Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_F01
(873 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q96HN2|SAHH3_HUMAN Putative adenosylhomocysteinase 3 (S-... 265 9e-71
sp|O43865|SAHH2_HUMAN Putative adenosylhomocysteinase 2 (S-... 265 1e-70
sp|P50245|SAHH2_DROME Putative adenosylhomocysteinase 2 (S-... 241 3e-63
sp|Q82WL1|SAHH_NITEU Adenosylhomocysteinase (S-adenosyl-L-h... 216 5e-56
sp|P61617|SAHH_GEOSL Adenosylhomocysteinase (S-adenosyl-L-h... 214 3e-55
sp|Q7NZF7|SAHH_CHRVO Adenosylhomocysteinase (S-adenosyl-L-h... 211 3e-54
sp|Q7WQX5|SAHH_BORBR Adenosylhomocysteinase (S-adenosyl-L-h... 208 2e-53
sp|Q7VUL8|SAHH_BORPE Adenosylhomocysteinase (S-adenosyl-L-h... 206 7e-53
sp|Q7U9Y3|SAHH_SYNPX Adenosylhomocysteinase (S-adenosyl-L-h... 205 2e-52
sp|Q8FXZ7|SAHH_BRUSU Adenosylhomocysteinase (S-adenosyl-L-h... 204 3e-52
>sp|Q96HN2|SAHH3_HUMAN Putative adenosylhomocysteinase 3 (S-adenosyl-L-homocysteine
hydrolase) (AdoHcyase)
Length = 611
Score = 265 bits (678), Expect = 9e-71
Identities = 123/226 (54%), Positives = 161/226 (71%)
Frame = -1
Query: 873 TDTTISGKIVLVCGYGSVGKGCCQALKGMGAQVLVAEIDPICSIQACIEGFRVVLMNASL 694
TD GK V+VCGYG VGKGCC ALK MG+ V V EIDPIC++QAC++GFR+V +N +
Sbjct: 386 TDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKLNEVI 445
Query: 693 PIADIIITCTGTLSLLNATDFEKLKDGCIVCNMGHPTSEIDIDSLQNKGVVWERIRDDVD 514
DI+ITCTG +++ +++K+ CIVCNMGH +EID+ SL+ + WER+R VD
Sbjct: 446 RQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPELTWERVRSQVD 505
Query: 513 YIILPSTKRIILIAQGRVANLNCXXXXXXXXXXXXTAQVLALIELYTATDGRYKNEIYLI 334
++I P KRI+L+A+GR+ NL+C T Q LALIELY A +GRYK ++YL+
Sbjct: 506 HVIWPDGKRIVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLL 565
Query: 333 PKKCDEVIARSHLSIFGAQLNELSDKQAKYLGVNKNGPFKTSYYRY 196
PKK DE +A HL F A L EL+D+QAKYLG+NKNGPFK +YYRY
Sbjct: 566 PKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYRY 611
>sp|O43865|SAHH2_HUMAN Putative adenosylhomocysteinase 2 (S-adenosyl-L-homocysteine
hydrolase) (AdoHcyase)
Length = 500
Score = 265 bits (677), Expect = 1e-70
Identities = 121/226 (53%), Positives = 160/226 (70%)
Frame = -1
Query: 873 TDTTISGKIVLVCGYGSVGKGCCQALKGMGAQVLVAEIDPICSIQACIEGFRVVLMNASL 694
TD GK V+VCGYG VGKGCC ALK +GA V + EIDPIC++QAC++GFRVV +N +
Sbjct: 275 TDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKLNEVI 334
Query: 693 PIADIIITCTGTLSLLNATDFEKLKDGCIVCNMGHPTSEIDIDSLQNKGVVWERIRDDVD 514
D++ITCTG +++ +++K+ CIVCNMGH +EID+ SL+ + WER+R VD
Sbjct: 335 RQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVD 394
Query: 513 YIILPSTKRIILIAQGRVANLNCXXXXXXXXXXXXTAQVLALIELYTATDGRYKNEIYLI 334
++I P KR++L+A+GR+ NL+C T Q LALIELY A +GRYK ++YL+
Sbjct: 395 HVIWPDGKRVVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLL 454
Query: 333 PKKCDEVIARSHLSIFGAQLNELSDKQAKYLGVNKNGPFKTSYYRY 196
PKK DE +A HL F A L EL+D QAKYLG+NKNGPFK +YYRY
Sbjct: 455 PKKMDEYVASLHLPSFDAHLTELTDDQAKYLGLNKNGPFKPNYYRY 500
>sp|P50245|SAHH2_DROME Putative adenosylhomocysteinase 2 (S-adenosyl-L-homocysteine
hydrolase 2) (AdoHcyase 2)
Length = 492
Score = 241 bits (614), Expect = 3e-63
Identities = 110/226 (48%), Positives = 156/226 (69%)
Frame = -1
Query: 873 TDTTISGKIVLVCGYGSVGKGCCQALKGMGAQVLVAEIDPICSIQACIEGFRVVLMNASL 694
TD GK V++CGYG VGKGC Q+LKG G V V E+DPIC++QA ++GFRVV +N +
Sbjct: 268 TDIMFGGKQVVICGYGDVGKGCAQSLKGQGCIVYVTEVDPICALQAAMDGFRVVRLNEVI 327
Query: 693 PIADIIITCTGTLSLLNATDFEKLKDGCIVCNMGHPTSEIDIDSLQNKGVVWERIRDDVD 514
D+++T TG +++ ++K+GCI+CNMGH SEID++ L + WER+R VD
Sbjct: 328 RTVDVVVTATGNKNVITRDHMNRMKNGCILCNMGHSCSEIDVNGLHTPELTWERVRSQVD 387
Query: 513 YIILPSTKRIILIAQGRVANLNCXXXXXXXXXXXXTAQVLALIELYTATDGRYKNEIYLI 334
+I P + IIL+A+GR+ NL+C + Q LALIEL++A GRYK+++YL+
Sbjct: 388 HIRWPDGRMIILLAEGRLVNLSCSTISSFVVSVASSTQALALIELFSA-PGRYKSDVYLL 446
Query: 333 PKKCDEVIARSHLSIFGAQLNELSDKQAKYLGVNKNGPFKTSYYRY 196
PKK DE +A HL+ F A L EL+D+Q+K++G+NK GPFK +YYRY
Sbjct: 447 PKKMDEYVASLHLATFDAHLTELTDEQSKFMGLNKAGPFKANYYRY 492
>sp|Q82WL1|SAHH_NITEU Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 478
Score = 216 bits (551), Expect = 5e-56
Identities = 110/228 (48%), Positives = 154/228 (67%), Gaps = 2/228 (0%)
Frame = -1
Query: 873 TDTTISGKIVLVCGYGSVGKGCCQALKGMGAQVLVAEIDPICSIQACIEGFRVVLMNASL 694
TD I+GKI +VCGYG VGKGC Q+L+G+GA V + EIDPIC++QA +EG+RVV M+ +
Sbjct: 255 TDVMIAGKIAVVCGYGDVGKGCAQSLRGLGATVWITEIDPICALQAAMEGYRVVTMDDAC 314
Query: 693 PIADIIITCTGTLSLLNATDFEKLKDGCIVCNMGHPTSEIDIDSLQNKGVVWERIRDDVD 514
ADI +T TG L ++ K+KD I+CN+GH SEIDI S+Q WE I+ VD
Sbjct: 315 DKADIFVTATGNLRVITHDHMLKMKDQSIICNIGHFDSEIDIASVQK--YQWENIKPQVD 372
Query: 513 YIILPSTKRIILIAQGRVANLNCXXXXXXXXXXXXTA-QVLALIELYTATDGR-YKNEIY 340
++I P+ +RII++AQGR+ NL C QVLA IEL+ +G+ Y+ ++Y
Sbjct: 373 HVIFPTGRRIIVLAQGRLVNLGCATGHPSFVMSSSFTNQVLAQIELW--QNGKDYQKKVY 430
Query: 339 LIPKKCDEVIARSHLSIFGAQLNELSDKQAKYLGVNKNGPFKTSYYRY 196
++PK+ DE++AR HL G +L EL+D+QA YL ++KNGP+K YRY
Sbjct: 431 VLPKRLDEMVARLHLGKLGVKLTELTDEQAHYLNLDKNGPYKPEMYRY 478
>sp|P61617|SAHH_GEOSL Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 475
Score = 214 bits (544), Expect = 3e-55
Identities = 106/227 (46%), Positives = 151/227 (66%), Gaps = 1/227 (0%)
Frame = -1
Query: 873 TDTTISGKIVLVCGYGSVGKGCCQALKGMGAQVLVAEIDPICSIQACIEGFRVVLMNASL 694
TD I+GK+ ++CGYG VGKGC QA++G+ AQV V EIDPIC++QA +EG+RVV M +
Sbjct: 252 TDVMIAGKVAVICGYGEVGKGCAQAMRGLQAQVWVTEIDPICALQAAMEGYRVVTMEYAA 311
Query: 693 PIADIIITCTGTLSLLNATDFEKLKDGCIVCNMGHPTSEIDIDSLQNKGVVWERIRDDVD 514
ADI +T TG ++++ + ++ IVCN+GH +EI++ +L K WE I+ VD
Sbjct: 312 DKADIFVTTTGNINVITHDHMKAMRHNAIVCNIGHFDNEIEVAAL--KQYQWENIKPQVD 369
Query: 513 YIILPSTKRIILIAQGRVANLNCXXXXXXXXXXXXTA-QVLALIELYTATDGRYKNEIYL 337
+II P +KRIIL+A+GR+ NL C A Q LA IEL+ G+Y +Y+
Sbjct: 370 HIIFPDSKRIILLAEGRLVNLGCATGHPSYVMSSSFANQTLAQIELF-CNPGKYPVGVYM 428
Query: 336 IPKKCDEVIARSHLSIFGAQLNELSDKQAKYLGVNKNGPFKTSYYRY 196
+PK+ DE +AR L GA L EL+D+QA Y+GV KNGP+K+++YRY
Sbjct: 429 LPKELDEKVARLQLKTLGAMLTELTDEQAAYIGVPKNGPYKSAHYRY 475
>sp|Q7NZF7|SAHH_CHRVO Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 466
Score = 211 bits (536), Expect = 3e-54
Identities = 105/227 (46%), Positives = 150/227 (66%), Gaps = 1/227 (0%)
Frame = -1
Query: 873 TDTTISGKIVLVCGYGSVGKGCCQALKGMGAQVLVAEIDPICSIQACIEGFRVVLMNASL 694
TD ++GK+ +V GYG VGKGC Q+L+G+GA V V EIDPIC++QA +EG+RVV M+
Sbjct: 243 TDVMVAGKVAVVLGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVRMDEVA 302
Query: 693 PIADIIITCTGTLSLLNATDFEKLKDGCIVCNMGHPTSEIDIDSLQNKGVVWERIRDDVD 514
ADI +T TG + ++ +K+++ I+CN+GH SEI++ SL+ WE I+ VD
Sbjct: 303 DQADIFVTATGNVGVITHEHMKKMRNNAIICNIGHFDSEIEVASLRQ--YQWENIKPQVD 360
Query: 513 YIILPSTKRIILIAQGRVANLNCXXXXXXXXXXXXTA-QVLALIELYTATDGRYKNEIYL 337
+II P KR+IL+A+GR+ NL C QVLA IEL+ A +Y+ ++Y+
Sbjct: 361 HIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELF-ANGHKYEKKVYV 419
Query: 336 IPKKCDEVIARSHLSIFGAQLNELSDKQAKYLGVNKNGPFKTSYYRY 196
+PK DE +AR HL+ GA+L ELSD+QA Y+ V K GP+K +YRY
Sbjct: 420 LPKHLDEKVARLHLARIGARLTELSDQQAAYISVPKQGPYKPDHYRY 466
>sp|Q7WQX5|SAHH_BORBR Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
sp|Q7W1Z7|SAHH_BORPA Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 472
Score = 208 bits (529), Expect = 2e-53
Identities = 106/227 (46%), Positives = 142/227 (62%), Gaps = 1/227 (0%)
Frame = -1
Query: 873 TDTTISGKIVLVCGYGSVGKGCCQALKGMGAQVLVAEIDPICSIQACIEGFRVVLMNASL 694
TD ++GKI +V GYG VGKGC QAL + AQV V EIDPIC++QA +EGF+VV M +
Sbjct: 248 TDVMVAGKIAVVAGYGDVGKGCAQALAALRAQVWVTEIDPICALQAAMEGFKVVTMEEAA 307
Query: 693 PIADIIITCTGTLSLLNATDFEKLKDGCIVCNMGHPTSEIDIDSLQNKGVVWERIRDDVD 514
ADI +T TG ++ E +KD IVCN+GH +EID+ L+N WE I+ VD
Sbjct: 308 AHADIFVTATGNYHVITRQHMEAMKDQAIVCNIGHFDNEIDVAGLEN--CQWEEIKPQVD 365
Query: 513 YIILPSTKRIILIAQGRVANLNCXXXXXXXXXXXXTA-QVLALIELYTATDGRYKNEIYL 337
++I P KRIIL+A+GR+ NL C A Q +A IEL+T + ++Y+
Sbjct: 366 HVIFPDGKRIILLAKGRLVNLGCATGHPSFVMSSSFANQTIAQIELFTRNEAYTTGQVYV 425
Query: 336 IPKKCDEVIARSHLSIFGAQLNELSDKQAKYLGVNKNGPFKTSYYRY 196
+PK DE +AR HL GA+L+ LS +QA Y+GV GPFK +YRY
Sbjct: 426 LPKHLDEKVARLHLKKLGAKLSTLSKQQADYIGVPVEGPFKPGHYRY 472
>sp|Q7VUL8|SAHH_BORPE Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 472
Score = 206 bits (524), Expect = 7e-53
Identities = 105/227 (46%), Positives = 141/227 (62%), Gaps = 1/227 (0%)
Frame = -1
Query: 873 TDTTISGKIVLVCGYGSVGKGCCQALKGMGAQVLVAEIDPICSIQACIEGFRVVLMNASL 694
TD ++GKI +V GYG VGKGC QAL + AQV V EIDPIC++QA +EGF+VV M +
Sbjct: 248 TDVMVAGKIAVVAGYGDVGKGCAQALVALRAQVWVTEIDPICALQAAMEGFKVVTMEEAA 307
Query: 693 PIADIIITCTGTLSLLNATDFEKLKDGCIVCNMGHPTSEIDIDSLQNKGVVWERIRDDVD 514
ADI +T TG ++ E +KD IVCN+GH +EID+ L+N WE I+ VD
Sbjct: 308 AHADIFVTATGNYHVITRQHMEAMKDQAIVCNIGHFDNEIDVAGLEN--CQWEEIKPQVD 365
Query: 513 YIILPSTKRIILIAQGRVANLNCXXXXXXXXXXXXTA-QVLALIELYTATDGRYKNEIYL 337
++I P KRIIL+A+GR+ NL C A Q +A IEL+T + ++Y+
Sbjct: 366 HVIFPDGKRIILLAKGRLVNLGCATGHPSFVMSSSFANQTIAQIELFTRNEAYTTGQVYV 425
Query: 336 IPKKCDEVIARSHLSIFGAQLNELSDKQAKYLGVNKNGPFKTSYYRY 196
+PK DE +AR HL G +L+ LS +QA Y+GV GPFK +YRY
Sbjct: 426 LPKHLDEKVARLHLKKLGVKLSTLSKQQADYIGVPVEGPFKPDHYRY 472
>sp|Q7U9Y3|SAHH_SYNPX Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 476
Score = 205 bits (521), Expect = 2e-52
Identities = 107/227 (47%), Positives = 143/227 (62%), Gaps = 1/227 (0%)
Frame = -1
Query: 873 TDTTISGKIVLVCGYGSVGKGCCQALKGMGAQVLVAEIDPICSIQACIEGFRVVLMNASL 694
TD ++GK LV GYG VGKG Q+L+G+GA V +AE+DPIC++QA +EG+RVV + +
Sbjct: 253 TDVMVAGKQALVMGYGDVGKGSAQSLRGLGATVCIAEVDPICALQAAMEGYRVVRLEDVV 312
Query: 693 PIADIIITCTGTLSLLNATDFEKLKDGCIVCNMGHPTSEIDIDSLQNKGVVWERIRDDVD 514
DI +T TG ++ EK+KD IVCN+GH +EID+ SL KG W+ I+ VD
Sbjct: 313 EEMDIFVTATGNYQVIRNEHLEKMKDEAIVCNIGHFDNEIDVASL--KGYEWDNIKPQVD 370
Query: 513 YIILPSTKRIILIAQGRVANLNCXXXXXXXXXXXXTA-QVLALIELYTATDGRYKNEIYL 337
+I LPS RIIL+A+GR+ NL C QVLA IEL+T Y E+Y+
Sbjct: 371 HITLPSGNRIILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELFT-KGNEYGKEVYV 429
Query: 336 IPKKCDEVIARSHLSIFGAQLNELSDKQAKYLGVNKNGPFKTSYYRY 196
+PK DE++AR HL GA+L ELS QA Y+ V GP+K +YRY
Sbjct: 430 LPKHLDEMVARLHLDRIGAKLTELSKDQADYINVPVEGPYKPDHYRY 476
>sp|Q8FXZ7|SAHH_BRUSU Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 466
Score = 204 bits (518), Expect = 3e-52
Identities = 104/227 (45%), Positives = 147/227 (64%), Gaps = 1/227 (0%)
Frame = -1
Query: 873 TDTTISGKIVLVCGYGSVGKGCCQALKGMGAQVLVAEIDPICSIQACIEGFRVVLMNASL 694
TD ++GK+ +VCGYG VGKG Q+L G GA+V V E+DPIC++QA ++GF VV ++ +
Sbjct: 243 TDVMMAGKVAVVCGYGDVGKGSAQSLAGAGARVKVTEVDPICALQAAMDGFEVVTLDDAA 302
Query: 693 PIADIIITCTGTLSLLNATDFEKLKDGCIVCNMGHPTSEIDIDSLQNKGVVWERIRDDVD 514
ADI++T TG ++ K+KD CIV N+GH +EI + +L+N + W ++ VD
Sbjct: 303 STADIVVTTTGNKDVITIDHMRKMKDMCIVGNIGHFDNEIQVAALRN--LKWTNVKPQVD 360
Query: 513 YIILPSTKRIILIAQGRVANL-NCXXXXXXXXXXXXTAQVLALIELYTATDGRYKNEIYL 337
I P KR+IL+++GR+ NL N T QVL IEL+T TD YKNE+Y+
Sbjct: 361 LIEFPDGKRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLGQIELFTRTDA-YKNEVYV 419
Query: 336 IPKKCDEVIARSHLSIFGAQLNELSDKQAKYLGVNKNGPFKTSYYRY 196
+PK DE +AR HL GA+L LS++QA Y+GV GPFK+ +YRY
Sbjct: 420 LPKHLDEKVARLHLDKLGAKLTVLSEEQAAYIGVTPQGPFKSEHYRY 466
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,314,575
Number of Sequences: 369166
Number of extensions: 1868212
Number of successful extensions: 4870
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4551
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4726
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8646143400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)