Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_B12
(907 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q96T60|PNKP_HUMAN Bifunctional polynucleotide phosphatas... 243 4e-64
sp|Q9JLV6|PNKP_MOUSE Bifunctional polynucleotide phosphatas... 238 2e-62
sp|Q19683|YZR5_CAEEL Hypothetical protein F21D5.5 in chromo... 206 9e-53
sp|O13911|PNK1_SCHPO Bifunctional polynucleotide phosphatas... 133 8e-31
sp|P21286|Y033_NPVAC Hypothetical 20.8 kDa protein in FGF-V... 107 6e-23
sp|Q03796|TPP1_YEAST Polynucleotide 3'-phosphatase (2'(3')-... 57 9e-08
sp|Q9HET9|TPP1_SACMI Polynucleotide 3'-phosphatase (2'(3')-... 50 1e-05
sp|Q87QK9|HIS7_VIBPA Histidine biosynthesis bifunctional pr... 43 0.001
sp|Q9KSX1|HIS7_VIBCH Histidine biosynthesis bifunctional pr... 41 0.005
sp|P62455|HIS7_PHOPR Histidine biosynthesis bifunctional pr... 40 0.009
>sp|Q96T60|PNKP_HUMAN Bifunctional polynucleotide phosphatase/kinase (Polynucleotide
kinase-3'-phosphatase) (DNA 5'-kinase/3'-phosphatase)
[Includes: Polynucleotide 3'-phosphatase
(2'(3')-polynucleotidase); Polynucleotide
5'-hydroxyl-kinase ]
Length = 521
Score = 243 bits (621), Expect = 4e-64
Identities = 137/299 (45%), Positives = 181/299 (60%), Gaps = 1/299 (0%)
Frame = +1
Query: 10 LVYTPSDIKSSEKIASFDLDGTLIDTKSGKKFAEGINDWKIKFNEIPNKLKTLEDEGYKL 189
LV+T + +K K+A FDLDGTLI T+SGK F G +DW+I + EIP KL+ LE EGYKL
Sbjct: 154 LVFTAAGVKPQGKVAGFDLDGTLITTRSGKVFPTGPSDWRILYPEIPRKLRELEAEGYKL 213
Query: 190 VIFTNQGGIEXXXXXXXXXXXXXXAIIEQLAVKIQVLVATNYSNVYRKPNTGMFDLLDKE 369
VIFTNQ I A++E+L V QVLVAT ++ +YRKP TGM+D L ++
Sbjct: 214 VIFTNQMSIGRGKLPAEEFKAKVEAVVEKLGVPFQVLVAT-HAGLYRKPVTGMWDHLQEQ 272
Query: 370 HNSGIKINCDESLYVGDAAGRVADWAP-KMKKDFSNSDRLFALNCHLKFYTPEAFFLQQE 546
N G I+ +S++VGDAAGR A+WAP + KKDFS +DRLFALN L F TPE FFL+
Sbjct: 273 ANDGTPISIGDSIFVGDAAGRPANWAPGRKKKDFSCADRLFALNLGLPFATPEEFFLKWP 332
Query: 547 EGEFKMPEFHPAETVKNCPTLMIKYDKFQKSASDIKDILPKDSSEVVLILMVGYPGSGKS 726
F++P F P TV L + + SAS +++ VG+PG+GKS
Sbjct: 333 AAGFELPAFDP-RTVSRSGPLCLPESRALLSASP------------EVVVAVGFPGAGKS 379
Query: 727 TFCKKYLEPLGFNVINRDTLKTWQKCVAETQSLFXXXXXXXXXXTNPDLATRDRYISAA 903
TF KK+L G+ +NRDTL +WQ+CV ++ TNPD A+R RY+ A
Sbjct: 380 TFLKKHLVSAGYVHVNRDTLGSWQRCVTTCETALKQGKRVAIDNTNPDAASRARYVQCA 438
>sp|Q9JLV6|PNKP_MOUSE Bifunctional polynucleotide phosphatase/kinase (Polynucleotide
kinase-3'-phosphatase) (DNA 5'-kinase/3'-phosphatase)
[Includes: Polynucleotide 3'-phosphatase
(2'(3')-polynucleotidase); Polynucleotide
5'-hydroxyl-kinase ]
Length = 522
Score = 238 bits (606), Expect = 2e-62
Identities = 137/299 (45%), Positives = 188/299 (62%), Gaps = 1/299 (0%)
Frame = +1
Query: 10 LVYTPSDIKSSEKIASFDLDGTLIDTKSGKKFAEGINDWKIKFNEIPNKLKTLEDEGYKL 189
LV+T S +K K+A+FDLDGTLI T+SGK F +DW+I + EIP KL+ L EGYKL
Sbjct: 153 LVFTASGVKPQGKVAAFDLDGTLITTRSGKVFPTSPSDWRILYPEIPKKLQELAAEGYKL 212
Query: 190 VIFTNQGGIEXXXXXXXXXXXXXXAIIEQLAVKIQVLVATNYSNVYRKPNTGMFDLLDKE 369
VIFTNQ GI A++E+L V QVLVAT ++ + RKP +GM+D L ++
Sbjct: 213 VIFTNQMGIGRGKLPAEVFKGKVEAVLEKLGVPFQVLVAT-HAGLNRKPVSGMWDHLQEQ 271
Query: 370 HNSGIKINCDESLYVGDAAGRVADWAP-KMKKDFSNSDRLFALNCHLKFYTPEAFFLQQE 546
N GI I+ ++S++VGDAAGR+A+WAP + KKDFS +DRLFALN L F TPE FFL+
Sbjct: 272 ANEGIPISVEDSVFVGDAAGRLANWAPGRKKKDFSCADRLFALNVGLPFATPEEFFLKWP 331
Query: 547 EGEFKMPEFHPAETVKNCPTLMIKYDKFQKSASDIKDILPKDSSEVVLILMVGYPGSGKS 726
F++P F P T+ + L + +S+S L + EVV + VG+PG+GKS
Sbjct: 332 AARFELPAFDP-RTISSAGPLYL-----PESSS-----LLSPNPEVV--VAVGFPGAGKS 378
Query: 727 TFCKKYLEPLGFNVINRDTLKTWQKCVAETQSLFXXXXXXXXXXTNPDLATRDRYISAA 903
TF +++L G+ +NRDTL +WQ+CV+ Q+ TNPD+ +R RYI A
Sbjct: 379 TFIQEHLVSAGYVHVNRDTLGSWQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCA 437
>sp|Q19683|YZR5_CAEEL Hypothetical protein F21D5.5 in chromosome IV
Length = 407
Score = 206 bits (523), Expect = 9e-53
Identities = 123/302 (40%), Positives = 170/302 (56%), Gaps = 4/302 (1%)
Frame = +1
Query: 10 LVYTPSDIKSSEKIASFDLDGTLIDTKSGKKFAEGINDWKIKFNEIPNKLKTLEDEGYKL 189
+++T S+ + EKIA+FD+DGTLI TKSGK F DW++ ++ IP+ K L +G+K+
Sbjct: 40 MIFTHSECEGKEKIAAFDMDGTLIKTKSGKVFPTNCQDWQLLYDSIPSDFKKLHSDGFKI 99
Query: 190 VIFTNQGGIEXXXXXXXXXXXXXXAIIEQLAVKIQVLVATNYSNVYRKPNTGMFDLLDKE 369
VIFTNQ GI AI+ +L + +Q V+ + YRKP GM++ L K
Sbjct: 100 VIFTNQKGIHAGKVDRNEFRKKIEAIVGKLGIPVQAFVSVAGGH-YRKPCVGMWNEL-KL 157
Query: 370 HNSGIKINCDESLYVGDAAGRVADWAPKMKKDFSNSDRLFALNCHLKFYTPEAFFLQQEE 549
N ++IN ES++VGDAAGR+ + KKD S +DR FA N +KF TPE FF
Sbjct: 158 RNDEVEINEKESIFVGDAAGRIKT-TSRPKKDHSYADRFFAANVGVKFQTPEEFF----- 211
Query: 550 GEFKMPEFHPAETVKNCPTLMIKYDKFQKSASDIKDILPKD----SSEVVLILMVGYPGS 717
G+ K+ E P +D + +I ++ P D SSE +ILMVG+PGS
Sbjct: 212 GKSKVDE----------PWGPPNFDPKNLFSEEITELEPHDAQLKSSEKEIILMVGFPGS 261
Query: 718 GKSTFCKKYLEPLGFNVINRDTLKTWQKCVAETQSLFXXXXXXXXXXTNPDLATRDRYIS 897
GKSTF K + ++NRDT+ TWQKCVA T+S T+PDL +R RYI
Sbjct: 262 GKSTFAKMLGHQHDYKIVNRDTIGTWQKCVAATRSYLADGKSVVIDNTSPDLESRKRYID 321
Query: 898 AA 903
A
Sbjct: 322 VA 323
>sp|O13911|PNK1_SCHPO Bifunctional polynucleotide phosphatase/kinase (Polynucleotide
kinase-3'-phosphatase) (DNA 5'-kinase/3'-phosphatase)
[Includes: Polynucleotide 3'-phosphatase
(2'(3')-polynucleotidase); Polynucleotide
5'-hydroxy-kinase ]
Length = 421
Score = 133 bits (334), Expect = 8e-31
Identities = 91/260 (35%), Positives = 128/260 (49%), Gaps = 1/260 (0%)
Frame = +1
Query: 31 IKSSEKIASFDLDGTLIDTKSGKKFAEGINDWKIKFNEIPNKLKTLEDEGYKLVIFTNQG 210
+K ++K +FDLDGTLI TKSG+ F++ DW + KLK L + Y LVIF+NQ
Sbjct: 64 LKKTKKFIAFDLDGTLIKTKSGRVFSKDAADWTWWHPSVVPKLKALYQDNYSLVIFSNQN 123
Query: 211 GIEXXXXXXXXXXXXXXAIIEQLAVKIQVLVATNYSNVYRKPNTGMFDLLDKEHNSGIKI 390
GI AI E L + I VL A + +RKP TGM++ K+ N I +
Sbjct: 124 GIPRKPSAGHTFQMKIRAIFESLDLPI-VLYAAILKDKFRKPLTGMWNSFLKDVNRSIDL 182
Query: 391 NCDESLYVGDAAGRVADWAPKMKKDFSNSDRLFALNCHLKFYTPEAFFLQQEEGEFKMPE 570
+ + YVGDAAGR D +++D FA N +KF TPE FFL
Sbjct: 183 SFIK--YVGDAAGRPG--------DHNSTDLKFAENIGIKFETPEQFFLGHSFVPPNFES 232
Query: 571 FHPAE-TVKNCPTLMIKYDKFQKSASDIKDILPKDSSEVVLILMVGYPGSGKSTFCKKYL 747
FHP V+N + + K S ++++VG+P SGKST + +
Sbjct: 233 FHPKNYLVRNSSSHPYHF---------------KKSEHQEIVVLVGFPSSGKSTLAESQI 277
Query: 748 EPLGFNVINRDTLKTWQKCV 807
G+ +N+D LKT KC+
Sbjct: 278 VTQGYERVNQDILKTKSKCI 297
>sp|P21286|Y033_NPVAC Hypothetical 20.8 kDa protein in FGF-VUBI intergenic region (ORF 1)
Length = 182
Score = 107 bits (266), Expect = 6e-23
Identities = 69/172 (40%), Positives = 96/172 (55%)
Frame = +1
Query: 16 YTPSDIKSSEKIASFDLDGTLIDTKSGKKFAEGINDWKIKFNEIPNKLKTLEDEGYKLVI 195
Y D KIA+FDLDGTLI +K+ KF + +DW++ +KLK L + GY LV+
Sbjct: 12 YAVHDGAKRTKIAAFDLDGTLISSKTRSKFPKNPDDWQLL--PCAHKLKRLYELGYDLVV 69
Query: 196 FTNQGGIEXXXXXXXXXXXXXXAIIEQLAVKIQVLVATNYSNVYRKPNTGMFDLLDKEHN 375
FTNQ + I + V I V+ N + +RKP+TGM+ + K+
Sbjct: 70 FTNQAHLGSGKIKASDLLYKLENIKKATGVPISFYVSPN-KDEHRKPDTGMWREMAKQFT 128
Query: 376 SGIKINCDESLYVGDAAGRVADWAPKMKKDFSNSDRLFALNCHLKFYTPEAF 531
I+ ++S YVGDAAGR+ +KDFS+SDR+FA N L+FYTPE F
Sbjct: 129 ---HIDKEQSFYVGDAAGRIN--LTTGQKDFSDSDRVFAKNLSLQFYTPEQF 175
>sp|Q03796|TPP1_YEAST Polynucleotide 3'-phosphatase (2'(3')-polynucleotidase) (DNA 3'
phosphatase) (Three prime phosphatase)
Length = 238
Score = 56.6 bits (135), Expect = 9e-08
Identities = 61/214 (28%), Positives = 83/214 (38%), Gaps = 52/214 (24%)
Frame = +1
Query: 49 IASFDLDGTLIDTKSGK-KFAEGINDWK-IKFNEIPNKLKTL-----EDEGYKLVIFTNQ 207
+ +FDLD T+I KS F+ +DW+ I FN + L L D +VIF+NQ
Sbjct: 31 VYAFDLDHTIIKPKSPNISFSRSASDWQFINFNSKKSTLDYLCNIIDNDPTAVIVIFSNQ 90
Query: 208 GGIEXXXXXXXXXXXXXXAIIEQL--------------------AVKIQVLVATNYSNV- 324
GG+ I+ L A K A N+S +
Sbjct: 91 GGVITVPRTSKSCTKYTNKILLFLKAIKNDERGETLSHRLWLYAAPKRPKTFAANHSKIT 150
Query: 325 -----------------YRKPNTGMFDLLDKEHNSGIKINCDES-------LYVGDAAGR 432
RKP TGM + ++ S +++ S Y GDAAGR
Sbjct: 151 FASLGESYNNDPNIFEKVRKPMTGMVEFFKRDLESAYRVSEQISPIKLNWIYYCGDAAGR 210
Query: 433 VADWAPKMKKDFSNSDRLFALNCHLKFYTPEAFF 534
KKDFS+SD FA N H++F PE F
Sbjct: 211 --------KKDFSDSDIKFAENLHVEFKYPEEIF 236
>sp|Q9HET9|TPP1_SACMI Polynucleotide 3'-phosphatase (2'(3')-polynucleotidase) (DNA 3'
phosphatase) (Three prime phosphatase)
Length = 245
Score = 49.7 bits (117), Expect = 1e-05
Identities = 58/216 (26%), Positives = 82/216 (37%), Gaps = 54/216 (25%)
Frame = +1
Query: 49 IASFDLDGTLIDTKS-GKKFAEGINDWKIKFNEIPNKLKTLE--------DEGYKLVIFT 201
+ +FDLD T+I KS K++ NDW+ F +K TL+ D +VIF+
Sbjct: 38 VYAFDLDHTIIKPKSPNAKYSRSANDWQ--FMNFDSKKSTLDYLFSITDNDLAAVIVIFS 95
Query: 202 NQGGIEXXXXXXXXXXXXXXAII------------EQLAVKIQVLVAT------------ 309
NQGG+ I E+L+ ++ + A
Sbjct: 96 NQGGVITVPRTSKSCSKYINKISLFLKAIENDKRGEKLSPRLWIYAAPKRPKTVVTNNKK 155
Query: 310 --------NYSN------VYRKPNTGMFDLLDKEHNSGIK-------INCDESLYVGDAA 426
+Y+N RKP TGM D + + I + Y GDAA
Sbjct: 156 ITFPSLCKSYNNDPEIFEKVRKPMTGMADFFRIDITDACRVLKTVPPIKLNWVYYCGDAA 215
Query: 427 GRVADWAPKMKKDFSNSDRLFALNCHLKFYTPEAFF 534
GR K DFS+SD FA H++F PE F
Sbjct: 216 GR--------KNDFSDSDIKFAEKLHVEFKYPEEVF 243
>sp|Q87QK9|HIS7_VIBPA Histidine biosynthesis bifunctional protein hisB [Includes:
Histidinol-phosphatase ; Imidazoleglycerol-phosphate
dehydratase (IGPD)]
Length = 357
Score = 42.7 bits (99), Expect = 0.001
Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 7/137 (5%)
Frame = +1
Query: 31 IKSSEKIASFDLDGTLIDTKSGKKFAEGINDWKIKFNEIPNKLKTLEDEGYKLVIFTNQG 210
+ +KI D DGTLI + ++ K++ IP+ L +L+D GY+LV+ TNQ
Sbjct: 1 MSKQQKILFIDRDGTLIVEPPIDFQVDRLDKLKLEPFVIPSLL-SLQDAGYRLVMVTNQD 59
Query: 211 GI---EXXXXXXXXXXXXXXAIIEQLAVKI-QVLVATNYSN---VYRKPNTGMFDLLDKE 369
G+ I E VK VL+ ++ RKP GM KE
Sbjct: 60 GLGTDSYPQEDFDAPHNMMMEIFESQGVKFDDVLICPHFEEDNCSCRKPKLGMV----KE 115
Query: 370 HNSGIKINCDESLYVGD 420
+ G K++ S+ +GD
Sbjct: 116 YLQGGKVDFQNSVVIGD 132
>sp|Q9KSX1|HIS7_VIBCH Histidine biosynthesis bifunctional protein hisB [Includes:
Histidinol-phosphatase ; Imidazoleglycerol-phosphate
dehydratase (IGPD)]
Length = 357
Score = 40.8 bits (94), Expect = 0.005
Identities = 40/137 (29%), Positives = 60/137 (43%), Gaps = 7/137 (5%)
Frame = +1
Query: 31 IKSSEKIASFDLDGTLIDTKSGKKFAEGINDWKIKFNEIPNKLKTLEDEGYKLVIFTNQG 210
+ +KI D DGTLI + ++ K++ IP+ LK L++ GY+LV+ TNQ
Sbjct: 1 MSKQQKILFIDRDGTLIVEPPVDFQVDRLDKLKLEPYVIPSLLK-LQEAGYRLVMVTNQD 59
Query: 211 GI---EXXXXXXXXXXXXXXAIIEQLAVKI-QVLVATNYSN---VYRKPNTGMFDLLDKE 369
G+ I E VK VL+ ++ RKP G L KE
Sbjct: 60 GLGTSSYPQADFDAPHNMMMDIFESQGVKFNDVLICPHFERDNCSCRKPKLG----LVKE 115
Query: 370 HNSGIKINCDESLYVGD 420
+ G K++ S +GD
Sbjct: 116 YLQGGKVDFKSSAVIGD 132
>sp|P62455|HIS7_PHOPR Histidine biosynthesis bifunctional protein hisB [Includes:
Histidinol-phosphatase ; Imidazoleglycerol-phosphate
dehydratase (IGPD)]
Length = 361
Score = 40.0 bits (92), Expect = 0.009
Identities = 26/60 (43%), Positives = 34/60 (56%)
Frame = +1
Query: 37 SSEKIASFDLDGTLIDTKSGKKFAEGINDWKIKFNEIPNKLKTLEDEGYKLVIFTNQGGI 216
S EKI D DGTLI + ++ K++ IP L TL+D GYKLV+ TNQ G+
Sbjct: 2 SKEKILFIDRDGTLIVEPPVDFQVDRLDKLKLEPFVIP-ALLTLQDAGYKLVMVTNQDGL 60
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.317 0.135 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100,089,856
Number of Sequences: 369166
Number of extensions: 2002530
Number of successful extensions: 6641
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6385
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6615
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9174518830
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)