Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_M19
(653 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P26599|PTBP1_HUMAN Polypyrimidine tract-binding protein ... 109 7e-24
sp|Q29099|PTBP1_PIG Polypyrimidine tract-binding protein 1 ... 108 2e-23
sp|Q00438|PTBP1_RAT Polypyrimidine tract-binding protein 1 ... 103 5e-22
sp|Q8BHD7|ROD1_MOUSE Regulator of differentiation 1 (Rod1) 99 1e-20
sp|Q9Z118|ROD1_RAT Regulator of differentiation 1 (Rod1) 99 1e-20
sp|O95758|ROD1_HUMAN Regulator of differentiation 1 (Rod1) 98 2e-20
sp|P17225|PTBP1_MOUSE Polypyrimidine tract-binding protein ... 68 2e-11
sp|Q921F4|HNRLL_MOUSE Heterogeneous nuclear ribonucleoprote... 50 7e-06
sp|Q8WVV9|HNRLL_HUMAN Heterogeneous nuclear ribonucleoprote... 50 7e-06
sp|P14866|HNRPL_HUMAN Heterogeneous nuclear ribonucleoprote... 42 0.001
>sp|P26599|PTBP1_HUMAN Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear
ribonucleoprotein I) (hnRNP I) (57 kDa RNA-binding
protein PPTB-1)
Length = 531
Score = 109 bits (272), Expect = 7e-24
Identities = 66/169 (39%), Positives = 96/169 (56%), Gaps = 2/169 (1%)
Frame = +3
Query: 3 EIMYNRKNTALVQFANEEFAQRALQYLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEA 182
+I++N+K ALVQ A+ AQ A+ +LNG L+GKP+ + SKH + + P G E++
Sbjct: 368 KILFNKKENALVQMADGNQAQLAMSHLNGHKLHGKPIRITLSKHQNV--QLpreGQEDQG 425
Query: 183 SGDRLHKEYVDSKLHRFKRSQSRNHANIYEPSKVLHIAGLVDDVSEEDIEALFQDNKFRV 362
L K+Y +S LHRFK+ S+N NI+ PS LH++ + VSEED++ LF N V
Sbjct: 426 ----LTKDYGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVSEEDLKVLFSSNGGVV 481
Query: 363 RKIRMFNSNGKKMXXXXXXXXXXXXXXXXXLHDYDLCGSN--LRVSFSK 503
+ + F + +KM LH++DL G N LRVSFSK
Sbjct: 482 KGFKFFQKD-RKMALIQMGSVEEAVQALIDLHNHDL-GENHHLRVSFSK 528
Score = 32.0 bits (71), Expect = 1.4
Identities = 15/48 (31%), Positives = 24/48 (50%), Gaps = 2/48 (4%)
Frame = +3
Query: 6 IMYNRKNTALVQFANEEFAQRALQYLNGVN--LYGKPLHVNFSKHDRI 143
+M KN A ++ EE A + Y V L G+P+++ FS H +
Sbjct: 89 LMLKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKEL 136
>sp|Q29099|PTBP1_PIG Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear
ribonucleoprotein I) (hnRNP I)
Length = 557
Score = 108 bits (269), Expect = 2e-23
Identities = 65/169 (38%), Positives = 96/169 (56%), Gaps = 2/169 (1%)
Frame = +3
Query: 3 EIMYNRKNTALVQFANEEFAQRALQYLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEA 182
+I++N+K ALVQ A+ AQ A+ +LNG L+GKP+ + SKH + + P G E++
Sbjct: 394 KILFNKKENALVQMADGSQAQLAMSHLNGHKLHGKPVRITLSKHQNV--QLpreGQEDQG 451
Query: 183 SGDRLHKEYVDSKLHRFKRSQSRNHANIYEPSKVLHIAGLVDDVSEEDIEALFQDNKFRV 362
L K+Y +S LHRFK+ S+N NI+ PS LH++ + +SEED++ LF N V
Sbjct: 452 ----LTKDYGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSISEEDLKILFSSNGGIV 507
Query: 363 RKIRMFNSNGKKMXXXXXXXXXXXXXXXXXLHDYDLCGSN--LRVSFSK 503
+ + F + +KM LH++DL G N LRVSFSK
Sbjct: 508 KGFKFFQKD-RKMALIQMGSVEEAIQALIDLHNHDL-GENHHLRVSFSK 554
Score = 32.0 bits (71), Expect = 1.4
Identities = 15/48 (31%), Positives = 24/48 (50%), Gaps = 2/48 (4%)
Frame = +3
Query: 6 IMYNRKNTALVQFANEEFAQRALQYLNGVN--LYGKPLHVNFSKHDRI 143
+M KN A ++ EE A + Y V L G+P+++ FS H +
Sbjct: 89 LMLKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKEL 136
>sp|Q00438|PTBP1_RAT Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear
ribonucleoprotein I) (hnRNP I) (Pyrimidine-binding
protein) (PYBP)
Length = 555
Score = 103 bits (256), Expect = 5e-22
Identities = 63/169 (37%), Positives = 95/169 (56%), Gaps = 2/169 (1%)
Frame = +3
Query: 3 EIMYNRKNTALVQFANEEFAQRALQYLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEA 182
+I++N+K ALV+ A+ AQ A+ +LNG L+GK + + SKH + + P G E++
Sbjct: 392 KILFNKKENALVEMADGSQAQLAMSHLNGHKLHGKSVRITLSKHQSV--QLpreGQEDQG 449
Query: 183 SGDRLHKEYVDSKLHRFKRSQSRNHANIYEPSKVLHIAGLVDDVSEEDIEALFQDNKFRV 362
L K+Y S LHRFK+ S+N NI+ PS LH++ + VSE+D+++LF N V
Sbjct: 450 ----LTKDYGSSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVSEDDLKSLFSSNGGVV 505
Query: 363 RKIRMFNSNGKKMXXXXXXXXXXXXXXXXXLHDYDLCGSN--LRVSFSK 503
+ + F + +KM LH++DL G N LRVSFSK
Sbjct: 506 KGFKFFQKD-RKMALIQMGSVEEAVQALIELHNHDL-GENHHLRVSFSK 552
Score = 32.3 bits (72), Expect = 1.1
Identities = 15/48 (31%), Positives = 25/48 (52%), Gaps = 2/48 (4%)
Frame = +3
Query: 6 IMYNRKNTALVQFANEEFAQRALQYLNGVN--LYGKPLHVNFSKHDRI 143
+M KN A ++ + EE A + Y V L G+P+++ FS H +
Sbjct: 88 LMLKGKNQAFIEMSTEEAANTMVNYYTSVAPVLRGQPIYIQFSNHKEL 135
>sp|Q8BHD7|ROD1_MOUSE Regulator of differentiation 1 (Rod1)
Length = 523
Score = 99.0 bits (245), Expect = 1e-20
Identities = 62/169 (36%), Positives = 93/169 (55%), Gaps = 2/169 (1%)
Frame = +3
Query: 3 EIMYNRKNTALVQFANEEFAQRALQYLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEA 182
+IM+N+K ALVQ A+ AQ A+ +L+G LYGK L SKH + + P G E++
Sbjct: 360 KIMFNKKENALVQMADASQAQLAMNHLSGQRLYGKVLRATLSKHQAV--QLpreGQEDQG 417
Query: 183 SGDRLHKEYVDSKLHRFKRSQSRNHANIYEPSKVLHIAGLVDDVSEEDIEALFQDNKFRV 362
L K++ +S LHRFK+ S+N NI+ PS LH++ + V+ +D++ LF + V
Sbjct: 418 ----LTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTMDDLKNLFTEAGCSV 473
Query: 363 RKIRMFNSNGKKMXXXXXXXXXXXXXXXXXLHDYDLCGSN--LRVSFSK 503
+ + F + +KM LH++DL G N LRVSFSK
Sbjct: 474 KAFKFFQKD-RKMALIQLGSVEEAIQALIELHNHDL-GENHHLRVSFSK 520
>sp|Q9Z118|ROD1_RAT Regulator of differentiation 1 (Rod1)
Length = 523
Score = 98.6 bits (244), Expect = 1e-20
Identities = 62/169 (36%), Positives = 93/169 (55%), Gaps = 2/169 (1%)
Frame = +3
Query: 3 EIMYNRKNTALVQFANEEFAQRALQYLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEA 182
+IM+N+K ALVQ A+ AQ A+ +L+G LYGK L SKH + + P G E++
Sbjct: 360 KIMFNKKENALVQMADASQAQIAMNHLSGQRLYGKVLRATLSKHQAV--QLpreGQEDQG 417
Query: 183 SGDRLHKEYVDSKLHRFKRSQSRNHANIYEPSKVLHIAGLVDDVSEEDIEALFQDNKFRV 362
L K++ +S LHRFK+ S+N NI+ PS LH++ + V+ +D++ LF + V
Sbjct: 418 ----LTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTMDDLKNLFTEAGCSV 473
Query: 363 RKIRMFNSNGKKMXXXXXXXXXXXXXXXXXLHDYDLCGSN--LRVSFSK 503
+ + F + +KM LH++DL G N LRVSFSK
Sbjct: 474 KAFKFFQKD-RKMALIQLGSVEEAIQALIELHNHDL-GENHHLRVSFSK 520
>sp|O95758|ROD1_HUMAN Regulator of differentiation 1 (Rod1)
Length = 521
Score = 98.2 bits (243), Expect = 2e-20
Identities = 62/169 (36%), Positives = 93/169 (55%), Gaps = 2/169 (1%)
Frame = +3
Query: 3 EIMYNRKNTALVQFANEEFAQRALQYLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEA 182
+IM+N+K ALVQ A+ AQ A+ +L+G LYGK L SKH + + P G E++
Sbjct: 358 KIMFNKKENALVQMADANQAQLAMNHLSGQRLYGKVLRATLSKHQAV--QLpreGQEDQG 415
Query: 183 SGDRLHKEYVDSKLHRFKRSQSRNHANIYEPSKVLHIAGLVDDVSEEDIEALFQDNKFRV 362
L K++ +S LHRFK+ S+N NI+ PS LH++ + V+ +D++ LF + V
Sbjct: 416 ----LTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTVDDLKNLFIEAGCSV 471
Query: 363 RKIRMFNSNGKKMXXXXXXXXXXXXXXXXXLHDYDLCGSN--LRVSFSK 503
+ + F + +KM LH++DL G N LRVSFSK
Sbjct: 472 KAFKFFQKD-RKMALIQLGSVEEAIQALIELHNHDL-GENHHLRVSFSK 518
>sp|P17225|PTBP1_MOUSE Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear
ribonucleoprotein I) (hnRNP I)
Length = 527
Score = 67.8 bits (164), Expect = 2e-11
Identities = 55/173 (31%), Positives = 83/173 (47%), Gaps = 6/173 (3%)
Frame = +3
Query: 3 EIMYNRKNTALVQFANEEFAQRALQYLNGVNLYGKPLHVNFSKHDRISH----RAPIAGS 170
+I++N+K ALVQ A+ AQ G+P + + +H + A +
Sbjct: 366 KILFNKKENALVQMADGSQAQ-----------LGEPPERAQAAREVSAHYTVQASECAAA 414
Query: 171 EEEASGDRLHKEYVDSKLHRFKRSQSRNHANIYEPSKVLHIAGLVDDVSEEDIEALFQDN 350
E L K+Y S L RFK+ S+N NI+ PS LH++ + VSE+D+++LF N
Sbjct: 415 REGQEDQGLTKDYGSSPL-RFKKPGSKNFQNIFPPSATLHLSNIPPSVSEDDLKSLFSSN 473
Query: 351 KFRVRKIRMFNSNGKKMXXXXXXXXXXXXXXXXXLHDYDLCGSN--LRVSFSK 503
V+ + F + +KM LH++DL G N LRVSFSK
Sbjct: 474 GGVVKGFKFFQKD-RKMALIQMGSVEEAVQALIELHNHDL-GENHHLRVSFSK 524
Score = 31.2 bits (69), Expect = 2.5
Identities = 15/48 (31%), Positives = 24/48 (50%), Gaps = 2/48 (4%)
Frame = +3
Query: 6 IMYNRKNTALVQFANEEFAQRALQYLNGVN--LYGKPLHVNFSKHDRI 143
+M KN A ++ EE A + Y V L G+P+++ FS H +
Sbjct: 88 LMLKGKNQAFIEMNTEEAANTMVNYYTSVAPVLRGQPIYIQFSNHKEL 135
>sp|Q921F4|HNRLL_MOUSE Heterogeneous nuclear ribonucleoprotein L-like
Length = 591
Score = 49.7 bits (117), Expect = 7e-06
Identities = 36/109 (33%), Positives = 54/109 (49%)
Frame = +3
Query: 27 TALVQFANEEFAQRALQYLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEASGDRLHKE 206
TALV+ +E +RA+ +LN V L+GK L+V SK H + E G +K+
Sbjct: 423 TALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSK----QHSVVPSQIFELEDGTSSYKD 478
Query: 207 YVDSKLHRFKRSQSRNHANIYEPSKVLHIAGLVDDVSEEDIEALFQDNK 353
+ SK +RF + + I PS VLH + V+EE L D++
Sbjct: 479 FAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHE 527
>sp|Q8WVV9|HNRLL_HUMAN Heterogeneous nuclear ribonucleoprotein L-like (Stromal
RNA-regulating factor) (BLOCK24 protein)
Length = 542
Score = 49.7 bits (117), Expect = 7e-06
Identities = 36/109 (33%), Positives = 54/109 (49%)
Frame = +3
Query: 27 TALVQFANEEFAQRALQYLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEASGDRLHKE 206
TALV+ +E +RA+ +LN V L+GK L+V SK H + E G +K+
Sbjct: 374 TALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSK----QHSVVPSQIFELEDGTSSYKD 429
Query: 207 YVDSKLHRFKRSQSRNHANIYEPSKVLHIAGLVDDVSEEDIEALFQDNK 353
+ SK +RF + + I PS VLH + V+EE L D++
Sbjct: 430 FAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHE 478
>sp|P14866|HNRPL_HUMAN Heterogeneous nuclear ribonucleoprotein L (hnRNP L)
Length = 558
Score = 42.4 bits (98), Expect = 0.001
Identities = 30/108 (27%), Positives = 53/108 (49%)
Frame = +3
Query: 3 EIMYNRKNTALVQFANEEFAQRALQYLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEA 182
+ M ++ A+V+ A+ RA+ +LN ++G+ L+V SK I G E+
Sbjct: 382 KFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKLNVCVSKQPAIMPGQSY-GLED-- 438
Query: 183 SGDRLHKEYVDSKLHRFKRSQSRNHANIYEPSKVLHIAGLVDDVSEED 326
G +K++ +S+ +RF + I PS VLH +V+EE+
Sbjct: 439 -GSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEEN 485
Score = 29.3 bits (64), Expect = 9.4
Identities = 20/57 (35%), Positives = 30/57 (52%), Gaps = 12/57 (21%)
Frame = +3
Query: 6 IMYNRKN--TALVQFANEEFAQRALQYLNGVNL----------YGKPLHVNFSKHDR 140
I+ RKN A+V+F + + AQRA LNG ++ Y KP +N K+D+
Sbjct: 193 IVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQ 249
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,244,865
Number of Sequences: 369166
Number of extensions: 1450905
Number of successful extensions: 3517
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3381
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3508
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5413810770
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)