Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_M23
(782 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 227 2e-59
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 227 2e-59
sp|P13277|CYSP1_HOMAM Digestive cysteine proteinase 1 precu... 221 1e-57
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 220 3e-57
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 218 1e-56
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 218 2e-56
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 218 2e-56
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 217 3e-56
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 216 4e-56
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 216 4e-56
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 227 bits (579), Expect = 2e-59
Identities = 111/212 (52%), Positives = 142/212 (66%), Gaps = 8/212 (3%)
Frame = +2
Query: 2 QGYVTSVKDQTRTCGSCWAFSTTGSLEGQFYRKYKRLVSLSEQQLVDCD--MKSYGCYGG 175
+GYVT VK+Q + CGSCWAFS TG+LEGQ +RK RL+SLSEQ LVDC + GC GG
Sbjct: 123 KGYVTPVKNQGQ-CGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGG 181
Query: 176 WVEDAVDYITQTGGIESEDDYPYLAKASLCKFNKSKIVARTAGYTTIEKNEIALAEALVN 355
++ A Y+ GG++SE+ YPY A CK+N VA G+ I K E AL +A+
Sbjct: 182 LMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVAT 241
Query: 356 VGPISIIIDASHRSFQLYKDGIYDEPQC-TEKVDHAVLLVGYG-----EEKSKYWIVKNS 517
VGPIS+ IDA H SF YK+GIY EP C +E +DH VL+VGYG + +KYW+VKNS
Sbjct: 242 VGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNS 301
Query: 518 WGRKWGKNGYIWMSKDKENQCSIASYAGFPKI 613
WG +WG GY+ M+KD+ N C IAS A +P +
Sbjct: 302 WGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 227 bits (579), Expect = 2e-59
Identities = 111/213 (52%), Positives = 145/213 (68%), Gaps = 9/213 (4%)
Frame = +2
Query: 2 QGYVTSVKDQTRTCGSCWAFSTTGSLEGQFYRKYKRLVSLSEQQLVDCDMK--SYGCYGG 175
+GYVT VK+Q + CGSCWAFS TG+LEGQ +RK +LVSLSEQ LVDC + GC GG
Sbjct: 123 KGYVTPVKNQ-KQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGG 181
Query: 176 WVEDAVDYITQTGGIESEDDYPYLAKASLCKFNKSKIVARTAGYTTIEKN-EIALAEALV 352
++ A Y+ + GG++SE+ YPY+A +CK+ VA G+T + E AL +A+
Sbjct: 182 FMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVA 241
Query: 353 NVGPISIIIDASHRSFQLYKDGIYDEPQCTEK-VDHAVLLVGYGEE-----KSKYWIVKN 514
VGPIS+ +DA H SFQ YK GIY EP C+ K +DH VL+VGYG E SKYW+VKN
Sbjct: 242 TVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKN 301
Query: 515 SWGRKWGKNGYIWMSKDKENQCSIASYAGFPKI 613
SWG +WG NGY+ ++KDK N C IA+ A +P +
Sbjct: 302 SWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
>sp|P13277|CYSP1_HOMAM Digestive cysteine proteinase 1 precursor
Length = 322
Score = 221 bits (564), Expect = 1e-57
Identities = 112/210 (53%), Positives = 146/210 (69%), Gaps = 6/210 (2%)
Frame = +2
Query: 2 QGYVTSVKDQTRTCGSCWAFSTTGSLEGQFYRKYKRLVSLSEQQLVDCDMKSY---GCYG 172
+G VT VKDQ + CGSCWAFSTTG +EGQ + K RLVSLSEQQLVDC SY GC G
Sbjct: 114 KGAVTPVKDQGQ-CGSCWAFSTTGGIEGQHFLKTGRLVSLSEQQLVDCAGGSYYNQGCNG 172
Query: 173 GWVEDAVDYITQTGGIESEDDYPYLAKASLCKFNKSKIVARTAGYTTI-EKNEIALAEAL 349
GWVE A+ Y+ GG+++E YPY A+ + C+FN + I A GY I + +E AL A
Sbjct: 173 GWVERAIMYVRDNGGVDTESSYPYEARDNTCRFNSNTIGATCTGYVGIAQGSESALKTAT 232
Query: 350 VNVGPISIIIDASHRSFQLYKDGIYDEPQC-TEKVDHAVLLVGYGEEKSK-YWIVKNSWG 523
++GPIS+ IDASHRSFQ Y G+Y EP C + ++DHAVL VGYG E + +W+VKNSW
Sbjct: 233 RDIGPISVAIDASHRSFQSYYTGVYYEPSCSSSQLDHAVLAVGYGSEGGQDFWLVKNSWA 292
Query: 524 RKWGKNGYIWMSKDKENQCSIASYAGFPKI 613
WG++GYI M++++ N C IA+ A +P +
Sbjct: 293 TSWGESGYIKMARNRNNNCGIATDACYPTV 322
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 220 bits (561), Expect = 3e-57
Identities = 111/210 (52%), Positives = 146/210 (69%), Gaps = 6/210 (2%)
Frame = +2
Query: 2 QGYVTSVKDQTRTCGSCWAFSTTGSLEGQFYRKYKRLVSLSEQQLVDCDMK--SYGCYGG 175
+G VT+VKDQ CGSCWAFS+TG+LEGQ +RK LVSLSEQ LVDC K + GC GG
Sbjct: 133 KGAVTAVKDQGH-CGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGG 191
Query: 176 WVEDAVDYITQTGGIESEDDYPYLAKASLCKFNKSKIVARTAGYTTI-EKNEIALAEALV 352
+++A YI GGI++E YPY A C FNK + A G+T I + +E +AEA+
Sbjct: 192 LMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVA 251
Query: 353 NVGPISIIIDASHRSFQLYKDGIYDEPQC-TEKVDHAVLLVGYGEEKS--KYWIVKNSWG 523
VGP+S+ IDASH SFQ Y +G+Y+EPQC + +DH VL+VG+G ++S YW+VKNSWG
Sbjct: 252 TVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWG 311
Query: 524 RKWGKNGYIWMSKDKENQCSIASYAGFPKI 613
WG G+I M ++KENQC IAS + +P +
Sbjct: 312 TTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 218 bits (556), Expect = 1e-56
Identities = 107/209 (51%), Positives = 142/209 (67%), Gaps = 5/209 (2%)
Frame = +2
Query: 2 QGYVTSVKDQTRTCGSCWAFSTTGSLEGQFYRKYKRLVSLSEQQLVDCDMK--SYGCYGG 175
+GYVT VK+Q + CGSCWAFS TG+LEGQ +RK +LVSLSEQ LVD + GC GG
Sbjct: 10 KGYVTPVKNQGQ-CGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQGNQGCNGG 68
Query: 176 WVEDAVDYITQTGGIESEDDYPYLAKASLCKFNKSKIVARTAGYTTIEKNEIALAEALVN 355
+++A YI + GG++SE+ YPY A + C + A+ G+ I + E AL +A+
Sbjct: 69 LMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFVDIPQREKALMKAVAT 128
Query: 356 VGPISIIIDASHRSFQLYKDGIYDEPQCTEK-VDHAVLLVGYGEE--KSKYWIVKNSWGR 526
VGPIS+ IDA H SFQ YK GIY +P C+ K +DH VL+VGYG E +K+WIVKNSWG
Sbjct: 129 VGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKFWIVKNSWGP 188
Query: 527 KWGKNGYIWMSKDKENQCSIASYAGFPKI 613
+WG GY+ M+KD+ N C IA+ A +P +
Sbjct: 189 EWGNKGYVKMAKDQNNHCGIATAASYPTV 217
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 218 bits (554), Expect = 2e-56
Identities = 107/213 (50%), Positives = 144/213 (67%), Gaps = 9/213 (4%)
Frame = +2
Query: 2 QGYVTSVKDQTRTCGSCWAFSTTGSLEGQFYRKYKRLVSLSEQQLVDCDMK--SYGCYGG 175
+GYVT+VK+Q + CGSCWAFS TG+LEGQ +RK +LVSLSEQ LVDC + GC GG
Sbjct: 123 KGYVTAVKNQGQ-CGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGG 181
Query: 176 WVEDAVDYITQTGGIESEDDYPYLAK-ASLCKFNKSKIVARTAGYTTIEKNEIALAEALV 352
+++A Y+ GG+++E+ YPYL + + C + A G+ I + E AL +A+
Sbjct: 182 LMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDIPQREKALMKAVA 241
Query: 353 NVGPISIIIDASHRSFQLYKDGIYDEPQCTEK-VDHAVLLVGYGEE-----KSKYWIVKN 514
VGPIS+ IDA H SFQ YK GIY +P C+ K +DH VL+VGYG E SK+WIVKN
Sbjct: 242 TVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNSSKFWIVKN 301
Query: 515 SWGRKWGKNGYIWMSKDKENQCSIASYAGFPKI 613
SWG +WG NGY+ M+KD+ N C I++ A +P +
Sbjct: 302 SWGPEWGWNGYVKMAKDQNNHCGISTAASYPTV 334
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 218 bits (554), Expect = 2e-56
Identities = 110/213 (51%), Positives = 143/213 (67%), Gaps = 9/213 (4%)
Frame = +2
Query: 2 QGYVTSVKDQTRTCGSCWAFSTTGSLEGQFYRKYKRLVSLSEQQLVDCDMK--SYGCYGG 175
+GYVT VK+Q + CGSCWAFS TG+LEGQ +RK +LVSLSEQ LVDC + GC GG
Sbjct: 123 KGYVTPVKNQGQ-CGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGG 181
Query: 176 WVEDAVDYITQTGGIESEDDYPYLAK-ASLCKFNKSKIVARTAGYTTIEKNEIALAEALV 352
+++A YI GG++SE+ YPYLA + C + A G+ I + E AL +A+
Sbjct: 182 LMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDIPQREKALMKAVA 241
Query: 353 NVGPISIIIDASHRSFQLYKDGIYDEPQCTEK-VDHAVLLVGYGEE-----KSKYWIVKN 514
VGPIS+ IDA H SFQ YK GIY +P C+ K +DH VL+VGYG E +K+WIVKN
Sbjct: 242 TVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSNNNKFWIVKN 301
Query: 515 SWGRKWGKNGYIWMSKDKENQCSIASYAGFPKI 613
SWG +WG NGY+ M+KD+ N C IA+ A +P +
Sbjct: 302 SWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 217 bits (552), Expect = 3e-56
Identities = 107/210 (50%), Positives = 141/210 (67%), Gaps = 8/210 (3%)
Frame = +2
Query: 2 QGYVTSVKDQTRTCGSCWAFSTTGSLEGQFYRKYKRLVSLSEQQLVDC--DMKSYGCYGG 175
+G VT VK+Q + CGSCWAFS +G LEGQ + K +L+SLSEQ LVDC D + GC GG
Sbjct: 123 KGCVTPVKNQGQ-CGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGG 181
Query: 176 WVEDAVDYITQTGGIESEDDYPYLAKASLCKFNKSKIVARTAGYTTIEKNEIALAEALVN 355
++ A YI + GG++SE+ YPY AK CK+ VA G+ I + E AL +A+
Sbjct: 182 LMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQQEKALMKAVAT 241
Query: 356 VGPISIIIDASHRSFQLYKDGIYDEPQCTEK-VDHAVLLVGYGEE-----KSKYWIVKNS 517
VGPIS+ +DASH S Q Y GIY EP C+ K +DH VL+VGYG E K KYW+VKNS
Sbjct: 242 VGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYGYEGTDSNKDKYWLVKNS 301
Query: 518 WGRKWGKNGYIWMSKDKENQCSIASYAGFP 607
WG++WG +GYI ++KD+ N C +A+ A +P
Sbjct: 302 WGKEWGMDGYIKIAKDRNNHCGLATAASYP 331
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 216 bits (551), Expect = 4e-56
Identities = 106/212 (50%), Positives = 143/212 (67%), Gaps = 8/212 (3%)
Frame = +2
Query: 2 QGYVTSVKDQTRTCGSCWAFSTTGSLEGQFYRKYKRLVSLSEQQLVDCDMK--SYGCYGG 175
+GYVT VK+Q + CGSCWAFS TG+LEGQ +RK +LVSLSEQ LVDC + GC GG
Sbjct: 123 KGYVTPVKNQGQ-CGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGG 181
Query: 176 WVEDAVDYITQTGGIESEDDYPYLAK-ASLCKFNKSKIVARTAGYTTIEKNEIALAEALV 352
+++A Y+ GG++SE+ YPYL + C + A G+ + + E AL +A+
Sbjct: 182 LMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQREKALMKAVA 241
Query: 353 NVGPISIIIDASHRSFQLYKDGIYDEPQCTEK-VDHAVLLVGYGEE----KSKYWIVKNS 517
+GPIS+ IDA H+SFQ YK GIY +P C+ K +DH VL+VGYG E +K+WIVKNS
Sbjct: 242 TLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSNNKFWIVKNS 301
Query: 518 WGRKWGKNGYIWMSKDKENQCSIASYAGFPKI 613
WG +WG NGY+ M+KD+ N C IA+ A +P +
Sbjct: 302 WGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 216 bits (551), Expect = 4e-56
Identities = 110/205 (53%), Positives = 136/205 (66%), Gaps = 4/205 (1%)
Frame = +2
Query: 11 VTSVKDQTRTCGSCWAFSTTGSLEGQFYRKYKRLVSLSEQQLVDC--DMKSYGCYGGWVE 184
VT VKDQ + CGSCWAFS TG+LEGQ + K LVSLSEQQLVDC D + GC GGW+
Sbjct: 118 VTPVKDQEQ-CGSCWAFSATGALEGQHFLKNDELVSLSEQQLVDCSTDYGNDGCGGGWMT 176
Query: 185 DAVDYITQTGGIESEDDYPYLAKASLCKFNKSKIVARTAGYTTIEKNEIALAEALVNVGP 364
A DYI GGI++E YPY A+ C+F+ + I A G ++ E AL EA+ VGP
Sbjct: 177 SAFDYIKDNGGIDTESSYPYEAEDRSCRFDANSIGAICTGSVEVQHTEEALQEAVSGVGP 236
Query: 365 ISIIIDASHRSFQLYKDGIYDEPQCTEK-VDHAVLLVGYGEEKSK-YWIVKNSWGRKWGK 538
IS+ IDASH SFQ Y G+Y E C+ +DH VL VGYG E +K YW+VKNSWG WG
Sbjct: 237 ISVAIDASHFSFQFYSSGVYYEQNCSPTFLDHGVLAVGYGTESTKDYWLVKNSWGSSWGD 296
Query: 539 NGYIWMSKDKENQCSIASYAGFPKI 613
GYI MS++++N C IAS +P +
Sbjct: 297 AGYIKMSRNRDNNCGIASEPSYPTV 321
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,926,055
Number of Sequences: 369166
Number of extensions: 1717083
Number of successful extensions: 4737
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4098
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4232
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7357347200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)