Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_F16
(393 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyr... 85 5e-17
sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin) 84 8e-17
sp|Q12955|ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin G) 83 2e-16
sp|P53355|DAPK1_HUMAN Death-associated protein kinase 1 (DA... 80 1e-15
sp|O15084|ANR28_HUMAN Ankyrin repeat domain protein 28 80 2e-15
sp|Q01484|ANK2_HUMAN Ankyrin-2 (Brain ankyrin) (Ankyrin B) ... 76 2e-14
sp|O89019|INVS_MOUSE Inversin (Inversion of embryo turning ... 75 5e-14
sp|Q96AX9|MIB2_HUMAN Ubiquitin ligase protein MIB2 (Mind bo... 75 5e-14
sp|Q9Y283|INVS_HUMAN Inversin (Inversion of embryo turning ... 74 1e-13
sp|Q6JAN1|INVS_CANFA Inversin (Inversion of embryo turning ... 74 1e-13
>sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin R)
Length = 1881
Score = 85.1 bits (209), Expect = 5e-17
Identities = 35/97 (36%), Positives = 57/97 (58%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNK 203
NK G P+HL + GH+ + +LI + A+ + GY P+H+A G+I +VK L+ ++
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Query: 204 CDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGIN 314
D++ K GY P+H A + GH DI+ +L+ N N
Sbjct: 725 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 78.2 bits (191), Expect = 6e-15
Identities = 30/99 (30%), Positives = 60/99 (60%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G P+HLA + GH +++ +L+ K+ + + NK G P+HL + GH+ + +LI + +
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 213 STSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDEI 329
+ + GY P+H+A G+I ++K L+ ++ +NA ++
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 733
Score = 77.4 bits (189), Expect = 1e-14
Identities = 34/95 (35%), Positives = 54/95 (56%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G+ P+H+ACK H+ +M++L+ I A + G P+H+A GH+ IVK L+
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 213 STSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
+ SN P+H+A GH ++ K L+ NK +NA
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Score = 72.8 bits (177), Expect = 2e-13
Identities = 29/87 (33%), Positives = 52/87 (59%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G P+H+A + G++ ++++L+D+ I K P+H A NGH+ I +IL+D+ I
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 213 STSNKYGYQPIHLACENGHIDIMKILI 293
K G PIH+A + H+D +++L+
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLL 325
Score = 72.0 bits (175), Expect = 4e-13
Identities = 34/95 (35%), Positives = 51/95 (53%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
I T K P+H A +NGH+ I +IL+D I A K G PIH+A + H+D V++L
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Query: 192 IDNKCDISTSNKYGYQPIHLACENGHIDIMKILID 296
+ +I P+H+A GH + K+L+D
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Score = 70.9 bits (172), Expect = 9e-13
Identities = 33/108 (30%), Positives = 59/108 (54%), Gaps = 3/108 (2%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
+ + GY P+H+A G+I ++K L+ + D++A K GY P+H A + GH DIV +L
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 192 IDNKCDISTSNKYGYQPIHLACENGHI---DIMKILIDNKCGINAHDE 326
+ N + + G P+ +A G+I D++K++ D + D+
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801
Score = 70.5 bits (171), Expect = 1e-12
Identities = 29/98 (29%), Positives = 59/98 (60%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNK 203
+K G+ P+H+A ++++ ++L+++ ++ + + G P+H+A G++ +V++L+D
Sbjct: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Query: 204 CDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
I T K P+H A NGH+ I +IL+D+ I A
Sbjct: 263 AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Score = 70.1 bits (170), Expect = 2e-12
Identities = 28/95 (29%), Positives = 54/95 (56%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
GY P+H+A K +++ + L+ +A + G P+HLA + GH ++V +L+ + +
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 213 STSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
+ NK G P+HL + GH+ + +LI + ++A
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Score = 69.3 bits (168), Expect = 3e-12
Identities = 29/106 (27%), Positives = 62/106 (58%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
DI+T N+ G +HLA K GH+ ++ L+ K+ + + K G +H+A G ++V+
Sbjct: 37 DINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRE 96
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
L++ +++ ++ G+ P+++A + H++++K L++N N E
Sbjct: 97 LVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE 142
Score = 68.9 bits (167), Expect = 3e-12
Identities = 26/87 (29%), Positives = 52/87 (59%)
Frame = +3
Query: 42 PIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTS 221
P+H+A + GH ++ K L+ K ++A K P+H A GH ++VK+L++N + + +
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499
Query: 222 NKYGYQPIHLACENGHIDIMKILIDNK 302
G+ P+H+A GH++ + L++ +
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKE 526
Score = 68.2 bits (165), Expect = 6e-12
Identities = 31/101 (30%), Positives = 53/101 (52%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
I + G P+H+A GH+ I+K L+ + + SN P+H+A GH ++ K L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 192 IDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGIN 314
+ NK ++ K P+H A GH +++K+L++N N
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Score = 67.8 bits (164), Expect = 8e-12
Identities = 30/105 (28%), Positives = 55/105 (52%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
I K G PIH+A + H+D +++L+ +I P+H+A GH + K+L
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Query: 192 IDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+D ++ G+ P+H+AC+ H+ +M++L+ I+A E
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402
Score = 67.8 bits (164), Expect = 8e-12
Identities = 24/87 (27%), Positives = 55/87 (63%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G+ P+H+A + GH++ + L++K+ + K G+ P+H+A + G + + ++L++
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 213 STSNKYGYQPIHLACENGHIDIMKILI 293
+ + K G P+H+A + ++DI+K+L+
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 65.1 bits (157), Expect = 5e-11
Identities = 26/105 (24%), Positives = 58/105 (55%)
Frame = +3
Query: 3 KCDISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIV 182
K ++ K P+H A + GH +++K+L++ + + + G+ P+H+A GH++ V
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
Query: 183 KILIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
L++ + + K G+ P+H+A + G + + ++L++ NA
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Score = 63.5 bits (153), Expect = 1e-10
Identities = 27/91 (29%), Positives = 50/91 (54%)
Frame = +3
Query: 42 PIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTS 221
P+H+A GH + K+L+DK ++ G+ P+H+AC+ H+ ++++L+ I
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 222 NKYGYQPIHLACENGHIDIMKILIDNKCGIN 314
+ G P+H+A GH+ I+K L+ N
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Score = 62.8 bits (151), Expect = 2e-10
Identities = 27/97 (27%), Positives = 55/97 (56%)
Frame = +3
Query: 27 KYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKC 206
K G+ P+H+A K G + + ++L+++ +A+ K G P+H+A + ++DIVK+L+
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 207 DISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
+ GY P+H+A + +++ + L+ NA
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Score = 60.8 bits (146), Expect = 9e-10
Identities = 23/95 (24%), Positives = 59/95 (62%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
+ T K G +H+A G ++++ L++ +++A ++ G+ P+++A + H+++VK L
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 192 IDNKCDISTSNKYGYQPIHLACENGHIDIMKILID 296
++N + + + + G+ P+ +A + GH +++ LI+
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 165
Score = 48.9 bits (115), Expect = 4e-06
Identities = 21/97 (21%), Positives = 52/97 (53%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
+++ ++ G+ P+++A + H++++K L++ + + + + G+ P+ +A + GH ++V
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDN 299
LI + T K +H+A N +L+ N
Sbjct: 163 LI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQN 195
Score = 48.9 bits (115), Expect = 4e-06
Identities = 19/93 (20%), Positives = 50/93 (53%)
Frame = +3
Query: 18 TFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILID 197
T K +H+A +N +L+ + +K G+ P+H+A ++++ ++L++
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 198 NKCDISTSNKYGYQPIHLACENGHIDIMKILID 296
++ + + G P+H+A G++ ++++L+D
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
Score = 47.8 bits (112), Expect = 8e-06
Identities = 23/91 (25%), Positives = 48/91 (52%)
Frame = +3
Query: 54 ACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTSNKYG 233
A ++G++D + DI+ N+ G +HLA + GH+ +V L+ + + T+ K G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 234 YQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+H+A G ++++ L++ +NA +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQ 109
Score = 45.4 bits (106), Expect = 4e-05
Identities = 22/79 (27%), Positives = 42/79 (53%), Gaps = 3/79 (3%)
Frame = +3
Query: 3 KCDISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHI--- 173
+ D++ K GY P+H A + GH DI+ +L+ + + G P+ +A G+I
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 783
Query: 174 DIVKILIDNKCDISTSNKY 230
D++K++ D + S+K+
Sbjct: 784 DVLKVVTDETSFVLVSDKH 802
>sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin)
Length = 1862
Score = 84.3 bits (207), Expect = 8e-17
Identities = 35/97 (36%), Positives = 57/97 (58%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNK 203
NK G P+HL + GH+ + +LI + A+ + GY P+H+A G+I +VK L+ ++
Sbjct: 661 NKSGLTPLHLVSQEGHVLVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 720
Query: 204 CDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGIN 314
D++ K GY P+H A + GH DI+ +L+ N N
Sbjct: 721 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 757
Score = 77.4 bits (189), Expect = 1e-14
Identities = 30/99 (30%), Positives = 60/99 (60%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G P+HLA + GH +++ +L+ K+ + + NK G P+HL + GH+ + +LI + +
Sbjct: 631 GVTPLHLAAQEGHTEMVALLLSKQANGNLGNKSGLTPLHLVSQEGHVLVADVLIKHGVTV 690
Query: 213 STSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDEI 329
+ + GY P+H+A G+I ++K L+ ++ +NA ++
Sbjct: 691 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 729
Score = 76.3 bits (186), Expect = 2e-14
Identities = 35/95 (36%), Positives = 53/95 (55%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G+ P+H+ACK HI +M++L+ I A + G P+H+A GH+ IVK L+
Sbjct: 367 GFTPLHIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 426
Query: 213 STSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
+ SN P+H+A GH ++ K L+ NK NA
Sbjct: 427 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANA 461
Score = 72.8 bits (177), Expect = 2e-13
Identities = 30/94 (31%), Positives = 54/94 (57%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G P+H+A + G++ ++++L+D+ I K P+H A NGH+ I +IL+D+ I
Sbjct: 235 GITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAPI 294
Query: 213 STSNKYGYQPIHLACENGHIDIMKILIDNKCGIN 314
K G PIH+A + H+D +++L+ I+
Sbjct: 295 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEID 328
Score = 72.4 bits (176), Expect = 3e-13
Identities = 34/95 (35%), Positives = 51/95 (53%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
I T K P+H A +NGH+ I +IL+D I A K G PIH+A + H+D V++L
Sbjct: 261 IETRTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 320
Query: 192 IDNKCDISTSNKYGYQPIHLACENGHIDIMKILID 296
+ +I P+H+A GH + K+L+D
Sbjct: 321 LQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 355
Score = 71.2 bits (173), Expect = 7e-13
Identities = 33/108 (30%), Positives = 59/108 (54%), Gaps = 3/108 (2%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
+ + GY P+H+A G+I ++K L+ + D++A K GY P+H A + GH DIV +L
Sbjct: 690 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 749
Query: 192 IDNKCDISTSNKYGYQPIHLACENGHI---DIMKILIDNKCGINAHDE 326
+ N + + G P+ +A G+I D++K++ D + D+
Sbjct: 750 LKNGASPNEVSSNGTTPLAIAKRLGYISVTDVLKVVTDETSVVLVSDK 797
Score = 70.1 bits (170), Expect = 2e-12
Identities = 29/98 (29%), Positives = 59/98 (60%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNK 203
+K G+ P+H+A ++++ ++L+++ ++ + + G P+H+A G++ +V++L+D
Sbjct: 199 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 258
Query: 204 CDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
I T K P+H A NGH+ I +IL+D+ I A
Sbjct: 259 AQIETRTKDELTPLHCAARNGHVRISEILLDHGAPIQA 296
Score = 69.3 bits (168), Expect = 3e-12
Identities = 29/106 (27%), Positives = 62/106 (58%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
DI+T N+ G +HLA K GH+ ++ L+ K+ + + K G +H+A G ++V+
Sbjct: 33 DINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRE 92
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
L++ +++ ++ G+ P+++A + H++++K L++N N E
Sbjct: 93 LVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE 138
Score = 69.3 bits (168), Expect = 3e-12
Identities = 29/95 (30%), Positives = 54/95 (56%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
GY P+H+A K I++ + L+ +A + G P+HLA + GH ++V +L+ + +
Sbjct: 598 GYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLLSKQANG 657
Query: 213 STSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
+ NK G P+HL + GH+ + +LI + ++A
Sbjct: 658 NLGNKSGLTPLHLVSQEGHVLVADVLIKHGVTVDA 692
Score = 68.6 bits (166), Expect = 4e-12
Identities = 31/105 (29%), Positives = 55/105 (52%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
I K G PIH+A + H+D +++L+ +I P+H+A GH + K+L
Sbjct: 294 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVL 353
Query: 192 IDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+D ++ G+ P+H+AC+ HI +M++L+ I+A E
Sbjct: 354 LDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTE 398
Score = 67.4 bits (163), Expect = 1e-11
Identities = 25/87 (28%), Positives = 54/87 (62%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G+ P+H A + GH+D L++K+ + K G+ P+H+A + G + + ++L+++
Sbjct: 499 GHTPLHTAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHP 558
Query: 213 STSNKYGYQPIHLACENGHIDIMKILI 293
+ + K G P+H+A + ++DI+K+L+
Sbjct: 559 NAAGKNGLTPLHVAVHHNNLDIVKLLL 585
Score = 65.1 bits (157), Expect = 5e-11
Identities = 31/101 (30%), Positives = 51/101 (50%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
I + G P+H+A GH+ I+K L+ + + SN P+H+A GH ++ K L
Sbjct: 393 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 452
Query: 192 IDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGIN 314
+ NK + K P+H A GH ++K+L++N N
Sbjct: 453 LQNKAKANAKAKDDQTPLHCAARIGHTGMVKLLLENGASPN 493
Score = 65.1 bits (157), Expect = 5e-11
Identities = 27/87 (31%), Positives = 47/87 (54%)
Frame = +3
Query: 42 PIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTS 221
P+H+A + GH ++ K L+ K +A K P+H A GH +VK+L++N + +
Sbjct: 436 PLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTGMVKLLLENGASPNLA 495
Query: 222 NKYGYQPIHLACENGHIDIMKILIDNK 302
G+ P+H A GH+D L++ +
Sbjct: 496 TTAGHTPLHTAAREGHVDTALALLEKE 522
Score = 63.9 bits (154), Expect = 1e-10
Identities = 28/91 (30%), Positives = 50/91 (54%)
Frame = +3
Query: 42 PIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTS 221
P+H+A GH + K+L+DK ++ G+ P+H+AC+ HI ++++L+ I
Sbjct: 337 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAV 396
Query: 222 NKYGYQPIHLACENGHIDIMKILIDNKCGIN 314
+ G P+H+A GH+ I+K L+ N
Sbjct: 397 TESGLTPLHVASFMGHLPIVKNLLQRGASPN 427
Score = 61.6 bits (148), Expect = 5e-10
Identities = 28/97 (28%), Positives = 54/97 (55%)
Frame = +3
Query: 27 KYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKC 206
K G+ P+H+A K G + + ++L++ +A+ K G P+H+A + ++DIVK+L+
Sbjct: 530 KKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 589
Query: 207 DISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
+ GY P+H+A + I++ + L+ NA
Sbjct: 590 SPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANA 626
Score = 61.2 bits (147), Expect = 7e-10
Identities = 24/92 (26%), Positives = 51/92 (55%)
Frame = +3
Query: 42 PIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTS 221
P+H A + GH ++K+L++ + + G+ P+H A GH+D L++ + +
Sbjct: 469 PLHCAARIGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTALALLEKEASQACM 528
Query: 222 NKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
K G+ P+H+A + G + + ++L+++ NA
Sbjct: 529 TKKGFTPLHVAAKYGKVRLAELLLEHDAHPNA 560
Score = 60.8 bits (146), Expect = 9e-10
Identities = 23/95 (24%), Positives = 59/95 (62%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
+ T K G +H+A G ++++ L++ +++A ++ G+ P+++A + H+++VK L
Sbjct: 67 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 126
Query: 192 IDNKCDISTSNKYGYQPIHLACENGHIDIMKILID 296
++N + + + + G+ P+ +A + GH +++ LI+
Sbjct: 127 LENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 161
Score = 48.9 bits (115), Expect = 4e-06
Identities = 21/97 (21%), Positives = 52/97 (53%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
+++ ++ G+ P+++A + H++++K L++ + + + + G+ P+ +A + GH ++V
Sbjct: 99 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 158
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDN 299
LI + T K +H+A N +L+ N
Sbjct: 159 LI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQN 191
Score = 48.9 bits (115), Expect = 4e-06
Identities = 19/93 (20%), Positives = 50/93 (53%)
Frame = +3
Query: 18 TFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILID 197
T K +H+A +N +L+ + +K G+ P+H+A ++++ ++L++
Sbjct: 164 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 223
Query: 198 NKCDISTSNKYGYQPIHLACENGHIDIMKILID 296
++ + + G P+H+A G++ ++++L+D
Sbjct: 224 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 256
Score = 47.8 bits (112), Expect = 8e-06
Identities = 23/91 (25%), Positives = 48/91 (52%)
Frame = +3
Query: 54 ACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTSNKYG 233
A ++G++D + DI+ N+ G +HLA + GH+ +V L+ + + T+ K G
Sbjct: 15 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 74
Query: 234 YQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+H+A G ++++ L++ +NA +
Sbjct: 75 NTALHIAALAGQDEVVRELVNYGANVNAQSQ 105
Score = 45.8 bits (107), Expect = 3e-05
Identities = 22/79 (27%), Positives = 42/79 (53%), Gaps = 3/79 (3%)
Frame = +3
Query: 3 KCDISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHI--- 173
+ D++ K GY P+H A + GH DI+ +L+ + + G P+ +A G+I
Sbjct: 720 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSNGTTPLAIAKRLGYISVT 779
Query: 174 DIVKILIDNKCDISTSNKY 230
D++K++ D + S+K+
Sbjct: 780 DVLKVVTDETSVVLVSDKH 798
>sp|Q12955|ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin G)
Length = 4377
Score = 82.8 bits (203), Expect = 2e-16
Identities = 30/103 (29%), Positives = 60/103 (58%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
D + + G +HLA + GH+D++ +L+ + +++ SNK G P+HLA + +++ ++
Sbjct: 656 DANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEV 715
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
L++ + K GY P+H+ C G+I I+ L+ + +NA
Sbjct: 716 LVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758
Score = 82.8 bits (203), Expect = 2e-16
Identities = 32/102 (31%), Positives = 58/102 (56%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
+++ NK G P+HLA + +++ ++L+++ + A K GY P+H+ C G+I IV
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNF 748
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGIN 314
L+ + ++ K GY P+H A + GH I+ +L+ N N
Sbjct: 749 LLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790
Score = 79.7 bits (195), Expect = 2e-15
Identities = 29/97 (29%), Positives = 63/97 (64%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
DI+ N+ G +HLA K GH++++ L+ ++ ++ A+ K G +H+A G ++VK+
Sbjct: 66 DINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKV 125
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDN 299
L+ N +++ ++ G+ P+++A + H++++K L+DN
Sbjct: 126 LVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDN 162
Score = 79.0 bits (193), Expect = 3e-15
Identities = 31/101 (30%), Positives = 60/101 (59%)
Frame = +3
Query: 27 KYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKC 206
K GY P+H+A K +DI L++ D +A + G +HLA + GH+D+V +L+
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA 688
Query: 207 DISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDEI 329
+++ SNK G P+HLA + +++ ++L++ ++A ++
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729
Score = 69.7 bits (169), Expect = 2e-12
Identities = 25/99 (25%), Positives = 60/99 (60%)
Frame = +3
Query: 3 KCDISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIV 182
+ ++ K G +H+A G +++K+L+ +++A ++ G+ P+++A + H+++V
Sbjct: 97 EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVV 156
Query: 183 KILIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDN 299
K L+DN S + + G+ P+ +A + GH ++ +L++N
Sbjct: 157 KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195
Score = 68.9 bits (167), Expect = 3e-12
Identities = 26/91 (28%), Positives = 55/91 (60%)
Frame = +3
Query: 42 PIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTS 221
P+H+A K G+ +++K+L+D+ I A + G P+H +GH +V++L+D I +
Sbjct: 271 PLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSK 330
Query: 222 NKYGYQPIHLACENGHIDIMKILIDNKCGIN 314
K G P+H+A + H++ +++L+ + ++
Sbjct: 331 TKNGLSPLHMATQGDHLNCVQLLLQHNVPVD 361
Score = 67.4 bits (163), Expect = 1e-11
Identities = 29/95 (30%), Positives = 54/95 (56%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G+ P+H+ACK I +M++L+ I A + G PIH+A GH++IV L+ +
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459
Query: 213 STSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
+T+N G +H+A +G ++++ L+ + + A
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEA 494
Score = 66.2 bits (160), Expect = 2e-11
Identities = 26/92 (28%), Positives = 53/92 (57%)
Frame = +3
Query: 42 PIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTS 221
P+H++ + G DI++ L+ + +A+ GY P+HL+ GH D+ L+D+ +S +
Sbjct: 502 PLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSIT 561
Query: 222 NKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
K G+ P+H+A + G +++ +L+ +A
Sbjct: 562 TKKGFTPLHVAAKYGKLEVANLLLQKSASPDA 593
Score = 65.1 bits (157), Expect = 5e-11
Identities = 26/95 (27%), Positives = 51/95 (53%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G P+H ++GH ++++L+D+ I + K G P+H+A + H++ V++L+ + +
Sbjct: 301 GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPV 360
Query: 213 STSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
+H+A GH + K+L+D K NA
Sbjct: 361 DDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNA 395
Score = 65.1 bits (157), Expect = 5e-11
Identities = 28/90 (31%), Positives = 52/90 (57%)
Frame = +3
Query: 45 IHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTSN 224
+H+A GH + K+L+DKK + +A G+ P+H+AC+ I ++++L+ + I
Sbjct: 371 LHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430
Query: 225 KYGYQPIHLACENGHIDIMKILIDNKCGIN 314
+ G PIH+A GH++I+ L+ + N
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMHHGASPN 460
Score = 64.7 bits (156), Expect = 6e-11
Identities = 25/88 (28%), Positives = 48/88 (54%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
GY P+HL+ + GH D+ L+D +S + K G+ P+H+A + G +++ +L+
Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP 591
Query: 213 STSNKYGYQPIHLACENGHIDIMKILID 296
+ K G P+H+A + + +L+D
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLD 619
Score = 64.7 bits (156), Expect = 6e-11
Identities = 27/96 (28%), Positives = 51/96 (53%)
Frame = +3
Query: 27 KYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKC 206
K G P+H+A + + +L+D+ A+ K GY P+H+A + +DI L++
Sbjct: 596 KSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGA 655
Query: 207 DISTSNKYGYQPIHLACENGHIDIMKILIDNKCGIN 314
D + + G +HLA + GH+D++ +L+ +N
Sbjct: 656 DANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691
Score = 64.3 bits (155), Expect = 8e-11
Identities = 29/102 (28%), Positives = 52/102 (50%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
+S K G+ P+H+A K G +++ +L+ K A+ K G P+H+A + + +L
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
Query: 192 IDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
+D + K GY P+H+A + +DI L++ NA
Sbjct: 618 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA 659
Score = 63.9 bits (154), Expect = 1e-10
Identities = 25/96 (26%), Positives = 55/96 (57%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNK 203
+K G+ P+H+A G+I++ +L+++ + + + P+H+A + G+ ++VK+L+D
Sbjct: 232 SKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRG 291
Query: 204 CDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGI 311
I + G P+H +GH ++++L+D I
Sbjct: 292 AKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327
Score = 62.4 bits (150), Expect = 3e-10
Identities = 26/100 (26%), Positives = 52/100 (52%)
Frame = +3
Query: 27 KYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKC 206
K G P+H+A + H++ +++L+ + +H+A GH + K+L+D K
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391
Query: 207 DISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+ + G+ P+H+AC+ I +M++L+ + I A E
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTE 431
Score = 61.6 bits (148), Expect = 5e-10
Identities = 27/88 (30%), Positives = 45/88 (51%)
Frame = +3
Query: 27 KYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKC 206
K GY P+H+ C G+I I+ L+ ++A K GY P+H A + GH I+ +L+ N
Sbjct: 728 KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNA 787
Query: 207 DISTSNKYGYQPIHLACENGHIDIMKIL 290
+ G + +A G+I ++ L
Sbjct: 788 SPNELTVNGNTALGIARRLGYISVVDTL 815
Score = 60.8 bits (146), Expect = 9e-10
Identities = 26/100 (26%), Positives = 51/100 (51%)
Frame = +3
Query: 15 STFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILI 194
+T N G +H+A ++G ++++ L+ + A K P+H++ G DIV+ L+
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519
Query: 195 DNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGIN 314
+ + GY P+HL+ GH D+ L+D+ ++
Sbjct: 520 QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559
Score = 59.3 bits (142), Expect = 3e-09
Identities = 25/91 (27%), Positives = 49/91 (53%)
Frame = +3
Query: 54 ACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTSNKYG 233
A + GH++ I DI+ N+ G +HLA + GH+++V L+ + ++ + K G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 234 YQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+H+A G +++K+L+ N +NA +
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQ 138
Score = 53.9 bits (128), Expect = 1e-07
Identities = 26/102 (25%), Positives = 49/102 (48%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
I + G PIH+A GH++I+ L+ + +N G +H+A +G ++V+ L
Sbjct: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Query: 192 IDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
+ + + K P+H++ G DI++ L+ NA
Sbjct: 486 VQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527
Score = 51.2 bits (121), Expect = 7e-07
Identities = 22/100 (22%), Positives = 51/100 (51%)
Frame = +3
Query: 18 TFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILID 197
T K +H+A + +L+ + +K G+ P+H+A G+I++ +L++
Sbjct: 197 TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLN 256
Query: 198 NKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
+ + + P+H+A + G+ +++K+L+D I+A
Sbjct: 257 RAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDA 296
Score = 33.9 bits (76), Expect = 0.12
Identities = 16/60 (26%), Positives = 28/60 (46%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
++ K GY P+H A + GH I+ +L+ + G + +A G+I +V L
Sbjct: 756 VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
>sp|P53355|DAPK1_HUMAN Death-associated protein kinase 1 (DAP kinase 1)
Length = 1432
Score = 80.1 bits (196), Expect = 1e-15
Identities = 32/94 (34%), Positives = 62/94 (65%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
D++ +K G+ +HLA + ++++K L+ + C + +++G P+H+AC++G++ IV
Sbjct: 538 DLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVA 597
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKIL 290
L + C++ SNKYG P+HLA NG +D+++ L
Sbjct: 598 LCEANCNLDISNKYGRTPLHLAANNGILDVVRYL 631
Score = 70.1 bits (170), Expect = 2e-12
Identities = 32/102 (31%), Positives = 57/102 (55%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
D++ NK+G P+ +A G+I I+++LI + I +K G ++ A +GH+D +K
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGIN 314
L +NKC + +K G +H+A GH D+ ++ + G N
Sbjct: 431 LSENKCPLDVKDKSGEMALHVAARYGHADVAQVQVLCSFGSN 472
Score = 68.6 bits (166), Expect = 4e-12
Identities = 28/103 (27%), Positives = 61/103 (59%)
Frame = +3
Query: 6 CDISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVK 185
C+++ N+ G P+ A G+ DI++ L + D++A +K G+ +HLA ++++K
Sbjct: 504 CNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIK 563
Query: 186 ILIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGIN 314
L+ C + +++G P+H+AC++G++ I+ L + C ++
Sbjct: 564 TLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLD 606
Score = 63.2 bits (152), Expect = 2e-10
Identities = 25/62 (40%), Positives = 42/62 (67%)
Frame = +3
Query: 6 CDISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVK 185
C + +++G P+H+ACK+G++ I+ L + C++ SNKYG P+HLA NG +D+V+
Sbjct: 570 CFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVR 629
Query: 186 IL 191
L
Sbjct: 630 YL 631
Score = 59.7 bits (143), Expect = 2e-09
Identities = 26/94 (27%), Positives = 52/94 (55%)
Frame = +3
Query: 42 PIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTS 221
P+H A +G+ + K L + C+++ N+ G P+ A G+ DIV+ L ++ D++
Sbjct: 483 PLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC 542
Query: 222 NKYGYQPIHLACENGHIDIMKILIDNKCGINAHD 323
+K G+ +HLA ++++K L+ C ++ D
Sbjct: 543 DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQD 576
Score = 58.2 bits (139), Expect = 6e-09
Identities = 29/110 (26%), Positives = 58/110 (52%), Gaps = 2/110 (1%)
Frame = +3
Query: 3 KCDISTFNKYGYQPIHLACKNGHIDI--MKILIDKKCDISASNKYGYQPIHLACENGHID 176
KC + +K G +H+A + GH D+ +++L + + +K P+H A +G+
Sbjct: 435 KCPLDVKDKSGEMALHVAARYGHADVAQVQVLCSFGSNPNIQDKEEETPLHCAAWHGYYS 494
Query: 177 IVKILIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+ K L + C+++ N+ G P+ A G+ DI++ L ++ +NA D+
Sbjct: 495 VAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDK 544
Score = 54.7 bits (130), Expect = 7e-08
Identities = 24/73 (32%), Positives = 43/73 (58%)
Frame = +3
Query: 108 DISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTSNKYGYQPIHLACENGHIDIMKI 287
D++ NK+G P+ +A G+I I+++LI I +K G ++ A +GH+D +K
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 288 LIDNKCGINAHDE 326
L +NKC ++ D+
Sbjct: 431 LSENKCPLDVKDK 443
Score = 37.7 bits (86), Expect = 0.008
Identities = 19/62 (30%), Positives = 29/62 (46%)
Frame = +3
Query: 6 CDISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVK 185
C++ NKYG P+HLA NG +D+++ L + A G LA H +
Sbjct: 603 CNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAG 662
Query: 186 IL 191
+L
Sbjct: 663 LL 664
>sp|O15084|ANR28_HUMAN Ankyrin repeat domain protein 28
Length = 1086
Score = 79.7 bits (195), Expect = 2e-15
Identities = 37/106 (34%), Positives = 62/106 (58%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
+I+ F+K + IH A GHI+++K+L+ +++ +K Y P+H A +G I +VK
Sbjct: 198 NINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKY 257
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
L+D D++ N YG P+H+AC NG ++ LID +N +E
Sbjct: 258 LLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNE 303
Score = 70.9 bits (172), Expect = 9e-13
Identities = 33/103 (32%), Positives = 59/103 (57%), Gaps = 1/103 (0%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
+++ +K Y P+H A +G I ++K L+D D++ N YG P+H+AC NG +V
Sbjct: 231 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNE 290
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDI-MKILIDNKCGIN 314
LID ++ N+ G+ P+H A + H + +++L+ N +N
Sbjct: 291 LIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVN 333
Score = 68.2 bits (165), Expect = 6e-12
Identities = 29/96 (30%), Positives = 60/96 (62%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
+++ ++ G +H A +GH +++K+L+ + +I+A +K + IH A GHI++VK+
Sbjct: 165 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 224
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILID 296
L+ + +++ +K Y P+H A +G I ++K L+D
Sbjct: 225 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLD 260
Score = 62.4 bits (150), Expect = 3e-10
Identities = 33/101 (32%), Positives = 52/101 (51%), Gaps = 1/101 (0%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNK 203
N+ P+HLA +GH +++L+ D+ N G P+ LA GH++ V +LI+
Sbjct: 580 NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQG 639
Query: 204 CDISTSNKYGYQ-PIHLACENGHIDIMKILIDNKCGINAHD 323
I + + PIH A NGH + +++LI N NA D
Sbjct: 640 ASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVD 680
Score = 58.5 bits (140), Expect = 5e-09
Identities = 27/106 (25%), Positives = 58/106 (54%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
D++ +K P+H+A N + + L+ +++ S++ G +H A +GH ++VK+
Sbjct: 132 DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKL 191
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
L+ +I+ +K + IH A GHI+++K+L+ + + D+
Sbjct: 192 LLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDK 237
Score = 58.2 bits (139), Expect = 6e-09
Identities = 28/101 (27%), Positives = 52/101 (51%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNK 203
+K G P+H+A + GH ++ LI D + +G P+HLA +G D + L+ +
Sbjct: 369 DKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSG 428
Query: 204 CDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
DI T + +G +H A G+++ + +L++ N D+
Sbjct: 429 FDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDK 469
Score = 57.0 bits (136), Expect = 1e-08
Identities = 26/99 (26%), Positives = 50/99 (50%)
Frame = +3
Query: 30 YGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCD 209
+G P+HLA +G D + L+ DI + +G +H A G+++ + +L++ D
Sbjct: 404 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 463
Query: 210 ISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+ +K+G P+H A N + + L+ + +N DE
Sbjct: 464 FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDE 502
Score = 56.6 bits (135), Expect = 2e-08
Identities = 27/96 (28%), Positives = 49/96 (51%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G P+ L+ NGH D + L++K ++ A +K+G +H GH + V L+ +
Sbjct: 686 GQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKC 745
Query: 213 STSNKYGYQPIHLACENGHIDIMKILIDNKCGINAH 320
+ G PIHL+ GHI ++ L+ + ++A+
Sbjct: 746 LLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDAN 781
Score = 54.3 bits (129), Expect = 9e-08
Identities = 28/106 (26%), Positives = 51/106 (48%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
D++ +K G P+H+ +G + +I I +K G P+H+A GH ++
Sbjct: 331 DVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINT 390
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
LI + D + +G P+HLA +G D + L+ + I+ D+
Sbjct: 391 LITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDD 436
Score = 52.8 bits (125), Expect = 3e-07
Identities = 24/95 (25%), Positives = 52/95 (54%)
Frame = +3
Query: 42 PIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTS 221
P+H A + + +++L+ D++A +K P+H+A N + + L+ +++ S
Sbjct: 110 PLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVS 169
Query: 222 NKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
++ G +H A +GH +++K+L+ INA D+
Sbjct: 170 DRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDK 204
Score = 52.8 bits (125), Expect = 3e-07
Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 12/115 (10%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGH-IDIMKILIDKKCDI-----------SASNKYGYQPIHLACENG 167
+K GY +H + GH + + I + D+ + N+ P+HLA +G
Sbjct: 535 DKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHG 594
Query: 168 HIDIVKILIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDEIV 332
H +++L+ + D+ N G P+ LA GH++ + +LI+ I D I+
Sbjct: 595 HHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYIL 649
Score = 52.8 bits (125), Expect = 3e-07
Identities = 25/102 (24%), Positives = 51/102 (50%), Gaps = 4/102 (3%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
++ +K+G +H GH + + L+ + G PIHL+ GHI ++
Sbjct: 711 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGA 770
Query: 189 LIDNKCDI----STSNKYGYQPIHLACENGHIDIMKILIDNK 302
L+ + + +T++ +GY +H AC NGH +++L++ +
Sbjct: 771 LLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 812
Score = 52.8 bits (125), Expect = 3e-07
Identities = 25/105 (23%), Positives = 56/105 (53%), Gaps = 2/105 (1%)
Frame = +3
Query: 15 STFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILI 194
+T + +GY +H AC NGH +++L++++ + + P+H A N + ++LI
Sbjct: 783 ATADNHGYTALHWACYNGHETCVELLLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEMLI 841
Query: 195 DN--KCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHD 323
D ++ ++ G P+H A H++ +++L+ + +N+ D
Sbjct: 842 DTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVD 886
Score = 49.3 bits (116), Expect = 3e-06
Identities = 24/91 (26%), Positives = 47/91 (51%), Gaps = 1/91 (1%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGHIDI-MKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDN 200
N+ G+ P+H A + H + +++L+ D++ +K G P+H+ +G + +I +
Sbjct: 302 NEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQS 361
Query: 201 KCDISTSNKYGYQPIHLACENGHIDIMKILI 293
I +K G P+H+A GH ++ LI
Sbjct: 362 GAVIDCEDKNGNTPLHIAARYGHELLINTLI 392
Score = 49.3 bits (116), Expect = 3e-06
Identities = 20/87 (22%), Positives = 46/87 (52%), Gaps = 1/87 (1%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
++ + G P+H A H++ +++L+ +++ + G P+ +A ENG + V++L
Sbjct: 849 VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 908
Query: 192 IDN-KCDISTSNKYGYQPIHLACENGH 269
+ + +++ + +HLAC GH
Sbjct: 909 VSSASAELTLQDNSKNTALHLACSKGH 935
Score = 47.0 bits (110), Expect = 1e-05
Identities = 20/82 (24%), Positives = 43/82 (52%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
DI T + +G +H A G+++ + +L++ D + +K+G P+H A N + +
Sbjct: 430 DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFA 489
Query: 189 LIDNKCDISTSNKYGYQPIHLA 254
L+ + ++ ++ G P+H A
Sbjct: 490 LVGSGASVNDLDERGCTPLHYA 511
Score = 45.1 bits (105), Expect = 5e-05
Identities = 22/94 (23%), Positives = 46/94 (48%)
Frame = +3
Query: 42 PIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTS 221
P+H A G +I+++LI ++A + P+H A + + V++L+ + D++
Sbjct: 77 PLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNAR 136
Query: 222 NKYGYQPIHLACENGHIDIMKILIDNKCGINAHD 323
+K P+H+A N + + L+ +N D
Sbjct: 137 DKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSD 170
Score = 43.9 bits (102), Expect = 1e-04
Identities = 24/109 (22%), Positives = 54/109 (49%), Gaps = 4/109 (3%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDK-KCDISASNKYGYQPIHLACENGHIDIVKI 188
+++ + G P+ +A +NG + +++L+ +++ + +HLAC GH +
Sbjct: 882 VNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALL 941
Query: 189 LIDNKCD---ISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+++ D I+ +N P+H+A NG +++ L+ + A DE
Sbjct: 942 ILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDE 990
Score = 43.5 bits (101), Expect = 2e-04
Identities = 24/97 (24%), Positives = 49/97 (50%)
Frame = +3
Query: 36 YQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDIS 215
Y + A NG D ++ LI KK D++ + P+H A G +I+++LI + ++
Sbjct: 42 YPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVN 101
Query: 216 TSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+ P+H A + + +++L+ + +NA D+
Sbjct: 102 AKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDK 138
Score = 42.0 bits (97), Expect = 4e-04
Identities = 24/74 (32%), Positives = 39/74 (52%), Gaps = 3/74 (4%)
Frame = +3
Query: 45 IHLACKNGHIDIMKILIDKKCD---ISASNKYGYQPIHLACENGHIDIVKILIDNKCDIS 215
+HLAC GH ++++K D I+A+N P+H+A NG +V+ L+ +
Sbjct: 927 LHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVL 986
Query: 216 TSNKYGYQPIHLAC 257
++ GY P LAC
Sbjct: 987 AVDENGYTPA-LAC 999
Score = 38.5 bits (88), Expect = 0.005
Identities = 20/88 (22%), Positives = 40/88 (45%), Gaps = 1/88 (1%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHID-IVK 185
D + +K+G P+H A N + + L+ ++ ++ G P+H A + ++
Sbjct: 463 DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLE 522
Query: 186 ILIDNKCDISTSNKYGYQPIHLACENGH 269
L+ N + +K GY +H + GH
Sbjct: 523 YLLRNDANPGVRDKQGYNAVHYSAAYGH 550
Score = 30.8 bits (68), Expect = 1.0
Identities = 15/62 (24%), Positives = 33/62 (53%), Gaps = 1/62 (1%)
Frame = +3
Query: 42 PIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHI-DIVKILIDNKCDIST 218
P+H+A +NG +++ L+ K + A ++ GY P N + D + +++ +S+
Sbjct: 962 PLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSS 1021
Query: 219 SN 224
S+
Sbjct: 1022 SS 1023
>sp|Q01484|ANK2_HUMAN Ankyrin-2 (Brain ankyrin) (Ankyrin B) (Ankyrin, nonerythroid)
Length = 3924
Score = 76.3 bits (186), Expect = 2e-14
Identities = 30/97 (30%), Positives = 61/97 (62%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
DI+T N+ G +HLA K GH+ +++ L+ + + ++ K G +H+A G ++VK+
Sbjct: 56 DINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKV 115
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDN 299
L+ +I+ ++ G+ P+++A + HID++K L++N
Sbjct: 116 LVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
Score = 72.0 bits (175), Expect = 4e-13
Identities = 29/96 (30%), Positives = 61/96 (63%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
+ + K G +H+A G +++K+L+ + +I+A ++ G+ P+++A + HID+VK L
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 192 IDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDN 299
++N + ST+ + G+ P+ +A + GH + IL++N
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185
Score = 72.0 bits (175), Expect = 4e-13
Identities = 32/97 (32%), Positives = 53/97 (54%)
Frame = +3
Query: 27 KYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKC 206
K G P+HLA + GH D++ +L+DK +I S K G +HLA + +++ IL +
Sbjct: 660 KQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA 719
Query: 207 DISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
D K GY P+ +AC G++ ++ L+ +NA
Sbjct: 720 DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 756
Score = 71.2 bits (173), Expect = 7e-13
Identities = 28/94 (29%), Positives = 56/94 (59%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G P+H+A K G+ +++K+L+D+ I A + G P+H A +GH +V++L++ +
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Query: 213 STSNKYGYQPIHLACENGHIDIMKILIDNKCGIN 314
K G P+H+A + H++ +K L+ +K ++
Sbjct: 326 LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Score = 69.7 bits (169), Expect = 2e-12
Identities = 32/101 (31%), Positives = 54/101 (53%)
Frame = +3
Query: 27 KYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKC 206
K GY P+H+A K + I L++ + + K G P+HLA + GH D+V +L+D
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
Query: 207 DISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDEI 329
+I S K G +HLA + +++ IL + +AH ++
Sbjct: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKL 727
Score = 68.9 bits (167), Expect = 3e-12
Identities = 30/95 (31%), Positives = 54/95 (56%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G+ P+H+ACK I +M++L+ I A + G PIH+A GH++IV +L+ N
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 213 STSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
+N G +H+A G +++++ L+ N ++A
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 492
Score = 66.2 bits (160), Expect = 2e-11
Identities = 31/103 (30%), Positives = 52/103 (50%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
+I K G +HLA + +++ IL D A K GY P+ +AC G++ +V
Sbjct: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
L+ +++ K GY P+H A + GH I+ +L+ + NA
Sbjct: 747 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Score = 65.5 bits (158), Expect = 4e-11
Identities = 27/95 (28%), Positives = 52/95 (54%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G P+H A ++GH ++++L+++ + A K G P+H+A + H++ VK L+ +K +
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 358
Query: 213 STSNKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
+H+A GH + K+L+D + NA
Sbjct: 359 DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393
Score = 65.1 bits (157), Expect = 5e-11
Identities = 27/85 (31%), Positives = 51/85 (60%)
Frame = +3
Query: 45 IHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTSN 224
+H+A GH + K+L+DK+ + +A G+ P+H+AC+ I ++++L+ I
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428
Query: 225 KYGYQPIHLACENGHIDIMKILIDN 299
+ G PIH+A GH++I+ +L+ N
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQN 453
Score = 64.7 bits (156), Expect = 6e-11
Identities = 24/92 (26%), Positives = 53/92 (57%)
Frame = +3
Query: 42 PIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTS 221
P+H+A + G +I+++L+ A+ GY P+H++ G +D+ +L++ S +
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 559
Query: 222 NKYGYQPIHLACENGHIDIMKILIDNKCGINA 317
K G+ P+H+A + G +D+ K+L+ + ++
Sbjct: 560 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591
Score = 64.7 bits (156), Expect = 6e-11
Identities = 28/95 (29%), Positives = 54/95 (56%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
D +T N GY P+H++ + G +D+ +L++ S + K G+ P+H+A + G +D+ K+
Sbjct: 524 DAATTN--GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKL 581
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILI 293
L+ + ++ K G P+H+A H D K+ +
Sbjct: 582 LLQRRAAADSAGKNGLTPLHVA---AHYDNQKVAL 613
Score = 63.9 bits (154), Expect = 1e-10
Identities = 24/98 (24%), Positives = 58/98 (59%)
Frame = +3
Query: 3 KCDISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIV 182
K ++ + G+ P+H+A G++++ +L+++ + + + G P+H+A + G+ ++V
Sbjct: 223 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 282
Query: 183 KILIDNKCDISTSNKYGYQPIHLACENGHIDIMKILID 296
K+L+D I + G P+H A +GH ++++L++
Sbjct: 283 KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320
Score = 63.2 bits (152), Expect = 2e-10
Identities = 30/98 (30%), Positives = 52/98 (53%)
Frame = +3
Query: 27 KYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKC 206
K G P+H+A + + +L++K A+ K GY P+H+A + + I L++
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653
Query: 207 DISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAH 320
+ + K G P+HLA + GH D++ +L+D G N H
Sbjct: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDK--GANIH 689
Score = 61.6 bits (148), Expect = 5e-10
Identities = 27/100 (27%), Positives = 51/100 (51%)
Frame = +3
Query: 27 KYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKC 206
K G P+H+A + H++ +K L+ K + +H+A GH + K+L+D +
Sbjct: 330 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 389
Query: 207 DISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+ + G+ P+H+AC+ I +M++L+ I A E
Sbjct: 390 NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 429
Score = 60.1 bits (144), Expect = 2e-09
Identities = 25/94 (26%), Positives = 50/94 (53%)
Frame = +3
Query: 15 STFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILI 194
S K G+ P+H+A K G +D+ K+L+ ++ ++ K G P+H+A + + +L+
Sbjct: 557 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Query: 195 DNKCDISTSNKYGYQPIHLACENGHIDIMKILID 296
+ + K GY P+H+A + + I L++
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650
Score = 57.4 bits (137), Expect = 1e-08
Identities = 25/94 (26%), Positives = 49/94 (52%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
D K GY P+ +AC G++ ++ L+ + +++A K GY P+H A + GH I+ +
Sbjct: 720 DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINV 779
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKIL 290
L+ + + + G + +A G+I ++ L
Sbjct: 780 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 54.3 bits (129), Expect = 9e-08
Identities = 21/91 (23%), Positives = 48/91 (52%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNK 203
N G +H+A + G +++++ L+ + A + P+H+A G +IV++L+ +
Sbjct: 461 NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Query: 204 CDISTSNKYGYQPIHLACENGHIDIMKILID 296
+ GY P+H++ G +D+ +L++
Sbjct: 521 AHPDAATTNGYTPLHISAREGQVDVASVLLE 551
Score = 53.1 bits (126), Expect = 2e-07
Identities = 24/91 (26%), Positives = 48/91 (52%)
Frame = +3
Query: 54 ACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTSNKYG 233
A + G++D + + DI+ N+ G +HLA + GH+ +V+ L+ + ++ K G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 234 YQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+H+A G +++K+L+ INA +
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQ 128
Score = 53.1 bits (126), Expect = 2e-07
Identities = 24/96 (25%), Positives = 49/96 (51%)
Frame = +3
Query: 12 ISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKIL 191
I + G PIH+A GH++I+ +L+ +N G +H+A G +++V+ L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Query: 192 IDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDN 299
+ N + + P+H+A G +I+++L+ +
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Score = 52.8 bits (125), Expect = 3e-07
Identities = 25/97 (25%), Positives = 51/97 (52%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
+I+ ++ G+ P+++A + HID++K L++ + S + + G+ P+ +A + GH V I
Sbjct: 122 NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAI 181
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDN 299
L++N T K +H+A +L+ N
Sbjct: 182 LLEN----DTKGKVRLPALHIAARKDDTKSAALLLQN 214
Score = 47.0 bits (110), Expect = 1e-05
Identities = 17/75 (22%), Positives = 45/75 (60%)
Frame = +3
Query: 93 IDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTSNKYGYQPIHLACENGHI 272
+ K ++ + + G+ P+H+A G++++ +L++ + + + G P+H+A + G+
Sbjct: 220 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNT 279
Query: 273 DIMKILIDNKCGINA 317
+++K+L+D I+A
Sbjct: 280 NMVKLLLDRGGQIDA 294
>sp|O89019|INVS_MOUSE Inversin (Inversion of embryo turning protein)
Length = 1062
Score = 75.1 bits (183), Expect = 5e-14
Identities = 34/105 (32%), Positives = 59/105 (56%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
DI+ +KYG +H A +GH+ +K+L+D + A++ + P+ ACE GH D+++
Sbjct: 349 DINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQT 408
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHD 323
LI + ++ G+ +H A G+ D+ +ILI+NK N D
Sbjct: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQD 453
Score = 63.5 bits (153), Expect = 1e-10
Identities = 27/88 (30%), Positives = 52/88 (59%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G+ +H A G+ D+ +ILI+ K + + + G P+ A G+I+ + +L++N D
Sbjct: 423 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482
Query: 213 STSNKYGYQPIHLACENGHIDIMKILID 296
+ +K G +H +C NG++D +K+L+D
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLD 510
Score = 62.0 bits (149), Expect = 4e-10
Identities = 29/93 (31%), Positives = 53/93 (56%), Gaps = 2/93 (2%)
Frame = +3
Query: 54 ACKNGHIDIMKILIDKKCDI--SASNKYGYQPIHLACENGHIDIVKILIDNKCDISTSNK 227
A G+ D+++ ++ K DI + S+KYG +H A +GH+ VK+L+DN + ++
Sbjct: 329 AAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDV 388
Query: 228 YGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+ P+ ACE GH D+++ LI ++ D+
Sbjct: 389 MKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQ 421
Score = 59.3 bits (142), Expect = 3e-09
Identities = 28/97 (28%), Positives = 53/97 (54%)
Frame = +3
Query: 36 YQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDIS 215
+ P+ AC+ GH D+++ LI + ++ G+ +H A G+ D+ +ILI+NK + +
Sbjct: 391 HTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPN 450
Query: 216 TSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+ G P+ A G+I+ M +L++N N D+
Sbjct: 451 VQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Score = 54.3 bits (129), Expect = 9e-08
Identities = 33/142 (23%), Positives = 62/142 (43%), Gaps = 36/142 (25%)
Frame = +3
Query: 6 CDISTFNKYGYQPIHLACKNGHIDIMKILIDK-KCDISASNKYGYQPIHLACENGHIDIV 182
C+I++++ P+H A GH I+ +L+++ K S+ G P+H A ++ + V
Sbjct: 246 CNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETV 305
Query: 183 KILID-----------------------------------NKCDISTSNKYGYQPIHLAC 257
K+ + + DI+ S+KYG +H A
Sbjct: 306 KVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHAAA 365
Query: 258 ENGHIDIMKILIDNKCGINAHD 323
+GH+ +K+L+DN ++A D
Sbjct: 366 LSGHVSTVKLLLDNDAQVDATD 387
Score = 48.5 bits (114), Expect = 5e-06
Identities = 24/91 (26%), Positives = 49/91 (53%), Gaps = 2/91 (2%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILID-KKCDISASNKYGYQPIHLACENGHIDIVKILID-NKC 206
G P+H A +G++ ++ +L + C+I++ + P+H A GH IV +L++ NK
Sbjct: 221 GRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKS 280
Query: 207 DISTSNKYGYQPIHLACENGHIDIMKILIDN 299
S+ G P+H A ++ + +K+ + +
Sbjct: 281 GTIPSDSQGATPLHYAAQSNFAETVKVFLQH 311
Score = 32.3 bits (72), Expect = 0.35
Identities = 14/61 (22%), Positives = 34/61 (55%), Gaps = 2/61 (3%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGHIDIMKILIDKKC--DISASNKYGYQPIHLACENGHIDIVKILID 197
+K G +H +C NG++D +K+L+D + +N+ Y P+ A ++++ +++
Sbjct: 486 DKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
Query: 198 N 200
+
Sbjct: 546 H 546
Score = 31.2 bits (69), Expect = 0.78
Identities = 16/87 (18%), Positives = 38/87 (43%), Gaps = 1/87 (1%)
Frame = +3
Query: 45 IHLACKNGHID-IMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTS 221
+H A NG + ++++ +++G P+ +D L+ D++ +
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKT 77
Query: 222 NKYGYQPIHLACENGHIDIMKILIDNK 302
+ +HLA + G+ MK+L+ +
Sbjct: 78 DHSRRTALHLAAQKGNYRFMKLLLTRR 104
Score = 31.2 bits (69), Expect = 0.78
Identities = 15/90 (16%), Positives = 40/90 (44%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNK 203
+++G P+ +D L+ D++ ++ +HLA + G+ +K+L+ +
Sbjct: 45 DRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRR 104
Query: 204 CDISTSNKYGYQPIHLACENGHIDIMKILI 293
+ + P+HL+ + + +L+
Sbjct: 105 ANWMQKDLEEMTPLHLSTRHRSPKCLALLL 134
>sp|Q96AX9|MIB2_HUMAN Ubiquitin ligase protein MIB2 (Mind bomb homolog 2) (Zinc finger ZZ
type with ankyrin repeat domain protein 1)
(Skeletrophin) (Novelzin) (Novel zinc finger protein)
(Putative NF-kappa-B-activating protein 002N)
Length = 1013
Score = 75.1 bits (183), Expect = 5e-14
Identities = 35/108 (32%), Positives = 62/108 (57%), Gaps = 2/108 (1%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGH-IDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVK 185
D++ N G+ +H A GH + + KIL + + A + G+ +HLA N H ++ +
Sbjct: 650 DVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQ 709
Query: 186 ILI-DNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
ILI + +CD++ N+ P+HLA + H+ ++ +L+D C +NA DE
Sbjct: 710 ILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 757
Score = 59.3 bits (142), Expect = 3e-09
Identities = 24/77 (31%), Positives = 47/77 (61%), Gaps = 1/77 (1%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILI-DKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCD 209
G+ +HLA N H ++ +ILI + +CD++ N+ P+HLA + H+ +V +L+D C
Sbjct: 692 GFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCS 751
Query: 210 ISTSNKYGYQPIHLACE 260
++ ++ G +H+A +
Sbjct: 752 VNAEDEEGDTALHVALQ 768
Score = 45.8 bits (107), Expect = 3e-05
Identities = 26/111 (23%), Positives = 56/111 (50%), Gaps = 4/111 (3%)
Frame = +3
Query: 6 CDISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIH--LACENGHIDI 179
C N +H+A + G +++++ L ++ CD++ + + P+H ++ G I
Sbjct: 580 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 639
Query: 180 VKILID-NKCDISTSNKYGYQPIHLACENGH-IDIMKILIDNKCGINAHDE 326
V++L + D++ +N G+ +H A GH + + KIL + ++A E
Sbjct: 640 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 690
Score = 43.9 bits (102), Expect = 1e-04
Identities = 15/53 (28%), Positives = 33/53 (62%)
Frame = +3
Query: 3 KCDISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACE 161
+CD++ N+ P+HLA + H+ ++ +L+D C ++A ++ G +H+A +
Sbjct: 716 RCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ 768
Score = 42.0 bits (97), Expect = 4e-04
Identities = 18/78 (23%), Positives = 36/78 (46%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G +H A + ++L+ C A N +H+A + G +++V+ L + CD+
Sbjct: 556 GNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDV 615
Query: 213 STSNKYGYQPIHLACENG 266
+ + + P+H A G
Sbjct: 616 NLPDAHSDTPLHSAISAG 633
>sp|Q9Y283|INVS_HUMAN Inversin (Inversion of embryo turning homolog) (Nephrocystin-2)
Length = 1065
Score = 73.9 bits (180), Expect = 1e-13
Identities = 33/105 (31%), Positives = 59/105 (56%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
DI+ +KYG +H A +GH+ +K+L++ + A++ + P+ ACE GH D+++
Sbjct: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT 408
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHD 323
LI + ++ G+ +H A G+ D+ +ILI+NK N D
Sbjct: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQD 453
Score = 63.5 bits (153), Expect = 1e-10
Identities = 27/88 (30%), Positives = 52/88 (59%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G+ +H A G+ D+ +ILI+ K + + + G P+ A G+I+ + +L++N D
Sbjct: 423 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482
Query: 213 STSNKYGYQPIHLACENGHIDIMKILID 296
+ +K G +H +C NG++D +K+L+D
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLD 510
Score = 59.3 bits (142), Expect = 3e-09
Identities = 28/97 (28%), Positives = 53/97 (54%)
Frame = +3
Query: 36 YQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDIS 215
+ P+ AC+ GH D+++ LI + ++ G+ +H A G+ D+ +ILI+NK + +
Sbjct: 391 HTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPN 450
Query: 216 TSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+ G P+ A G+I+ M +L++N N D+
Sbjct: 451 VQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Score = 58.9 bits (141), Expect = 4e-09
Identities = 27/93 (29%), Positives = 52/93 (55%), Gaps = 2/93 (2%)
Frame = +3
Query: 54 ACKNGHIDIMKILIDKKCDI--SASNKYGYQPIHLACENGHIDIVKILIDNKCDISTSNK 227
A G D+++ ++ K DI + ++KYG +H A +GH+ VK+L++N + ++
Sbjct: 329 AAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDV 388
Query: 228 YGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+ P+ ACE GH D+++ LI ++ D+
Sbjct: 389 MKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQ 421
Score = 51.6 bits (122), Expect = 6e-07
Identities = 31/142 (21%), Positives = 62/142 (43%), Gaps = 36/142 (25%)
Frame = +3
Query: 6 CDISTFNKYGYQPIHLACKNGHIDIMKILIDK-KCDISASNKYGYQPIHLACENGHIDIV 182
C+I++++ P+H A GH I+ +L+++ K S+ G P+H A ++ + V
Sbjct: 246 CNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETV 305
Query: 183 KIL-----------------------------------IDNKCDISTSNKYGYQPIHLAC 257
K+ + + DI+ ++KYG +H A
Sbjct: 306 KVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAA 365
Query: 258 ENGHIDIMKILIDNKCGINAHD 323
+GH+ +K+L++N ++A D
Sbjct: 366 LSGHVSTVKLLLENNAQVDATD 387
Score = 48.5 bits (114), Expect = 5e-06
Identities = 24/89 (26%), Positives = 48/89 (53%), Gaps = 2/89 (2%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILID-KKCDISASNKYGYQPIHLACENGHIDIVKILID-NKC 206
G P+H A +G++ ++ +L + C+I++ + P+H A GH IV +L++ NK
Sbjct: 221 GRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKS 280
Query: 207 DISTSNKYGYQPIHLACENGHIDIMKILI 293
S+ G P+H A ++ + +K+ +
Sbjct: 281 GTIPSDSQGATPLHYAAQSNFAETVKVFL 309
Score = 32.3 bits (72), Expect = 0.35
Identities = 14/61 (22%), Positives = 34/61 (55%), Gaps = 2/61 (3%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGHIDIMKILIDKKC--DISASNKYGYQPIHLACENGHIDIVKILID 197
+K G +H +C NG++D +K+L+D + +N+ Y P+ A ++++ +++
Sbjct: 486 DKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
Query: 198 N 200
+
Sbjct: 546 H 546
Score = 30.4 bits (67), Expect = 1.3
Identities = 16/87 (18%), Positives = 38/87 (43%), Gaps = 1/87 (1%)
Frame = +3
Query: 45 IHLACKNGHID-IMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTS 221
+H A NG + ++++ +++G P+ +D L+ D++ +
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 222 NKYGYQPIHLACENGHIDIMKILIDNK 302
+ +HLA + G+ MK+L+ +
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRR 104
Score = 30.0 bits (66), Expect = 1.7
Identities = 15/90 (16%), Positives = 39/90 (43%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNK 203
+++G P+ +D L+ D++ ++ +HLA + G+ +K+L+ +
Sbjct: 45 DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104
Query: 204 CDISTSNKYGYQPIHLACENGHIDIMKILI 293
+ + P+HL + + +L+
Sbjct: 105 ANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
>sp|Q6JAN1|INVS_CANFA Inversin (Inversion of embryo turning homolog)
Length = 1081
Score = 73.9 bits (180), Expect = 1e-13
Identities = 33/105 (31%), Positives = 59/105 (56%)
Frame = +3
Query: 9 DISTFNKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKI 188
DI+ +KYG +H A +GH+ +K+L++ + A++ + P+ ACE GH D+++
Sbjct: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT 408
Query: 189 LIDNKCDISTSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHD 323
LI + ++ G+ +H A G+ D+ +ILI+NK N D
Sbjct: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQD 453
Score = 63.5 bits (153), Expect = 1e-10
Identities = 27/88 (30%), Positives = 52/88 (59%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDI 212
G+ +H A G+ D+ +ILI+ K + + + G P+ A G+I+ + +L++N D
Sbjct: 423 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482
Query: 213 STSNKYGYQPIHLACENGHIDIMKILID 296
+ +K G +H +C NG++D +K+L+D
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLD 510
Score = 59.3 bits (142), Expect = 3e-09
Identities = 28/97 (28%), Positives = 53/97 (54%)
Frame = +3
Query: 36 YQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDIS 215
+ P+ AC+ GH D+++ LI + ++ G+ +H A G+ D+ +ILI+NK + +
Sbjct: 391 HTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPN 450
Query: 216 TSNKYGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+ G P+ A G+I+ M +L++N N D+
Sbjct: 451 VQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Score = 58.9 bits (141), Expect = 4e-09
Identities = 27/93 (29%), Positives = 52/93 (55%), Gaps = 2/93 (2%)
Frame = +3
Query: 54 ACKNGHIDIMKILIDKKCDI--SASNKYGYQPIHLACENGHIDIVKILIDNKCDISTSNK 227
A G D+++ ++ K DI + ++KYG +H A +GH+ VK+L++N + ++
Sbjct: 329 AAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDV 388
Query: 228 YGYQPIHLACENGHIDIMKILIDNKCGINAHDE 326
+ P+ ACE GH D+++ LI ++ D+
Sbjct: 389 MKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQ 421
Score = 51.6 bits (122), Expect = 6e-07
Identities = 31/142 (21%), Positives = 62/142 (43%), Gaps = 36/142 (25%)
Frame = +3
Query: 6 CDISTFNKYGYQPIHLACKNGHIDIMKILIDK-KCDISASNKYGYQPIHLACENGHIDIV 182
C+I++++ P+H A GH I+ +L+++ K S+ G P+H A ++ + V
Sbjct: 246 CNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETV 305
Query: 183 KIL-----------------------------------IDNKCDISTSNKYGYQPIHLAC 257
K+ + + DI+ ++KYG +H A
Sbjct: 306 KVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAA 365
Query: 258 ENGHIDIMKILIDNKCGINAHD 323
+GH+ +K+L++N ++A D
Sbjct: 366 LSGHVSTVKLLLENNAQVDATD 387
Score = 48.5 bits (114), Expect = 5e-06
Identities = 24/89 (26%), Positives = 48/89 (53%), Gaps = 2/89 (2%)
Frame = +3
Query: 33 GYQPIHLACKNGHIDIMKILID-KKCDISASNKYGYQPIHLACENGHIDIVKILID-NKC 206
G P+H A +G++ ++ +L + C+I++ + P+H A GH IV +L++ NK
Sbjct: 221 GRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKS 280
Query: 207 DISTSNKYGYQPIHLACENGHIDIMKILI 293
S+ G P+H A ++ + +K+ +
Sbjct: 281 GTIPSDSQGATPLHYAAQSNFAETVKVFL 309
Score = 32.3 bits (72), Expect = 0.35
Identities = 14/61 (22%), Positives = 34/61 (55%), Gaps = 2/61 (3%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGHIDIMKILIDKKC--DISASNKYGYQPIHLACENGHIDIVKILID 197
+K G +H +C NG++D +K+L+D + +N+ Y P+ A ++++ +++
Sbjct: 486 DKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
Query: 198 N 200
+
Sbjct: 546 H 546
Score = 31.6 bits (70), Expect = 0.60
Identities = 16/90 (17%), Positives = 40/90 (44%)
Frame = +3
Query: 24 NKYGYQPIHLACKNGHIDIMKILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNK 203
+++G P+ +D L+ D++ ++ +HLA + G+ +K+L+ +
Sbjct: 45 DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104
Query: 204 CDISTSNKYGYQPIHLACENGHIDIMKILI 293
+ + P+HLA + + +L+
Sbjct: 105 ANWMQKDLEEMTPLHLATRHKSPKCLALLL 134
Score = 30.0 bits (66), Expect = 1.7
Identities = 17/87 (19%), Positives = 38/87 (43%), Gaps = 1/87 (1%)
Frame = +3
Query: 45 IHLACKNGHIDIM-KILIDKKCDISASNKYGYQPIHLACENGHIDIVKILIDNKCDISTS 221
+H A NG + +++I +++G P+ +D L+ D++ +
Sbjct: 18 VHAAAINGDKGALHRLIIGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 222 NKYGYQPIHLACENGHIDIMKILIDNK 302
+ +HLA + G+ MK+L+ +
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRR 104
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,981,728
Number of Sequences: 369166
Number of extensions: 750833
Number of successful extensions: 3758
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 1702
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3189
length of database: 68,354,980
effective HSP length: 96
effective length of database: 50,620,420
effective search space used: 1721094280
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)