Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_P10
(455 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransf... 118 7e-27
sp|O59816|ODP2_SCHPO Dihydrolipoyllysine-residue acetyltran... 118 7e-27
sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltran... 114 8e-26
sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltran... 112 3e-25
sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X compo... 107 1e-23
sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltran... 106 3e-23
sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X compo... 104 1e-22
sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltran... 104 1e-22
sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltran... 104 1e-22
sp|Q9R9N3|ODP2_RHIME Dihydrolipoyllysine-residue acetyltran... 100 3e-21
>sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex) (PDC-E2) (70 kDa mitochondrial autoantigen of
primary biliary cirrhosis) (PBC)
Length = 555
Score = 118 bits (295), Expect = 7e-27
Identities = 68/130 (52%), Positives = 82/130 (63%), Gaps = 1/130 (0%)
Frame = +3
Query: 6 SGLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTA 185
+GLITPIVF A L I+S + LA KAR KLQP EF GGTFTISNLGMFGIK F+A
Sbjct: 427 AGLITPIVFNAHIKGLETIASDVVSLASKAREGKLQPHEFQGGTFTISNLGMFGIKNFSA 486
Query: 186 IINSPQAAILAVGAGIPHLAHDPANPSKPKSVTK-MRFTLCADARIIDETSASEFVSRVK 362
IIN PQA ILA+GA L PA+ K V M TL D R++D +++++ K
Sbjct: 487 IINPPQACILAIGASEDKLI--PADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLAEFK 544
Query: 363 SYLENPSFLL 392
YLE P +L
Sbjct: 545 KYLEKPVTML 554
>sp|O59816|ODP2_SCHPO Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex, mitochondrial precursor (E2)
(Dihydrolipoamide acetyltransferase component of
pyruvate dehydrogenase complex) (PDC-E2)
Length = 483
Score = 118 bits (295), Expect = 7e-27
Identities = 60/125 (48%), Positives = 81/125 (64%)
Frame = +3
Query: 6 SGLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTA 185
SGLITP++ L LA IS+ + ++ARNNKL+P+E+ GGTFTISNLGMF + +FTA
Sbjct: 354 SGLITPVIRNTHALGLAEISTLAKDYGQRARNNKLKPEEYQGGTFTISNLGMFPVDQFTA 413
Query: 186 IINSPQAAILAVGAGIPHLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKS 365
IIN PQA ILAVG + + D + K M+ TL +D R++D A+ F + +K
Sbjct: 414 IINPPQACILAVGTTVDTVVPDSTSEKGFKVAPIMKCTLSSDHRVVDGAMAARFTTALKK 473
Query: 366 YLENP 380
LENP
Sbjct: 474 ILENP 478
>sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex, mitochondrial precursor (Pyruvate
dehydrogenase complex E2 subunit) (PDCE2) (E2)
(Dihydrolipoamide S-acetyltransferase component of
pyruvate dehydrogenase complex) (PDC-E2) (70 kDa
mitochondrial autoantigen of primary biliary cirrhosis)
(PBC) (M2 antigen complex 70 kDa subunit)
Length = 614
Score = 114 bits (286), Expect = 8e-26
Identities = 65/130 (50%), Positives = 83/130 (63%), Gaps = 1/130 (0%)
Frame = +3
Query: 6 SGLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTA 185
+GLITPIVF A + I++ + LA KAR KLQP EF GGTFTISNLGMFGIK F+A
Sbjct: 486 AGLITPIVFNAHIKGVETIANDVVSLATKAREGKLQPHEFQGGTFTISNLGMFGIKNFSA 545
Query: 186 IINSPQAAILAVGAGIPHLAHDPANPSKPKSV-TKMRFTLCADARIIDETSASEFVSRVK 362
IIN PQA ILA+GA L PA+ K V + M TL D R++D +++++ +
Sbjct: 546 IINPPQACILAIGASEDKLV--PADNEKGFDVASMMSVTLSCDHRVVDGAVGAQWLAEFR 603
Query: 363 SYLENPSFLL 392
YLE P +L
Sbjct: 604 KYLEKPITML 613
>sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex, mitochondrial precursor (E2)
(Dihydrolipoamide acetyltransferase component of
pyruvate dehydrogenase complex) (PDC-E2)
Length = 592
Score = 112 bits (281), Expect = 3e-25
Identities = 63/130 (48%), Positives = 85/130 (65%), Gaps = 2/130 (1%)
Frame = +3
Query: 9 GLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAI 188
GL TPIV G D L +IS+++ +LAEKA+N KL P EF GTFTISNLGM GIK+F A+
Sbjct: 464 GLFTPIVRGVDMKGLNSISTSVKQLAEKAQNGKLHPSEFESGTFTISNLGMLGIKQFAAV 523
Query: 189 INSPQAAILAVGAG--IPHLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVK 362
IN PQAAILA+ + L++ P +P ++ T + TL D R+ID +E++ K
Sbjct: 524 INPPQAAILALVPQKLVSFLSNKPDSPY--ETATILSVTLSCDHRVIDGAVGAEWLKSFK 581
Query: 363 SYLENPSFLL 392
Y+ENP L+
Sbjct: 582 DYVENPIKLI 591
>sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X component, mitochondrial precursor
(Dihydrolipoamide dehydrogenase-binding protein of
pyruvate dehydrogenase complex) (Lipoyl-containing
pyruvate dehydrogenase complex component X) (E3-binding
protein) (E3BP) (proX)
Length = 501
Score = 107 bits (267), Expect = 1e-23
Identities = 56/128 (43%), Positives = 83/128 (64%), Gaps = 2/128 (1%)
Frame = +3
Query: 3 ESGLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFT 182
+ GL+TPI+ A + I+ ++ L++KAR+ KL P+E+ GG+F+ISNLGMFGI EFT
Sbjct: 370 DKGLLTPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNLGMFGIDEFT 429
Query: 183 AIINSPQAAILAVGAGIP--HLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSR 356
A+IN PQA ILAVG P L D +K + + T+ +D+R++D+ A+ F+
Sbjct: 430 AVINPPQACILAVGRFRPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKS 489
Query: 357 VKSYLENP 380
K+ LENP
Sbjct: 490 FKANLENP 497
>sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 408
Score = 106 bits (264), Expect = 3e-23
Identities = 58/130 (44%), Positives = 81/130 (62%)
Frame = +3
Query: 3 ESGLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFT 182
E+G++TPIV A+K + +S + L +KA++NKL P EF GG FTISNLGM+GIK F
Sbjct: 281 ENGIVTPIVKDANKKNIIELSREMKTLIKKAKDNKLTPIEFQGGGFTISNLGMYGIKNFN 340
Query: 183 AIINSPQAAILAVGAGIPHLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVK 362
AIIN+PQ+ I+ VGA + T M TL AD R+ID ++EF++ K
Sbjct: 341 AIINTPQSCIMGVGASTKRAI---VKNDQIIIATIMDVTLSADHRVIDGAVSAEFLASFK 397
Query: 363 SYLENPSFLL 392
++ENP +L
Sbjct: 398 RFIENPVLML 407
>sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X component, mitochondrial precursor
(Dihydrolipoamide dehydrogenase-binding protein of
pyruvate dehydrogenase complex) (Lipoyl-containing
pyruvate dehydrogenase complex component X)
Length = 501
Score = 104 bits (259), Expect = 1e-22
Identities = 55/128 (42%), Positives = 81/128 (63%), Gaps = 2/128 (1%)
Frame = +3
Query: 3 ESGLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFT 182
+ GLITPI+ A + I+ ++ L++KAR+ KL P+E+ GG+F+ISNLGMFGI EF
Sbjct: 370 DKGLITPIIKDAAAKGIQEIADSVKVLSKKARDGKLMPEEYQGGSFSISNLGMFGIDEFA 429
Query: 183 AIINSPQAAILAVGAGIP--HLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSR 356
A+IN PQA ILAVG P L D + + + T+ +D+R++D+ A+ F+
Sbjct: 430 AVINPPQACILAVGRFRPVLKLTEDEEGNPQLQQHQLITVTMSSDSRVVDDELATRFLET 489
Query: 357 VKSYLENP 380
K+ LENP
Sbjct: 490 FKANLENP 497
>sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 412
Score = 104 bits (259), Expect = 1e-22
Identities = 56/130 (43%), Positives = 79/130 (60%)
Frame = +3
Query: 3 ESGLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFT 182
E+GL+TPIV A++ + +S + L +KA++NKL P+EF GG FTISNLGM+GIK F
Sbjct: 285 ENGLVTPIVKNANQKNILELSREMKALIKKAKDNKLTPEEFQGGGFTISNLGMYGIKNFN 344
Query: 183 AIINSPQAAILAVGAGIPHLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVK 362
AIIN PQ+ I+ VGA + T M TL AD R++D +EF+ K
Sbjct: 345 AIINPPQSCIMGVGASAKRAI---VKNDQITIATIMDVTLSADHRVVDGAVGAEFLVAFK 401
Query: 363 SYLENPSFLL 392
++E+P +L
Sbjct: 402 KFIESPVLML 411
>sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 440
Score = 104 bits (259), Expect = 1e-22
Identities = 60/133 (45%), Positives = 83/133 (62%), Gaps = 2/133 (1%)
Frame = +3
Query: 3 ESGLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFT 182
E GLITPI+ AD L+A+S + EL +AR +LQPQE+ GGT +ISN+GMFGIK+F
Sbjct: 312 EGGLITPILKQADTKSLSALSVEMKELIARAREGRLQPQEYQGGTSSISNMGMFGIKQFN 371
Query: 183 AIINSPQAAILAVGAG--IPHLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSR 356
A+IN PQA+ILA+G+G P + D + ++T D R+ID A+ F+S
Sbjct: 372 AVINPPQASILAIGSGERRPWVIDDAITIATVATITG-----SFDHRVIDGADAAAFMSA 426
Query: 357 VKSYLENPSFLLA 395
K +E P +LA
Sbjct: 427 FKHLVEKPLGILA 439
>sp|Q9R9N3|ODP2_RHIME Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 447
Score = 99.8 bits (247), Expect = 3e-21
Identities = 52/128 (40%), Positives = 77/128 (60%)
Frame = +3
Query: 9 GLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAI 188
GLITPIV A+ L+AIS+ + +L ++A+ KL+P+E+ GGT +SN+GM G+K+F A+
Sbjct: 322 GLITPIVRQAELKSLSAISNEMKDLGKRAKERKLKPEEYQGGTTAVSNMGMMGVKDFAAV 381
Query: 189 INSPQAAILAVGAGIPHLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKSY 368
+N P A ILAVGAG + + M TL D R +D +E ++ K Y
Sbjct: 382 VNPPHATILAVGAGEDRVV---VRNKEMVIANVMTVTLSTDHRCVDGALGAELLAAFKRY 438
Query: 369 LENPSFLL 392
+ENP +L
Sbjct: 439 IENPMGML 446
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,540,710
Number of Sequences: 369166
Number of extensions: 1198745
Number of successful extensions: 3514
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3381
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3480
length of database: 68,354,980
effective HSP length: 101
effective length of database: 49,696,745
effective search space used: 2484837250
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)