Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_G22
(571 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P24156|L2CC_DROME L(2)37Cc protein 203 2e-52
sp|P67778|PHB_MOUSE Prohibitin (B-cell receptor associated ... 193 3e-49
sp|P35232|PHB_HUMAN Prohibitin 191 8e-49
sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex prote... 189 5e-48
sp|P40961|PHB_YEAST Prohibitin 167 2e-41
sp|P50085|PHB2_YEAST Prohibitin-2 132 8e-31
sp|O35129|PHB2_MOUSE Prohibitin-2 (B-cell receptor-associat... 131 1e-30
sp|Q5XIH7|PHB2_RAT Prohibitin-2 (B-cell receptor-associated... 131 1e-30
sp|P50093|PHB2_CAEEL Mitochondrial prohibitin complex prote... 123 3e-28
sp|O28852|Y1420_ARCFU Hypothetical protein AF1420 40 0.005
>sp|P24156|L2CC_DROME L(2)37Cc protein
Length = 276
Score = 203 bits (517), Expect = 2e-52
Identities = 103/176 (58%), Positives = 133/176 (75%)
Frame = +3
Query: 3 QPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTT 182
+P+ + LPKIYT LG D++ERVLPSI EVLK VVAQFDA +LITQRE+VSQ+V++ LT
Sbjct: 97 RPIPDQLPKIYTILGQDYDERVLPSIAPEVLKAVVAQFDAGELITQREMVSQRVSQELTV 156
Query: 183 RADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEG 362
RA FG LDDISLTHLTFG EF+ ++VEKAEQ+KLA+IISAEG
Sbjct: 157 RAKQFGFILDDISLTHLTFGREFTLAVEMKQVAQQEAEKARFVVEKAEQQKLASIISAEG 216
Query: 363 DSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTLINLPA 530
D++AA LLAKSF + G+G +EL+RI+ +E+IA+ LS++R + YLP Q TL+NLP+
Sbjct: 217 DAEAAGLLAKSFGEAGDGLVELRRIEAAEDIAYQLSRSRGVAYLPSGQSTLLNLPS 272
>sp|P67778|PHB_MOUSE Prohibitin (B-cell receptor associated protein 32) (BAP 32)
sp|P67779|PHB_RAT Prohibitin
Length = 272
Score = 193 bits (490), Expect = 3e-49
Identities = 99/175 (56%), Positives = 131/175 (74%)
Frame = +3
Query: 3 QPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTT 182
+PVA LP+IYT++G D++ERVLPSIT E+LK+VVA+FDA +LITQRELVS++V++ LT
Sbjct: 97 RPVASQLPRIYTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTE 156
Query: 183 RADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEG 362
RA FGL LDD+SLTHLTFG EF+ ++VEKAEQ+K AAIISAEG
Sbjct: 157 RAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEG 216
Query: 363 DSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTLINLP 527
DS+AA L+A S G+G IEL++++ +E+IA+ LS++RNI YLP Q L+ LP
Sbjct: 217 DSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLP 271
>sp|P35232|PHB_HUMAN Prohibitin
Length = 272
Score = 191 bits (486), Expect = 8e-49
Identities = 98/175 (56%), Positives = 131/175 (74%)
Frame = +3
Query: 3 QPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTT 182
+PVA LP+I+T++G D++ERVLPSIT E+LK+VVA+FDA +LITQRELVS++V++ LT
Sbjct: 97 RPVASQLPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTE 156
Query: 183 RADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEG 362
RA FGL LDD+SLTHLTFG EF+ ++VEKAEQ+K AAIISAEG
Sbjct: 157 RAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEG 216
Query: 363 DSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTLINLP 527
DS+AA L+A S G+G IEL++++ +E+IA+ LS++RNI YLP Q L+ LP
Sbjct: 217 DSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLP 271
>sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex protein 1 (Prohibitin-1)
Length = 275
Score = 189 bits (479), Expect = 5e-48
Identities = 96/174 (55%), Positives = 124/174 (71%)
Frame = +3
Query: 3 QPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTT 182
+P + LP IY N+GLD+ ERVLPSIT EVLK VVAQFDA ++ITQRE+VSQ+ + L
Sbjct: 100 RPSPDRLPNIYLNIGLDYAERVLPSITNEVLKAVVAQFDAHEMITQREVVSQRASVALRE 159
Query: 183 RADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEG 362
RA FGL LDDI++THL FG EF+ YLVEKAEQ K+AA+ +AEG
Sbjct: 160 RAAQFGLLLDDIAITHLNFGREFTEAVEMKQVAQQEAEKARYLVEKAEQMKIAAVTTAEG 219
Query: 363 DSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTLINL 524
D+QAA LLAK+F G+G +EL++I+ +EEIA ++KN+N+ YLP Q TL+NL
Sbjct: 220 DAQAAKLLAKAFASAGDGLVELRKIEAAEEIAERMAKNKNVTYLPGNQQTLLNL 273
>sp|P40961|PHB_YEAST Prohibitin
Length = 287
Score = 167 bits (422), Expect = 2e-41
Identities = 79/167 (47%), Positives = 122/167 (73%)
Frame = +3
Query: 3 QPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTT 182
+P LP IY NLGLD++ERVLPSI EVLK++VAQFDA++LITQRE++SQK+ + L+T
Sbjct: 99 RPEVLQLPAIYQNLGLDYDERVLPSIGNEVLKSIVAQFDAAELITQREIISQKIRKELST 158
Query: 183 RADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEG 362
RA+ FG+ L+D+S+TH+TFG EF+ +LVEKAEQE+ A++I AEG
Sbjct: 159 RANEFGIKLEDVSITHMTFGPEFTKAVEQKQIAQQDAERAKFLVEKAEQERQASVIRAEG 218
Query: 363 DSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDK 503
++++A ++K+ + G+G + ++R++ S++IA L+ + N+VYLP +
Sbjct: 219 EAESAEFISKALAKVGDGLLLIRRLEASKDIAQTLANSSNVVYLPSQ 265
>sp|P50085|PHB2_YEAST Prohibitin-2
Length = 315
Score = 132 bits (331), Expect = 8e-31
Identities = 71/173 (41%), Positives = 108/173 (62%)
Frame = +3
Query: 3 QPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTT 182
+P LP IY LG D++ERVLPSI EVLK VVAQF+AS LITQRE VS+ + E L
Sbjct: 128 RPDVVQLPTIYRTLGQDYDERVLPSIVNEVLKAVVAQFNASQLITQREKVSRLIRENLVR 187
Query: 183 RADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEG 362
RA F + LDD+S+T++TF EF+ ++V+KA QEK ++ A+G
Sbjct: 188 RASKFNILLDDVSITYMTFSPEFTNAVEAKQIAQQDAQRAAFVVDKARQEKQGMVVRAQG 247
Query: 363 DSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTLIN 521
++++A L+ ++ + ++EL+R+ T+ +IA +L+ + N V L D + L+N
Sbjct: 248 EAKSAELIGEAIKK-SRDYVELKRLDTARDIAKILASSPNRVIL-DNEALLLN 298
>sp|O35129|PHB2_MOUSE Prohibitin-2 (B-cell receptor-associated protein BAP37) (Repressor
of estrogen receptor activity)
sp|Q99623|PHB2_HUMAN Prohibitin-2 (B-cell receptor-associated protein BAP37) (Repressor
of estrogen receptor activity) (D-prohibitin)
Length = 299
Score = 131 bits (329), Expect = 1e-30
Identities = 69/164 (42%), Positives = 109/164 (66%)
Frame = +3
Query: 3 QPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTT 182
+P A+ LP +Y LGLD+EERVLPSI EVLK+VVA+F+AS LITQR VS + LT
Sbjct: 111 RPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTE 170
Query: 183 RADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEG 362
RA +F L LDD+++T L+F E++ +LVEKA+QE+ I+ AEG
Sbjct: 171 RAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEG 230
Query: 363 DSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYL 494
+++AA +L ++ ++ G+I+L++I+ ++ I+ ++ ++N +YL
Sbjct: 231 EAEAAKMLGEALSK-NPGYIKLRKIRAAQNISKTIATSQNRIYL 273
>sp|Q5XIH7|PHB2_RAT Prohibitin-2 (B-cell receptor-associated protein BAP37) (BAP-37)
Length = 299
Score = 131 bits (329), Expect = 1e-30
Identities = 69/164 (42%), Positives = 109/164 (66%)
Frame = +3
Query: 3 QPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTT 182
+P A+ LP +Y LGLD+EERVLPSI EVLK+VVA+F+AS LITQR VS + LT
Sbjct: 111 RPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTE 170
Query: 183 RADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEG 362
RA +F L LDD+++T L+F E++ +LVEKA+QE+ I+ AEG
Sbjct: 171 RAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEG 230
Query: 363 DSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYL 494
+++AA +L ++ ++ G+I+L++I+ ++ I+ ++ ++N +YL
Sbjct: 231 EAEAAKMLGEALSK-NPGYIKLRKIRAAQNISKTIATSQNRIYL 273
>sp|P50093|PHB2_CAEEL Mitochondrial prohibitin complex protein 2 (Prohibitin-2)
Length = 286
Score = 123 bits (309), Expect = 3e-28
Identities = 71/174 (40%), Positives = 109/174 (62%)
Frame = +3
Query: 3 QPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTT 182
+P E L IY LG ++EERVLPSI EVLK VVA+F+AS LITQR+ VS V + L
Sbjct: 102 RPNPEHLVHIYRTLGQNWEERVLPSICNEVLKGVVAKFNASQLITQRQQVSMLVRKTLIE 161
Query: 183 RADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEG 362
RA +F + LDD+SLT L F ++S + VE+A+Q+K I+ AEG
Sbjct: 162 RALDFNIILDDVSLTELAFSPQYSAAVEAKQVAAQEAQRATFYVERAKQQKQEKIVQAEG 221
Query: 363 DSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTLINL 524
++++A LL ++ GF++L++I+ +++IA ++S++ N YLP G ++N+
Sbjct: 222 EAESAKLLGEAMKN-DPGFLKLRKIRAAQKIARIVSESGNKTYLP-TGGLMLNI 273
>sp|O28852|Y1420_ARCFU Hypothetical protein AF1420
Length = 249
Score = 39.7 bits (91), Expect = 0.005
Identities = 26/124 (20%), Positives = 63/124 (50%), Gaps = 2/124 (1%)
Frame = +3
Query: 93 LKTVVAQFDASDLITQRELVSQKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXX 272
L++++ Q + +++++R+ ++ K+ +++ + +G+ + + + + E
Sbjct: 115 LRSIIGQAELDEVLSERDKLNVKLQQIIDEETNPWGIKVTAVEIKDVELPEEMRRIMA-- 172
Query: 273 XXXXXXXXXXXYLVEKAEQEKLAAIISAEGDSQAALLLAKSFNQC--GEGFIELQRIQTS 446
+ +AE+E+ + II AEG+ QAA+ L ++ + EG I L+ +QT
Sbjct: 173 ------------MQAEAERERRSKIIRAEGEYQAAMKLREAADVLAQSEGAILLRYLQTL 220
Query: 447 EEIA 458
EI+
Sbjct: 221 NEIS 224
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,978,006
Number of Sequences: 369166
Number of extensions: 995613
Number of successful extensions: 2478
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2441
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2464
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 4177115900
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)