Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_A18
(909 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9EQQ0|SUV92_MOUSE Histone-lysine N-methyltransferase, H... 218 1e-56
sp|Q9H5I1|SUV92_HUMAN Histone-lysine N-methyltransferase, H... 214 2e-55
sp|O43463|SUV91_HUMAN Histone-lysine N-methyltransferase, H... 211 2e-54
sp|O54864|SUV91_MOUSE Histone-lysine N-methyltransferase, H... 208 1e-53
sp|P45975|SUV9_DROME Histone-lysine N-methyltransferase, H3... 177 3e-44
sp|O60016|CLR4_SCHPO Histone-lysine N-methyltransferase, H3... 164 4e-40
sp|Q96KQ7|EHMT2_HUMAN Histone-lysine N-methyltransferase, H... 148 2e-35
sp|Q9Z148|EHMT2_MOUSE Histone-lysine N-methyltransferase, H... 146 9e-35
sp|Q9H9B1|EHMT1_HUMAN Histone-lysine N-methyltransferase, H... 140 5e-33
sp|Q8VZ17|SUV6_ARATH Histone-lysine N-methyltransferase, H3... 139 8e-33
>sp|Q9EQQ0|SUV92_MOUSE Histone-lysine N-methyltransferase, H3 lysine-9 specific 2 (Histone
H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Suppressor
of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2)
Length = 477
Score = 218 bits (556), Expect = 1e-56
Identities = 120/271 (44%), Positives = 158/271 (58%), Gaps = 2/271 (0%)
Frame = +3
Query: 3 GPPLDFQFITDY-VSNGIEIHSNPPIGCHCETSCLENKKDCSFIHGGDPPYTITGKVIPR 179
GPPLDF +I +Y + GI I+S GC C T C +K C G Y ++ +
Sbjct: 231 GPPLDFYYINEYRPAPGISINSEATFGCSC-TDCFFDKC-CPAEAGVVLAYNKKQQIKIQ 288
Query: 180 VGVPVYECNSACTCDINCRYRVVQRGVKLQLKIFRTVNR-GWGLKTLTKIVKGNFIMEYL 356
G P+YECNS C C C R+VQ+G + L IF+T N GWG+KTL KI + +F+MEY+
Sbjct: 289 PGTPIYECNSRCRCGPECPNRIVQKGTQYSLCIFKTSNGCGWGVKTLVKIKRMSFVMEYV 348
Query: 357 GEIVTVDEAEERGKLYDQQNLTYLFDLDFAGDPEFTVDAYKKGNMSHFINHSCNPNMTSR 536
GE++T +EAE RG+ YD + +TYLFDLD+ D EFTVDA + GN+SHF+NHSC+PN+
Sbjct: 349 GEVITSEEAERRGQFYDNKGITYLFDLDYESD-EFTVDAARYGNVSHFVNHSCDPNLQVF 407
Query: 537 CVFINNLDIRMPRIAFYADRDIRSGEELTFDYMMTGAMSGNKENEGXXXXXXXXXINVNT 716
VFI+NLD R+PRIA ++ R I +GEELTFDY M G SG ++ +
Sbjct: 408 SVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKG--SGEASSDSIDHSPAKKRV---- 461
Query: 717 KYXXXXXXXXXXQVTGRVPCLCDAANCRKYL 809
R C C A CR YL
Sbjct: 462 ----------------RTQCKCGAETCRGYL 476
>sp|Q9H5I1|SUV92_HUMAN Histone-lysine N-methyltransferase, H3 lysine-9 specific 2 (Histone
H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Suppressor
of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2)
Length = 410
Score = 214 bits (546), Expect = 2e-55
Identities = 119/271 (43%), Positives = 158/271 (58%), Gaps = 2/271 (0%)
Frame = +3
Query: 3 GPPLDFQFITDYV-SNGIEIHSNPPIGCHCETSCLENKKDCSFIHGGDPPYTITGKVIPR 179
GPP DF +I +Y + GI + + GC C T C +K C G Y ++
Sbjct: 164 GPPSDFYYINEYKPAPGISLVNEATFGCSC-TDCFF-QKCCPAEAGVLLAYNKNQQIKIP 221
Query: 180 VGVPVYECNSACTCDINCRYRVVQRGVKLQLKIFRTVN-RGWGLKTLTKIVKGNFIMEYL 356
G P+YECNS C C +C R+VQ+G + L IFRT N RGWG+KTL KI + +F+MEY+
Sbjct: 222 PGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYV 281
Query: 357 GEIVTVDEAEERGKLYDQQNLTYLFDLDFAGDPEFTVDAYKKGNMSHFINHSCNPNMTSR 536
GE++T +EAE RG+ YD + +TYLFDLD+ D EFTVDA + GN+SHF+NHSC+PN+
Sbjct: 282 GEVITSEEAERRGQFYDNKGITYLFDLDYESD-EFTVDAARYGNVSHFVNHSCDPNLQVF 340
Query: 537 CVFINNLDIRMPRIAFYADRDIRSGEELTFDYMMTGAMSGNKENEGXXXXXXXXXINVNT 716
VFI+NLD R+PRIA ++ R I +GEELTFDY M G SG+ ++ +
Sbjct: 341 NVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKG--SGDISSDSIDHSPAKKRV---- 394
Query: 717 KYXXXXXXXXXXQVTGRVPCLCDAANCRKYL 809
R C C A CR YL
Sbjct: 395 ----------------RTVCKCGAVTCRGYL 409
>sp|O43463|SUV91_HUMAN Histone-lysine N-methyltransferase, H3 lysine-9 specific 1 (Histone
H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Suppressor
of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)
Length = 412
Score = 211 bits (538), Expect = 2e-54
Identities = 124/280 (44%), Positives = 165/280 (58%), Gaps = 11/280 (3%)
Frame = +3
Query: 3 GPPLDFQFITDY-VSNGIEIHSNPPIGCHCETSCLENKKDCSFIH-GGDPP--------Y 152
GPP F +I +Y V GI ++ +GC C+ DC + GG P Y
Sbjct: 155 GPPRAFVYINEYRVGEGITLNQ-VAVGCECQ--------DCLWAPTGGCCPGASLHKFAY 205
Query: 153 TITGKVIPRVGVPVYECNSACTCDINCRYRVVQRGVKLQLKIFRTVN-RGWGLKTLTKIV 329
G+V R G+P+YECNS C C +C RVVQ+G++ L IFRT + RGWG++TL KI
Sbjct: 206 NDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIR 265
Query: 330 KGNFIMEYLGEIVTVDEAEERGKLYDQQNLTYLFDLDFAGDPEFTVDAYKKGNMSHFINH 509
K +F+MEY+GEI+T +EAE RG++YD+Q TYLFDLD+ D +TVDA GN+SHF+NH
Sbjct: 266 KNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDV-YTVDAAYYGNISHFVNH 324
Query: 510 SCNPNMTSRCVFINNLDIRMPRIAFYADRDIRSGEELTFDYMMTGAMSGNKENEGXXXXX 689
SC+PN+ VFI+NLD R+PRIAF+A R IR+GEELTFDY M + E+
Sbjct: 325 SCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQ-VDPVDMESTRMDSNF 383
Query: 690 XXXXINVNTKYXXXXXXXXXXQVTGRVPCLCDAANCRKYL 809
+ + K R+ C C +CRKYL
Sbjct: 384 GLAGLPGSPKKRV------------RIECKCGTESCRKYL 411
>sp|O54864|SUV91_MOUSE Histone-lysine N-methyltransferase, H3 lysine-9 specific 1 (Histone
H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Suppressor
of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)
(Position-effect variegation 3-9 homolog)
Length = 412
Score = 208 bits (530), Expect = 1e-53
Identities = 110/217 (50%), Positives = 146/217 (67%), Gaps = 5/217 (2%)
Frame = +3
Query: 3 GPPLDFQFITDY-VSNGIEIHSNPPIGCHCETSCLENKKDC---SFIHGGDPPYTITGKV 170
GPP F +I +Y V GI ++ +GC C+ L C + +H Y G+V
Sbjct: 155 GPPRSFVYINEYRVGEGITLNQ-VAVGCECQDCLLAPTGGCCPGASLHKF--AYNDQGQV 211
Query: 171 IPRVGVPVYECNSACTCDINCRYRVVQRGVKLQLKIFRTVN-RGWGLKTLTKIVKGNFIM 347
+ G P+YECNS C C +C RVVQ+G++ L IFRT + RGWG++TL KI K +F+M
Sbjct: 212 RLKAGQPIYECNSRCCCGYDCPNRVVQKGIRYDLCIFRTNDGRGWGVRTLEKIRKNSFVM 271
Query: 348 EYLGEIVTVDEAEERGKLYDQQNLTYLFDLDFAGDPEFTVDAYKKGNMSHFINHSCNPNM 527
EY+GEI+T +EAE RG++YD+Q TYLFDLD+ D +TVDA GN+SHF+NHSC+PN+
Sbjct: 272 EYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDV-YTVDAAYYGNISHFVNHSCDPNL 330
Query: 528 TSRCVFINNLDIRMPRIAFYADRDIRSGEELTFDYMM 638
VFI+NLD R+PRIAF+A R I +GEELTFDY M
Sbjct: 331 QVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDYNM 367
>sp|P45975|SUV9_DROME Histone-lysine N-methyltransferase, H3 lysine-9 specific (Histone
H3-K9 methyltransferase) (H3-K9-HMTase) (Suppressor of
variegation protein 3-9)
Length = 635
Score = 177 bits (450), Expect = 3e-44
Identities = 101/252 (40%), Positives = 140/252 (55%), Gaps = 7/252 (2%)
Frame = +3
Query: 75 IGCHCETS---CLENKKDCSFIHGGDPPYT-ITGKVIPRVGVPVYECNSACTCDINCRYR 242
+GC C C + K C+ G Y T ++ R G +YECNS C+CD +C R
Sbjct: 410 VGCKCTEDTEECTASTKCCARFAGELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNR 469
Query: 243 VVQRGVKLQLKIFRTVN-RGWGLKTLTKIVKGNFIMEYLGEIVTVDEAEERGKLYDQQNL 419
+VQ G ++ L +F+T N GWG++ T + KG F+ EY+GEI+T DEA ERGK YD
Sbjct: 470 LVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGR 529
Query: 420 TYLFDLDF--AGDPEFTVDAYKKGNMSHFINHSCNPNMTSRCVFINNLDIRMPRIAFYAD 593
TYLFDLD+ A D E+T+DA GN+SHFINHSC+PN+ +I +L++ +P + F+
Sbjct: 530 TYLFDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTL 589
Query: 594 RDIRSGEELTFDYMMTGAMSGNKENEGXXXXXXXXXINVNTKYXXXXXXXXXXQVTGRVP 773
R I++GEEL+FDY+ +NE N++T RV
Sbjct: 590 RPIKAGEELSFDYI-------RADNEDVPYE------NLSTAV--------------RVE 622
Query: 774 CLCDAANCRKYL 809
C C NCRK L
Sbjct: 623 CRCGRDNCRKVL 634
>sp|O60016|CLR4_SCHPO Histone-lysine N-methyltransferase, H3 lysine-9 specific (Histone
H3-K9 methyltransferase) (H3-K9-HMTase) (Cryptic loci
regulator 4)
Length = 490
Score = 164 bits (414), Expect = 4e-40
Identities = 95/219 (43%), Positives = 125/219 (57%), Gaps = 10/219 (4%)
Frame = +3
Query: 6 PPLDFQFITDYVSNGIEIHSNPPI--GCHCET--SC-LENKKDCSFIHGGDPP----YTI 158
P LDFQFI+ Y I +P GC+C + C L N C + D P Y
Sbjct: 233 PSLDFQFISQYRLTQGVIPPDPNFQSGCNCSSLGGCDLNNPSRCECLDDLDEPTHFAYDA 292
Query: 159 TGKVIPRVGVPVYECNSACTCDINCRYRVVQRGVKLQLKIFRTVNRGWGLKTLTKIVKGN 338
G+V G +YECNS C+C + C RVVQRG L L+IF+T +GWG+++L G
Sbjct: 293 QGRVRADTGAVIYECNSFCSCSMECPNRVVQRGRTLPLEIFKTKEKGWGVRSLRFAPAGT 352
Query: 339 FIMEYLGEIVTVDEAEERGKLYDQQNLTYLFDLDFAGD-PEFTVDAYKKGNMSHFINHSC 515
FI YLGE++T EA +R K YD +TYLFDLD D E+TVDA G++S F NHSC
Sbjct: 353 FITCYLGEVITSAEAAKRDKNYDDDGITYLFDLDMFDDASEYTVDAQNYGDVSRFFNHSC 412
Query: 516 NPNMTSRCVFINNLDIRMPRIAFYADRDIRSGEELTFDY 632
+PN+ N+ + +AF+A +DI+ EELTFDY
Sbjct: 413 SPNIAIYSAVRNHGFRTIYDLAFFAIKDIQPLEELTFDY 451
>sp|Q96KQ7|EHMT2_HUMAN Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (Histone
H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic
histone-lysine N-methyltransferase 2) (HLA-B associated
transcript 8) (G9a protein)
Length = 1210
Score = 148 bits (373), Expect = 2e-35
Identities = 70/147 (47%), Positives = 102/147 (69%)
Frame = +3
Query: 192 VYECNSACTCDINCRYRVVQRGVKLQLKIFRTVNRGWGLKTLTKIVKGNFIMEYLGEIVT 371
++ECN AC+C NC+ RVVQ G+K++L+++RT GWG++ L I +G FI EY+GE+++
Sbjct: 1014 IFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELIS 1073
Query: 372 VDEAEERGKLYDQQNLTYLFDLDFAGDPEFTVDAYKKGNMSHFINHSCNPNMTSRCVFIN 551
EA+ R ++ +YLFDLD + +DA GN+S FINH C+PN+ VF+
Sbjct: 1074 DAEADVR------EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFML 1127
Query: 552 NLDIRMPRIAFYADRDIRSGEELTFDY 632
+ D+R PRIAF++ RDIR+GEEL FDY
Sbjct: 1128 HQDLRFPRIAFFSSRDIRTGEELGFDY 1154
>sp|Q9Z148|EHMT2_MOUSE Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (Histone
H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic
histone-lysine N-methyltransferase 2) (HLA-B associated
transcript 8) (G9a protein)
Length = 1263
Score = 146 bits (368), Expect = 9e-35
Identities = 69/147 (46%), Positives = 102/147 (69%)
Frame = +3
Query: 192 VYECNSACTCDINCRYRVVQRGVKLQLKIFRTVNRGWGLKTLTKIVKGNFIMEYLGEIVT 371
++ECN AC+C +C+ RVVQ G+K++L+++RT GWG++ L I +G FI EY+GE+++
Sbjct: 1067 IFECNQACSCWRSCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELIS 1126
Query: 372 VDEAEERGKLYDQQNLTYLFDLDFAGDPEFTVDAYKKGNMSHFINHSCNPNMTSRCVFIN 551
EA+ R ++ +YLFDLD + +DA GN+S FINH C+PN+ VF+
Sbjct: 1127 DAEADVR------EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFML 1180
Query: 552 NLDIRMPRIAFYADRDIRSGEELTFDY 632
+ D+R PRIAF++ RDIR+GEEL FDY
Sbjct: 1181 HQDLRFPRIAFFSSRDIRTGEELGFDY 1207
>sp|Q9H9B1|EHMT1_HUMAN Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (Histone
H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic
histone-lysine N-methyltransferase 1) (Eu-HMTase1)
(G9a-like protein 1) (GLP1)
Length = 1267
Score = 140 bits (353), Expect = 5e-33
Identities = 69/165 (41%), Positives = 105/165 (63%), Gaps = 4/165 (2%)
Frame = +3
Query: 150 YTITGKVIPRVGVP----VYECNSACTCDINCRYRVVQRGVKLQLKIFRTVNRGWGLKTL 317
Y G+++P + ++ECN AC+C NCR RVVQ G++ +L+++RT + GWG+++L
Sbjct: 1053 YDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSL 1112
Query: 318 TKIVKGNFIMEYLGEIVTVDEAEERGKLYDQQNLTYLFDLDFAGDPEFTVDAYKKGNMSH 497
I G F+ EY+GE+++ EA+ R + +YLFDLD + +DA GN+S
Sbjct: 1113 QDIPPGTFVCEYVGELISDSEADVR------EEDSYLFDLDNKDGEVYCIDARFYGNVSR 1166
Query: 498 FINHSCNPNMTSRCVFINNLDIRMPRIAFYADRDIRSGEELTFDY 632
FINH C PN+ VF+ + D+R PRIAF++ R I +GE+L FDY
Sbjct: 1167 FINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDY 1211
>sp|Q8VZ17|SUV6_ARATH Histone-lysine N-methyltransferase, H3 lysine-9 specific 6 (Histone
H3-K9 methyltransferase 6) (H3-K9-HMTase 6) (Suppressor
of variegation 3-9 homolog 6) (Su(var)3-9 homolog 6)
Length = 790
Score = 139 bits (351), Expect = 8e-33
Identities = 90/271 (33%), Positives = 133/271 (49%), Gaps = 24/271 (8%)
Frame = +3
Query: 69 PPIGCHCETSCLENK-KDCSFI--HGGDPPYTITGKVIPRVGVPVYECNSACTCDINCRY 239
PP C C T C E + + C+ + +GG+ PY G ++ +YEC C C +C
Sbjct: 549 PPKSCCCTTRCTEAEARVCACVEKNGGEIPYNFDGAIVGAKPT-IYECGPLCKCPSSCYL 607
Query: 240 RVVQRGVKLQLKIFRTVNRGWGLKTLTKIVKGNFIMEYLGEIVTVDEAEER--------- 392
RV Q G+KL L+IF+T +RGWG++ L I G+FI EY+GE++ EAE R
Sbjct: 608 RVTQHGIKLPLEIFKTKSRGWGVRCLKSIPIGSFICEYVGELLEDSEAERRIGNDEYLFD 667
Query: 393 -GKLYDQQNLTYLFDLDFA---------GDPE--FTVDAYKKGNMSHFINHSCNPNMTSR 536
G YD + +L GD FT+DA KGN+ FINHSC+PN+ ++
Sbjct: 668 IGNRYDNSLAQGMSELMLGTQAGRSMAEGDESSGFTIDAASKGNVGRFINHSCSPNLYAQ 727
Query: 537 CVFINNLDIRMPRIAFYADRDIRSGEELTFDYMMTGAMSGNKENEGXXXXXXXXXINVNT 716
V ++ D R+P + F+A +I +EL +DY A+ ++++G N+
Sbjct: 728 NVLYDHEDSRIPHVMFFAQDNIPPLQELCYDY--NYALDQVRDSKG----------NIKQ 775
Query: 717 KYXXXXXXXXXXQVTGRVPCLCDAANCRKYL 809
K PC C AA CR+ L
Sbjct: 776 K-----------------PCFCGAAVCRRRL 789
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,925,832
Number of Sequences: 369166
Number of extensions: 1793618
Number of successful extensions: 4390
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4143
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4286
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9222552960
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)