Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_E05
(874 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P24156|L2CC_DROME L(2)37Cc protein 319 7e-87
sp|P67778|PHB_MOUSE Prohibitin (B-cell receptor associated ... 302 9e-82
sp|P35232|PHB_HUMAN Prohibitin 300 3e-81
sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex prote... 294 2e-79
sp|P40961|PHB_YEAST Prohibitin 270 4e-72
sp|O35129|PHB2_MOUSE Prohibitin-2 (B-cell receptor-associat... 221 3e-57
sp|Q5XIH7|PHB2_RAT Prohibitin-2 (B-cell receptor-associated... 221 3e-57
sp|P50085|PHB2_YEAST Prohibitin-2 219 8e-57
sp|P50093|PHB2_CAEEL Mitochondrial prohibitin complex prote... 206 9e-53
sp|O28852|Y1420_ARCFU Hypothetical protein AF1420 57 9e-08
>sp|P24156|L2CC_DROME L(2)37Cc protein
Length = 276
Score = 319 bits (817), Expect = 7e-87
Identities = 156/245 (63%), Positives = 195/245 (79%)
Frame = +3
Query: 99 YTVPGGHRAVIFDRISGVRQEVVGEGTHFLIPWIQRPIIYDIRTRPRNIPVNTGSKDLQK 278
Y V GGHRAVIFDR +G+++ VVGEGTHF IPW+QRPII+DIR++PRN+PV TGSKDLQ
Sbjct: 28 YNVEGGHRAVIFDRFTGIKENVVGEGTHFFIPWVQRPIIFDIRSQPRNVPVITGSKDLQN 87
Query: 279 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 458
VNITLRILY+P+ + LPKIYT LG D++ERVLPSI EVLK VVAQFDA +LITQRE+VS
Sbjct: 88 VNITLRILYRPIPDQLPKIYTILGQDYDERVLPSIAPEVLKAVVAQFDAGELITQREMVS 147
Query: 459 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 638
Q+V++ LT RA FG LDDISLTHLTFG EF+ ++VEKAEQ+K
Sbjct: 148 QRVSQELTVRAKQFGFILDDISLTHLTFGREFTLAVEMKQVAQQEAEKARFVVEKAEQQK 207
Query: 639 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTL 818
LA+IISAEGD++AA LLAKSF + G+G +EL+RI+ +E+IA+ LS++R + YLP Q TL
Sbjct: 208 LASIISAEGDAEAAGLLAKSFGEAGDGLVELRRIEAAEDIAYQLSRSRGVAYLPSGQSTL 267
Query: 819 INLPA 833
+NLP+
Sbjct: 268 LNLPS 272
>sp|P67778|PHB_MOUSE Prohibitin (B-cell receptor associated protein 32) (BAP 32)
sp|P67779|PHB_RAT Prohibitin
Length = 272
Score = 302 bits (773), Expect = 9e-82
Identities = 151/244 (61%), Positives = 190/244 (77%)
Frame = +3
Query: 99 YTVPGGHRAVIFDRISGVRQEVVGEGTHFLIPWIQRPIIYDIRTRPRNIPVNTGSKDLQK 278
Y V GHRAVIFDR GV+ VVGEGTHFLIPW+Q+PII+D R+RPRN+PV TGSKDLQ
Sbjct: 28 YNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQN 87
Query: 279 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 458
VNITLRIL++PVA LP+IYT++G D++ERVLPSIT E+LK+VVA+FDA +LITQRELVS
Sbjct: 88 VNITLRILFRPVASQLPRIYTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVS 147
Query: 459 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 638
++V++ LT RA FGL LDD+SLTHLTFG EF+ ++VEKAEQ+K
Sbjct: 148 RQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQK 207
Query: 639 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTL 818
AAIISAEGDS+AA L+A S G+G IEL++++ +E+IA+ LS++RNI YLP Q L
Sbjct: 208 KAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVL 267
Query: 819 INLP 830
+ LP
Sbjct: 268 LQLP 271
>sp|P35232|PHB_HUMAN Prohibitin
Length = 272
Score = 300 bits (769), Expect = 3e-81
Identities = 150/244 (61%), Positives = 190/244 (77%)
Frame = +3
Query: 99 YTVPGGHRAVIFDRISGVRQEVVGEGTHFLIPWIQRPIIYDIRTRPRNIPVNTGSKDLQK 278
Y V GHRAVIFDR GV+ VVGEGTHFLIPW+Q+PII+D R+RPRN+PV TGSKDLQ
Sbjct: 28 YNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQN 87
Query: 279 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 458
VNITLRIL++PVA LP+I+T++G D++ERVLPSIT E+LK+VVA+FDA +LITQRELVS
Sbjct: 88 VNITLRILFRPVASQLPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVS 147
Query: 459 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 638
++V++ LT RA FGL LDD+SLTHLTFG EF+ ++VEKAEQ+K
Sbjct: 148 RQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQK 207
Query: 639 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTL 818
AAIISAEGDS+AA L+A S G+G IEL++++ +E+IA+ LS++RNI YLP Q L
Sbjct: 208 KAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVL 267
Query: 819 INLP 830
+ LP
Sbjct: 268 LQLP 271
>sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex protein 1 (Prohibitin-1)
Length = 275
Score = 294 bits (752), Expect = 2e-79
Identities = 147/243 (60%), Positives = 182/243 (74%)
Frame = +3
Query: 99 YTVPGGHRAVIFDRISGVRQEVVGEGTHFLIPWIQRPIIYDIRTRPRNIPVNTGSKDLQK 278
Y V GG RAVIFDR SGV+ EVVGEGTHFLIPW+Q+PII+DIR+ PR + TGSKDLQ
Sbjct: 31 YNVDGGQRAVIFDRFSGVKNEVVGEGTHFLIPWVQKPIIFDIRSTPRAVTTITGSKDLQN 90
Query: 279 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 458
VNITLRIL++P + LP IY N+GLD+ ERVLPSIT EVLK VVAQFDA ++ITQRE+VS
Sbjct: 91 VNITLRILHRPSPDRLPNIYLNIGLDYAERVLPSITNEVLKAVVAQFDAHEMITQREVVS 150
Query: 459 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 638
Q+ + L RA FGL LDDI++THL FG EF+ YLVEKAEQ K
Sbjct: 151 QRASVALRERAAQFGLLLDDIAITHLNFGREFTEAVEMKQVAQQEAEKARYLVEKAEQMK 210
Query: 639 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTL 818
+AA+ +AEGD+QAA LLAK+F G+G +EL++I+ +EEIA ++KN+N+ YLP Q TL
Sbjct: 211 IAAVTTAEGDAQAAKLLAKAFASAGDGLVELRKIEAAEEIAERMAKNKNVTYLPGNQQTL 270
Query: 819 INL 827
+NL
Sbjct: 271 LNL 273
>sp|P40961|PHB_YEAST Prohibitin
Length = 287
Score = 270 bits (690), Expect = 4e-72
Identities = 125/236 (52%), Positives = 183/236 (77%)
Frame = +3
Query: 99 YTVPGGHRAVIFDRISGVRQEVVGEGTHFLIPWIQRPIIYDIRTRPRNIPVNTGSKDLQK 278
Y V GG R VIFDRI+GV+Q+VVGEGTHFL+PW+Q+ IIYD+RT+P++I NTG+KDLQ
Sbjct: 30 YDVKGGSRGVIFDRINGVKQQVVGEGTHFLVPWLQKAIIYDVRTKPKSIATNTGTKDLQM 89
Query: 279 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 458
V++TLR+L++P LP IY NLGLD++ERVLPSI EVLK++VAQFDA++LITQRE++S
Sbjct: 90 VSLTLRVLHRPEVLQLPAIYQNLGLDYDERVLPSIGNEVLKSIVAQFDAAELITQREIIS 149
Query: 459 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 638
QK+ + L+TRA+ FG+ L+D+S+TH+TFG EF+ +LVEKAEQE+
Sbjct: 150 QKIRKELSTRANEFGIKLEDVSITHMTFGPEFTKAVEQKQIAQQDAERAKFLVEKAEQER 209
Query: 639 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDK 806
A++I AEG++++A ++K+ + G+G + ++R++ S++IA L+ + N+VYLP +
Sbjct: 210 QASVIRAEGEAESAEFISKALAKVGDGLLLIRRLEASKDIAQTLANSSNVVYLPSQ 265
>sp|O35129|PHB2_MOUSE Prohibitin-2 (B-cell receptor-associated protein BAP37) (Repressor
of estrogen receptor activity)
sp|Q99623|PHB2_HUMAN Prohibitin-2 (B-cell receptor-associated protein BAP37) (Repressor
of estrogen receptor activity) (D-prohibitin)
Length = 299
Score = 221 bits (562), Expect = 3e-57
Identities = 114/234 (48%), Positives = 163/234 (69%), Gaps = 1/234 (0%)
Frame = +3
Query: 99 YTVPGGHRAVIFDRISGVRQE-VVGEGTHFLIPWIQRPIIYDIRTRPRNIPVNTGSKDLQ 275
+TV GGHRA+ F+RI GV+Q+ ++ EG HF IPW Q PIIYDIR RPR I TGSKDLQ
Sbjct: 41 FTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQ 100
Query: 276 KVNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELV 455
VNI+LR+L +P A+ LP +Y LGLD+EERVLPSI EVLK+VVA+F+AS LITQR V
Sbjct: 101 MVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQV 160
Query: 456 SQKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQE 635
S + LT RA +F L LDD+++T L+F E++ +LVEKA+QE
Sbjct: 161 SLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQE 220
Query: 636 KLAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYL 797
+ I+ AEG+++AA +L ++ ++ G+I+L++I+ ++ I+ ++ ++N +YL
Sbjct: 221 QRQKIVQAEGEAEAAKMLGEALSK-NPGYIKLRKIRAAQNISKTIATSQNRIYL 273
>sp|Q5XIH7|PHB2_RAT Prohibitin-2 (B-cell receptor-associated protein BAP37) (BAP-37)
Length = 299
Score = 221 bits (562), Expect = 3e-57
Identities = 114/234 (48%), Positives = 163/234 (69%), Gaps = 1/234 (0%)
Frame = +3
Query: 99 YTVPGGHRAVIFDRISGVRQE-VVGEGTHFLIPWIQRPIIYDIRTRPRNIPVNTGSKDLQ 275
+TV GGHRA+ F+RI GV+Q+ ++ EG HF IPW Q PIIYDIR RPR I TGSKDLQ
Sbjct: 41 FTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQ 100
Query: 276 KVNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELV 455
VNI+LR+L +P A+ LP +Y LGLD+EERVLPSI EVLK+VVA+F+AS LITQR V
Sbjct: 101 MVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQV 160
Query: 456 SQKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQE 635
S + LT RA +F L LDD+++T L+F E++ +LVEKA+QE
Sbjct: 161 SLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQE 220
Query: 636 KLAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYL 797
+ I+ AEG+++AA +L ++ ++ G+I+L++I+ ++ I+ ++ ++N +YL
Sbjct: 221 QRQKIVQAEGEAEAAKMLGEALSK-NPGYIKLRKIRAAQNISKTIATSQNRIYL 273
>sp|P50085|PHB2_YEAST Prohibitin-2
Length = 315
Score = 219 bits (558), Expect = 8e-57
Identities = 109/242 (45%), Positives = 158/242 (65%)
Frame = +3
Query: 99 YTVPGGHRAVIFDRISGVRQEVVGEGTHFLIPWIQRPIIYDIRTRPRNIPVNTGSKDLQK 278
+ V GGHRA+++ RI GV + EGTHF+ PW+ PIIYD+R +PRN+ TG+KDLQ
Sbjct: 59 FNVDGGHRAIVYSRIHGVSSRIFNEGTHFIFPWLDTPIIYDVRAKPRNVASLTGTKDLQM 118
Query: 279 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 458
VNIT R+L +P LP IY LG D++ERVLPSI EVLK VVAQF+AS LITQRE VS
Sbjct: 119 VNITCRVLSRPDVVQLPTIYRTLGQDYDERVLPSIVNEVLKAVVAQFNASQLITQREKVS 178
Query: 459 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 638
+ + E L RA F + LDD+S+T++TF EF+ ++V+KA QEK
Sbjct: 179 RLIRENLVRRASKFNILLDDVSITYMTFSPEFTNAVEAKQIAQQDAQRAAFVVDKARQEK 238
Query: 639 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTL 818
++ A+G++++A L+ ++ + ++EL+R+ T+ +IA +L+ + N V L D + L
Sbjct: 239 QGMVVRAQGEAKSAELIGEAIKK-SRDYVELKRLDTARDIAKILASSPNRVIL-DNEALL 296
Query: 819 IN 824
+N
Sbjct: 297 LN 298
>sp|P50093|PHB2_CAEEL Mitochondrial prohibitin complex protein 2 (Prohibitin-2)
Length = 286
Score = 206 bits (523), Expect = 9e-53
Identities = 112/243 (46%), Positives = 158/243 (65%)
Frame = +3
Query: 99 YTVPGGHRAVIFDRISGVRQEVVGEGTHFLIPWIQRPIIYDIRTRPRNIPVNTGSKDLQK 278
+TV GHRA++F+RI G+ ++ EG HF IPW Q PIIYDIR RP I TGSKDLQ
Sbjct: 33 FTVEAGHRAIMFNRIGGLSTDLYKEGLHFRIPWFQYPIIYDIRARPNQIRSPTGSKDLQM 92
Query: 279 VNITLRILYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVS 458
VNI LR+L +P E L IY LG ++EERVLPSI EVLK VVA+F+AS LITQR+ VS
Sbjct: 93 VNIGLRVLSRPNPEHLVHIYRTLGQNWEERVLPSICNEVLKGVVAKFNASQLITQRQQVS 152
Query: 459 QKVNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEK 638
V + L RA +F + LDD+SLT L F ++S + VE+A+Q+K
Sbjct: 153 MLVRKTLIERALDFNIILDDVSLTELAFSPQYSAAVEAKQVAAQEAQRATFYVERAKQQK 212
Query: 639 LAAIISAEGDSQAALLLAKSFNQCGEGFIELQRIQTSEEIAHLLSKNRNIVYLPDKQGTL 818
I+ AEG++++A LL ++ GF++L++I+ +++IA ++S++ N YLP G +
Sbjct: 213 QEKIVQAEGEAESAKLLGEAMKN-DPGFLKLRKIRAAQKIARIVSESGNKTYLP-TGGLM 270
Query: 819 INL 827
+N+
Sbjct: 271 LNI 273
>sp|O28852|Y1420_ARCFU Hypothetical protein AF1420
Length = 249
Score = 56.6 bits (135), Expect = 9e-08
Identities = 49/221 (22%), Positives = 105/221 (47%), Gaps = 7/221 (3%)
Frame = +3
Query: 120 RAVIF--DRISGVRQEVVGEGTHFLIPWIQRPIIYDIRTRPRNIPVNTGSKDLQKVNITL 293
R VIF R+ G R G G F+IP ++ ++ D+RT ++P + + K N+T+
Sbjct: 28 RGVIFRLGRLVGAR----GPGLFFIIPILENMVVVDLRTVTYDVP---SQEVVTKDNVTV 80
Query: 294 RI---LYKPVAEMLPKIYTNLGLDFEERVLPSITYEVLKTVVAQFDASDLITQRELVSQK 464
++ +Y V + + + L T L++++ Q + +++++R+ ++ K
Sbjct: 81 KVNAVVYYRVVDPAKAVTEVFDYQYATAQLAQTT---LRSIIGQAELDEVLSERDKLNVK 137
Query: 465 VNEMLTTRADNFGLTLDDISLTHLTFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLA 644
+ +++ + +G+ + + + + E + +AE+E+ +
Sbjct: 138 LQQIIDEETNPWGIKVTAVEIKDVELPEEMRRIMA--------------MQAEAERERRS 183
Query: 645 AIISAEGDSQAALLLAKSFNQC--GEGFIELQRIQTSEEIA 761
II AEG+ QAA+ L ++ + EG I L+ +QT EI+
Sbjct: 184 KIIRAEGEYQAAMKLREAADVLAQSEGAILLRYLQTLNEIS 224
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,356,106
Number of Sequences: 369166
Number of extensions: 1759127
Number of successful extensions: 4345
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4221
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4325
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8646143400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)