Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_O08
(789 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O00410|IMB3_HUMAN Importin beta-3 (Karyopherin beta-3) (... 174 2e-43
sp|O60518|RNBP6_HUMAN Ran-binding protein 6 (RanBP6) 174 2e-43
sp|Q8BIV3|RNBP6_MOUSE Ran-binding protein 6 (RanBP6) 173 4e-43
sp|Q8BKC5|IMB3_MOUSE Importin beta-3 (Karyopherin beta-3) (... 171 2e-42
sp|O74476|IMB3_SCHPO Importin beta-3 subunit 119 1e-26
sp|P32337|IMB3_YEAST Importin beta-3 subunit (Karyopherin b... 69 1e-11
sp|Q8VI75|IPO4_MOUSE Importin-4 (Importin 4a) (Imp4a) (Ran-... 52 1e-06
sp|Q8TEX9|IPO4_HUMAN Importin-4 (Importin 4b) (Imp4b) (Ran-... 45 2e-04
sp|O60100|IMB4_SCHPO Probable importin beta-4 subunit (Kary... 44 7e-04
sp|Q86VP6|CAND1_HUMAN Cullin-associated NEDD8-dissociated p... 35 0.31
>sp|O00410|IMB3_HUMAN Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)
Length = 1097
Score = 174 bits (442), Expect = 2e-43
Identities = 82/233 (35%), Positives = 144/233 (61%)
Frame = +1
Query: 10 VIKLIDPSRPWSDLQYGLCFLDDLLEFTGHDSWQHCCTLLPVFRSAIEHPIPEVRQAAAY 189
++ LI P RPW D Q+GLC DD++E S+++ L + PEVRQAAAY
Sbjct: 868 IVNLICPHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYFLRPMLQYVCDNSPEVRQAAAY 927
Query: 190 GFGLMAIHGGPQYQQFLSEVSEIMMRIMSNKNCRDVDNNLSTENVISALTKICKYQPNCI 369
G G+MA +GG Y+ F +E +++R++ + + + +N +TEN ISA+ KI K++P+C+
Sbjct: 928 GLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENVNATENCISAVGKIMKFKPDCV 987
Query: 370 LGGDVNRFLEVWLTWLPVYEDEEETPYVYGYLCELLENNNPVIIGSDNSNLGRVVKAIAT 549
+V L WL+WLP++ED+EE + YLC+L+E+N+P+++G +N+NL ++ IA
Sbjct: 988 ---NVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLIESNHPIVLGPNNTNLPKIFSIIAE 1044
Query: 550 CITKEALPVDNEVYRRCLGIIRMIQTNEQFFNQCVQNLSDDEKMSLIRALDRA 708
EA+ ++ +R ++R +QT+ + +C+ LS +++ ++ L+ A
Sbjct: 1045 GEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIAQLSPEQQAAIQELLNSA 1097
>sp|O60518|RNBP6_HUMAN Ran-binding protein 6 (RanBP6)
Length = 1105
Score = 174 bits (442), Expect = 2e-43
Identities = 86/233 (36%), Positives = 141/233 (60%)
Frame = +1
Query: 10 VIKLIDPSRPWSDLQYGLCFLDDLLEFTGHDSWQHCCTLLPVFRSAIEHPIPEVRQAAAY 189
++ LI SRPW D Q+GLC DD++E S+++ + PEVRQAAAY
Sbjct: 876 IVNLICSSRPWPDRQWGLCIFDDIIEHCSPTSFKYVEYFRWPMLLNMRDNNPEVRQAAAY 935
Query: 190 GFGLMAIHGGPQYQQFLSEVSEIMMRIMSNKNCRDVDNNLSTENVISALTKICKYQPNCI 369
G G+MA GG Y+ SE ++++++ N + N ++TEN ISA+ KI K++PNC+
Sbjct: 936 GLGVMAQFGGDDYRSLCSEAVPLLVKVIKCANSKTKKNVIATENCISAIGKILKFKPNCV 995
Query: 370 LGGDVNRFLEVWLTWLPVYEDEEETPYVYGYLCELLENNNPVIIGSDNSNLGRVVKAIAT 549
+V+ L WL+WLP++ED+EE +LC+L+E+N+PV+IG +NSNL +++ IA
Sbjct: 996 ---NVDEVLPHWLSWLPLHEDKEEAIQTLSFLCDLIESNHPVVIGPNNSNLPKIISIIAE 1052
Query: 550 CITKEALPVDNEVYRRCLGIIRMIQTNEQFFNQCVQNLSDDEKMSLIRALDRA 708
E + ++ +R ++R +QT+E + +CV L D+++ +L L+ A
Sbjct: 1053 GKINETINYEDPCAKRLANVVRQVQTSEDLWLECVSQLDDEQQEALQELLNFA 1105
>sp|Q8BIV3|RNBP6_MOUSE Ran-binding protein 6 (RanBP6)
Length = 439
Score = 173 bits (439), Expect = 4e-43
Identities = 86/233 (36%), Positives = 140/233 (60%)
Frame = +1
Query: 10 VIKLIDPSRPWSDLQYGLCFLDDLLEFTGHDSWQHCCTLLPVFRSAIEHPIPEVRQAAAY 189
++ LI SRPW D Q+GLC DD++E S+++ + PEVRQAAAY
Sbjct: 210 IVNLICSSRPWPDRQWGLCIFDDIIEHCSPTSFKYVEYFRWPMLLNMRDNNPEVRQAAAY 269
Query: 190 GFGLMAIHGGPQYQQFLSEVSEIMMRIMSNKNCRDVDNNLSTENVISALTKICKYQPNCI 369
G G+MA GG Y+ SE ++++++ N + N ++TEN ISA+ KI K++PNC+
Sbjct: 270 GLGVMAQFGGDDYRSLCSEAVPLLVKVIKCANSKTKKNVIATENCISAIGKILKFKPNCV 329
Query: 370 LGGDVNRFLEVWLTWLPVYEDEEETPYVYGYLCELLENNNPVIIGSDNSNLGRVVKAIAT 549
+V+ L WL+WLP++ED+EE +LC+L+E+N+PV+IG +NSNL +++ IA
Sbjct: 330 ---NVDEVLPHWLSWLPLHEDKEEAIQTLNFLCDLIESNHPVVIGPNNSNLPKIISIIAE 386
Query: 550 CITKEALPVDNEVYRRCLGIIRMIQTNEQFFNQCVQNLSDDEKMSLIRALDRA 708
E + ++ +R ++R IQT+E+ + +C L D+++ +L L A
Sbjct: 387 GKINETISHEDPCAKRLANVVRQIQTSEELWLECTSQLDDEQQEALHELLSFA 439
>sp|Q8BKC5|IMB3_MOUSE Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)
Length = 1097
Score = 171 bits (433), Expect = 2e-42
Identities = 80/233 (34%), Positives = 141/233 (60%)
Frame = +1
Query: 10 VIKLIDPSRPWSDLQYGLCFLDDLLEFTGHDSWQHCCTLLPVFRSAIEHPIPEVRQAAAY 189
++ LI P RPW D Q+GLC DD++E S+++ + + PEVRQAAAY
Sbjct: 868 IVNLICPQRPWPDRQWGLCIFDDIVEHCSPASFKYAEYFISPMLQYVCDNSPEVRQAAAY 927
Query: 190 GFGLMAIHGGPQYQQFLSEVSEIMMRIMSNKNCRDVDNNLSTENVISALTKICKYQPNCI 369
G G+MA GG Y+ F ++ +++R++ + +N +TEN ISA+ KI K++P+C+
Sbjct: 928 GLGVMAQFGGDNYRPFCTDALPLLVRVIQAPEAKTKENVNATENCISAVGKIMKFKPDCV 987
Query: 370 LGGDVNRFLEVWLTWLPVYEDEEETPYVYGYLCELLENNNPVIIGSDNSNLGRVVKAIAT 549
+V L WL+WLP++ED+EE + YLC+L+E+N+P+++G +N+NL ++ IA
Sbjct: 988 ---NVEEVLPHWLSWLPLHEDKEEAVQTFSYLCDLIESNHPIVLGPNNTNLPKIFSIIAE 1044
Query: 550 CITKEALPVDNEVYRRCLGIIRMIQTNEQFFNQCVQNLSDDEKMSLIRALDRA 708
EA+ ++ +R ++R +QT+ + +C+ LS +++ ++ L+ A
Sbjct: 1045 GEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIAQLSPEQQAAIQELLNSA 1097
>sp|O74476|IMB3_SCHPO Importin beta-3 subunit
Length = 1095
Score = 119 bits (297), Expect = 1e-26
Identities = 55/149 (36%), Positives = 87/149 (58%)
Frame = +1
Query: 52 QYGLCFLDDLLEFTGHDSWQHCCTLLPVFRSAIEHPIPEVRQAAAYGFGLMAIHGGPQYQ 231
Q+ LC +DDL+EFTG DSW + LP I+ PE+RQAA+YG G+ A HGG Y
Sbjct: 886 QWALCMMDDLIEFTGPDSWNYKDHFLPYLAEGIQSSEPEIRQAASYGIGVAAQHGGELYA 945
Query: 232 QFLSEVSEIMMRIMSNKNCRDVDNNLSTENVISALTKICKYQPNCILGGDVNRFLEVWLT 411
+ S + +++ + RD + +TEN+ A+ KIC++ + D+++ + W+
Sbjct: 946 EICSSALPALFKMLELPDARDEEQIYATENICVAICKICRFCSQRV--QDLDKVVTYWIN 1003
Query: 412 WLPVYEDEEETPYVYGYLCELLENNNPVI 498
LPV DE++ PY Y +L EL+E N+ +
Sbjct: 1004 TLPVTHDEDDAPYAYTFLAELMEQNHVAV 1032
>sp|P32337|IMB3_YEAST Importin beta-3 subunit (Karyopherin beta-3 subunit) (Protein
secretion enhancer 1)
Length = 1089
Score = 69.3 bits (168), Expect = 1e-11
Identities = 43/173 (24%), Positives = 81/173 (46%), Gaps = 1/173 (0%)
Frame = +1
Query: 55 YGLCFLDDLLEFTGHDSWQHCCTLLPVFRSAIEHPIPEVRQAAAYGFGLMAIHGGPQYQQ 234
+ L + DL+++ G + +P + P +RQAA+Y G+ A + Y
Sbjct: 878 FALVVIGDLIQYGGEQTASMKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYAD 937
Query: 235 FLSEVSEIMMRIMSNKNCRDVDNNLSTENVISALTKIC-KYQPNCILGGDVNRFLEVWLT 411
+ +++I+ + +N STEN +A+ KI Y N +V+ + W
Sbjct: 938 VCIPTLDTLVQIVDFPGSKLEENRSSTENASAAIAKILYAYNSNI---PNVDTYTANWFK 994
Query: 412 WLPVYEDEEETPYVYGYLCELLENNNPVIIGSDNSNLGRVVKAIATCITKEAL 570
LP D+E + Y +L +L+ENN+P++ SN+ VV ++ + + +L
Sbjct: 995 TLPTITDKEAASFNYQFLSQLIENNSPIVCA--QSNISAVVDSVIQALNERSL 1045
>sp|Q8VI75|IPO4_MOUSE Importin-4 (Importin 4a) (Imp4a) (Ran-binding protein 4) (RanBP4)
Length = 1082
Score = 52.4 bits (124), Expect = 1e-06
Identities = 49/206 (23%), Positives = 89/206 (43%)
Frame = +1
Query: 70 LDDLLEFTGHDSWQHCCTLLPVFRSAIEHPIPEVRQAAAYGFGLMAIHGGPQYQQFLSEV 249
L + ++ G S Q L PV + PEVR A +G G++A HGG Q ++
Sbjct: 883 LAESIQGLGTASAQFVSRLFPVLLNNAREADPEVRSNAIFGLGVLAEHGGCPAQDHFPKL 942
Query: 250 SEIMMRIMSNKNCRDVDNNLSTENVISALTKICKYQPNCILGGDVNRFLEVWLTWLPVYE 429
+++ +++ + ++ +N+ AL ++ P +G + L L LP+ E
Sbjct: 943 LGLLLPLLARER-----HDRVRDNICGALARVLMASP---VGKTEPQVLATLLRALPLKE 994
Query: 430 DEEETPYVYGYLCELLENNNPVIIGSDNSNLGRVVKAIATCITKEALPVDNEVYRRCLGI 609
D EE G+L L NNP + S L R+ I + +P D + L +
Sbjct: 995 DMEEW-LTIGHLFSFLHQNNPEQVVDVASELLRICSLI---LPDNRIPPDTKAALLLL-L 1049
Query: 610 IRMIQTNEQFFNQCVQNLSDDEKMSL 687
+ + + F+ + +L +D+ L
Sbjct: 1050 TFLAKQHTDSFHTALGSLPNDKAQEL 1075
>sp|Q8TEX9|IPO4_HUMAN Importin-4 (Importin 4b) (Imp4b) (Ran-binding protein 4) (RanBP4)
Length = 1081
Score = 45.1 bits (105), Expect = 2e-04
Identities = 37/141 (26%), Positives = 64/141 (45%)
Frame = +1
Query: 70 LDDLLEFTGHDSWQHCCTLLPVFRSAIEHPIPEVRQAAAYGFGLMAIHGGPQYQQFLSEV 249
L + ++ G S Q LLPV S + PEVR A +G G++A HGG Q+ ++
Sbjct: 882 LAETIQGLGAASAQFVSRLLPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKL 941
Query: 250 SEIMMRIMSNKNCRDVDNNLSTENVISALTKICKYQPNCILGGDVNRFLEVWLTWLPVYE 429
++ +++ + ++ +N+ AL ++ P + L L LP+ E
Sbjct: 942 LGLLFPLLARER-----HDRVRDNICGALARLLMASPT---RKPEPQVLAALLHALPLKE 993
Query: 430 DEEETPYVYGYLCELLENNNP 492
D EE + G L L ++P
Sbjct: 994 DLEEWVTI-GRLFSFLYQSSP 1013
>sp|O60100|IMB4_SCHPO Probable importin beta-4 subunit (Karyopherin beta-4 subunit)
(Importin 123)
Length = 1067
Score = 43.5 bits (101), Expect = 7e-04
Identities = 34/163 (20%), Positives = 71/163 (43%)
Frame = +1
Query: 133 VFRSAIEHPIPEVRQAAAYGFGLMAIHGGPQYQQFLSEVSEIMMRIMSNKNCRDVDNNLS 312
+F +A+E EVR AAY GL+ + + + + + R +
Sbjct: 898 LFMAALEDSEGEVRSNAAYSMGLLCQFSTEDLSSEYLNILQKLQPFFTQEVFR-----TA 952
Query: 313 TENVISALTKICKYQPNCILGGDVNRFLEVWLTWLPVYEDEEETPYVYGYLCELLENNNP 492
+N I ++++ + N I V++ L + + LP+ ED E +Y + L NP
Sbjct: 953 LDNAIGCISRLILHNQNAI---PVDQVLPIVFSKLPLKEDYLENAPLYHMILALYRQQNP 1009
Query: 493 VIIGSDNSNLGRVVKAIATCITKEALPVDNEVYRRCLGIIRMI 621
++ +LG ++ A+ +T +++E+ L +++ I
Sbjct: 1010 CLV----QHLGELIPVFASVLTGSPEQLNDELRSELLSMVKEI 1048
>sp|Q86VP6|CAND1_HUMAN Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and
neddylation-dissociated protein 1) (p120 CAND1)
(TBP-interacting protein TIP120A) (TBP-interacting
protein of 120 kDa A)
Length = 1230
Score = 34.7 bits (78), Expect = 0.31
Identities = 42/170 (24%), Positives = 72/170 (42%), Gaps = 9/170 (5%)
Frame = +1
Query: 124 LLPVFRSAIEHPIPEVRQAAAYGFGLMAIHGGPQYQQFLSE--VSEIMMRIMSNKNCRDV 297
L V A P EV+ AA+Y G +++ P+Y F+ + S+ + + + +++
Sbjct: 857 LKSVILEAFSSPSEEVKSAASYALGSISVGNLPEYLPFVLQEITSQPKRQYLLLHSLKEI 916
Query: 298 DNNLS-------TENVISALTKICKYQPNCILGGDVNRFLEVWLTWLPVYEDEEETPYVY 456
++ S EN+ + L K C+ C G N E L L + + E P +
Sbjct: 917 ISSASVVGLKPYVENIWALLLKHCE----CAEEGTRNVVAEC-LGKLTLIDPETLLPRLK 971
Query: 457 GYLCELLENNNPVIIGSDNSNLGRVVKAIATCITKEALPVDNEVYRRCLG 606
GYL I GS + VV A+ I+ P+D + + C+G
Sbjct: 972 GYL----------ISGSSYAR-SSVVTAVKFTISDHPQPID-PLLKNCIG 1009
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,419,163
Number of Sequences: 369166
Number of extensions: 1659307
Number of successful extensions: 5857
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5658
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5843
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7454154400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)