Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_D08
(741 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 302 5e-82
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 301 9e-82
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 298 8e-81
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 297 2e-80
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 296 4e-80
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 295 7e-80
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 295 9e-80
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 295 9e-80
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 290 2e-78
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 288 8e-78
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 302 bits (774), Expect = 5e-82
Identities = 152/217 (70%), Positives = 166/217 (76%), Gaps = 2/217 (0%)
Frame = +2
Query: 56 PKSVDWRKKGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQ 235
PKSVDW KKGYVTPVKNQGQCGSCW+FS TGALEGQ FRK +LVSLSEQ LVD S+
Sbjct: 2 PKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQG 61
Query: 236 NNGCNGGLMDNAFQYIQKY-GLESEADYPYTAMDGPCKYDSTKVVAHCTGFVDIKKGNEK 412
N GCNGGLMDNAFQYI++ GL+SE YPY A D C Y A TGFVDI + EK
Sbjct: 62 NQGCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFVDIPQ-REK 120
Query: 413 DLTKAVATVGPISVAIDASRPSFQLYKGGIYNEVNCSSNNLDHGVLAVGYGAEGKNH-FW 589
L KAVATVGPISVAIDA SFQ YK GIY + +CSS +LDHGVL VGYG EG N+ FW
Sbjct: 121 ALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKFW 180
Query: 590 IVKNSWGPTWGISGYIKMSKDKKNQCGIATMASYPTV 700
IVKNSWGP WG GY+KM+KD+ N CGIAT ASYPTV
Sbjct: 181 IVKNSWGPEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 301 bits (772), Expect = 9e-82
Identities = 150/231 (64%), Positives = 170/231 (73%), Gaps = 5/231 (2%)
Frame = +2
Query: 23 IFMPPENMDNYPKSVDWRKKGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSE 202
+F P +D PKSVDWRKKGYVTPVKNQ QCGSCW+FS TGALEGQ FRK +LVSLSE
Sbjct: 105 VFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSE 163
Query: 203 QQLVDCSKDYQNNGCNGGLMDNAFQYIQKY-GLESEADYPYTAMDGPCKYDSTKVVAHCT 379
Q LVDCS+ N GCNGG M AFQY+++ GL+SE YPY A+D CKY VA+ T
Sbjct: 164 QNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDT 223
Query: 380 GFVDIKKGNEKDLTKAVATVGPISVAIDASRPSFQLYKGGIYNEVNCSSNNLDHGVLAVG 559
GF + G EK L KAVATVGPISVA+DA SFQ YK GIY E +CSS NLDHGVL VG
Sbjct: 224 GFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVG 283
Query: 560 YGAEGKN----HFWIVKNSWGPTWGISGYIKMSKDKKNQCGIATMASYPTV 700
YG EG N +W+VKNSWGP WG +GY+K++KDK N CGIAT ASYP V
Sbjct: 284 YGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 298 bits (764), Expect = 8e-81
Identities = 152/221 (68%), Positives = 166/221 (75%), Gaps = 6/221 (2%)
Frame = +2
Query: 56 PKSVDWRKKGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQ 235
PKSVDW KKGYVTPVKNQGQCGSCW+FS TGALEGQ FRK +LVSLSEQ LVDCS+
Sbjct: 115 PKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQG 174
Query: 236 NNGCNGGLMDNAFQYIQ-KYGLESEADYPYTAMD-GPCKYDSTKVVAHCTGFVDIKKGNE 409
N GCNGGLMDNAFQYI+ GL+SE YPY A D C Y A+ TGFVDI + E
Sbjct: 175 NQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDIPQ-RE 233
Query: 410 KDLTKAVATVGPISVAIDASRPSFQLYKGGIYNEVNCSSNNLDHGVLAVGYGAEG----K 577
K L KAVATVGPISVAIDA SFQ YK GIY + +CS +LDHGVL VGYG EG
Sbjct: 234 KALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSNN 293
Query: 578 NHFWIVKNSWGPTWGISGYIKMSKDKKNQCGIATMASYPTV 700
N FWIVKNSWGP WG +GY+KM+KD+ N CGIAT ASYPTV
Sbjct: 294 NKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 297 bits (761), Expect = 2e-80
Identities = 148/220 (67%), Positives = 167/220 (75%), Gaps = 5/220 (2%)
Frame = +2
Query: 56 PKSVDWRKKGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQ 235
PKSVDWR+KG VTPVKNQGQCGSCW+FS +G LEGQ F K +L+SLSEQ LVDCS
Sbjct: 115 PKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQG 174
Query: 236 NNGCNGGLMDNAFQYIQKY-GLESEADYPYTAMDGPCKYDSTKVVAHCTGFVDIKKGNEK 412
N GCNGGLMD AFQYI++ GL+SE YPY A DG CKY + VA+ TGFVDI + EK
Sbjct: 175 NQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEK 233
Query: 413 DLTKAVATVGPISVAIDASRPSFQLYKGGIYNEVNCSSNNLDHGVLAVGYGAEG----KN 580
L KAVATVGPISVA+DAS PS Q Y GIY E NCSS NLDHGVL VGYG EG KN
Sbjct: 234 ALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKN 293
Query: 581 HFWIVKNSWGPTWGISGYIKMSKDKKNQCGIATMASYPTV 700
+W+VKNSWG WG+ GYIK++KD+ N CG+AT ASYP V
Sbjct: 294 KYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 296 bits (758), Expect = 4e-80
Identities = 146/220 (66%), Positives = 168/220 (76%), Gaps = 5/220 (2%)
Frame = +2
Query: 56 PKSVDWRKKGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQ 235
PK+VDWR+KG VTPVKNQGQCGSCW+FS +G LEGQ F K +L+SLSEQ LVDCS D
Sbjct: 115 PKTVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQG 174
Query: 236 NNGCNGGLMDNAFQYIQKY-GLESEADYPYTAMDGPCKYDSTKVVAHCTGFVDIKKGNEK 412
N GCNGGLMD AFQYI++ GL+SE YPY A DG CKY + VA+ TGFVDI + EK
Sbjct: 175 NQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQ-QEK 233
Query: 413 DLTKAVATVGPISVAIDASRPSFQLYKGGIYNEVNCSSNNLDHGVLAVGYGAEG----KN 580
L KAVATVGPISVA+DAS PS Q Y GIY E NCSS +LDHGVL VGYG EG K+
Sbjct: 234 ALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYGYEGTDSNKD 293
Query: 581 HFWIVKNSWGPTWGISGYIKMSKDKKNQCGIATMASYPTV 700
+W+VKNSWG WG+ GYIK++KD+ N CG+AT ASYP V
Sbjct: 294 KYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIV 333
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 295 bits (756), Expect = 7e-80
Identities = 141/227 (62%), Positives = 172/227 (75%), Gaps = 2/227 (0%)
Frame = +2
Query: 26 FMPPENMDNYPKSVDWRKKGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQ 205
++PP ++ PKSVDWR+ G VT VK+QG CGSCW+FS+TGALEGQHFRK LVSLSEQ
Sbjct: 114 YIPPAHV-TVPKSVDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQ 172
Query: 206 QLVDCSKDYQNNGCNGGLMDNAFQYIQ-KYGLESEADYPYTAMDGPCKYDSTKVVAHCTG 382
LVDCS Y NNGCNGGLMDNAF+YI+ G+++E YPY +D C ++ + A TG
Sbjct: 173 NLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTG 232
Query: 383 FVDIKKGNEKDLTKAVATVGPISVAIDASRPSFQLYKGGIYNEVNCSSNNLDHGVLAVGY 562
FVDI +G+E+ + KAVAT+GP+SVAIDAS SFQLY G+YNE C NLDHGVL VGY
Sbjct: 233 FVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGY 292
Query: 563 GA-EGKNHFWIVKNSWGPTWGISGYIKMSKDKKNQCGIATMASYPTV 700
G E +W+VKNSWG TWG GYIKM++++ NQCGIAT +SYPTV
Sbjct: 293 GTDESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYPTV 339
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 295 bits (755), Expect = 9e-80
Identities = 146/220 (66%), Positives = 167/220 (75%), Gaps = 5/220 (2%)
Frame = +2
Query: 56 PKSVDWRKKGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQ 235
P+SVDWR+KGYVTPVKNQGQCGSCW+FS TGALEGQ FRK +L+SLSEQ LVDCS
Sbjct: 115 PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQG 174
Query: 236 NNGCNGGLMDNAFQYIQ-KYGLESEADYPYTAMDGPCKYDSTKVVAHCTGFVDIKKGNEK 412
N GCNGGLMD AFQY+Q GL+SE YPY A + CKY+ VA+ TGFVDI K EK
Sbjct: 175 NEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEK 233
Query: 413 DLTKAVATVGPISVAIDASRPSFQLYKGGIYNEVNCSSNNLDHGVLAVGYGAEG----KN 580
L KAVATVGPISVAIDA SF YK GIY E +CSS ++DHGVL VGYG E N
Sbjct: 234 ALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNN 293
Query: 581 HFWIVKNSWGPTWGISGYIKMSKDKKNQCGIATMASYPTV 700
+W+VKNSWG WG+ GY+KM+KD++N CGIA+ ASYPTV
Sbjct: 294 KYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 295 bits (755), Expect = 9e-80
Identities = 148/220 (67%), Positives = 167/220 (75%), Gaps = 5/220 (2%)
Frame = +2
Query: 56 PKSVDWRKKGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQ 235
PKSVDWR+KGYVTPVKNQGQCGSCW+FS TGALEGQ FRK +LVSLSEQ LVDCS+
Sbjct: 115 PKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQG 174
Query: 236 NNGCNGGLMDNAFQYIQ-KYGLESEADYPYTAMD-GPCKYDSTKVVAHCTGFVDIKKGNE 409
N GCNGGLMDNAF+Y++ GL+SE YPY D C Y A+ TGFVD+ + E
Sbjct: 175 NEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQ-RE 233
Query: 410 KDLTKAVATVGPISVAIDASRPSFQLYKGGIYNEVNCSSNNLDHGVLAVGYGAEG---KN 580
K L KAVAT+GPISVAIDA SFQ YK GIY + +CSS +LDHGVL VGYG EG N
Sbjct: 234 KALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSNN 293
Query: 581 HFWIVKNSWGPTWGISGYIKMSKDKKNQCGIATMASYPTV 700
FWIVKNSWGP WG +GY+KM+KD+ N CGIAT ASYPTV
Sbjct: 294 KFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 290 bits (743), Expect = 2e-78
Identities = 146/221 (66%), Positives = 166/221 (75%), Gaps = 6/221 (2%)
Frame = +2
Query: 56 PKSVDWRKKGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQ 235
PKSVDWR+KGYVT VKNQGQCGSCW+FS TGALEGQ FRK +LVSLSEQ LVDCS+
Sbjct: 115 PKSVDWREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQG 174
Query: 236 NNGCNGGLMDNAFQYIQ-KYGLESEADYPYTAMD-GPCKYDSTKVVAHCTGFVDIKKGNE 409
N GCNGGLMDNAFQY++ GL++E YPY + C Y A+ TGFVDI + E
Sbjct: 175 NQGCNGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDIPQ-RE 233
Query: 410 KDLTKAVATVGPISVAIDASRPSFQLYKGGIYNEVNCSSNNLDHGVLAVGYGAEG----K 577
K L KAVATVGPISVAIDA SFQ YK GIY + +CSS +LDHGVL VGYG EG
Sbjct: 234 KALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNS 293
Query: 578 NHFWIVKNSWGPTWGISGYIKMSKDKKNQCGIATMASYPTV 700
+ FWIVKNSWGP WG +GY+KM+KD+ N CGI+T ASYPTV
Sbjct: 294 SKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGISTAASYPTV 334
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 288 bits (738), Expect = 8e-78
Identities = 139/235 (59%), Positives = 172/235 (73%), Gaps = 2/235 (0%)
Frame = +2
Query: 2 NRNYSRTIFMPPENMDNYPKSVDWRKKGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRK 181
+ ++ F+ P ++ PKSVDWR KG VT VK+QG CGSCW+FS+TGALEGQHFRK
Sbjct: 108 DESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSG 166
Query: 182 QLVSLSEQQLVDCSKDYQNNGCNGGLMDNAFQYIQ-KYGLESEADYPYTAMDGPCKYDST 358
LVSLSEQ LVDCS Y NNGCNGGLMDNAF+YI+ G+++E YPY A+D C ++
Sbjct: 167 VLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKG 226
Query: 359 KVVAHCTGFVDIKKGNEKDLTKAVATVGPISVAIDASRPSFQLYKGGIYNEVNCSSNNLD 538
V A GF DI +G+EK + +AVATVGP+SVAIDAS SFQ Y G+YNE C + NLD
Sbjct: 227 TVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLD 286
Query: 539 HGVLAVGYGA-EGKNHFWIVKNSWGPTWGISGYIKMSKDKKNQCGIATMASYPTV 700
HGVL VG+G E +W+VKNSWG TWG G+IKM ++K+NQCGIA+ +SYP V
Sbjct: 287 HGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,297,711
Number of Sequences: 369166
Number of extensions: 1816395
Number of successful extensions: 5569
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4836
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5012
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6679696800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)