Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_B18
(698 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q14847|LASP1_HUMAN LIM and SH3 domain protein 1 (LASP-1)... 133 5e-31
sp|Q61792|LASP1_MOUSE LIM and SH3 domain protein 1 (LASP-1)... 132 9e-31
sp|Q99MZ8|LASP1_RAT LIM and SH3 domain protein 1 (LASP-1) 132 9e-31
sp|P20929|NEBU_HUMAN Nebulin 83 8e-16
sp|Q8I7C3|LAS1_DROME LIM and SH3 domain protein Lasp 80 7e-15
sp|P34416|LASP1_CAEEL LIM and SH3 domain protein F42H10.3 79 1e-14
sp|O76041|NEBL_HUMAN Nebulette (Actin-binding Z-disk protein) 75 1e-13
sp|P38479|ABP1_SACEX Actin-binding protein 59 1e-08
sp|Q9BX66|SRBS1_HUMAN Sorbin and SH3 domain-containing prot... 57 6e-08
sp|P42522|MYOC_DICDI Myosin IC heavy chain 55 1e-07
>sp|Q14847|LASP1_HUMAN LIM and SH3 domain protein 1 (LASP-1) (MLN 50)
Length = 261
Score = 133 bits (334), Expect = 5e-31
Identities = 83/227 (36%), Positives = 108/227 (47%), Gaps = 52/227 (22%)
Frame = +3
Query: 6 RINLEMKNYKGYNKMPYCSAHYPTQKFTTITDTPENKRLAQLTQ---------------- 137
++ L MKNYKGY K PYC+AHYP Q FT + DTPEN RL Q ++
Sbjct: 36 KMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKG 95
Query: 138 --------------------NVSNINYHKQFNEERNNFKSYETNNPPQRFENNDNNANDD 257
+SNI YH++F + R E P +R ++ D ++
Sbjct: 96 KGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERR-DSQDGSSYRR 154
Query: 258 GRQNEQAPRI-TKINARQVLPQSPV-QRVPSQVEPEV--------------KYKCLYEYM 389
+ +Q I T Q Q PV Q EP +Y+ +Y+Y
Sbjct: 155 PLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYS 214
Query: 390 ATDNDEVSFSEGDIIINGEVIDQGWMTGTVERTGEHGMLPFNYVEKI 530
A D DEVSF +GD I+N + ID GWM GTVERTG+ GMLP NYVE I
Sbjct: 215 AADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVEAI 261
>sp|Q61792|LASP1_MOUSE LIM and SH3 domain protein 1 (LASP-1) (MLN 50)
Length = 263
Score = 132 bits (332), Expect = 9e-31
Identities = 81/229 (35%), Positives = 107/229 (46%), Gaps = 54/229 (23%)
Frame = +3
Query: 6 RINLEMKNYKGYNKMPYCSAHYPTQKFTTITDTPENKRLAQLTQ---------------- 137
++ L MKNYKGY K PYC+AHYP Q FT + DTPEN RL Q ++
Sbjct: 36 KMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKG 95
Query: 138 --------------------NVSNINYHKQFNEERNNFKSYETNNPPQRFENNDNNANDD 257
+SNI YH++F + R E P +R + ++
Sbjct: 96 KGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGVEPERREAQDSSSYRRP 155
Query: 258 GRQNEQAPRITKINARQVLPQSPVQRVPSQV----EPEV--------------KYKCLYE 383
Q + P +A V Q Q++ S EP +Y+ +Y+
Sbjct: 156 TEQQQPQPHHIPTSA-PVYQQPQQQQMTSSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYD 214
Query: 384 YMATDNDEVSFSEGDIIINGEVIDQGWMTGTVERTGEHGMLPFNYVEKI 530
Y A D DEVSF +GD I+N + ID GWM GTVERTG+ GMLP NYVE I
Sbjct: 215 YSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVEAI 263
>sp|Q99MZ8|LASP1_RAT LIM and SH3 domain protein 1 (LASP-1)
Length = 263
Score = 132 bits (332), Expect = 9e-31
Identities = 80/228 (35%), Positives = 104/228 (45%), Gaps = 53/228 (23%)
Frame = +3
Query: 6 RINLEMKNYKGYNKMPYCSAHYPTQKFTTITDTPENKRLAQLTQ---------------- 137
++ L MKNYKGY K PYC+AHYP Q FT + DTPEN RL Q ++
Sbjct: 36 KMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKG 95
Query: 138 --------------------NVSNINYHKQFNEERNNFKSYETNNPPQRFENNDNNANDD 257
+SNI YH++F + R E P +R + ++
Sbjct: 96 KGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGIEPERREAQDSSSYRRP 155
Query: 258 GRQNEQAPRITKINARQVLPQSPVQRVPSQ---VEPEV--------------KYKCLYEY 386
Q + P +A Q PS EP +Y+ +Y+Y
Sbjct: 156 TEQQQPQPHHIPTSAPVYQQPQQQQVTPSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDY 215
Query: 387 MATDNDEVSFSEGDIIINGEVIDQGWMTGTVERTGEHGMLPFNYVEKI 530
A D DEVSF +GD I+N + ID GWM GTVERTG+ GMLP NYVE I
Sbjct: 216 SAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVEAI 263
>sp|P20929|NEBU_HUMAN Nebulin
Length = 6669
Score = 82.8 bits (203), Expect = 8e-16
Identities = 40/72 (55%), Positives = 50/72 (69%), Gaps = 1/72 (1%)
Frame = +3
Query: 318 QSPVQRVPSQVEPEVK-YKCLYEYMATDNDEVSFSEGDIIINGEVIDQGWMTGTVERTGE 494
Q+ V +PS K ++ +Y+YMA D DEVSF +GD IIN + ID+GWM GTV+RTG
Sbjct: 6598 QTTVSSIPSHPSTAGKIFRAMYDYMAADADEVSFKDGDAIINVQAIDEGWMYGTVQRTGR 6657
Query: 495 HGMLPFNYVEKI 530
GMLP NYVE I
Sbjct: 6658 TGMLPANYVEAI 6669
Score = 36.2 bits (82), Expect = 0.086
Identities = 15/58 (25%), Positives = 31/58 (53%)
Frame = +3
Query: 81 KFTTITDTPENKRLAQLTQNVSNINYHKQFNEERNNFKSYETNNPPQRFENNDNNAND 254
K + DTPE +R+ + +++S + YH+ F + + F T+ +R + N + +D
Sbjct: 6413 KAAYVLDTPEMRRVRETQRHISTVKYHEDFEKHKGCFTPVVTDPITERVKKNMQDFSD 6470
Score = 33.9 bits (76), Expect = 0.43
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 5/81 (6%)
Frame = +3
Query: 24 KNYKGYNKMPYCSAH----YPTQ-KFTTITDTPENKRLAQLTQNVSNINYHKQFNEERNN 188
+ Y K+ C H +P + KFT +TD+P + T+ +S++NY + ER
Sbjct: 724 QEYDAIKKLDQCKDHTYKVHPDKTKFTAVTDSPVLLQAQLNTKQLSDLNYKAKHEGER-- 781
Query: 189 FKSYETNNPPQRFENNDNNAN 251
FK + + PQ ++ N N
Sbjct: 782 FKCHIPADAPQFIQHRVNAYN 802
Score = 33.9 bits (76), Expect = 0.43
Identities = 13/34 (38%), Positives = 24/34 (70%)
Frame = +3
Query: 81 KFTTITDTPENKRLAQLTQNVSNINYHKQFNEER 182
KFT+I DTPE+ R ++ + +S+I Y ++N+ +
Sbjct: 5451 KFTSIVDTPEHLRTTKVNKQISDILYKLEYNKAK 5484
Score = 32.3 bits (72), Expect = 1.2
Identities = 14/52 (26%), Positives = 28/52 (53%)
Frame = +3
Query: 66 HYPTQKFTTITDTPENKRLAQLTQNVSNINYHKQFNEERNNFKSYETNNPPQ 221
H +TT+ +T + + ++T++VS+ NY K+F +E+ PP+
Sbjct: 5659 HLAQGSYTTLPETRDTVHVKEVTKHVSDTNYKKKFVKEKGKSNYSIMLEPPE 5710
Score = 30.0 bits (66), Expect = 6.1
Identities = 20/81 (24%), Positives = 39/81 (48%), Gaps = 5/81 (6%)
Frame = +3
Query: 24 KNYKGYNKMPYCSAH----YPTQ-KFTTITDTPENKRLAQLTQNVSNINYHKQFNEERNN 188
+ Y+ K+ C H +P + KFT +TD+P + ++ +S++NY + E+
Sbjct: 477 QEYEAIKKLDQCKDHTYKVHPDKTKFTQVTDSPVLLQAQVNSKQLSDLNYKAKHESEK-- 534
Query: 189 FKSYETNNPPQRFENNDNNAN 251
FK + + P ++ N N
Sbjct: 535 FKCHIPPDTPAFIQHKVNAYN 555
>sp|Q8I7C3|LAS1_DROME LIM and SH3 domain protein Lasp
Length = 657
Score = 79.7 bits (195), Expect = 7e-15
Identities = 49/123 (39%), Positives = 66/123 (53%)
Frame = +3
Query: 159 HKQFNEERNNFKSYETNNPPQRFENNDNNANDDGRQNEQAPRITKINARQVLPQSPVQRV 338
H+Q+ ++ + E +PPQ+ +Q Q P + + +Q QS RV
Sbjct: 556 HQQYYQQVQMMQQQE--HPPQQ------------QQMRQQPSYSSLQEKQSR-QSTAMRV 600
Query: 339 PSQVEPEVKYKCLYEYMATDNDEVSFSEGDIIINGEVIDQGWMTGTVERTGEHGMLPFNY 518
Y+ +Y+Y A D DEVSF EGD+I E ID GWMTG VERTG+ GMLP NY
Sbjct: 601 ---------YRAIYDYEAQDVDEVSFREGDVIFEVESIDSGWMTGRVERTGKTGMLPANY 651
Query: 519 VEK 527
VE+
Sbjct: 652 VEQ 654
Score = 77.0 bits (188), Expect = 4e-14
Identities = 35/82 (42%), Positives = 47/82 (57%)
Frame = +3
Query: 9 INLEMKNYKGYNKMPYCSAHYPTQKFTTITDTPENKRLAQLTQNVSNINYHKQFNEERNN 188
+ L MK YKGYNKMPYC AH P K T I DTPE KR+A+ T+ SN+ YH F + +
Sbjct: 37 MTLNMKTYKGYNKMPYCEAHIPKAKATAIADTPELKRIAENTKIQSNVKYHADFEKAKGK 96
Query: 189 FKSYETNNPPQRFENNDNNAND 254
F + R + N + ++
Sbjct: 97 FTQVADDPETLRIKQNTKHISN 118
>sp|P34416|LASP1_CAEEL LIM and SH3 domain protein F42H10.3
Length = 335
Score = 79.0 bits (193), Expect = 1e-14
Identities = 41/87 (47%), Positives = 52/87 (59%), Gaps = 4/87 (4%)
Frame = +3
Query: 276 APRITKINARQVLPQSPVQRVPSQVEPEVK----YKCLYEYMATDNDEVSFSEGDIIING 443
AP + + P S + S + P K K +Y+Y A D DE+SF EGDII+N
Sbjct: 237 APPPSSNSISSTSPHSTLSSPQSTISPTGKAGFAVKAIYDYAAADKDEISFLEGDIIVNC 296
Query: 444 EVIDQGWMTGTVERTGEHGMLPFNYVE 524
E ID GWMTGTV+RT + GMLP NYV+
Sbjct: 297 EKIDDGWMTGTVQRTLQWGMLPANYVQ 323
Score = 71.2 bits (173), Expect = 2e-12
Identities = 37/119 (31%), Positives = 65/119 (54%), Gaps = 3/119 (2%)
Frame = +3
Query: 9 INLEMKNYKGYNKMPYCSAHYPTQKFTTITDTPENKRLAQLTQNVSNINYHKQFNEERNN 188
+ L MKNYKGY+K PYC HYP + + DTPE +R+A+ T+N SNI YH ++ + +
Sbjct: 39 MTLNMKNYKGYDKRPYCDPHYPKTVASVMADTPEMRRIAENTKNQSNIKYHAEYEKMKGT 98
Query: 189 FKSYETNNPPQRFENN---DNNANDDGRQNEQAPRITKINARQVLPQSPVQRVPSQVEP 356
+ +R + N +N + G +++A R ++ ++ + +P P+ + P
Sbjct: 99 KIEIADDPEMERLKKNTQVQSNVSYHGVLDQKA-RQEEVRPKEEISPNP---TPTPISP 153
>sp|O76041|NEBL_HUMAN Nebulette (Actin-binding Z-disk protein)
Length = 1014
Score = 75.5 bits (184), Expect = 1e-13
Identities = 32/53 (60%), Positives = 40/53 (75%)
Frame = +3
Query: 366 YKCLYEYMATDNDEVSFSEGDIIINGEVIDQGWMTGTVERTGEHGMLPFNYVE 524
Y+ +Y+Y A D DEVSF +GD I+N + ID GWM GTV+RTG GMLP NY+E
Sbjct: 959 YRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIE 1011
Score = 30.8 bits (68), Expect = 3.6
Identities = 15/45 (33%), Positives = 26/45 (57%)
Frame = +3
Query: 87 TTITDTPENKRLAQLTQNVSNINYHKQFNEERNNFKSYETNNPPQ 221
T I+D PE KR+ + +N+SN+ Y +Q N+K+ + P+
Sbjct: 634 TAISDPPELKRVKENQKNISNLQYKEQ------NYKATPVSMTPE 672
Score = 30.0 bits (66), Expect = 6.1
Identities = 12/28 (42%), Positives = 19/28 (67%)
Frame = +3
Query: 84 FTTITDTPENKRLAQLTQNVSNINYHKQ 167
++TI DTPE +R+ QN+S + Y K+
Sbjct: 571 YSTIADTPEIQRIKTTQQNISAVFYKKE 598
Score = 30.0 bits (66), Expect = 6.1
Identities = 24/96 (25%), Positives = 46/96 (47%), Gaps = 1/96 (1%)
Frame = +3
Query: 87 TTITDTPENKRLAQLTQNVSNINYHKQFNEERNNFKSYETNNPPQRFENNDNNANDDGRQ 266
T + D+PE +R+ + QN+S++ Y ++ + ++PP+ +N N Q
Sbjct: 603 TAVKDSPEIERVKKNQQNISSVKYKEEIKH------ATAISDPPELKRVKENQKNISNLQ 656
Query: 267 -NEQAPRITKINARQVLPQSPVQRVPSQVEPEVKYK 371
EQ + T ++ + + V+R Q+ VKYK
Sbjct: 657 YKEQNYKATPVSMTPEIER--VRRNQEQLS-AVKYK 689
Score = 29.6 bits (65), Expect = 8.0
Identities = 13/30 (43%), Positives = 19/30 (63%)
Frame = +3
Query: 78 QKFTTITDTPENKRLAQLTQNVSNINYHKQ 167
Q+ T I+D PE KR + +N+SN+ Y Q
Sbjct: 693 QRGTAISDPPELKRAKENQKNISNVYYRGQ 722
>sp|P38479|ABP1_SACEX Actin-binding protein
Length = 617
Score = 58.9 bits (141), Expect = 1e-08
Identities = 32/89 (35%), Positives = 49/89 (55%), Gaps = 3/89 (3%)
Frame = +3
Query: 264 QNEQAPRITKINARQVLPQSPVQRVPSQVEPEVKYKCL---YEYMATDNDEVSFSEGDII 434
+ E+AP + +R +P P QR EP + Y+Y A +++E++F+E D I
Sbjct: 526 EEEEAPA-PSLPSRGSVPPPPPQRAVEPEEPAAEAPWATAEYDYEAGEDNELTFAENDKI 584
Query: 435 INGEVIDQGWMTGTVERTGEHGMLPFNYV 521
IN E +D W G +E TG+ G+ P NYV
Sbjct: 585 INIEFVDDDWWLGELETTGQKGLFPSNYV 613
>sp|Q9BX66|SRBS1_HUMAN Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated
protein) (CAP) (SH3 domain protein 5) (SH3P12)
Length = 1292
Score = 56.6 bits (135), Expect = 6e-08
Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 4/106 (3%)
Frame = +3
Query: 225 FENNDNNANDDGRQNEQAPRITKINARQVLPQSPVQRVP---SQVEPEV-KYKCLYEYMA 392
F ++ + R EQA R PQ+ +RV SQ ++ Y+ LY Y+
Sbjct: 1185 FPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIP 1244
Query: 393 TDNDEVSFSEGDIIINGEVIDQGWMTGTVERTGEHGMLPFNYVEKI 530
++DE+ +GDI+ E D GW GT RT + G P NYV+ +
Sbjct: 1245 QNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 33.9 bits (76), Expect = 0.43
Identities = 18/69 (26%), Positives = 30/69 (43%)
Frame = +3
Query: 324 PVQRVPSQVEPEVKYKCLYEYMATDNDEVSFSEGDIIINGEVIDQGWMTGTVERTGEHGM 503
P + P QV + + + E+SF +G+ I +D+ W G + T G+
Sbjct: 858 PKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGI 917
Query: 504 LPFNYVEKI 530
P YV+ I
Sbjct: 918 FPITYVDVI 926
Score = 32.0 bits (71), Expect = 1.6
Identities = 16/49 (32%), Positives = 25/49 (51%)
Frame = +3
Query: 378 YEYMATDNDEVSFSEGDIIINGEVIDQGWMTGTVERTGEHGMLPFNYVE 524
+++ A E+ +GDI+ + IDQ W G E G G+ P Y+E
Sbjct: 802 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 848
>sp|P42522|MYOC_DICDI Myosin IC heavy chain
Length = 1181
Score = 55.5 bits (132), Expect = 1e-07
Identities = 29/72 (40%), Positives = 42/72 (58%)
Frame = +3
Query: 315 PQSPVQRVPSQVEPEVKYKCLYEYMATDNDEVSFSEGDIIINGEVIDQGWMTGTVERTGE 494
PQ + P+ P+ +Y LYEY A DE++F E D+I + +D W G + RT +
Sbjct: 1111 PQPTPMKKPAAPPPQ-QYIALYEYDAMQPDELTFKENDVINLIKKVDADWWQGELVRTKQ 1169
Query: 495 HGMLPFNYVEKI 530
GMLP NYV++I
Sbjct: 1170 IGMLPSNYVQQI 1181
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,949,388
Number of Sequences: 369166
Number of extensions: 1341766
Number of successful extensions: 5649
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4229
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4938
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6073541875
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)