Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_P22-2
(568 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9EQU5|SET_MOUSE SET protein (Phosphatase 2A inhibitor I... 156 4e-38
sp|Q63945|SET_RAT SET protein (Phosphatase 2A inhibitor I2P... 154 1e-37
sp|Q01105|SET_HUMAN SET protein (Phosphatase 2A inhibitor I... 149 4e-36
sp|P53997|SET_DROME SET protein 146 3e-35
sp|Q18240|SPR2_CAEEL Suppressor of presenilin 2 138 1e-32
sp|Q9UJ04|TSYL4_HUMAN Testis-specific Y-encoded-like protei... 94 2e-19
sp|Q01534|TSPY1_HUMAN Testis-specific Y-encoded protein 1 94 2e-19
sp|Q8VD63|TSYL4_MOUSE Testis-specific Y-encoded-like protei... 90 4e-18
sp|O88852|TSYL1_MOUSE Testis-specific Y-encoded-like protei... 89 6e-18
sp|P13825|ASP_PLAFS Aspartic acid-rich protein precursor 89 8e-18
>sp|Q9EQU5|SET_MOUSE SET protein (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A)
(Template-activating factor I) (TAF-I)
Length = 289
Score = 156 bits (394), Expect = 4e-38
Identities = 82/188 (43%), Positives = 116/188 (61%), Gaps = 2/188 (1%)
Frame = +2
Query: 11 ASAPKIQ-KTESNGKVDQDQVLNSLIEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQP 187
A+APK++ K+ S G ++ IE IDEVQ++ID+LNEQASEEIL+VE+K+N+ RQP
Sbjct: 19 AAAPKLEDKSASPGLPKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQP 78
Query: 188 LFQQRANLIKTIPNFWINALSNHPQLMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIM 367
FQ+R+ LI IPNFW+ NHPQ+ L+ E DE+ L LT ++V EF+DIKSG++I
Sbjct: 79 FFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDF 138
Query: 368 TFSPNEYFNNTTITKSIHVGES-EIKTTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXX 544
F N YF N ++K H+ ES + + + WK GK+ K +++ N
Sbjct: 139 YFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQN--KASRKRQHE 196
Query: 545 XPISFMQW 568
P SF W
Sbjct: 197 EPESFFTW 204
>sp|Q63945|SET_RAT SET protein (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A)
(Template-activating factor I) (TAF-I) (Liver
regeneration-related protein LRRGR00002)
Length = 289
Score = 154 bits (390), Expect = 1e-37
Identities = 81/187 (43%), Positives = 115/187 (61%), Gaps = 2/187 (1%)
Frame = +2
Query: 14 SAPKIQ-KTESNGKVDQDQVLNSLIEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPL 190
+APK++ K+ S G ++ IE IDEVQ++ID+LNEQASEEIL+VE+K+N+ RQP
Sbjct: 20 AAPKLEDKSASPGLPKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPF 79
Query: 191 FQQRANLIKTIPNFWINALSNHPQLMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMT 370
FQ+R+ LI IPNFW+ NHPQ+ L+ E DE+ L LT ++V EF+DIKSG++I
Sbjct: 80 FQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFY 139
Query: 371 FSPNEYFNNTTITKSIHVGES-EIKTTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXXX 547
F N YF N ++K H+ ES + + + WK GK+ K +++ N
Sbjct: 140 FDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQN--KASRKRQHEE 197
Query: 548 PISFMQW 568
P SF W
Sbjct: 198 PESFFTW 204
>sp|Q01105|SET_HUMAN SET protein (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A)
(Template-activating factor I) (TAF-I) (HLA-DR
associated protein II) (PHAPII) (Inhibitor of granzyme
A-activated DNase) (IGAAD)
Length = 290
Score = 149 bits (377), Expect = 4e-36
Identities = 75/163 (46%), Positives = 103/163 (63%), Gaps = 1/163 (0%)
Frame = +2
Query: 83 IEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNHPQ 262
IE IDEVQ++ID+LNEQASEEIL+VE+K+N+ RQP FQ+R+ LI IPNFW+ NHPQ
Sbjct: 45 IEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQ 104
Query: 263 LMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGES-EI 439
+ L+ E DE+ L LT ++V EF+DIKSG++I F N YF N ++K H+ ES +
Sbjct: 105 VSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDP 164
Query: 440 KTTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXXXPISFMQW 568
+ + WK GK+ K +++ N P SF W
Sbjct: 165 SSKSTEIKWKSGKDLTKRSSQTQN--KASRKRQHEEPESFFTW 205
>sp|P53997|SET_DROME SET protein
Length = 269
Score = 146 bits (369), Expect = 3e-35
Identities = 71/177 (40%), Positives = 111/177 (62%), Gaps = 14/177 (7%)
Frame = +2
Query: 8 MASAPKIQKTE-------SNGKVDQDQVLNSLIEKIDEVQSDIDKLNEQASEEILEVEKK 166
M+S PK K + ++ ++ + +E+ID Q++ID LNE+ASEEIL+VE+K
Sbjct: 1 MSSVPKRAKLDGAPADGNTSAAAGNNEEESEALEQIDACQNEIDALNEKASEEILKVEQK 60
Query: 167 FNQKRQPLFQQRANLIKTIPNFWINALSNHPQLMTLITEHDEDLLQSLTSLDVEEFDDIK 346
+N+ R+P +++R+ L+K IPNFW+ + NHPQ+ ++ E +E+ L +L L+VEEF+DIK
Sbjct: 61 YNKLRKPCYEKRSELVKRIPNFWVTSFINHPQVSGILDEEEEECLHALNKLEVEEFEDIK 120
Query: 347 SGFKIIMTFSPNEYFNNTTITKSIHVGESEIK-------TTCDPVDWKEGKNFVKSL 496
SG++I F N YF N +TK H+ + +T P+ WKEGKN +K L
Sbjct: 121 SGYRINFHFDENPYFENKVLTKEFHLNSAAASENGDWPASTSTPIKWKEGKNLLKLL 177
>sp|Q18240|SPR2_CAEEL Suppressor of presenilin 2
Length = 312
Score = 138 bits (347), Expect = 1e-32
Identities = 68/137 (49%), Positives = 90/137 (65%)
Frame = +2
Query: 68 VLNSLIEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINAL 247
V LIE +D +Q +D ++E A+EE+L+VE+ FNQKR P++++R L I NFW A
Sbjct: 27 VKEKLIE-LDAIQHQLDVMSENAAEEVLKVEQIFNQKRLPIYEKRKKLTTKIDNFWQTAF 85
Query: 248 SNHPQLMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVG 427
NH L T I E EDLL +L L+V+EF+D++SGFKIIMTF PNEYF N ITKS H+
Sbjct: 86 LNHHLLSTAIPEEQEDLLAALRDLEVQEFEDLRSGFKIIMTFDPNEYFTNEVITKSYHLQ 145
Query: 428 ESEIKTTCDPVDWKEGK 478
T ++WKE K
Sbjct: 146 SESPSTEITEIEWKENK 162
>sp|Q9UJ04|TSYL4_HUMAN Testis-specific Y-encoded-like protein 4 (TSPY-like 4)
Length = 414
Score = 94.4 bits (233), Expect = 2e-19
Identities = 43/138 (31%), Positives = 78/138 (56%), Gaps = 1/138 (0%)
Frame = +2
Query: 71 LNSLIEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALS 250
+N+ ++ ++ + ++ +N QA L++E+KF + R+ Q+R+ +I+ IP FW+ A
Sbjct: 200 INNCMDSLEAIDQELSNVNAQADRAFLQLERKFGRMRRLHMQRRSFIIQNIPGFWVTAFR 259
Query: 251 NHPQLMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGE 430
NHPQL +I+ DED+L+ + +L+VEE ++G K F N YF N + K
Sbjct: 260 NHPQLSPMISGQDEDMLRYMINLEVEELKHPRAGCKFKFIFQGNPYFRNEGLVKEYERRS 319
Query: 431 S-EIKTTCDPVDWKEGKN 481
S + + P+ W G++
Sbjct: 320 SGRVVSLSTPIRWHRGQD 337
>sp|Q01534|TSPY1_HUMAN Testis-specific Y-encoded protein 1
Length = 308
Score = 94.0 bits (232), Expect = 2e-19
Identities = 46/131 (35%), Positives = 77/131 (58%), Gaps = 1/131 (0%)
Frame = +2
Query: 77 SLIEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNH 256
S +E++ VQ +++ +N QA + +K ++R+P +R +I+++P FW N ++NH
Sbjct: 107 SALEELLAVQVELEPVNAQARKAFSRQREKMERRRKPHLDRRGAVIQSVPGFWANVIANH 166
Query: 257 PQLMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGESE 436
PQ+ LIT+ DED+L + SL+VEE KI++ F N YF N ITK V +E
Sbjct: 167 PQMSALITDEDEDMLSYMVSLEVEEEKHPVHLCKIMLFFRSNPYFQNKVITKEYLVNITE 226
Query: 437 IKTT-CDPVDW 466
+ + P++W
Sbjct: 227 YRASHSTPIEW 237
>sp|Q8VD63|TSYL4_MOUSE Testis-specific Y-encoded-like protein 4 (TSPY-like 4)
Length = 406
Score = 89.7 bits (221), Expect = 4e-18
Identities = 41/133 (30%), Positives = 73/133 (54%), Gaps = 1/133 (0%)
Frame = +2
Query: 83 IEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNHPQ 262
++ ++ + ++ +N QA L++E+KF + R+ Q+R+ +I+ IP FW+ A NHPQ
Sbjct: 196 MDSLEAIDQELSNVNAQADRAFLQLERKFGRMRRLHMQRRSFIIQNIPGFWVTAFRNHPQ 255
Query: 263 LMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGES-EI 439
L +I+ DED+++ + +L+VEE + G K F N YF N + K S +
Sbjct: 256 LSPMISGQDEDMMRYMINLEVEELKQPRVGCKFKFIFQSNPYFRNEGLVKEYERRSSGRV 315
Query: 440 KTTCDPVDWKEGK 478
+ P+ W G+
Sbjct: 316 VSLSTPIRWHRGQ 328
>sp|O88852|TSYL1_MOUSE Testis-specific Y-encoded-like protein 1 (TSPY-like 1)
Length = 379
Score = 89.4 bits (220), Expect = 6e-18
Identities = 44/129 (34%), Positives = 71/129 (55%), Gaps = 1/129 (0%)
Frame = +2
Query: 92 IDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNHPQLMT 271
++ +Q ++D +N QA +E+KF + R+ ++R +I+ IP FW+ A NHPQL
Sbjct: 174 LEAIQLELDTVNAQADRAFQHLEQKFGRMRRHYLERRNYIIQNIPGFWMTAFRNHPQLSA 233
Query: 272 LITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGES-EIKTT 448
+I D ++L+ +TSL+V+E K+G K F N YF N I K V S + +
Sbjct: 234 MIRGRDAEMLRYVTSLEVKELRHPKTGCKFKFFFRRNPYFRNKLIVKEYEVRSSGRVVSL 293
Query: 449 CDPVDWKEG 475
P+ W+ G
Sbjct: 294 STPIIWRRG 302
>sp|P13825|ASP_PLAFS Aspartic acid-rich protein precursor
Length = 253
Score = 89.0 bits (219), Expect = 8e-18
Identities = 44/138 (31%), Positives = 79/138 (57%), Gaps = 3/138 (2%)
Frame = +2
Query: 101 VQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNHPQLMTLIT 280
VQ DI++L+ + + E + ++K++++K++PLF++R +I+ IP FW N L HP L ++
Sbjct: 20 VQKDIEQLDIKCAHEQMNIQKQYDEKKKPLFEKRDEIIQKIPGFWANTLRKHPALSDIVP 79
Query: 281 EHDEDLLQSLTSLDVEEFDDIKSGFKIIMTF--SPNEYFNNTTITKSIHVGESEIKTT-C 451
E D D+L L LD+++ D +KI F E+ T+ K + ++ K C
Sbjct: 80 E-DIDILNHLVKLDLKDNMDNNGSYKITFIFGEKAKEFMEPLTLVKHVTFDNNQEKVVEC 138
Query: 452 DPVDWKEGKNFVKSLNES 505
+ WKEGKN + ++ +
Sbjct: 139 TRIKWKEGKNPIAAVTHN 156
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,353,287
Number of Sequences: 369166
Number of extensions: 1126881
Number of successful extensions: 4351
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4151
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4327
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 4127973360
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)