Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_P06
(808 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9BY32|ITPA_HUMAN Inosine triphosphate pyrophosphatase (... 110 3e-24
sp|Q9D892|ITPA_MOUSE Inosine triphosphate pyrophosphatase (... 108 2e-23
sp|P47119|HAM1_YEAST HAM1 protein 97 5e-20
sp|Q57679|NTPA_METJA Nucleoside-triphosphatase (Nucleoside ... 80 9e-15
sp|Q8TV07|HAM1_METKA HAM1 protein homolog 75 3e-13
sp|Q5JEX8|HAM1_PYRKO HAM1 protein homolog 69 2e-11
sp|Q8TJS1|HAM1_METAC HAM1 protein homolog 66 1e-10
sp|Q8PZ91|HAM1_METMA HAM1 protein homolog 64 6e-10
sp|Q8U446|HAM1_PYRFU HAM1 protein homolog 63 8e-10
sp|Q8A327|HAM1_BACTN HAM1 protein homolog 63 8e-10
>sp|Q9BY32|ITPA_HUMAN Inosine triphosphate pyrophosphatase (ITPase) (Inosine
triphosphatase) (Putative oncogene protein hlc14-06-p)
Length = 194
Score = 110 bits (276), Expect = 3e-24
Identities = 65/148 (43%), Positives = 84/148 (56%)
Frame = +1
Query: 322 EISLLKAKYAYSIIKEPVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLRKML 501
EIS+ K + A ++ PV VEDT LCFNAL G+PGPYIKWF+ EK K +GL ++L
Sbjct: 51 EISIQKCQEAVRQVQGPVLVEDTCLCFNALGGLPGPYIKWFL-----EKLKP-EGLHQLL 104
Query: 502 VGFNDFRAEAVTIISYYDPKIMQDPKAFIGKMLGEIVEPRGPMDFDWDCVFQPVAQCQDT 681
GF D A A+ + Q + F G+ G IV PRG DF WD FQP
Sbjct: 105 AGFEDKSAYALCTFALSTGDPSQPVRLFRGRTSGRIVAPRGCQDFGWDPCFQP----DGY 160
Query: 682 LQTYAEMDYKYKNKISNRYNAAQEFKKF 765
QTYAEM KN +S+R+ A E +++
Sbjct: 161 EQTYAEMPKAEKNAVSHRFRALLELQEY 188
>sp|Q9D892|ITPA_MOUSE Inosine triphosphate pyrophosphatase (ITPase) (Inosine
triphosphatase)
Length = 198
Score = 108 bits (270), Expect = 2e-23
Identities = 64/148 (43%), Positives = 84/148 (56%)
Frame = +1
Query: 322 EISLLKAKYAYSIIKEPVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLRKML 501
EIS+ K + A ++ PV VEDT LCFNAL G+PGPYIKWF+ +K K +GL ++L
Sbjct: 51 EISIQKCREAARQVQGPVLVEDTCLCFNALGGLPGPYIKWFL-----QKLKP-EGLHQLL 104
Query: 502 VGFNDFRAEAVTIISYYDPKIMQDPKAFIGKMLGEIVEPRGPMDFDWDCVFQPVAQCQDT 681
GF D A A+ + Q F G+ G+IV PRG DF WD FQP
Sbjct: 105 AGFEDKSAYALCTFALSTGDPSQPVLLFRGQTSGQIVMPRGSRDFGWDPCFQP----DGY 160
Query: 682 LQTYAEMDYKYKNKISNRYNAAQEFKKF 765
QTYAEM KN IS+R+ A + +++
Sbjct: 161 EQTYAEMPKSEKNTISHRFRALHKLQEY 188
>sp|P47119|HAM1_YEAST HAM1 protein
Length = 197
Score = 97.1 bits (240), Expect = 5e-20
Identities = 64/153 (41%), Positives = 85/153 (55%), Gaps = 2/153 (1%)
Frame = +1
Query: 325 ISLLKAKYAYSIIKE--PVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLRKM 498
I+L K K A + + + PVFVEDT+L F+ G+PG YIKWF+ K L+ + KM
Sbjct: 54 IALAKGKQAVAALGKGKPVFVEDTALRFDEFNGLPGAYIKWFL------KSMGLEKIVKM 107
Query: 499 LVGFNDFRAEAVTIISYYDPKIMQDPKAFIGKMLGEIVEPRGPMDFDWDCVFQPVAQCQD 678
L F + AEAVT I + D + + F G G+IV RGP F WD +F+P
Sbjct: 108 LEPFENKNAEAVTTICFADSR--GEYHFFQGITRGKIVPSRGPTTFGWDSIFEPF---DS 162
Query: 679 TLQTYAEMDYKYKNKISNRYNAAQEFKKFLLQN 777
TYAEM KN IS+R A +FK++L QN
Sbjct: 163 HGLTYAEMSKDAKNAISHRGKAFAQFKEYLYQN 195
>sp|Q57679|NTPA_METJA Nucleoside-triphosphatase (Nucleoside triphosphate
phosphohydrolase) (NTPase)
Length = 193
Score = 79.7 bits (195), Expect = 9e-15
Identities = 54/159 (33%), Positives = 86/159 (54%)
Frame = +1
Query: 295 YTGISREIIEISLLKAKYAYSIIKEPVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFK 474
Y I + E++ AK+ Y+I+K+PV VED+ AL G PG Y K FV +
Sbjct: 43 YPEIQGTLEEVAEFGAKWVYNILKKPVIVEDSGFFVEALNGFPGTYSK-FVQETIGN--- 98
Query: 475 KLQGLRKMLVGFNDFRAEAVTIISYYDPKIMQDPKAFIGKMLGEIVEPRGPMDFDWDCVF 654
+G+ K+L G ++ A T+I Y D ++ K + + E + +G F +D +F
Sbjct: 99 --EGILKLLEGKDNRNAYFKTVIGYCDENGVRLFKGIVKGRVSEEIRSKG-YGFAYDSIF 155
Query: 655 QPVAQCQDTLQTYAEMDYKYKNKISNRYNAAQEFKKFLL 771
P ++ +T+AEM + K++IS+R A +EFKKFLL
Sbjct: 156 IP----EEEERTFAEMTTEEKSQISHRKKAFEEFKKFLL 190
>sp|Q8TV07|HAM1_METKA HAM1 protein homolog
Length = 188
Score = 74.7 bits (182), Expect = 3e-13
Identities = 52/160 (32%), Positives = 81/160 (50%), Gaps = 3/160 (1%)
Frame = +1
Query: 307 SREIIEISLLKAKYAYSIIKEPVFVEDTSLCFNALYGMPGPYIKWFVH--GNLDEKFKKL 480
S + EI+ A+Y + +PV VED+ L AL G PGPY + GN
Sbjct: 39 SDSLEEIAAYGARYCAESLGQPVIVEDSGLFIEALNGFPGPYSAYVFDTIGN-------- 90
Query: 481 QGLRKMLVGFNDFRAEAVTIISYYDPKIMQDPKAFIGKMLGEIV-EPRGPMDFDWDCVFQ 657
+G+ K+L G + +AE ++++ Y +P P F G++ G I EPRG F +D +F
Sbjct: 91 EGILKLLEGEENRKAEFISVVGYCEPG--GRPVTFTGEIRGRIAEEPRGEEGFGYDPIFI 148
Query: 658 PVAQCQDTLQTYAEMDYKYKNKISNRYNAAQEFKKFLLQN 777
P + T+AE+ + K KIS+R A + F ++ N
Sbjct: 149 PEGED----STFAELGVEEKCKISHRTKALERFAEWYKNN 184
>sp|Q5JEX8|HAM1_PYRKO HAM1 protein homolog
Length = 184
Score = 68.6 bits (166), Expect = 2e-11
Identities = 49/153 (32%), Positives = 81/153 (52%), Gaps = 1/153 (0%)
Frame = +1
Query: 322 EISLLKAKYAYSIIKEPVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLRKML 501
E++ AK+ + P F++D+ L AL G PG Y + K QG+ K+L
Sbjct: 44 EVAEYGAKWLAQRVDGPFFLDDSGLFVEALKGFPGVYSAYVY------KTIGYQGILKLL 97
Query: 502 VGFNDFRAEAVTIISYYDPKIMQDPKAFIGKMLGEIV-EPRGPMDFDWDCVFQPVAQCQD 678
G + +A ++I+Y+D ++ F G++ G+I EPRG F +D +F P +
Sbjct: 98 QGEKNRKAHFKSVIAYWDGEL----HIFTGRVDGKIATEPRGSGGFGFDPIFIP----EG 149
Query: 679 TLQTYAEMDYKYKNKISNRYNAAQEFKKFLLQN 777
+T+AEM + KN+IS+R A +EF +L +N
Sbjct: 150 FDRTFAEMTTEEKNRISHRGRALREFANWLKEN 182
>sp|Q8TJS1|HAM1_METAC HAM1 protein homolog
Length = 184
Score = 65.9 bits (159), Expect = 1e-10
Identities = 49/149 (32%), Positives = 77/149 (51%), Gaps = 1/149 (0%)
Frame = +1
Query: 313 EIIEISLLKAKYAYSIIKEPVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLR 492
E+ I+ A+Y + + PV V+D+ + NAL G PGPY ++ +++K L+ L
Sbjct: 42 ELEPIAAHGAQYVANKLNMPVMVDDSGIFINALNGFPGPYSRF-----VEDKLGNLKVL- 95
Query: 493 KMLVGFNDFRAEAVTIISYYDPKIMQDPKAFIGKMLGEIV-EPRGPMDFDWDCVFQPVAQ 669
KM+ G D A T+I Y +P ++P F G + G+I E RG F +D +F+
Sbjct: 96 KMMEGEEDRTAYFKTVIGYCEPG--KEPLVFPGVVEGKIAYEERGTGGFGYDPIFEYQG- 152
Query: 670 CQDTLQTYAEMDYKYKNKISNRYNAAQEF 756
T+ E+ KNK+S+R A EF
Sbjct: 153 -----LTFGELGDTEKNKVSHRRRAVDEF 176
>sp|Q8PZ91|HAM1_METMA HAM1 protein homolog
Length = 184
Score = 63.5 bits (153), Expect = 6e-10
Identities = 48/154 (31%), Positives = 76/154 (49%), Gaps = 1/154 (0%)
Frame = +1
Query: 313 EIIEISLLKAKYAYSIIKEPVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLR 492
E+ I+ A+Y + + PV V+D+ + NAL G PGPY + FV L +
Sbjct: 42 ELEPIAANGAQYVANKLNMPVMVDDSGIFINALNGFPGPYSR-FVEDKLGN-----PKVL 95
Query: 493 KMLVGFNDFRAEAVTIISYYDPKIMQDPKAFIGKMLGEIV-EPRGPMDFDWDCVFQPVAQ 669
K++ G D A T+I Y +P Q+P F G + G+I E RG F +D +F+
Sbjct: 96 KLMEGEKDRSAYFKTVIGYCEPG--QEPLVFPGVVEGKIAYEERGTGGFGYDPIFEYNG- 152
Query: 670 CQDTLQTYAEMDYKYKNKISNRYNAAQEFKKFLL 771
T+ E+ + KNK+S+R A F ++ +
Sbjct: 153 -----MTFGELGDEEKNKVSHRRRAVDNFLEWFI 181
>sp|Q8U446|HAM1_PYRFU HAM1 protein homolog
Length = 185
Score = 63.2 bits (152), Expect = 8e-10
Identities = 43/140 (30%), Positives = 72/140 (51%), Gaps = 1/140 (0%)
Frame = +1
Query: 361 IKEPVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLRKMLVGFNDFRAEAVTI 540
+ +P +ED+ L AL G PG Y + K L G+ K++ G + +A ++
Sbjct: 57 VDKPFIIEDSGLFIEALNGFPGVYSAYVY------KTIGLDGILKLMEGIENRKAYFKSV 110
Query: 541 ISYYDPKIMQDPKAFIGKMLGEIV-EPRGPMDFDWDCVFQPVAQCQDTLQTYAEMDYKYK 717
I +YD +I F+G++ G I E RG F +D +F P +T+AEM + K
Sbjct: 111 IGFYDGEI----HLFVGEVRGRISNEKRGLHGFGYDPIFVP----DGFDKTFAEMSTEEK 162
Query: 718 NKISNRYNAAQEFKKFLLQN 777
N +S+R A +EF +++ +N
Sbjct: 163 NSVSHRGKALKEFYRWMKEN 182
>sp|Q8A327|HAM1_BACTN HAM1 protein homolog
Length = 193
Score = 63.2 bits (152), Expect = 8e-10
Identities = 49/150 (32%), Positives = 77/150 (51%), Gaps = 3/150 (2%)
Frame = +1
Query: 328 SLLKAKYAYSIIKEPVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLRKMLVG 507
+LLK+ + Y + F +DT L AL G PG Y + G + ++ L L G
Sbjct: 51 ALLKSSFIYRNYQLDCFADDTGLEVEALNGAPGVYSARYAEGEGHDAQANMRKLLHELEG 110
Query: 508 FNDFRAEAVTIISYYDPKIMQDPKAFI--GKMLGEIV-EPRGPMDFDWDCVFQPVAQCQD 678
+ +A+ T IS ++ D K ++ G + GEI+ E RG F +D +F+P +
Sbjct: 111 KENRKAQFRTAIS-----LILDGKEYLFEGVIKGEIIKEKRGDSGFGYDPIFKP----EG 161
Query: 679 TLQTYAEMDYKYKNKISNRYNAAQEFKKFL 768
QT+AE+ + KNKIS+R A Q+ +FL
Sbjct: 162 YEQTFAELGNETKNKISHRALAVQKLCEFL 191
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,840,885
Number of Sequences: 369166
Number of extensions: 1656176
Number of successful extensions: 3725
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3616
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3699
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7666799535
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)