Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_C14
(924 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P79287|MMP20_PIG Matrix metalloproteinase-20 precursor (... 118 2e-26
sp|O18767|MMP20_BOVIN Matrix metalloproteinase-20 precursor... 118 3e-26
sp|O60882|MMP20_HUMAN Matrix metalloproteinase-20 precursor... 117 3e-26
sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor... 114 3e-25
sp|P57748|MMP20_MOUSE Matrix metalloproteinase-20 precursor... 112 1e-24
sp|O77656|MMP13_BOVIN Collagenase 3 precursor (Matrix metal... 111 3e-24
sp|O62806|MMP13_RABIT Collagenase 3 precursor (Matrix metal... 110 6e-24
sp|P33435|MMP13_MOUSE Collagenase 3 precursor (Matrix metal... 110 7e-24
sp|O18927|MMP13_HORSE Collagenase 3 precursor (Matrix metal... 109 1e-23
sp|P45452|MMP13_HUMAN Collagenase 3 precursor (Matrix metal... 107 5e-23
>sp|P79287|MMP20_PIG Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 483
Score = 118 bits (296), Expect = 2e-26
Identities = 93/285 (32%), Positives = 133/285 (46%), Gaps = 7/285 (2%)
Frame = +2
Query: 11 KWDKGT-TYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLS 187
KW K T TYR ++ +MT E+ +A+ + L WS+A + F +V+ + + +S
Sbjct: 116 KWKKNTLTYRI----SKYTPSMTPAEVDKAMEMALQAWSSAVPLSFVRVNAGEADIM-IS 170
Query: 188 FADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKED 358
F +H D YP D P G LAHAF P G + HFD+AE+WT G +
Sbjct: 171 FETGDH------------GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGM-N 216
Query: 359 GINLRLVAAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYG---T 529
G NL VAAHE GHA+GL HS DP+ALM P Y Y + F LP DD +G +YG T
Sbjct: 217 GFNLFTVAAHEFGHALGLAHSTDPSALMYPTY-KYQNPYGFHLPKDDVKGIQALYGPRKT 275
Query: 530 KNGKVFVRSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRV 709
GK V S ++C+ ++ A + D+ R +H + R
Sbjct: 276 FTGKPTVPHGPPHNPSL--PDICDSSSSFDAVTMLGKELLFFRDRIFWRRQVHLMSGIR- 332
Query: 710 DASFKTLQLPNQLFDSDALFYDYSGRRFVFFKGNRVFSANGVKLE 844
S T P + + DA + FFKG + G +++
Sbjct: 333 -PSTITSSFPQLMSNVDAAYEVADRGMAYFFKGPHYWITRGFQMQ 376
>sp|O18767|MMP20_BOVIN Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 481
Score = 118 bits (295), Expect = 3e-26
Identities = 92/285 (32%), Positives = 133/285 (46%), Gaps = 7/285 (2%)
Frame = +2
Query: 11 KWDKGT-TYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLS 187
KW K T TYR ++ +MT E+ RA+ + L WS+A + F +++ + + +S
Sbjct: 114 KWKKNTLTYRI----SKYTPSMTPAEVDRAMEMALRAWSSAVPLNFVRINAGEADIM-IS 168
Query: 188 FADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKED 358
F +H D YP D P G LAHAF P G + HFD+AE+WT G +
Sbjct: 169 FETGDH------------GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-N 214
Query: 359 GINLRLVAAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTK-- 532
G NL VAAHE GHA+GL HS DP+ALM P Y Y + F+LP DD +G +YG +
Sbjct: 215 GFNLFTVAAHEFGHALGLAHSTDPSALMFPTY-KYQNPYGFRLPKDDVKGIQALYGPRRA 273
Query: 533 -NGKVFVRSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRV 709
+GK S +LC+ A + + D+ R +H + R
Sbjct: 274 FSGKPTAPHGPPHNPSI--PDLCDSNLSFDAVTMLGKELLLFRDRIFWRRQVHLMSGIR- 330
Query: 710 DASFKTLQLPNQLFDSDALFYDYSGRRFVFFKGNRVFSANGVKLE 844
S T P + + DA + FFKG + G +++
Sbjct: 331 -PSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQMQ 374
>sp|O60882|MMP20_HUMAN Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 483
Score = 117 bits (294), Expect = 3e-26
Identities = 90/285 (31%), Positives = 136/285 (47%), Gaps = 7/285 (2%)
Frame = +2
Query: 11 KWDKGT-TYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLS 187
KW K T TYR ++ +M+ E+ +A+ + L WS+A + F ++++ + + +S
Sbjct: 116 KWKKNTLTYRI----SKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIM-IS 170
Query: 188 FADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKED 358
F + +H D YP D P G LAHAF P G + HFD+AE+WT G +
Sbjct: 171 FENGDH------------GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-N 216
Query: 359 GINLRLVAAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNG 538
G NL VAAHE GHA+GL HS DP+ALM P Y Y + F LP DD +G +YG +
Sbjct: 217 GFNLFTVAAHEFGHALGLAHSTDPSALMYPTY-KYKNPYGFHLPKDDVKGIQALYGPR-- 273
Query: 539 KVFVRS---NKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRV 709
KVF+ + +LC+ ++ A + + D+ R +H R
Sbjct: 274 KVFLGKPTLPHAPHHKPSIPDLCDSSSSFDAVTMLGKELLLFKDRIFWRRQVHLRTGIR- 332
Query: 710 DASFKTLQLPNQLFDSDALFYDYSGRRFVFFKGNRVFSANGVKLE 844
S T P + + DA + FFKG + G +++
Sbjct: 333 -PSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQMQ 376
>sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor (MMP-19) (Matrix
metalloproteinase RASI)
Length = 527
Score = 114 bits (286), Expect = 3e-25
Identities = 88/282 (31%), Positives = 127/282 (45%), Gaps = 15/282 (5%)
Frame = +2
Query: 20 KGTTYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADA 199
K T+R + P+T++L ++ AL YWS+ + F +V + LSF
Sbjct: 108 KNLTFRIF----NVPSTLSLPRVRAALHQAFKYWSSVAPLTFREVKAGWADI-RLSFHGR 162
Query: 200 EHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNGNLHFDSAEEWTEGKEDGINLRLV 379
+ + N F + PG VLAHA P G++HFD E WTEG G+NLR++
Sbjct: 163 QSLYCS--NTF----------DGPGKVLAHADIPELGSIHFDKDELWTEGTYQGVNLRII 210
Query: 380 AAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKN-------- 535
AAHE+GHA+GL HS ALMAP Y GY + FKL DD G +YG ++
Sbjct: 211 AAHEVGHALGLGHSRYTQALMAPVYAGY--QPFFKLHPDDVAGIQALYGKRSPETRDEEE 268
Query: 536 -------GKVFVRSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSN 694
V + + E + + + + D ++ VTD
Sbjct: 269 ETEMLTVSPVTAKPGPMPNPCSGEVDAMVLGPRGKTYAFKGDYVWTVTDSG-------PG 321
Query: 695 NSFRVDASFKTLQLPNQLFDSDALFYDYSGRRFVFFKGNRVF 820
F++ A ++ LP L DA Y RR FFKGN+V+
Sbjct: 322 PLFQISALWE--GLPGNL---DAAVYSPRTRRTHFFKGNKVW 358
>sp|P57748|MMP20_MOUSE Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 482
Score = 112 bits (280), Expect = 1e-24
Identities = 90/285 (31%), Positives = 132/285 (46%), Gaps = 7/285 (2%)
Frame = +2
Query: 11 KWDKGT-TYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLS 187
KW K TYR ++ +M+ E+ +A+ + L WSTA + F ++++ + + +S
Sbjct: 115 KWKKNILTYRI----SKYTPSMSPTEVDKAIQMALHAWSTAVPLNFVRINSGEADIM-IS 169
Query: 188 FADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKED 358
F +H D YP D P G LAHAF P G + HFD+AE+WT G +
Sbjct: 170 FETGDH------------GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-N 215
Query: 359 GINLRLVAAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKN- 535
G NL VAAHE GHA+GL HS DP+ALM P Y Y + F LP DD +G +YG +
Sbjct: 216 GFNLFTVAAHEFGHALGLGHSTDPSALMYPTY-KYQNPYRFHLPKDDVKGIQALYGPRKI 274
Query: 536 --GKVFVRSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRV 709
GK + + S +LC+ ++ A + D+ R +H R
Sbjct: 275 FPGKPTMPHIPPHKPSI--PDLCDSSSSFDAVTMLGKELLFFKDRIFWRRQVHLPTGIR- 331
Query: 710 DASFKTLQLPNQLFDSDALFYDYSGRRFVFFKGNRVFSANGVKLE 844
S T P + + DA + FFKG + G ++
Sbjct: 332 -PSTITSSFPQLMSNVDAAYEVAERGIAFFFKGPHYWVTRGFHMQ 375
>sp|O77656|MMP13_BOVIN Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 471
Score = 111 bits (277), Expect = 3e-24
Identities = 87/290 (30%), Positives = 125/290 (43%), Gaps = 10/290 (3%)
Frame = +2
Query: 11 KWDK-GTTYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLS 187
KW K TYR + +T E+++A WS + F ++ N + +S
Sbjct: 112 KWSKMNLTYRIV----NYTPDLTHSEVEKAFRKAFKVWSDVTPLNFTRIHNGTADIM-IS 166
Query: 188 FADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKED 358
F EH + YP D P G+LAHAF P G+ HFD E WT +
Sbjct: 167 FGTKEHGDF------------YPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK- 212
Query: 359 GINLRLVAAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNG 538
G NL LVAAHE GH++GL HS DP ALM P Y Y ++ F LPDDD QG +YG +
Sbjct: 213 GYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY-TYTGKSHFMLPDDDVQGIQSLYGPGDE 271
Query: 539 KVFVRSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSF----- 703
+ + K ++ L IT++ D + +V + SF
Sbjct: 272 DPYSKHPKTPDKCDPSLSLDAITSLRGETLIFKDRFFWRLHPQQVEAELFLTKSFGPELP 331
Query: 704 -RVDASFKTLQLPNQLFDSDALFYDYSGRRFVFFKGNRVFSANGVKLENL 850
R+DA+++ S L + + GR+F G + K+ L
Sbjct: 332 NRIDAAYE--------HPSHDLIFIFRGRKFWALSGYDILEDYPKKISEL 373
>sp|O62806|MMP13_RABIT Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 471
Score = 110 bits (275), Expect = 6e-24
Identities = 87/279 (31%), Positives = 126/279 (45%), Gaps = 5/279 (1%)
Frame = +2
Query: 11 KWDK-GTTYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLS 187
KW + TYR + +T E+++A WS + F ++ N + +S
Sbjct: 112 KWSQTNLTYRIV----NYTPDLTHSEVEKAFKKAFKVWSDVTPLNFTRIHNGTADIM-IS 166
Query: 188 FADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKED 358
F EH + YP D P G+LAHAF P G+ HFD E WT +
Sbjct: 167 FGTKEHGDF------------YPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK- 212
Query: 359 GINLRLVAAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNG 538
G NL LVAAHE GH++GL HS DP ALM P Y Y ++ F LPDDD QG +YG +
Sbjct: 213 GYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY-TYTGKSHFMLPDDDVQGIQSLYGPGDE 271
Query: 539 KVFVRSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDAS 718
+ K ++ L IT++ D + +V + SF
Sbjct: 272 DPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSF----- 326
Query: 719 FKTLQLPNQLFDSDALFYDYSGRRFVF-FKGNRVFSANG 832
+LPN++ DA Y++ R +F F+G + ++ NG
Sbjct: 327 --WPELPNRI---DAA-YEHPARDLIFIFRGKKFWAPNG 359
>sp|P33435|MMP13_MOUSE Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 472
Score = 110 bits (274), Expect = 7e-24
Identities = 87/279 (31%), Positives = 127/279 (45%), Gaps = 5/279 (1%)
Frame = +2
Query: 11 KWDK-GTTYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLS 187
KW + TYR + M+ E+++A WS + F ++ + + +S
Sbjct: 113 KWSQTNLTYRIV----NYTPDMSHSEVEKAFRKAFKVWSDVTPLNFTRIYDGTADIM-IS 167
Query: 188 FADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKED 358
F EH + YP D P G+LAHAF P G+ HFD E WT +
Sbjct: 168 FGTKEHGDF------------YPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK- 213
Query: 359 GINLRLVAAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNG 538
G NL +VAAHE+GH++GL HS DP ALM P Y Y ++ F LPDDD QG F+YG +
Sbjct: 214 GYNLFIVAAHELGHSLGLDHSKDPGALMFPIY-TYTGKSHFMLPDDDVQGIQFLYGPGDE 272
Query: 539 KVFVRSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDAS 718
+ K E+ L IT++ D + +V + SF
Sbjct: 273 DPNPKHPKTPEKCDPALSLDAITSLRGETMIFKDRFFWRLHPQQVEAELFLTKSF----- 327
Query: 719 FKTLQLPNQLFDSDALFYDYSGRRFVF-FKGNRVFSANG 832
+LPN + DA Y++ R +F F+G + ++ NG
Sbjct: 328 --WPELPNHV---DAA-YEHPSRDLMFIFRGRKFWALNG 360
>sp|O18927|MMP13_HORSE Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 472
Score = 109 bits (273), Expect = 1e-23
Identities = 87/279 (31%), Positives = 126/279 (45%), Gaps = 5/279 (1%)
Frame = +2
Query: 11 KWDK-GTTYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLS 187
KW K TYR + +T E+++A WS + F ++ N + +S
Sbjct: 113 KWPKMNLTYRIV----NYTPDLTHSEVEKAFKKAFKVWSDVTPLNFTRLYNGTADIM-IS 167
Query: 188 FADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKED 358
F EH + YP D P G+LAHAF P G+ HFD E WT +
Sbjct: 168 FGTKEHGDF------------YPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK- 213
Query: 359 GINLRLVAAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNG 538
G NL LVAAHE GH++GL HS DP ALM P Y Y ++ F LPDDD QG ++YG +
Sbjct: 214 GYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY-TYTGKSHFVLPDDDVQGIQYLYGPGDE 272
Query: 539 KVFVRSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDAS 718
+ K ++ L IT++ D + V + SF
Sbjct: 273 DPNPKHPKTPDKCDPSLSLDAITSLRGETMVFKDRFFWRLHPQLVDAELFLTKSF----- 327
Query: 719 FKTLQLPNQLFDSDALFYDYSGRRFVF-FKGNRVFSANG 832
+LPN++ DA Y++ + +F F+G + ++ NG
Sbjct: 328 --WPELPNRI---DAA-YEHPSKDLIFIFRGRKFWALNG 360
>sp|P45452|MMP13_HUMAN Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 471
Score = 107 bits (267), Expect = 5e-23
Identities = 86/278 (30%), Positives = 122/278 (43%), Gaps = 4/278 (1%)
Frame = +2
Query: 11 KWDK-GTTYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLS 187
KW K TYR + MT E+++A WS + F ++ + + +S
Sbjct: 112 KWSKMNLTYRIV----NYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIM-IS 166
Query: 188 FADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKED 358
F EH + YP D P G+LAHAF P G+ HFD E WT +
Sbjct: 167 FGIKEHGDF------------YPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK- 212
Query: 359 GINLRLVAAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNG 538
G NL LVAAHE GH++GL HS DP ALM P Y Y ++ F LPDDD QG +YG +
Sbjct: 213 GYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY-TYTGKSHFMLPDDDVQGIQSLYGPGDE 271
Query: 539 KVFVRSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDAS 718
+ K ++ L IT++ D + +V + SF
Sbjct: 272 DPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSF----- 326
Query: 719 FKTLQLPNQLFDSDALFYDYSGRRFVFFKGNRVFSANG 832
+LPN++ DA + S F+G + ++ NG
Sbjct: 327 --WPELPNRI---DAAYEHPSHDLIFIFRGRKFWALNG 359
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 103,903,966
Number of Sequences: 369166
Number of extensions: 2157010
Number of successful extensions: 6495
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6008
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6338
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9462723610
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)