/271 (22%), Positives = 105/271 (38%), Gaps = 29/271 (10%)
Frame = +2
Query: 140 KDLNSVTNLQKKHNLLESDISSHQ--DRIDSFLQQADQ----------FVHDNHFDADAI 283
K N+ NLQ NL E ++ + D D + Q D+ + + + A A+
Sbjct: 229 KKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAV 288
Query: 284 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 463
+ K+I ++ E L ++ L A + WI + +
Sbjct: 289 EGKRIGKVLDHAMEAEHLVEKYESL------------ASELLQWIEQTIVTLNDRQLANS 336
Query: 464 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEG------QKMIDGNH---YANRDIEKKID 616
L GVQN ++ + + P+ E N Q + N+ Y R+ + I
Sbjct: 337 LSGVQNQLQSFNSYRT--VEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTpre-GRLIS 393
Query: 617 DMKNLWSDLKNKADKRRQLLDDSLEAQQYLAD--------ASEAESWMREKEPLVGSTEF 772
D+ W L+ +R L L Q+ L A+ E+W+ E + LV F
Sbjct: 394 DINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNF 453
Query: 773 GKDEDSTEALLKKHDALMADIEAYRSTIDSL 865
G + + EA ++KH+A+ DI AY + ++
Sbjct: 454 GLELAAVEAAVRKHEAIETDIVAYSGRVQAV 484
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,529,734
Number of Sequences: 369166
Number of extensions: 1581810
Number of successful extensions: 7152
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6117
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6847
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8598109270
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)