Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_C06
(827 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q5IS35|DNC_MACFA Mitochondrial deoxynucleotide carrier (... 189 6e-48
sp|Q9DAM5|DNC_MOUSE Mitochondrial deoxynucleotide carrier (... 186 9e-47
sp|Q5NVC1|DNC_PONPY Mitochondrial deoxynucleotide carrier (... 184 2e-46
sp|Q9HC21|DNC_HUMAN Mitochondrial deoxynucleotide carrier (... 184 3e-46
sp|P53257|YG2O_YEAST Putative mitochondrial carrier YGR096W 116 9e-26
sp|Q01888|GDC_BOVIN Grave's disease carrier protein (GDC) (... 96 9e-20
sp|P16260|GDC_HUMAN Grave's disease carrier protein (GDC) (... 95 2e-19
sp|P38702|LEU5_YEAST Mitochondrial carrier protein LEU5 92 2e-18
sp|P16261|GDC_RAT Grave'S disease carrier protein (GDC) (Mi... 89 2e-17
sp|P29518|BT1_MAIZE Brittle-1 protein, chloroplast precursor 87 7e-17
>sp|Q5IS35|DNC_MACFA Mitochondrial deoxynucleotide carrier (Solute carrier family 25,
member 19)
Length = 320
Score = 189 bits (481), Expect = 6e-48
Identities = 113/258 (43%), Positives = 155/258 (60%), Gaps = 3/258 (1%)
Frame = +2
Query: 53 QIDYAIAGACGGFVSRAVVQPLDVVKIRFQLQVEPI-QKNTDGKYKGIAQAVRCILKEEG 229
++ A+AG+ G V+RA++ P DV+KIRFQLQ E + +++ + KY GI QA R IL+EEG
Sbjct: 15 KLQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRRDPNAKYHGIFQASRQILQEEG 74
Query: 230 LKAFWKGHISSQIQAVTFSLVQFSSYEFIN--VYLWPYLKISEASVLMSSKTFILGSLAG 403
L AFWKGHI +QI ++ + VQF S+E + V+ E SV F+ G LA
Sbjct: 75 LTAFWKGHIPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSV-----HFVCGGLAA 129
Query: 404 STATIFTQPFDVFRTRFAAQGEPKTYPTLTSAIIMLTKNEGLHGLFRGLVPSLLLIAPQT 583
TAT+ P DV RTRFAAQGEPK Y TL A+ + ++EG ++GL P+L+ I P
Sbjct: 130 CTATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYA 189
Query: 584 GFQFFFYNFSNKILAKIFKKWQKQENYSEIHKIGILQSALSGGIAGSMAKICVYPVDIIK 763
G QF Y+ K KW +E K LQ+ L G AG ++K YP+D+ K
Sbjct: 190 GLQFSCYS-----SLKHLYKWAMP---AEGKKNENLQNLLCGSGAGVISKTLTYPLDLFK 241
Query: 764 KRMQVHGFEVARSKFGKL 817
KR+QV GFE AR+ FG++
Sbjct: 242 KRLQVGGFEHARAAFGQV 259
Score = 87.4 bits (215), Expect = 4e-17
Identities = 60/196 (30%), Positives = 94/196 (47%), Gaps = 12/196 (6%)
Frame = +2
Query: 59 DYAIAGACGGFVS---RAVVQPLDVVKIRFQLQVEPIQKNTDGKYKGIAQAVRCILKEEG 229
++++ CGG + V P+DV++ RF Q EP NT + AV + + EG
Sbjct: 117 EFSVHFVCGGLAACTATLTVHPVDVLRTRFAAQGEPKVYNT------LRHAVGTMYRSEG 170
Query: 230 LKAFWKGHISSQIQAVTFSLVQFSSYEFINVYLWPYLKISEASVLMSSKTFILGSLAGST 409
+ F+KG + I ++ +QFS Y + +L+ + +E + + + GS AG
Sbjct: 171 PQVFYKGLAPTLIAIFPYAGLQFSCYSSLK-HLYKWAMPAEGKKNENLQNLLCGSGAGVI 229
Query: 410 ATIFTQPFDVFRTRF---------AAQGEPKTYPTLTSAIIMLTKNEGLHGLFRGLVPSL 562
+ T P D+F+ R AA G+ + Y L + + EG G F+GL PSL
Sbjct: 230 SKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSL 289
Query: 563 LLIAPQTGFQFFFYNF 610
L A TGF FF+Y F
Sbjct: 290 LKAALSTGFMFFWYEF 305
>sp|Q9DAM5|DNC_MOUSE Mitochondrial deoxynucleotide carrier (Solute carrier family 25
member 19)
Length = 318
Score = 186 bits (471), Expect = 9e-47
Identities = 106/261 (40%), Positives = 157/261 (60%), Gaps = 4/261 (1%)
Frame = +2
Query: 47 HGQIDYAIAGACGGFVSRAVVQPLDVVKIRFQLQVEPI-QKNTDGKYKGIAQAVRCILKE 223
+ +++ A+AG+ GFV+RA++ PLDV+KIRFQLQ+E + + + KY GI QA + IL+E
Sbjct: 13 NSKLEVAVAGSVSGFVTRALISPLDVIKIRFQLQIERLCPSDPNAKYHGIFQAAKQILQE 72
Query: 224 EGLKAFWKGHISSQIQAVTFSLVQFSSYEFINVYLWPYLKISEASVLMS---SKTFILGS 394
EG +AFWKGH+ +QI ++ + VQF ++E + L+ +A++ + S F+ G
Sbjct: 73 EGPRAFWKGHVPAQILSIGYGAVQFLAFEELTELLY------QANLYQTHQFSAHFVCGG 126
Query: 395 LAGSTATIFTQPFDVFRTRFAAQGEPKTYPTLTSAIIMLTKNEGLHGLFRGLVPSLLLIA 574
L+ TAT+ P DV RTR AAQGEPK Y L AI + K EG ++GL P+++ I
Sbjct: 127 LSAGTATLTVHPVDVLRTRLAAQGEPKIYNNLREAIRTMYKTEGPFVFYKGLTPTVIAIF 186
Query: 575 PQTGFQFFFYNFSNKILAKIFKKWQKQENYSEIHKIGILQSALSGGIAGSMAKICVYPVD 754
P G QF Y + + KQ G L++ L G +G ++K YP+D
Sbjct: 187 PYAGLQFSCYRSLKRAYDWLIPPDGKQ--------TGNLKNLLCGCGSGVISKTFTYPLD 238
Query: 755 IIKKRMQVHGFEVARSKFGKL 817
+IKKR+QV GFE ARS FG++
Sbjct: 239 LIKKRLQVGGFEHARSAFGQV 259
Score = 77.0 bits (188), Expect = 6e-14
Identities = 56/188 (29%), Positives = 86/188 (45%), Gaps = 13/188 (6%)
Frame = +2
Query: 80 CGGF---VSRAVVQPLDVVKIRFQLQVEPIQKNTDGKYKGIAQAVRCILKEEGLKAFWKG 250
CGG + V P+DV++ R Q EP Y + +A+R + K EG F+KG
Sbjct: 124 CGGLSAGTATLTVHPVDVLRTRLAAQGEP------KIYNNLREAIRTMYKTEGPFVFYKG 177
Query: 251 HISSQIQAVTFSLVQFSSYEFIN-VYLWPYLKISEASVLMSSKTFILGSLAGSTATIFTQ 427
+ I ++ +QFS Y + Y W L + + K + G +G + FT
Sbjct: 178 LTPTVIAIFPYAGLQFSCYRSLKRAYDW--LIPPDGKQTGNLKNLLCGCGSGVISKTFTY 235
Query: 428 PFDVFRTRF---------AAQGEPKTYPTLTSAIIMLTKNEGLHGLFRGLVPSLLLIAPQ 580
P D+ + R +A G+ ++Y L + + EG G F+GL PSL+ A
Sbjct: 236 PLDLIKKRLQVGGFEHARSAFGQVRSYRGLLDLTQQVLQEEGTRGFFKGLSPSLMKAALS 295
Query: 581 TGFQFFFY 604
TGF FF+Y
Sbjct: 296 TGFMFFWY 303
Score = 43.9 bits (102), Expect = 5e-04
Identities = 27/96 (28%), Positives = 49/96 (51%), Gaps = 4/96 (4%)
Frame = +2
Query: 50 GQIDYAIAGACGGFVSRAVVQPLDVVKIRFQLQVEPIQKNTDGK---YKGIAQAVRCILK 220
G + + G G +S+ PLD++K R Q+ ++ G+ Y+G+ + +L+
Sbjct: 215 GNLKNLLCGCGSGVISKTFTYPLDLIKKRLQVGGFEHARSAFGQVRSYRGLLDLTQQVLQ 274
Query: 221 EEGLKAFWKGHISSQIQAVTFSLVQFSSYE-FINVY 325
EEG + F+KG S ++A + F YE F N++
Sbjct: 275 EEGTRGFFKGLSPSLMKAALSTGFMFFWYELFCNLF 310
>sp|Q5NVC1|DNC_PONPY Mitochondrial deoxynucleotide carrier (Solute carrier family 25,
member 19)
Length = 320
Score = 184 bits (468), Expect = 2e-46
Identities = 114/256 (44%), Positives = 154/256 (60%), Gaps = 5/256 (1%)
Frame = +2
Query: 65 AIAGACGGFVSRAVVQPLDVVKIRFQLQVEPIQKNT-DGKYKGIAQAVRCILKEEGLKAF 241
A+AG+ G V+RA++ P DV+KIRFQLQ E + ++ + KY GI QA R IL+EEG AF
Sbjct: 19 AVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPNAKYHGILQASRQILQEEGPTAF 78
Query: 242 WKGHISSQIQAVTFSLVQFSSYEFIN--VYLWPYLKISEASVLMSSKTFILGSLAGSTAT 415
WKGHI +QI ++ + VQF S+E + V+ E SV F+ G LA AT
Sbjct: 79 WKGHIPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSV-----HFVCGGLAACMAT 133
Query: 416 IFTQPFDVFRTRFAAQGEPKTYPTLTSAIIMLTKNEGLHGLFRGLVPSLLLIAPQTGFQF 595
+ P DV RTRFAAQGEPK Y TL A+ + ++EG ++GL P+L+ I P G QF
Sbjct: 134 LTVHPVDVLRTRFAAQGEPKVYNTLCHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQF 193
Query: 596 FFYNFSNKILAK--IFKKWQKQENYSEIHKIGILQSALSGGIAGSMAKICVYPVDIIKKR 769
Y+ S K L K I + +K EN LQ+ L G AG ++K YP+D+ KKR
Sbjct: 194 SCYS-SLKHLYKWAIPAEGKKNEN---------LQNLLCGSGAGVISKTLTYPLDLFKKR 243
Query: 770 MQVHGFEVARSKFGKL 817
+QV GFE AR+ FG++
Sbjct: 244 LQVGGFEHARAAFGQV 259
Score = 87.4 bits (215), Expect = 4e-17
Identities = 60/196 (30%), Positives = 95/196 (48%), Gaps = 12/196 (6%)
Frame = +2
Query: 59 DYAIAGACGGF---VSRAVVQPLDVVKIRFQLQVEPIQKNTDGKYKGIAQAVRCILKEEG 229
++++ CGG ++ V P+DV++ RF Q EP NT + AV + + EG
Sbjct: 117 EFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNT------LCHAVGTMYRSEG 170
Query: 230 LKAFWKGHISSQIQAVTFSLVQFSSYEFINVYLWPYLKISEASVLMSSKTFILGSLAGST 409
+ F+KG + I ++ +QFS Y + +L+ + +E + + + GS AG
Sbjct: 171 PQVFYKGLAPTLIAIFPYAGLQFSCYSSLK-HLYKWAIPAEGKKNENLQNLLCGSGAGVI 229
Query: 410 ATIFTQPFDVFRTRF---------AAQGEPKTYPTLTSAIIMLTKNEGLHGLFRGLVPSL 562
+ T P D+F+ R AA G+ + Y L + + EG G F+GL PSL
Sbjct: 230 SKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSL 289
Query: 563 LLIAPQTGFQFFFYNF 610
L A TGF FF+Y F
Sbjct: 290 LKAALSTGFMFFWYEF 305
>sp|Q9HC21|DNC_HUMAN Mitochondrial deoxynucleotide carrier (Solute carrier family 25,
member 19) (Mitochondrial uncoupling protein 1)
Length = 320
Score = 184 bits (466), Expect = 3e-46
Identities = 113/256 (44%), Positives = 153/256 (59%), Gaps = 5/256 (1%)
Frame = +2
Query: 65 AIAGACGGFVSRAVVQPLDVVKIRFQLQVEPIQKNT-DGKYKGIAQAVRCILKEEGLKAF 241
A+AG+ G V+RA++ P DV+KIRFQLQ E + ++ KY GI QA R IL+EEG AF
Sbjct: 19 AVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAF 78
Query: 242 WKGHISSQIQAVTFSLVQFSSYEFIN--VYLWPYLKISEASVLMSSKTFILGSLAGSTAT 415
WKGH+ +QI ++ + VQF S+E + V+ E SV F+ G LA AT
Sbjct: 79 WKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSV-----HFVCGGLAACMAT 133
Query: 416 IFTQPFDVFRTRFAAQGEPKTYPTLTSAIIMLTKNEGLHGLFRGLVPSLLLIAPQTGFQF 595
+ P DV RTRFAAQGEPK Y TL A+ + ++EG ++GL P+L+ I P G QF
Sbjct: 134 LTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQF 193
Query: 596 FFYNFSNKILAK--IFKKWQKQENYSEIHKIGILQSALSGGIAGSMAKICVYPVDIIKKR 769
Y+ S K L K I + +K EN LQ+ L G AG ++K YP+D+ KKR
Sbjct: 194 SCYS-SLKHLYKWAIPAEGKKNEN---------LQNLLCGSGAGVISKTLTYPLDLFKKR 243
Query: 770 MQVHGFEVARSKFGKL 817
+QV GFE AR+ FG++
Sbjct: 244 LQVGGFEHARAAFGQV 259
Score = 85.9 bits (211), Expect = 1e-16
Identities = 60/196 (30%), Positives = 94/196 (47%), Gaps = 12/196 (6%)
Frame = +2
Query: 59 DYAIAGACGGF---VSRAVVQPLDVVKIRFQLQVEPIQKNTDGKYKGIAQAVRCILKEEG 229
++++ CGG ++ V P+DV++ RF Q EP NT + AV + + EG
Sbjct: 117 EFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNT------LRHAVGTMYRSEG 170
Query: 230 LKAFWKGHISSQIQAVTFSLVQFSSYEFINVYLWPYLKISEASVLMSSKTFILGSLAGST 409
+ F+KG + I ++ +QFS Y + +L+ + +E + + + GS AG
Sbjct: 171 PQVFYKGLAPTLIAIFPYAGLQFSCYSSLK-HLYKWAIPAEGKKNENLQNLLCGSGAGVI 229
Query: 410 ATIFTQPFDVFRTRF---------AAQGEPKTYPTLTSAIIMLTKNEGLHGLFRGLVPSL 562
+ T P D+F+ R AA G+ + Y L + + EG G F+GL PSL
Sbjct: 230 SKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSL 289
Query: 563 LLIAPQTGFQFFFYNF 610
L A TGF FF Y F
Sbjct: 290 LKAALSTGFMFFSYEF 305
>sp|P53257|YG2O_YEAST Putative mitochondrial carrier YGR096W
Length = 314
Score = 116 bits (290), Expect = 9e-26
Identities = 75/243 (30%), Positives = 121/243 (49%), Gaps = 7/243 (2%)
Frame = +2
Query: 68 IAGACGGFVSRAVVQPLDVVKIRFQLQVEPIQKNTDGKYKGIAQAVRCILKEEGLKAFWK 247
+AGA G ++R++ P+D +KIR QL K + + + R ++K EG+++FWK
Sbjct: 21 LAGAVSGLLARSITAPMDTIKIRLQLTPANGLKPFGSQ---VMEVARSMIKNEGIRSFWK 77
Query: 248 GHISSQIQAVTFSLVQFSSYEFINVYLWPYLKISEASVLMSSKTFILGSLAGSTATIFTQ 427
G+I + VT+ QFSSY N YL P+ + + ++G+ AG T++I +
Sbjct: 78 GNIPGSLLYVTYGSAQFSSYSLFNRYLTPF------GLEARLHSLVVGAFAGITSSIVSY 131
Query: 428 PFDVFRTRFAAQGEPKTYPTLTSAIIMLTKNEGLHGLFRGLVPSLLLIAPQTGFQFFFYN 607
PFDV RTR A + + ++T + + K EGL G F+G + S+ I F Y
Sbjct: 132 PFDVLRTRLVANNQMHSM-SITREVRDIWKLEGLPGFFKGSIASMTTITLTASIMFGTYE 190
Query: 608 F------SNKILAKIFKKWQKQE-NYSEIHKIGILQSALSGGIAGSMAKICVYPVDIIKK 766
N+ KKW+ N+S +G I G +AKI +P++ I++
Sbjct: 191 TIRIYCDENEKTTAAHKKWELATLNHS------------AGTIGGVIAKIITFPLETIRR 238
Query: 767 RMQ 775
RMQ
Sbjct: 239 RMQ 241
Score = 60.1 bits (144), Expect = 7e-09
Identities = 54/196 (27%), Positives = 78/196 (39%), Gaps = 17/196 (8%)
Frame = +2
Query: 68 IAGACGGFVSRAVVQPLDVVKIRFQLQVEPIQKNTDGKYKGIAQAVRCILKEEGLKAFWK 247
+ GA G S V P DV++ R + N I + VR I K EGL F+K
Sbjct: 117 VVGAFAGITSSIVSYPFDVLRTR-------LVANNQMHSMSITREVRDIWKLEGLPGFFK 169
Query: 248 GHISSQIQAVTFSLVQFSSYEFINVYLWPYLKISEASVLMSSKTF--ILGSLAGSTATIF 421
G I+S + + F +YE I +Y K + A T G++ G A I
Sbjct: 170 GSIASMTTITLTASIMFGTYETIRIYCDENEKTTAAHKKWELATLNHSAGTIGGVIAKII 229
Query: 422 TQPFDVFRTRF---------------AAQGEPKTYPTLTSAIIMLTKNEGLHGLFRGLVP 556
T P + R R + G K Y + +L K EG+ L+RG++
Sbjct: 230 TFPLETIRRRMQFMNSKHLEKFSRHSSVYGSYKGYGFARIGLQIL-KQEGVSSLYRGILV 288
Query: 557 SLLLIAPQTGFQFFFY 604
+L P T F+ Y
Sbjct: 289 ALSKTIPTTFVSFWGY 304
Score = 41.2 bits (95), Expect = 0.004
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 8/97 (8%)
Frame = +2
Query: 71 AGACGGFVSRAVVQPLDVVKIRFQLQ----VEPIQKNTD--GKYKG--IAQAVRCILKEE 226
AG GG +++ + PL+ ++ R Q +E +++ G YKG A+ ILK+E
Sbjct: 218 AGTIGGVIAKIITFPLETIRRRMQFMNSKHLEKFSRHSSVYGSYKGYGFARIGLQILKQE 277
Query: 227 GLKAFWKGHISSQIQAVTFSLVQFSSYEFINVYLWPY 337
G+ + ++G + + + + + V F YE YL Y
Sbjct: 278 GVSSLYRGILVALSKTIPTTFVSFWGYETAIHYLRMY 314
>sp|Q01888|GDC_BOVIN Grave's disease carrier protein (GDC) (Mitochondrial solute carrier
protein homolog)
Length = 330
Score = 96.3 bits (238), Expect = 9e-20
Identities = 69/242 (28%), Positives = 118/242 (48%), Gaps = 5/242 (2%)
Frame = +2
Query: 68 IAGACGGFVSRAVVQPLDVVKIRFQLQVEPIQKNTDGKYKGIAQAVRCILKEEGLKAFWK 247
+AG G ++ V PLD VK+ Q N ++ G+ +R + K+EG +K
Sbjct: 39 LAGGIAGCCAKTTVAPLDRVKVLLQAH------NHHYRHLGVFSTLRAVPKKEGYLGLYK 92
Query: 248 GHISSQIQAVTFSLVQFSSYEFINVYLWPYLKISEASVLMSSKTFILGSLAGSTATIFTQ 427
G+ + I+ + +QF ++E + L +S + GS+AG TA I T
Sbjct: 93 GNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGVSG-----HVHRLMAGSMAGMTAVICTY 147
Query: 428 PFDVFRTRFAAQGEPK-TYPTLTSAI-IMLTKNEGLHGLFRGLVPSLLLIAPQTGFQFFF 601
P D+ R R A Q + + TY + A + K G G +RGL+P++L +AP G FF
Sbjct: 148 PLDMVRVRLAFQVKGEHTYTGIIHAFKTIYAKEGGFLGFYRGLMPTILGMAPYAGVSFFT 207
Query: 602 YNFSNKILAKIFKKWQKQENYSEIHKIGILQ---SALSGGIAGSMAKICVYPVDIIKKRM 772
+ + K + + S+ + +L+ + L GG+AG++A+ YP D+ ++RM
Sbjct: 208 FG-TLKSVGLSYAPTLLGRPSSDNPNVLVLKTHINLLCGGVAGAIAQTISYPFDVTRRRM 266
Query: 773 QV 778
Q+
Sbjct: 267 QL 268
Score = 50.4 bits (119), Expect = 6e-06
Identities = 36/140 (25%), Positives = 63/140 (45%), Gaps = 3/140 (2%)
Frame = +2
Query: 374 KTFILGSLAGSTATIFTQPFDVFRTRFAAQGEPKTYPTLTSAIIMLTKNEGLHGLFRGLV 553
++F+ G +AG A P D + A + + S + + K EG GL++G
Sbjct: 36 RSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYRHLGVFSTLRAVPKKEGYLGLYKGNG 95
Query: 554 PSLLLIAPQTGFQFF-FYNFSNKILAKIFKKWQKQENYSEIHKIGILQSALSGGIAGSMA 730
++ I P QF F ++ I K+ +H++ ++G +AG A
Sbjct: 96 AMMIRIFPYGAIQFMAFEHYKTLITTKLGVS-------GHVHRL------MAGSMAGMTA 142
Query: 731 KICVYPVDIIKKRM--QVHG 784
IC YP+D+++ R+ QV G
Sbjct: 143 VICTYPLDMVRVRLAFQVKG 162
Score = 33.5 bits (75), Expect = 0.73
Identities = 16/31 (51%), Positives = 21/31 (67%)
Frame = +2
Query: 689 LQSALSGGIAGSMAKICVYPVDIIKKRMQVH 781
L+S L+GGIAG AK V P+D +K +Q H
Sbjct: 35 LRSFLAGGIAGCCAKTTVAPLDRVKVLLQAH 65
>sp|P16260|GDC_HUMAN Grave's disease carrier protein (GDC) (Grave's disease autoantigen)
(GDA) (Mitochondrial solute carrier protein homolog)
Length = 332
Score = 95.1 bits (235), Expect = 2e-19
Identities = 69/242 (28%), Positives = 117/242 (48%), Gaps = 5/242 (2%)
Frame = +2
Query: 68 IAGACGGFVSRAVVQPLDVVKIRFQLQVEPIQKNTDGKYKGIAQAVRCILKEEGLKAFWK 247
+AG+ G ++ V PLD VK+ Q N K+ G+ A+R + ++EG +K
Sbjct: 41 LAGSIAGCCAKTTVAPLDRVKVLLQAH------NHHYKHLGVFSALRAVPQKEGFLGLYK 94
Query: 248 GHISSQIQAVTFSLVQFSSYEFINVYLWPYLKISEASVLMSSKTFILGSLAGSTATIFTQ 427
G+ + I+ + +QF ++E + L IS + GS+AG TA I T
Sbjct: 95 GNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISG-----HVHRLMAGSMAGMTAVICTD 149
Query: 428 PFDVFRTRFAAQ--GEPKTYPTLTSAIIMLTKNEGLHGLFRGLVPSLLLIAPQTGFQFFF 601
P D+ R R A Q GE + + + + K G G +RGL+P++L +AP G FF
Sbjct: 150 PVDMVRVRLAFQVKGEHRYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFT 209
Query: 602 YNFSNKILAKIFKKWQKQENYSEIHKIGILQ---SALSGGIAGSMAKICVYPVDIIKKRM 772
+ + K + S+ + +L+ + L GG+A ++A+ YP D+ ++RM
Sbjct: 210 FG-TLKSVGLSHAPTLLGSPSSDNPNVLVLKTHVNLLCGGVARAIAQTISYPFDVTRRRM 268
Query: 773 QV 778
Q+
Sbjct: 269 QL 270
Score = 49.3 bits (116), Expect = 1e-05
Identities = 37/140 (26%), Positives = 64/140 (45%), Gaps = 3/140 (2%)
Frame = +2
Query: 374 KTFILGSLAGSTATIFTQPFDVFRTRFAAQGEPKTYPTLTSAIIMLTKNEGLHGLFRGLV 553
++F+ GS+AG A P D + A + + SA+ + + EG GL++G
Sbjct: 38 RSFLAGSIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNG 97
Query: 554 PSLLLIAPQTGFQFF-FYNFSNKILAKIFKKWQKQENYSEIHKIGILQSALSGGIAGSMA 730
++ I P QF F ++ I K+ +H++ ++G +AG A
Sbjct: 98 AMMIRIFPYGAIQFMAFEHYKTLITTKLGIS-------GHVHRL------MAGSMAGMTA 144
Query: 731 KICVYPVDIIKKRM--QVHG 784
IC PVD+++ R+ QV G
Sbjct: 145 VICTDPVDMVRVRLAFQVKG 164
Score = 31.2 bits (69), Expect = 3.6
Identities = 15/31 (48%), Positives = 20/31 (64%)
Frame = +2
Query: 689 LQSALSGGIAGSMAKICVYPVDIIKKRMQVH 781
L+S L+G IAG AK V P+D +K +Q H
Sbjct: 37 LRSFLAGSIAGCCAKTTVAPLDRVKVLLQAH 67
>sp|P38702|LEU5_YEAST Mitochondrial carrier protein LEU5
Length = 357
Score = 91.7 bits (226), Expect = 2e-18
Identities = 79/284 (27%), Positives = 128/284 (45%), Gaps = 32/284 (11%)
Frame = +2
Query: 23 TMKLSNPRHGQIDYAI----AGACGGFVSRAVVQPLDVVKIRFQLQVEPIQKNTDGKYKG 190
T K S R+ DY + AG G ++ ++ PLD +KI FQ K T G G
Sbjct: 20 TQKTSFDRNS-FDYIVRSGLAGGISGSCAKTLIAPLDRIKILFQTSNPHYTKYT-GSLIG 77
Query: 191 IAQAVRCILKEEGLKAFWKGHISSQIQAVTFSLVQFSSYEFINVYLWPYLKISEASVLMS 370
+ +A + I +G++ F++GH ++ ++ ++ V+F +YE I L P +
Sbjct: 78 LVEAAKHIWINDGVRGFFQGHSATLLRIFPYAAVKFVAYEQIRNTLIPSKEFES-----H 132
Query: 371 SKTFILGSLAGSTATIFTQPFDVFRTRFAAQGE----------PKTYPTLTSAIIMLTKN 520
+ + GSLAG + T P D+ R R A + E K Y SA L KN
Sbjct: 133 WRRLVSGSLAGLCSVFITYPLDLVRVRLAYETEHKRVKLGRIIKKIYKEPASA--TLIKN 190
Query: 521 EGLHGLF-------RGLVPSLLLIAPQTGFQFFFYNFSNKILAKIFKKWQKQENYSEIHK 679
+ + F RG VP++L + P G FF ++ + +L F SE +
Sbjct: 191 DYIPNWFCHWCNFYRGYVPTVLGMIPYAGVSFFAHDLLHDVLKSPFFAPYSVLELSEDDE 250
Query: 680 IGILQ-----------SALSGGIAGSMAKICVYPVDIIKKRMQV 778
+ +Q +SGG+AG ++ YP +II++R+QV
Sbjct: 251 LERVQKKQRRPLRTWAELISGGLAGMASQTAAYPFEIIRRRLQV 294
Score = 48.5 bits (114), Expect = 2e-05
Identities = 45/212 (21%), Positives = 89/212 (41%), Gaps = 33/212 (15%)
Frame = +2
Query: 68 IAGACGGFVSRAVVQPLDVVKIRFQLQVEPIQKNTDGKYKGIAQ--AVRCILKEEGLKA- 238
++G+ G S + PLD+V++R + E + K I + A ++K + +
Sbjct: 137 VSGSLAGLCSVFITYPLDLVRVRLAYETEHKRVKLGRIIKKIYKEPASATLIKNDYIPNW 196
Query: 239 ------FWKGHISSQIQAVTFSLVQFSSYEFIN-----VYLWPY--LKISEASVLMSSKT 379
F++G++ + + + ++ V F +++ ++ + PY L++SE L +
Sbjct: 197 FCHWCNFYRGYVPTVLGMIPYAGVSFFAHDLLHDVLKSPFFAPYSVLELSEDDELERVQK 256
Query: 380 -----------FILGSLAGSTATIFTQPFDVFRTRFAAQG-EPKT-----YPTLTSAIIM 508
I G LAG + PF++ R R PKT + +++ +
Sbjct: 257 KQRRPLRTWAELISGGLAGMASQTAAYPFEIIRRRLQVSALSPKTMYDHKFQSISEIAHI 316
Query: 509 LTKNEGLHGLFRGLVPSLLLIAPQTGFQFFFY 604
+ K G+ G F GL + + P FF Y
Sbjct: 317 IFKERGVRGFFVGLSIGYIKVTPMVACSFFVY 348
>sp|P16261|GDC_RAT Grave'S disease carrier protein (GDC) (Mitochondrial solute carrier
protein homolog)
Length = 322
Score = 88.6 bits (218), Expect = 2e-17
Identities = 70/246 (28%), Positives = 118/246 (47%), Gaps = 9/246 (3%)
Frame = +2
Query: 68 IAGACGGFVSRAVVQPLDVVKIRFQLQVEPIQKNTDGKYKGIAQAVRCILKEEGLKAFWK 247
+AG+ G ++ V PLD VK+ Q N K+ G+ +R + ++EG +K
Sbjct: 41 LAGSIAGCCAKTTVAPLDRVKVLLQAH------NHHYKHLGVLSPLRAVPQKEGYLGLYK 94
Query: 248 GHISSQIQAVTFSLVQFSSYEFINVYLWPYLKISEASVLMSSKTFILGSLAGS---TATI 418
G+ + I+ + +QF ++E ++ L +S + GS+AG TA I
Sbjct: 95 GNGAMMIRIFPYGAIQFMAFEHYKTFITTKLGVSG-----HVHRLMAGSMAGKMSMTAVI 149
Query: 419 FTQPFDVFRTRFAAQ--GEPKTYPTLTSAI-IMLTKNEGLHGLFRGLVPSLLLIAPQTGF 589
T P DV R R A Q GE TY + A + K G G +RGL+P++L +AP
Sbjct: 150 CTYPLDVVRVRLAFQVKGE-HTYSGIIHAFKTIYAKEGGFLGFYRGLMPTILGMAPYASV 208
Query: 590 QFFFYNFSNKILAKIFKKWQKQENYSEIHKIGILQ---SALSGGIAGSMAKICVYPVDII 760
FF + + K + + S+ + +L+ + L GG+A ++A+ YP D+
Sbjct: 209 SFFTFG-TLKSVGLSYAPTLLGRPSSDNPNVLVLKTHINLLCGGVARAIAQTISYPFDVT 267
Query: 761 KKRMQV 778
++RMQ+
Sbjct: 268 RRRMQL 273
Score = 48.1 bits (113), Expect = 3e-05
Identities = 37/143 (25%), Positives = 65/143 (45%), Gaps = 6/143 (4%)
Frame = +2
Query: 374 KTFILGSLAGSTATIFTQPFDVFRTRFAAQGEPKTYPTLTSAIIMLTKNEGLHGLFRGLV 553
++F+ GS+AG A P D + A + + S + + + EG GL++G
Sbjct: 38 RSFLAGSIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVLSPLRAVPQKEGYLGLYKGNG 97
Query: 554 PSLLLIAPQTGFQFF-FYNFSNKILAKIFKKWQKQENYSEIHKIGILQSALSGGIAGSM- 727
++ I P QF F ++ I K+ +H++ ++G +AG M
Sbjct: 98 AMMIRIFPYGAIQFMAFEHYKTFITTKLGVS-------GHVHRL------MAGSMAGKMS 144
Query: 728 --AKICVYPVDIIKKRM--QVHG 784
A IC YP+D+++ R+ QV G
Sbjct: 145 MTAVICTYPLDVVRVRLAFQVKG 167
Score = 31.2 bits (69), Expect = 3.6
Identities = 15/31 (48%), Positives = 20/31 (64%)
Frame = +2
Query: 689 LQSALSGGIAGSMAKICVYPVDIIKKRMQVH 781
L+S L+G IAG AK V P+D +K +Q H
Sbjct: 37 LRSFLAGSIAGCCAKTTVAPLDRVKVLLQAH 67
>sp|P29518|BT1_MAIZE Brittle-1 protein, chloroplast precursor
Length = 436
Score = 86.7 bits (213), Expect = 7e-17
Identities = 60/237 (25%), Positives = 117/237 (49%)
Frame = +2
Query: 68 IAGACGGFVSRAVVQPLDVVKIRFQLQVEPIQKNTDGKYKGIAQAVRCILKEEGLKAFWK 247
++GA G VSR V PL+ IR L V I ++ +A + I++ EG ++
Sbjct: 139 VSGAIAGAVSRTFVAPLET--IRTHLMVGSIGVDS------MAGVFQWIMQNEGWTGLFR 190
Query: 248 GHISSQIQAVTFSLVQFSSYEFINVYLWPYLKISEASVLMSSKTFILGSLAGSTATIFTQ 427
G+ + ++ ++ +Y+ +L P K E + + G+LAG +T+ T
Sbjct: 191 GNAVNVLRVAPSKAIEHFTYDTAKKFLTP--KGDEPPKIPIPTPLVAGALAGFASTLCTY 248
Query: 428 PFDVFRTRFAAQGEPKTYPTLTSAIIMLTKNEGLHGLFRGLVPSLLLIAPQTGFQFFFYN 607
P ++ +TR E Y + A + + ++EG L+RGL PSL+ + P F+ Y
Sbjct: 249 PMELIKTRVTI--EKDVYDNVAHAFVKILRDEGPSELYRGLTPSLIGVVPYAACNFYAY- 305
Query: 608 FSNKILAKIFKKWQKQENYSEIHKIGILQSALSGGIAGSMAKICVYPVDIIKKRMQV 778
+ L +++++ + ++ +G + + L G AG++A +P+++ +K+MQV
Sbjct: 306 ---ETLKRLYRRATGRRPGAD---VGPVATLLIGSAAGAIASSATFPLEVARKQMQV 356
Score = 80.5 bits (197), Expect = 5e-15
Identities = 55/188 (29%), Positives = 86/188 (45%), Gaps = 2/188 (1%)
Frame = +2
Query: 68 IAGACGGFVSRAVVQPLDVVKIRFQLQVEPIQKNTDGKYKGIAQAVRCILKEEGLKAFWK 247
+AGA GF S P++++K R ++ + Y +A A IL++EG ++
Sbjct: 234 VAGALAGFASTLCTYPMELIKTRVTIEKDV--------YDNVAHAFVKILRDEGPSELYR 285
Query: 248 GHISSQIQAVTFSLVQFSSYEFINVYLWPYLKISEASVLMSSKTFILGSLAGSTATIFTQ 427
G S I V ++ F +YE + + + T ++GS AG+ A+ T
Sbjct: 286 GLTPSLIGVVPYAACNFYAYETLKRLYRRATGRRPGADVGPVATLLIGSAAGAIASSATF 345
Query: 428 PFDVFRTRF--AAQGEPKTYPTLTSAIIMLTKNEGLHGLFRGLVPSLLLIAPQTGFQFFF 601
P +V R + A G + Y + AI + K EG GL+RGL PS + + P G F
Sbjct: 346 PLEVARKQMQVGAVGGRQVYQNVLHAIYCILKKEGAGGLYRGLGPSCIKLMPAAGIAFMC 405
Query: 602 YNFSNKIL 625
Y KIL
Sbjct: 406 YEACKKIL 413
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,879,634
Number of Sequences: 369166
Number of extensions: 1660835
Number of successful extensions: 4804
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3756
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4203
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8004331590
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)