Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_H04-1
(493 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P35237|SPB6_HUMAN Placental thrombin inhibitor (Cytoplas... 82 9e-16
sp|Q96P15|SPB11_HUMAN Serpin B11 81 1e-15
sp|P30740|ILEU_HUMAN Leukocyte elastase inhibitor (LEI) (Se... 80 2e-15
sp|P50453|SPB9_HUMAN Cytoplasmic antiproteinase 3 (CAP3) (C... 79 7e-15
sp|Q96P63|SPB12_HUMAN Serpin B12 79 7e-15
sp|Q9D7P9|SPB12_MOUSE Serpin B12 78 1e-14
sp|P05619|ILEU_HORSE Leukocyte elastase inhibitor (LEI) (Se... 77 2e-14
sp|P80229|ILEU_PIG Leukocyte elastase inhibitor (LEI) (Serp... 77 2e-14
sp|O08800|SPB8_MOUSE Serpin B8 76 4e-14
sp|P48594|SCCA2_HUMAN Squamous cell carcinoma antigen 2 (SC... 76 5e-14
>sp|P35237|SPB6_HUMAN Placental thrombin inhibitor (Cytoplasmic antiproteinase) (CAP)
(Protease inhibitor 6) (PI-6) (Serpin B6)
Length = 376
Score = 81.6 bits (200), Expect = 9e-16
Identities = 43/111 (38%), Positives = 65/111 (58%), Gaps = 3/111 (2%)
Frame = +2
Query: 2 FKIDTEMDLKYLMGLLGVTDVFDPEKADLKGISDENLSVDKAIHKTFLDVNEHGVEAAAA 181
FK++ D++ ++ LG+TD F+ KAD G+S +LS+ K +HK+F++VNE G EAAAA
Sbjct: 274 FKLEESYDMESVLRNLGMTDAFELGKADFSGMSQTDLSLSKVVHKSFVEVNEEGTEAAAA 333
Query: 182 TA---MSICCMSMPFFANETPIEFIVDEPFLLSVYNNAADAIVFLGRVNDP 325
TA M C +P F D PFL + ++ + I+F GR + P
Sbjct: 334 TAAIMMMRCARFVP--------RFCADHPFLFFIQHSKTNGILFCGRFSSP 376
>sp|Q96P15|SPB11_HUMAN Serpin B11
Length = 392
Score = 81.3 bits (199), Expect = 1e-15
Identities = 46/109 (42%), Positives = 68/109 (62%), Gaps = 1/109 (0%)
Frame = +2
Query: 2 FKIDTEMDLKYLMGLLGVTDVFDPEKADLKGISD-ENLSVDKAIHKTFLDVNEHGVEAAA 178
FK++ + +L L+ LGVTD+F+ KADL G+S + L + KAIHK++LDV+E G EAAA
Sbjct: 289 FKLEIKYELNSLLKPLGVTDLFNQVKADLSGMSPTKGLYLSKAIHKSYLDVSEEGTEAAA 348
Query: 179 ATAMSICCMSMPFFANETPIEFIVDEPFLLSVYNNAADAIVFLGRVNDP 325
AT SI S+P A +F + PFL + + + I+F G++ P
Sbjct: 349 ATGDSIAVKSLPMRA-----QFKANHPFLFFIRHTHTNTILFCGKLASP 392
>sp|P30740|ILEU_HUMAN Leukocyte elastase inhibitor (LEI) (Serpin B1) (Monocyte/neutrophil
elastase inhibitor) (M/NEI) (EI)
Length = 379
Score = 80.5 bits (197), Expect = 2e-15
Identities = 45/110 (40%), Positives = 67/110 (60%), Gaps = 2/110 (1%)
Frame = +2
Query: 2 FKIDTEMDLKYLMGLLGVTDVFDPEKADLKGISD-ENLSVDKAIHKTFLDVNEHGVEAAA 178
FK++ L + LGV D+F+ KADL G+S ++ + K +HK+F++VNE G EAAA
Sbjct: 276 FKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAA 335
Query: 179 ATA-MSICCMSMPFFANETPIEFIVDEPFLLSVYNNAADAIVFLGRVNDP 325
ATA ++ CM MP F D PFL + +N++ +I+FLGR + P
Sbjct: 336 ATAGIATFCMLMP------EENFTADHPFLFFIRHNSSGSILFLGRFSSP 379
>sp|P50453|SPB9_HUMAN Cytoplasmic antiproteinase 3 (CAP3) (CAP-3) (Protease inhibitor 9)
(Serpin B9)
Length = 376
Score = 78.6 bits (192), Expect = 7e-15
Identities = 43/112 (38%), Positives = 67/112 (59%), Gaps = 4/112 (3%)
Frame = +2
Query: 2 FKIDTEMDLKYLMGLLGVTDVFDPEKADLKGISDE-NLSVDKAIHKTFLDVNEHGVEAAA 178
FK+ + D++ ++ LG+ D F KADL +S E +L + K +HK+F++VNE G EAAA
Sbjct: 272 FKLQEDYDMESVLRHLGIVDAFQQGKADLSAMSAERDLCLSKFVHKSFVEVNEEGTEAAA 331
Query: 179 ATAMSI---CCMSMPFFANETPIEFIVDEPFLLSVYNNAADAIVFLGRVNDP 325
A++ + CCM E+ F D PFL + +N A++I+F GR + P
Sbjct: 332 ASSCFVVAECCM-------ESGPRFCADHPFLFFIRHNRANSILFCGRFSSP 376
>sp|Q96P63|SPB12_HUMAN Serpin B12
Length = 405
Score = 78.6 bits (192), Expect = 7e-15
Identities = 43/109 (39%), Positives = 65/109 (59%), Gaps = 1/109 (0%)
Frame = +2
Query: 2 FKIDTEMDLKYLMGLLGVTDVFDPEKADLKGISDE-NLSVDKAIHKTFLDVNEHGVEAAA 178
F ++ DL ++ +G+TD+FD +ADL GIS NL + K IHKTF++V+E+G +AAA
Sbjct: 302 FTLEDSYDLNSILQDMGITDIFDETRADLTGISPSPNLYLSKIIHKTFVEVDENGTQAAA 361
Query: 179 ATAMSICCMSMPFFANETPIEFIVDEPFLLSVYNNAADAIVFLGRVNDP 325
AT + S+ + +EF + PFL + +N I+F GRV P
Sbjct: 362 ATGAVVSERSL-----RSWVEFNANHPFLFFIRHNKTQTILFYGRVCSP 405
>sp|Q9D7P9|SPB12_MOUSE Serpin B12
Length = 423
Score = 77.8 bits (190), Expect = 1e-14
Identities = 42/109 (38%), Positives = 66/109 (60%), Gaps = 1/109 (0%)
Frame = +2
Query: 2 FKIDTEMDLKYLMGLLGVTDVFDPEKADLKGIS-DENLSVDKAIHKTFLDVNEHGVEAAA 178
F ++ DLK ++ +G+ DVFD KADL GIS NL + K +HKTF++V+E G +AAA
Sbjct: 320 FNLEDSYDLKSILQDMGIKDVFDETKADLTGISKSPNLYLSKIVHKTFVEVDEMGTQAAA 379
Query: 179 ATAMSICCMSMPFFANETPIEFIVDEPFLLSVYNNAADAIVFLGRVNDP 325
A+ + ++P + +EF + PFL + +N +++F GRV P
Sbjct: 380 ASGVVAAEKALPSW-----VEFNANHPFLFFIRHNPTQSLLFCGRVYCP 423
>sp|P05619|ILEU_HORSE Leukocyte elastase inhibitor (LEI) (Serpin B1)
Length = 379
Score = 77.4 bits (189), Expect = 2e-14
Identities = 48/110 (43%), Positives = 65/110 (59%), Gaps = 2/110 (1%)
Frame = +2
Query: 2 FKIDTEMDLKYLMGLLGVTDVFDPEKADLKGISD-ENLSVDKAIHKTFLDVNEHGVEAAA 178
FK++ DL + LGV D+F+ KADL G+S +L V K IHK+F+D+NE G EAAA
Sbjct: 276 FKLEESYDLTSHLARLGVQDLFNRGKADLSGMSGARDLFVSKIIHKSFVDLNEEGTEAAA 335
Query: 179 ATAMSI-CCMSMPFFANETPIEFIVDEPFLLSVYNNAADAIVFLGRVNDP 325
ATA +I M MP F D PF+ + +N + I+FLGR + P
Sbjct: 336 ATAGTIMLAMLMP------EENFNADHPFIFFIRHNPSANILFLGRFSSP 379
>sp|P80229|ILEU_PIG Leukocyte elastase inhibitor (LEI) (Serpin B1) (Leucocyte neutral
proteinase inhibitor) (LNPI)
Length = 378
Score = 77.0 bits (188), Expect = 2e-14
Identities = 44/110 (40%), Positives = 68/110 (61%), Gaps = 2/110 (1%)
Frame = +2
Query: 2 FKIDTEMDLKYLMGLLGVTDVFDPEKADLKGISD-ENLSVDKAIHKTFLDVNEHGVEAAA 178
F+++ DL + LGV D+F +ADL G+S+ +L + K +HK F++VNE G EAAA
Sbjct: 276 FRLEESYDLNAPLARLGVQDLFG-SRADLTGMSEARDLFISKVVHKAFVEVNEEGTEAAA 334
Query: 179 ATA-MSICCMSMPFFANETPIEFIVDEPFLLSVYNNAADAIVFLGRVNDP 325
ATA +++ M MP +FI D PF+ + +N + I+FLGR++ P
Sbjct: 335 ATAGIAVFAMLMP------EEDFIADHPFIFFIRHNPSSNILFLGRLSSP 378
>sp|O08800|SPB8_MOUSE Serpin B8
Length = 374
Score = 76.3 bits (186), Expect = 4e-14
Identities = 41/111 (36%), Positives = 65/111 (58%), Gaps = 4/111 (3%)
Frame = +2
Query: 5 KIDTEMDLKYLMGLLGVTDVFDPEKADLKGISDE-NLSVDKAIHKTFLDVNEHGVEAAAA 181
K++ DL+ ++ LG+TD F+ +AD G++ + N+ V K HK F++VNE G EAAAA
Sbjct: 272 KLEESYDLETVLQNLGMTDAFEETRADFSGMTTKKNVPVSKVAHKCFVEVNEEGTEAAAA 331
Query: 182 TAM---SICCMSMPFFANETPIEFIVDEPFLLSVYNNAADAIVFLGRVNDP 325
TA+ + CC + P F D PFL ++++ +I+F GR + P
Sbjct: 332 TAVIRNARCCRTEP--------RFCADHPFLFFIWHHKTSSILFCGRFSSP 374
>sp|P48594|SCCA2_HUMAN Squamous cell carcinoma antigen 2 (SCCA-2) (Leupin)
Length = 390
Score = 75.9 bits (185), Expect = 5e-14
Identities = 43/109 (39%), Positives = 66/109 (60%), Gaps = 1/109 (0%)
Frame = +2
Query: 2 FKIDTEMDLKYLMGLLGVTDVFDPEKADLKGIS-DENLSVDKAIHKTFLDVNEHGVEAAA 178
FK++ DLK + +G+ ++F+ + ADL G++ LSV K +HK F++V E GVEAAA
Sbjct: 287 FKMEESYDLKDTLRTMGMVNIFNGD-ADLSGMTWSHGLSVSKVLHKAFVEVTEEGVEAAA 345
Query: 179 ATAMSICCMSMPFFANETPIEFIVDEPFLLSVYNNAADAIVFLGRVNDP 325
ATA+ + +S P T EF + PFL + N ++I+F GR + P
Sbjct: 346 ATAVVVVELSSP----STNEEFCCNHPFLFFIRQNKTNSILFYGRFSSP 390
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,945,648
Number of Sequences: 369166
Number of extensions: 966793
Number of successful extensions: 2901
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2666
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2739
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 3020232610
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)