Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_M24
(666 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q19673|TYR3_CAEEL Putative tyrosinase-like protein tyr-3... 116 6e-26
sp|Q20191|NAS13_CAEEL Zinc metalloproteinase nas-13 precurs... 65 2e-10
sp|Q90Y54|JAG1B_BRARE Jagged-1b precursor (Jagged1b) (Jagged3) 65 2e-10
sp|P78504|JAG1_HUMAN Jagged-1 precursor (Jagged1) (hJ1) (CD... 64 5e-10
sp|P34269|TYR1_CAEEL Putative tyrosinase-like protein tyr-1... 61 3e-09
sp|Q9QXX0|JAG1_MOUSE Jagged-1 precursor (Jagged1) 60 7e-09
sp|Q63722|JAG1_RAT Jagged-1 precursor (Jagged1) 60 7e-09
sp|Q6DI48|DLLA_BRARE Delta-like protein A precursor (DeltaA... 58 3e-08
sp|P55115|NAS15_CAEEL Zinc metalloproteinase nas-15 precurs... 57 3e-08
sp|Q9QYE5|JAG2_MOUSE Jagged-2 precursor (Jagged2) 57 4e-08
>sp|Q19673|TYR3_CAEEL Putative tyrosinase-like protein tyr-3 precursor
Length = 683
Score = 116 bits (290), Expect = 6e-26
Identities = 64/212 (30%), Positives = 88/212 (41%), Gaps = 36/212 (16%)
Frame = +1
Query: 16 NCLNSHESCDTWADRGECASNPGYMLVSCKKACNVC----GKENKCADYRKRCPIMAKYG 183
+C N +E C W+ +GEC NP YM V CK +C C +C+D C + ++ G
Sbjct: 461 SCFNENECCGPWSAKGECQKNPVYMNVWCKASCRQCTPNYNINEECSDRHTNCAMWSRSG 520
Query: 184 LCESDPSFMLQNCKESCGVC---------------------------DGSSKNRP----- 267
C +P +M +NC+ SC C + +N P
Sbjct: 521 ECNKNPLWMSENCRSSCQKCGRSRAATCGGGGGADSISNPTTMPPATNNGQQNTPCDSPM 580
Query: 268 CVDANQDCAGWAASHECETNPSWMLYNCKKSCNHCRDARLESISNPNCKDLQIHCLYWAN 447
C + +Q C WA +C +NP +M CK SC CR + P C D C WA
Sbjct: 581 CYNEDQCCPIWAQRGQCRSNPGYMTCQCKVSCGVCRP---NYVYGP-CADYHYDCAAWAR 636
Query: 448 AGECQLNPGWAKQNCPFSCQHCGGCRDLIQNC 543
GEC N W +NC SC C + L C
Sbjct: 637 RGECLKNK-WMPENCRRSCNTCVNQQQLAARC 667
Score = 106 bits (264), Expect = 6e-23
Identities = 63/203 (31%), Positives = 89/203 (43%), Gaps = 35/203 (17%)
Frame = +1
Query: 121 CGKENKCADYRKRCPIMAKYGLCESDPSFMLQNCKESCGVCDGSSK-NRPCVDANQDCAG 297
C EN+C C + G C+ +P +M CK SC C + N C D + +CA
Sbjct: 462 CFNENEC------CGPWSAKGECQKNPVYMNVWCKASCRQCTPNYNINEECSDRHTNCAM 515
Query: 298 WAASHECETNPSWMLYNCKKSCNHCRDAR---------LESISNPN-------------- 408
W+ S EC NP WM NC+ SC C +R +SISNP
Sbjct: 516 WSRSGECNKNPLWMSENCRSSCQKCGRSRAATCGGGGGADSISNPTTMPPATNNGQQNTP 575
Query: 409 -----CKDLQIHCLYWANAGECQLNPGWAKQNCPFSCQHC------GGCRDLIQNCQNFA 555
C + C WA G+C+ NPG+ C SC C G C D +C +A
Sbjct: 576 CDSPMCYNEDQCCPIWAQRGQCRSNPGYMTCQCKVSCGVCRPNYVYGPCADYHYDCAAWA 635
Query: 556 NQGYCKTNEVYMNQSCKKTCGFC 624
+G C N+ +M ++C+++C C
Sbjct: 636 RRGECLKNK-WMPENCRRSCNTC 657
Score = 76.6 bits (187), Expect = 5e-14
Identities = 34/81 (41%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Frame = +1
Query: 10 NPNCLNSHESCDTWADRGECASNPGYMLVSCKKACNVCGKE---NKCADYRKRCPIMAKY 180
+P C N + C WA RG+C SNPGYM CK +C VC CADY C A+
Sbjct: 578 SPMCYNEDQCCPIWAQRGQCRSNPGYMTCQCKVSCGVCRPNYVYGPCADYHYDCAAWARR 637
Query: 181 GLCESDPSFMLQNCKESCGVC 243
G C + +M +NC+ SC C
Sbjct: 638 GECLKN-KWMPENCRRSCNTC 657
>sp|Q20191|NAS13_CAEEL Zinc metalloproteinase nas-13 precursor (Nematode astacin 13)
Length = 527
Score = 65.1 bits (157), Expect = 2e-10
Identities = 36/84 (42%), Positives = 41/84 (48%), Gaps = 5/84 (5%)
Frame = +1
Query: 136 KCADYRKRCPIMAKYGLCESDPS--FMLQNCKESCGVCDGSSKNRP-CVDANQDCAGWAA 306
KC D RK C +A+ G CES S FM +NC SCG C K + C DA C WA
Sbjct: 444 KCEDRRKDCEFLARAGHCESRFSIRFMTENCANSCGKCIAEEKRKEVCEDARTWCERWAN 503
Query: 307 SHECETN--PSWMLYNCKKSCNHC 372
S C +M C KSCN C
Sbjct: 504 SGMCNQTVFKDYMRQKCAKSCNFC 527
Score = 49.3 bits (116), Expect = 9e-06
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 11/83 (13%)
Frame = +1
Query: 409 CKDLQIHCLYWANAGECQ--LNPGWAKQNCPFSCQHCGG-------CRDLIQNCQNFANQ 561
C+D + C + A AG C+ + + +NC SC C C D C+ +AN
Sbjct: 445 CEDRRKDCEFLARAGHCESRFSIRFMTENCANSCGKCIAEEKRKEVCEDARTWCERWANS 504
Query: 562 GYCKTN--EVYMNQSCKKTCGFC 624
G C + YM Q C K+C FC
Sbjct: 505 GMCNQTVFKDYMRQKCAKSCNFC 527
Score = 47.8 bits (112), Expect = 3e-05
Identities = 28/86 (32%), Positives = 38/86 (44%), Gaps = 4/86 (4%)
Frame = +1
Query: 268 CVDANQDCAGWAASHECETNPS--WMLYNCKKSCNHCRDARLESISNPNCKDLQIHCLYW 441
C D +DC A + CE+ S +M NC SC C E C+D + C W
Sbjct: 445 CEDRRKDCEFLARAGHCESRFSIRFMTENCANSCGKCI---AEEKRKEVCEDARTWCERW 501
Query: 442 ANAGECQ--LNPGWAKQNCPFSCQHC 513
AN+G C + + +Q C SC C
Sbjct: 502 ANSGMCNQTVFKDYMRQKCAKSCNFC 527
Score = 42.7 bits (99), Expect = 8e-04
Identities = 25/83 (30%), Positives = 34/83 (40%), Gaps = 8/83 (9%)
Frame = +1
Query: 19 CLNSHESCDTWADRGECASNPG--YMLVSCKKACNVCGKENK----CADYRKRCPIMAKY 180
C + + C+ A G C S +M +C +C C E K C D R C A
Sbjct: 445 CEDRRKDCEFLARAGHCESRFSIRFMTENCANSCGKCIAEEKRKEVCEDARTWCERWANS 504
Query: 181 GLCESD--PSFMLQNCKESCGVC 243
G+C +M Q C +SC C
Sbjct: 505 GMCNQTVFKDYMRQKCAKSCNFC 527
Score = 31.2 bits (69), Expect = 2.5
Identities = 12/39 (30%), Positives = 23/39 (58%), Gaps = 2/39 (5%)
Frame = +1
Query: 514 GGCRDLIQNCQNFANQGYCKT--NEVYMNQSCKKTCGFC 624
G C D ++C+ A G+C++ + +M ++C +CG C
Sbjct: 443 GKCEDRRKDCEFLARAGHCESRFSIRFMTENCANSCGKC 481
>sp|Q90Y54|JAG1B_BRARE Jagged-1b precursor (Jagged1b) (Jagged3)
Length = 1213
Score = 64.7 bits (156), Expect = 2e-10
Identities = 55/237 (23%), Positives = 87/237 (36%), Gaps = 34/237 (14%)
Frame = +1
Query: 19 CLNSHESCDTWADRGECASNPGYMLVSCKKACNVCGKENKCAD----------YRKRCPI 168
CLN +T D+ +C+ GY V+C++A + C N CA+ Y C I
Sbjct: 303 CLNGGTCSNTGPDKYQCSCEDGYSGVNCERAEHAC-LSNPCANGGTCKETSQGYECHCAI 361
Query: 169 MAKYGLCESDPSFMLQN-CK----------------------ESCGVCDGSSKNRPCVDA 279
CE + N CK ++C + +++PCV+A
Sbjct: 362 GWSGTSCEINVDDCTPNQCKHGGTCQDLVNGFKCACPPHWTGKTCQIDANECEDKPCVNA 421
Query: 280 NQDCAGWAASHECETNPSWMLYNCKKSCNHCRDARLESISNPNCKDLQIHCLYWANAGEC 459
+ C ++ CE P W NC + N C+ + ++ CKDL N C
Sbjct: 422 -KSCHNLIGAYFCECLPGWSGQNCDININDCKG---QCLNGGTCKDL-------VNGYRC 470
Query: 460 QLNPGWAKQNCPFSCQHCGGCRDLI-QNCQNFANQGYCKTNEVYMNQSCKKTCGFCR 627
PG+ + C C L CQ+ N C + Q C+ +C+
Sbjct: 471 LCPPGYTGEQCEKDVDECASSPCLNGGRCQDEVNGFQCLCPAGFSGQLCQLDIDYCK 527
Score = 34.7 bits (78), Expect = 0.23
Identities = 47/226 (20%), Positives = 77/226 (34%), Gaps = 24/226 (10%)
Frame = +1
Query: 19 CLNSHESCDTWADRGECASNPGYMLVSCKKACNVCGKENKCADYRKRCPIMAKYGLCESD 198
CLN C + +C G+ C+ + C K N C + +C +A C+
Sbjct: 493 CLNGGR-CQDEVNGFQCLCPAGFSGQLCQLDIDYC-KPNPCQN-GAQCFNLASDYFCKCP 549
Query: 199 PSFMLQNCKE--------SCGVCDG-----SSKNRP----------CVDANQDCAGWAAS 309
+ +NC SC V D +S + P C + +
Sbjct: 550 DDYEGKNCSHLKDHCRTTSCQVIDSCTVAVASNSTPEGVRYISSNVCGPHGRCRSQAGGQ 609
Query: 310 HECETNPSWMLYNCKKSCNHCRDARLESISNPNCKDLQIHCLYWANAGECQLNPGWAKQN 489
CE + C ++ N C SNP C++ C+ N +C GW +
Sbjct: 610 FTCECQEGFRGTYCHENINDCE-------SNP-CRNGGT-CIDKVNVYQCICADGWEGVH 660
Query: 490 CPFSCQHCGGCRDLIQN-CQNFANQGYCKTNEVYMNQSCKKTCGFC 624
C + C L + CQ+ N YC+ + ++C C
Sbjct: 661 CEINIDDCSLNPCLNKGACQDLVNDFYCECRNGWKGKTCHSRDSQC 706
Score = 33.1 bits (74), Expect = 0.67
Identities = 25/119 (21%), Positives = 45/119 (37%)
Frame = +1
Query: 25 NSHESCDTWADRGECASNPGYMLVSCKKACNVCGKENKCADYRKRCPIMAKYGLCESDPS 204
N+ +C D +C +PG+ +C A N N C + C + C
Sbjct: 712 NNGGTCHDEGDTFKCRCSPGWEGATCNIAKNSSCLPNPC-ENGGTCVVNGDSFNCVCKEG 770
Query: 205 FMLQNCKESCGVCDGSSKNRPCVDANQDCAGWAASHECETNPSWMLYNCKKSCNHCRDA 381
+ C E+ C+ PC ++ C + CE P + +C+ + N C+ +
Sbjct: 771 WEGSTCTENTNDCN----PHPCYNSG-TCVDGENWYRCECAPGFAGPDCRININECQSS 824
Score = 29.3 bits (64), Expect = 9.7
Identities = 38/166 (22%), Positives = 60/166 (36%), Gaps = 12/166 (7%)
Frame = +1
Query: 10 NPNCLNSHESCDTWADRGECASNPGYMLVSCKKA---CN--VCGKENKCAD----YRKRC 162
NP CLN +C + C G+ +C C+ C C D ++ RC
Sbjct: 671 NP-CLNKG-ACQDLVNDFYCECRNGWKGKTCHSRDSQCDEATCNNGGTCHDEGDTFKCRC 728
Query: 163 PIMAKYGLCE-SDPSFMLQNCKESCGVC--DGSSKNRPCVDANQDCAGWAASHECETNPS 333
+ C + S L N E+ G C +G S N C + + +++C +P
Sbjct: 729 SPGWEGATCNIAKNSSCLPNPCENGGTCVVNGDSFNCVCKEGWEGSTCTENTNDCNPHPC 788
Query: 334 WMLYNCKKSCNHCRDARLESISNPNCKDLQIHCLYWANAGECQLNP 471
+ C N R + P+C+ N ECQ +P
Sbjct: 789 YNSGTCVDGENWYRCECAPGFAGPDCR---------ININECQSSP 825
>sp|P78504|JAG1_HUMAN Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen)
Length = 1218
Score = 63.5 bits (153), Expect = 5e-10
Identities = 59/248 (23%), Positives = 92/248 (37%), Gaps = 41/248 (16%)
Frame = +1
Query: 7 SNPNCLNSHESC--DTWADRG---------ECASNPGYMLVSCKKACNVCGKENKCADYR 153
S PNC + +C D +RG EC +PG+ +C + C N +
Sbjct: 329 SGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNN--CSHG 386
Query: 154 KRCPIMAKYGLCESDPSFMLQNCKESCGVCDGSSKNRPCVDANQDCAGWAASHECETNPS 333
C + C P + + C+ C+ +PCV+A + C AS+ C+ P
Sbjct: 387 GTCQDLVNGFKCVCPPQWTGKTCQLDANECEA----KPCVNA-KSCKNLIASYYCDCLPG 441
Query: 334 WMLYNCKKSCNHC-----RDARLESISN------------PNC-KDLQI----------H 429
WM NC + N C DA + N +C +D+ H
Sbjct: 442 WMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGH 501
Query: 430 CLYWANAGECQLNPGWAKQNCPFSCQHC--GGCRDLIQNCQNFANQGYCKTNEVYMNQSC 603
C N +C G++ C +C C++ Q C N A+ +CK E Y ++C
Sbjct: 502 CQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQ-CYNRASDYFCKCPEDYEGKNC 560
Query: 604 KKTCGFCR 627
CR
Sbjct: 561 SHLKDHCR 568
Score = 56.2 bits (134), Expect = 7e-08
Identities = 46/190 (24%), Positives = 71/190 (37%), Gaps = 7/190 (3%)
Frame = +1
Query: 19 CLNSHESCDTWADRGECASNPGYMLVSCKKACNVCGKENKCADYRKRCPIMAKYGLCESD 198
CLN +T D+ +C+ GY +C+ A + C + C + R C + CE
Sbjct: 306 CLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHAC-LSDPCHN-RGSCKETSLGFECECS 363
Query: 199 PSFMLQNCKESCGVCDGSSKNRPCVDANQDCAGWAASHECETNPSWMLYNCKKSCNHCRD 378
P + C + C ++ + C +C P W C+ N C
Sbjct: 364 PGWTGPTCSTNIDDCSPNNCSH-----GGTCQDLVNGFKCVCPPQWTGKTCQLDANECEA 418
Query: 379 ARLESISNPNCKDLQIHCLYWANAGECQLNPGWAKQNCPFS-------CQHCGGCRDLIQ 537
++ +CK+L I Y C PGW QNC + CQ+ CRDL+
Sbjct: 419 K--PCVNAKSCKNL-IASYY------CDCLPGWMGQNCDININDCLGQCQNDASCRDLVN 469
Query: 538 NCQNFANQGY 567
+ GY
Sbjct: 470 GYRCICPPGY 479
Score = 33.9 bits (76), Expect = 0.39
Identities = 49/237 (20%), Positives = 81/237 (34%), Gaps = 40/237 (16%)
Frame = +1
Query: 37 SCDTWADRGECASNPGYMLVSCKKACNVCGK---------ENKCADYRKRCPIMAKYGLC 189
SC + C PGY C++ + C +N+ ++ CP LC
Sbjct: 463 SCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLC 522
Query: 190 ESDPSFMLQNCKESCGVCDGSSKNRPCVDANQDCAGWAASHECETNPSWMLYNCKKSCNH 369
+ D + N PC + Q C A+ + C+ + NC +H
Sbjct: 523 QLDIDYCEPN---------------PCQNGAQ-CYNRASDYFCKCPEDYEGKNCSHLKDH 566
Query: 370 CRDARLESI--------SNPNCKDLQI--------HCLYWANAG---ECQLNPGWAKQNC 492
CR E I SN + ++ H + +G C N G+ C
Sbjct: 567 CRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYC 626
Query: 493 PFS--------CQHCGGCRDLIQNCQNFANQG----YCKTNEVYMNQSCKKTCGFCR 627
+ C++ G C D + + + + G YC+TN +Q+ G CR
Sbjct: 627 HENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCR 683
>sp|P34269|TYR1_CAEEL Putative tyrosinase-like protein tyr-1 precursor
Length = 601
Score = 60.8 bits (146), Expect = 3e-09
Identities = 30/98 (30%), Positives = 43/98 (43%)
Frame = +1
Query: 268 CVDANQDCAGWAASHECETNPSWMLYNCKKSCNHCRDARLESISNPNCKDLQIHCLYWAN 447
C + + C W+ +EC TN +M C+KSC C+ + +N C D I C YW
Sbjct: 480 CYNEDPCCNQWSRQNECRTNTVYMNRYCRKSCGLCQS----NDNNRGCHDRHISCAYWRG 535
Query: 448 AGECQLNPGWAKQNCPFSCQHCGGCRDLIQNCQNFANQ 561
C W +NC +C C + Q C + A Q
Sbjct: 536 QNFCTRRRQWMAENCQATCGWCN--MNEAQLCASVARQ 571
Score = 60.5 bits (145), Expect = 4e-09
Identities = 23/81 (28%), Positives = 40/81 (49%)
Frame = +1
Query: 130 ENKCADYRKRCPIMAKYGLCESDPSFMLQNCKESCGVCDGSSKNRPCVDANQDCAGWAAS 309
++ C + C ++ C ++ +M + C++SCG+C + NR C D + CA W
Sbjct: 477 QSNCYNEDPCCNQWSRQNECRTNTVYMNRYCRKSCGLCQSNDNNRGCHDRHISCAYWRGQ 536
Query: 310 HECETNPSWMLYNCKKSCNHC 372
+ C WM NC+ +C C
Sbjct: 537 NFCTRRRQWMAENCQATCGWC 557
Score = 56.6 bits (135), Expect = 6e-08
Identities = 24/80 (30%), Positives = 37/80 (46%), Gaps = 3/80 (3%)
Frame = +1
Query: 16 NCLNSHESCDTWADRGECASNPGYMLVSCKKACNVCGKENK---CADYRKRCPIMAKYGL 186
NC N C+ W+ + EC +N YM C+K+C +C + C D C
Sbjct: 479 NCYNEDPCCNQWSRQNECRTNTVYMNRYCRKSCGLCQSNDNNRGCHDRHISCAYWRGQNF 538
Query: 187 CESDPSFMLQNCKESCGVCD 246
C +M +NC+ +CG C+
Sbjct: 539 CTRRRQWMAENCQATCGWCN 558
Score = 50.4 bits (119), Expect = 4e-06
Identities = 23/79 (29%), Positives = 36/79 (45%), Gaps = 6/79 (7%)
Frame = +1
Query: 406 NCKDLQIHCLYWANAGECQLNPGWAKQNCPFSCQHCG------GCRDLIQNCQNFANQGY 567
NC + C W+ EC+ N + + C SC C GC D +C + Q +
Sbjct: 479 NCYNEDPCCNQWSRQNECRTNTVYMNRYCRKSCGLCQSNDNNRGCHDRHISCAYWRGQNF 538
Query: 568 CKTNEVYMNQSCKKTCGFC 624
C +M ++C+ TCG+C
Sbjct: 539 CTRRRQWMAENCQATCGWC 557
Score = 42.4 bits (98), Expect = 0.001
Identities = 14/29 (48%), Positives = 21/29 (72%)
Frame = +1
Query: 541 CQNFANQGYCKTNEVYMNQSCKKTCGFCR 627
C ++ Q C+TN VYMN+ C+K+CG C+
Sbjct: 487 CNQWSRQNECRTNTVYMNRYCRKSCGLCQ 515
>sp|Q9QXX0|JAG1_MOUSE Jagged-1 precursor (Jagged1)
Length = 1218
Score = 59.7 bits (143), Expect = 7e-09
Identities = 50/211 (23%), Positives = 85/211 (40%), Gaps = 2/211 (0%)
Frame = +1
Query: 1 DNSNPNCLNSHESCDTWADRGECASNPGYMLVSCKKACNVCGKENKCADYRKRCPIMAKY 180
D+ +PN + +C + +C P + +C+ N C + C + R ++A Y
Sbjct: 376 DDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANEC-EAKPCVNARSCKNLIASY 434
Query: 181 GLCESDPSFMLQNCKESCGVCDGSSKNRPCVDANQDCAGWAASHECETNPSWMLYNCKKS 360
C+ P +M QNC + C G +N + C + C P + +C++
Sbjct: 435 -YCDCLPGWMGQNCDININDCLGQCQN------DASCRDLVNGYRCICPPGYAGDHCERD 487
Query: 361 CNHCRDARLESISNPNCKDLQIHCLYWANAGECQLNPGWAKQNCPFSCQHC--GGCRDLI 534
+ C SNP C + HC N +C G++ C +C C++
Sbjct: 488 IDEC-------ASNP-CLN-GGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGA 538
Query: 535 QNCQNFANQGYCKTNEVYMNQSCKKTCGFCR 627
Q C N A+ +CK E Y ++C CR
Sbjct: 539 Q-CYNRASDYFCKCPEDYEGKNCSHLKDHCR 568
Score = 56.2 bits (134), Expect = 7e-08
Identities = 46/190 (24%), Positives = 71/190 (37%), Gaps = 7/190 (3%)
Frame = +1
Query: 19 CLNSHESCDTWADRGECASNPGYMLVSCKKACNVCGKENKCADYRKRCPIMAKYGLCESD 198
CLN +T D+ +C+ GY +C+ A + C + C + R C + CE
Sbjct: 306 CLNRGTCSNTGPDKYQCSCPEGYSGPNCEIAEHAC-LSDPCHN-RGSCKETSSGFECECS 363
Query: 199 PSFMLQNCKESCGVCDGSSKNRPCVDANQDCAGWAASHECETNPSWMLYNCKKSCNHCRD 378
P + C + C ++ + C +C P W C+ N C
Sbjct: 364 PGWTGPTCSTNIDDCSPNNCSH-----GGTCQDLVNGFKCVCPPQWTGKTCQLDANECEA 418
Query: 379 ARLESISNPNCKDLQIHCLYWANAGECQLNPGWAKQNCPFS-------CQHCGGCRDLIQ 537
++ +CK+L I Y C PGW QNC + CQ+ CRDL+
Sbjct: 419 K--PCVNARSCKNL-IASYY------CDCLPGWMGQNCDININDCLGQCQNDASCRDLVN 469
Query: 538 NCQNFANQGY 567
+ GY
Sbjct: 470 GYRCICPPGY 479
Score = 39.7 bits (91), Expect = 0.007
Identities = 40/177 (22%), Positives = 61/177 (34%), Gaps = 14/177 (7%)
Frame = +1
Query: 115 NVCGKENKCADYRKRCPIMAKYGLCESDPSFMLQNCKESCGVCDGSSKNRPCVDANQDCA 294
NVCG KC K+ C+ + F C E+ C+ + PC + C
Sbjct: 597 NVCGPHGKCKSQSG-----GKF-TCDCNKGFTGTYCHENINDCESN----PCKNGGT-CI 645
Query: 295 GWAASHECETNPSWMLYNCKKSCNHCRDARLESISNP-----NCKDLQIHCLYWANAGEC 459
S++C + W +C+ + N C NP C+DL N C
Sbjct: 646 DGVNSYKCICSDGWEGAHCENNINDCS-------QNPCHYGGTCRDL-------VNDFYC 691
Query: 460 QLNPGWAKQNC--------PFSCQHCGGCRDLIQNCQNFANQGYCKTN-EVYMNQSC 603
GW + C +C + G C D + + G+ T + N SC
Sbjct: 692 DCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEVDTFKCMCPGGWEGTTCNIARNSSC 748
Score = 32.3 bits (72), Expect = 1.1
Identities = 28/131 (21%), Positives = 45/131 (34%), Gaps = 9/131 (6%)
Frame = +1
Query: 37 SCDTWADRGECASNPGYMLVSCKKACNVCGK---------ENKCADYRKRCPIMAKYGLC 189
SC + C PGY C++ + C +N+ ++ CP LC
Sbjct: 463 SCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLC 522
Query: 190 ESDPSFMLQNCKESCGVCDGSSKNRPCVDANQDCAGWAASHECETNPSWMLYNCKKSCNH 369
+ D + N PC + Q C A+ + C+ + NC +H
Sbjct: 523 QLDIDYCEPN---------------PCQNGAQ-CYNRASDYFCKCPEDYEGKNCSHLKDH 566
Query: 370 CRDARLESISN 402
CR E I +
Sbjct: 567 CRTTTCEVIDS 577
>sp|Q63722|JAG1_RAT Jagged-1 precursor (Jagged1)
Length = 1219
Score = 59.7 bits (143), Expect = 7e-09
Identities = 50/211 (23%), Positives = 85/211 (40%), Gaps = 2/211 (0%)
Frame = +1
Query: 1 DNSNPNCLNSHESCDTWADRGECASNPGYMLVSCKKACNVCGKENKCADYRKRCPIMAKY 180
D+ +PN + +C + +C P + +C+ N C + C + R ++A Y
Sbjct: 376 DDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANEC-EAKPCVNARSCKNLIASY 434
Query: 181 GLCESDPSFMLQNCKESCGVCDGSSKNRPCVDANQDCAGWAASHECETNPSWMLYNCKKS 360
C+ P +M QNC + C G +N + C + C P + +C++
Sbjct: 435 -YCDCLPGWMGQNCDININDCLGQCQN------DASCRDLVNGYRCICPPGYAGDHCERD 487
Query: 361 CNHCRDARLESISNPNCKDLQIHCLYWANAGECQLNPGWAKQNCPFSCQHC--GGCRDLI 534
+ C SNP C + HC N +C G++ C +C C++
Sbjct: 488 IDEC-------ASNP-CLN-GGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGA 538
Query: 535 QNCQNFANQGYCKTNEVYMNQSCKKTCGFCR 627
Q C N A+ +CK E Y ++C CR
Sbjct: 539 Q-CYNRASDYFCKCPEDYEGKNCSHLKDHCR 568
Score = 56.2 bits (134), Expect = 7e-08
Identities = 46/190 (24%), Positives = 71/190 (37%), Gaps = 7/190 (3%)
Frame = +1
Query: 19 CLNSHESCDTWADRGECASNPGYMLVSCKKACNVCGKENKCADYRKRCPIMAKYGLCESD 198
CLN +T D+ +C+ GY +C+ A + C + C + R C + CE
Sbjct: 306 CLNRGTCSNTGPDKYQCSCPEGYSGPNCEIAEHAC-LSDPCHN-RGSCKETSSGFECECS 363
Query: 199 PSFMLQNCKESCGVCDGSSKNRPCVDANQDCAGWAASHECETNPSWMLYNCKKSCNHCRD 378
P + C + C ++ + C +C P W C+ N C
Sbjct: 364 PGWTGPTCSTNIDDCSPNNCSH-----GGTCQDLVNGFKCVCPPQWTGKTCQLDANECEA 418
Query: 379 ARLESISNPNCKDLQIHCLYWANAGECQLNPGWAKQNCPFS-------CQHCGGCRDLIQ 537
++ +CK+L I Y C PGW QNC + CQ+ CRDL+
Sbjct: 419 K--PCVNARSCKNL-IASYY------CDCLPGWMGQNCDININDCLGQCQNDASCRDLVN 469
Query: 538 NCQNFANQGY 567
+ GY
Sbjct: 470 GYRCICPPGY 479
Score = 43.1 bits (100), Expect = 6e-04
Identities = 48/223 (21%), Positives = 76/223 (34%), Gaps = 28/223 (12%)
Frame = +1
Query: 19 CLNSHESCDTWADRGECASNPGYMLVSCKKAC--------------NVCGKENKCADYRK 156
C +E + + C + P ++ SC A NVCG KC
Sbjct: 551 CPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKC----- 605
Query: 157 RCPIMAKYGLCESDPSFMLQNCKESCGVCDGSSKNRPCVDANQDCAGWAASHECETNPSW 336
+ K+ C+ + F C E+ C+G+ PC + C S++C + W
Sbjct: 606 KSESGGKF-TCDCNKGFTGTYCHENINDCEGN----PCTNGGT-CIDGVNSYKCICSDGW 659
Query: 337 MLYNCKKSCNHCRDARLESISNP-----NCKDLQIHCLYWANAGECQLNPGWAKQNC--- 492
+C+ + N C NP C+DL N C GW + C
Sbjct: 660 EGAHCENNINDCS-------QNPCHYGGTCRDL-------VNDFYCDCKNGWKGKTCHSR 705
Query: 493 -----PFSCQHCGGCRDLIQNCQNFANQGYCKTN-EVYMNQSC 603
+C + G C D + + G+ T + N SC
Sbjct: 706 DSQCDEATCNNGGTCYDEVDTFKCMCPGGWEGTTCNIARNSSC 748
Score = 32.0 bits (71), Expect = 1.5
Identities = 28/131 (21%), Positives = 45/131 (34%), Gaps = 9/131 (6%)
Frame = +1
Query: 37 SCDTWADRGECASNPGYMLVSCKKACNVCGK---------ENKCADYRKRCPIMAKYGLC 189
SC + C PGY C++ + C +N+ ++ CP LC
Sbjct: 463 SCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLC 522
Query: 190 ESDPSFMLQNCKESCGVCDGSSKNRPCVDANQDCAGWAASHECETNPSWMLYNCKKSCNH 369
+ D + N PC + Q C A+ + C+ + NC +H
Sbjct: 523 QLDIDYCEPN---------------PCQNGAQ-CYNRASDYFCKCPEDYEGKNCSHLKDH 566
Query: 370 CRDARLESISN 402
CR E I +
Sbjct: 567 CRTTPCEVIDS 577
>sp|Q6DI48|DLLA_BRARE Delta-like protein A precursor (DeltaA protein)
Length = 772
Score = 57.8 bits (138), Expect = 3e-08
Identities = 51/212 (24%), Positives = 77/212 (36%), Gaps = 9/212 (4%)
Frame = +1
Query: 19 CLNSHESCDTWADRGECASNPGYMLVSCKKACNVCGKENKCADYRKRCPIMAKYGLCESD 198
CLN +T C+ PG+ SC+ N C N C + C M C
Sbjct: 300 CLNGATCSNTGQGSYTCSCRPGFSGASCEIEVNEC-TGNPCRN-GGSCTDMENTYSCTCP 357
Query: 199 PSFMLQNCKESCGVC-DGSSKNRPCVDANQDCAGWAASHECETNPSWMLYNCKKSCNHCR 375
P F +NC+ S C DG PC + + + C+ + +NC+K +HC
Sbjct: 358 PGFYGKNCELSAMTCADG-----PCFNGGRCADNPDGGYFCQCPTGYAGFNCEKKIDHC- 411
Query: 376 DARLESISNPNCKDLQIHCLYWANAGECQLNPGWAKQNCP--------FSCQHCGGCRDL 531
S+ C + C+ N+ CQ G+ NC + CQ+ G
Sbjct: 412 -------SSSPCSN-GARCVDLVNSYLCQCPDGFTGMNCDRAGDECSMYPCQNGG----- 458
Query: 532 IQNCQNFANQGYCKTNEVYMNQSCKKTCGFCR 627
CQ A+ C Y ++C C+
Sbjct: 459 --TCQEGASGYMCTCPPGYTGRNCSSPVSRCQ 488
Score = 40.4 bits (93), Expect = 0.004
Identities = 44/212 (20%), Positives = 74/212 (34%), Gaps = 8/212 (3%)
Frame = +1
Query: 13 PNCLNSHESCDTWADRGECASNPGYMLVSCKKACNVCGKENKCADYRKRCPIMAKYGLCE 192
P C H C+ GEC G+ + C+ C + C +G C+
Sbjct: 230 PGCDEEHGFCEK---PGECKCRVGFK----GRYCDECIRYPGCL-----------HGTCQ 271
Query: 193 SDPSFMLQNCKESCG--VCDGS----SKNRPCVDANQDCAGWAASHECETNPSWMLYNCK 354
NC+E G C+ + ++PC++ S+ C P + +C+
Sbjct: 272 QPWQC---NCQEGWGGLFCNQDLNYCTHHKPCLNGATCSNTGQGSYTCSCRPGFSGASCE 328
Query: 355 KSCNHCRDARLESISNPNCKDLQIHCLYWANAGECQLNPGWAKQNCPFSCQHC--GGCRD 528
N C + +C D++ N C PG+ +NC S C G C +
Sbjct: 329 IEVNECTGNPCR--NGGSCTDME-------NTYSCTCPPGFYGKNCELSAMTCADGPCFN 379
Query: 529 LIQNCQNFANQGYCKTNEVYMNQSCKKTCGFC 624
+ N +C+ Y +C+K C
Sbjct: 380 GGRCADNPDGGYFCQCPTGYAGFNCEKKIDHC 411
>sp|P55115|NAS15_CAEEL Zinc metalloproteinase nas-15 precursor (Nematode astacin 15)
Length = 571
Score = 57.4 bits (137), Expect = 3e-08
Identities = 49/218 (22%), Positives = 73/218 (33%), Gaps = 53/218 (24%)
Frame = +1
Query: 19 CLNSHESCDTWADRGECASNPGYMLVSCKKACNVC--GKENK------------------ 138
C N CD A +G C NPG+M +C +C +C KE +
Sbjct: 354 CRNLRGDCDDLAKQGWCIRNPGWMRANCPISCGMCIPTKETQKPYVQTTTQAATTTARPQ 413
Query: 139 -----------------------CADYRKRCPIMAKYGLCESDPSFMLQNCKESCGVC-- 243
C D R C ++ C+ +FM C +SCG C
Sbjct: 414 KPVTQPIQPLPPVPPLPPTTPEDCEDLRVDCLVLVSQRYCKISQNFMKSYCAKSCGFCFK 473
Query: 244 ---DGSSKNRPCVDANQDCAGWAASHECETNPSWMLYNCKKSCNHCRDARLESIS----N 402
NRP V + + +P+ + K+ S
Sbjct: 474 PPPTEIPDNRPTVVTTRPLVTLPPAVIRSRSPAPPVSTTTKAAPTTSTTSAAPYSPTPLP 533
Query: 403 PNCKDLQIHCLYWANAGECQ-LNPGWAKQNCPFSCQHC 513
C D + C +W +AG C+ + + K+NCP SC C
Sbjct: 534 SECSDRKHFCSHWKSAGFCEGIFMNYMKKNCPASCGLC 571
Score = 52.8 bits (125), Expect = 8e-07
Identities = 31/118 (26%), Positives = 41/118 (34%), Gaps = 46/118 (38%)
Frame = +1
Query: 409 CKDLQIHCLYWANAGECQLNPGWAKQNCPFSCQHC------------------------- 513
C++L+ C A G C NPGW + NCP SC C
Sbjct: 354 CRNLRGDCDDLAKQGWCIRNPGWMRANCPISCGMCIPTKETQKPYVQTTTQAATTTARPQ 413
Query: 514 ---------------------GGCRDLIQNCQNFANQGYCKTNEVYMNQSCKKTCGFC 624
C DL +C +Q YCK ++ +M C K+CGFC
Sbjct: 414 KPVTQPIQPLPPVPPLPPTTPEDCEDLRVDCLVLVSQRYCKISQNFMKSYCAKSCGFC 471
Score = 51.6 bits (122), Expect = 2e-06
Identities = 35/131 (26%), Positives = 56/131 (42%), Gaps = 2/131 (1%)
Frame = +1
Query: 127 KENKCADYRKRCPIMAKYGLCESDPSFMLQNCKESCGVCDGSSK-NRPCVDANQDCAGWA 303
K ++C + R C +AK G C +P +M NC SCG+C + + +P V A
Sbjct: 350 KPSECRNLRGDCDDLAKQGWCIRNPGWMRANCPISCGMCIPTKETQKPYVQTTTQAATTT 409
Query: 304 A-SHECETNPSWMLYNCKKSCNHCRDARLESISNPNCKDLQIHCLYWANAGECQLNPGWA 480
A + T P L L + +C+DL++ CL + C+++ +
Sbjct: 410 ARPQKPVTQPIQPLPPVPP---------LPPTTPEDCEDLRVDCLVLVSQRYCKISQNFM 460
Query: 481 KQNCPFSCQHC 513
K C SC C
Sbjct: 461 KSYCAKSCGFC 471
>sp|Q9QYE5|JAG2_MOUSE Jagged-2 precursor (Jagged2)
Length = 1247
Score = 57.0 bits (136), Expect = 4e-08
Identities = 48/199 (24%), Positives = 73/199 (36%), Gaps = 12/199 (6%)
Frame = +1
Query: 7 SNPNCLNSHESCDTWADRGECASNPGYMLVSCKKACNVCGKENKCADYRKRCPIMAKYGL 186
S+ C+N + D+ CA GY+ +C++A + C N CA+ G
Sbjct: 313 SHHPCVNGGTCINAEPDQYLCACPDGYLGKNCERAEHACAS-NPCANG----------GS 361
Query: 187 CESDPSFMLQNCKE-----SCGVCDGSSKNRPCVDANQDCAGWAASHECETNPSWMLYNC 351
C PS +C +C + + PC A C EC W+ C
Sbjct: 362 CHEVPSGFECHCPSGWSGPTCALDIDECASNPCA-AGGTCVDQVDGFECICPEQWVGATC 420
Query: 352 KKSCNHCRDARLESISNPNCKDLQIHCLYWANAGECQLNPGWAKQNCPFS-------CQH 510
+ N C ++ +CK+L C PGW NC + CQH
Sbjct: 421 QLDANECEGK--PCLNAFSCKNL-------IGGYYCDCLPGWKGINCQININDCHGQCQH 471
Query: 511 CGGCRDLIQNCQNFANQGY 567
G C+DL+ Q +G+
Sbjct: 472 GGTCKDLVNGYQCVCPRGF 490
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,837,500
Number of Sequences: 369166
Number of extensions: 1804394
Number of successful extensions: 6166
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4903
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5782
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5608903050
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)