Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_M14
(782 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransf... 178 2e-44
sp|O59816|ODP2_SCHPO Dihydrolipoyllysine-residue acetyltran... 176 6e-44
sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X compo... 172 9e-43
sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltran... 172 9e-43
sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltran... 167 2e-41
sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X compo... 164 3e-40
sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltran... 160 3e-39
sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltran... 154 3e-37
sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltran... 152 1e-36
sp|P20285|ODP2_NEUCR Dihydrolipoyllysine-residue acetyltran... 144 4e-34
>sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex) (PDC-E2) (70 kDa mitochondrial autoantigen of
primary biliary cirrhosis) (PBC)
Length = 555
Score = 178 bits (451), Expect = 2e-44
Identities = 109/244 (44%), Positives = 146/244 (59%), Gaps = 4/244 (1%)
Frame = +2
Query: 59 PPTTRPAAQPEXXXXXXHVDVPLTNMRQTIARRMAASKSSIPHRYSTGEAS---XXXXXX 229
PP R A P +D+P++N+R+ IA+R+ SK +IPH Y + + +
Sbjct: 315 PPGPRVAPTPAGVF----IDIPISNIRRVIAQRLMQSKQTIPHYYLSVDVNMGEVLLVRK 370
Query: 230 XXXXXXDQRGLVLSVNDFIVKAASLALRLVPEINNGLNADGTIKINHNIDISVAVASESG 409
+ +G + SVNDFI+KA++LA VPE N+ D I+ NH +D+SVAV++ +G
Sbjct: 371 ELNKMLEGKGKI-SVNDFIIKASALACLKVPEANSSW-MDTVIRQNHVVDVSVAVSTPAG 428
Query: 410 LITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAII 589
LITPIVF A L I+S + LA KAR KLQP EF GGTFTISNLGMFGIK F+AII
Sbjct: 429 LITPIVFNAHIKGLETIASDVVSLASKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAII 488
Query: 590 NSPQAAILAVGAGIPHLAHDPANPSKPKSVTK-MRFTLCADARIIDETSASEFVSRVKSY 766
N PQA ILA+GA L PA+ K V M TL D R++D +++++ K Y
Sbjct: 489 NPPQACILAIGASEDKLI--PADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLAEFKKY 546
Query: 767 LENP 778
LE P
Sbjct: 547 LEKP 550
>sp|O59816|ODP2_SCHPO Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex, mitochondrial precursor (E2)
(Dihydrolipoamide acetyltransferase component of pyruvate
dehydrogenase complex) (PDC-E2)
Length = 483
Score = 176 bits (446), Expect = 6e-44
Identities = 106/262 (40%), Positives = 145/262 (55%), Gaps = 12/262 (4%)
Frame = +2
Query: 29 IDRSRLSPVCPP----------TTRPAAQPEXXXXXXHVDVPLTNMRQTIARRMAASKSS 178
+D PV P TT A+ + + D+PL+NMR+ IA R+A SK+
Sbjct: 218 VDIENFKPVVAPKPSNEAAAKATTPAASAADAAAPGDYEDLPLSNMRKIIASRLAESKNM 277
Query: 179 IPHRYSTGEASXXXXXXXXXXXXDQRG--LVLSVNDFIVKAASLALRLVPEINNGLNADG 352
PH Y T + LSVND ++KA + ALR VPE+N D
Sbjct: 278 NPHYYVTVSVNMEKIIRLRAALNAMADGRYKLSVNDLVIKATTAALRQVPEVNAAWMGD- 336
Query: 353 TIKINHNIDISVAVASESGLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGG 532
I+ N+DIS+AVA+ SGLITP++ L LA IS+ + ++ARNNKL+P+E+ GG
Sbjct: 337 FIRQYKNVDISMAVATPSGLITPVIRNTHALGLAEISTLAKDYGQRARNNKLKPEEYQGG 396
Query: 533 TFTISNLGMFGIKEFTAIINSPQAAILAVGAGIPHLAHDPANPSKPKSVTKMRFTLCADA 712
TFTISNLGMF + +FTAIIN PQA ILAVG + + D + K M+ TL +D
Sbjct: 397 TFTISNLGMFPVDQFTAIINPPQACILAVGTTVDTVVPDSTSEKGFKVAPIMKCTLSSDH 456
Query: 713 RIIDETSASEFVSRVKSYLENP 778
R++D A+ F + +K LENP
Sbjct: 457 RVVDGAMAARFTTALKKILENP 478
>sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X component, mitochondrial precursor
(Dihydrolipoamide dehydrogenase-binding protein of
pyruvate dehydrogenase complex) (Lipoyl-containing
pyruvate dehydrogenase complex component X) (E3-binding
protein) (E3BP) (proX)
Length = 501
Score = 172 bits (436), Expect = 9e-43
Identities = 97/245 (39%), Positives = 150/245 (61%), Gaps = 2/245 (0%)
Frame = +2
Query: 50 PVCPPTTRPAAQPEXXXXXXHVDVPLTNMRQTIARRMAASKSSIPHRYSTGEASXXXXXX 229
PV PP + P QP ++P +N+R+ IA+R+ SKS++PH Y+T +
Sbjct: 258 PVIPPVSTPG-QPNAVGTF--TEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLK 314
Query: 230 XXXXXXDQRGLVLSVNDFIVKAASLALRLVPEINNGLNADGTIKINHNIDISVAVASESG 409
+ +SVNDFI+KAA++ L+ +P++N + +G ++ IDISVAVA++ G
Sbjct: 315 VRQDLVKD-DIKVSVNDFIIKAAAVTLKQMPDVNVSWDGEGPKQLPF-IDISVAVATDKG 372
Query: 410 LITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAII 589
L+TPI+ A + I+ ++ L++KAR+ KL P+E+ GG+F+ISNLGMFGI EFTA+I
Sbjct: 373 LLTPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNLGMFGIDEFTAVI 432
Query: 590 NSPQAAILAVGAGIP--HLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKS 763
N PQA ILAVG P L D +K + + T+ +D+R++D+ A+ F+ K+
Sbjct: 433 NPPQACILAVGRFRPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKSFKA 492
Query: 764 YLENP 778
LENP
Sbjct: 493 NLENP 497
>sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex, mitochondrial precursor (Pyruvate
dehydrogenase complex E2 subunit) (PDCE2) (E2)
(Dihydrolipoamide S-acetyltransferase component of
pyruvate dehydrogenase complex) (PDC-E2) (70 kDa
mitochondrial autoantigen of primary biliary cirrhosis)
(PBC) (M2 antigen complex 70 kDa subunit)
Length = 614
Score = 172 bits (436), Expect = 9e-43
Identities = 106/245 (43%), Positives = 143/245 (58%), Gaps = 6/245 (2%)
Frame = +2
Query: 62 PTTRPAAQPEXXXXXXHVDVPLTNMRQTIARRMAASKSSIPHRY-----STGEASXXXXX 226
P T P P D+P++N+R+ IA+R+ SK +IPH Y + GE
Sbjct: 373 PPTGPGMAP--VPTGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSIDVNMGEVLLVRKE 430
Query: 227 XXXXXXXDQRGLVLSVNDFIVKAASLALRLVPEINNGLNADGTIKINHNIDISVAVASES 406
+ +SVNDFI+KA++LA VPE N+ D I+ NH +D+SVAV++ +
Sbjct: 431 LNKILEGRSK---ISVNDFIIKASALACLKVPEANSSW-MDTVIRQNHVVDVSVAVSTPA 486
Query: 407 GLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAI 586
GLITPIVF A + I++ + LA KAR KLQP EF GGTFTISNLGMFGIK F+AI
Sbjct: 487 GLITPIVFNAHIKGVETIANDVVSLATKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAI 546
Query: 587 INSPQAAILAVGAGIPHLAHDPANPSKPKSV-TKMRFTLCADARIIDETSASEFVSRVKS 763
IN PQA ILA+GA L PA+ K V + M TL D R++D +++++ +
Sbjct: 547 INPPQACILAIGASEDKLV--PADNEKGFDVASMMSVTLSCDHRVVDGAVGAQWLAEFRK 604
Query: 764 YLENP 778
YLE P
Sbjct: 605 YLEKP 609
>sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex, mitochondrial precursor (E2)
(Dihydrolipoamide acetyltransferase component of pyruvate
dehydrogenase complex) (PDC-E2)
Length = 592
Score = 167 bits (424), Expect = 2e-41
Identities = 100/223 (44%), Positives = 135/223 (60%), Gaps = 2/223 (0%)
Frame = +2
Query: 116 DVPLTNMRQTIARRMAASKSSIPHRYSTGEASXXXXXXXXXXXXDQRGLVLSVNDFIVKA 295
D+P +N+R+ A R+ SK +IPH Y T E + +SVNDFIVKA
Sbjct: 368 DIPHSNIRKVTAARLTESKQTIPHYYLTMECRVDKLLKLRSELNAMNTVKISVNDFIVKA 427
Query: 296 ASLALRLVPEINNGLNADGTIKINHNIDISVAVASESGLITPIVFGADKLPLAAISSTIH 475
+ ALR P +N+ D I+ HNIDI+VAV + GL TPIV G D L +IS+++
Sbjct: 428 SLPALRDNPVVNSTWT-DQFIRRYHNIDINVAVNTPQGLFTPIVRGVDMKGLNSISTSVK 486
Query: 476 ELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAIINSPQAAILAVGAG--IPHLAHD 649
+LAEKA+N KL P EF GTFTISNLGM GIK+F A+IN PQAAILA+ + L++
Sbjct: 487 QLAEKAQNGKLHPSEFESGTFTISNLGMLGIKQFAAVINPPQAAILALVPQKLVSFLSNK 546
Query: 650 PANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKSYLENP 778
P +P ++ T + TL D R+ID +E++ K Y+ENP
Sbjct: 547 PDSPY--ETATILSVTLSCDHRVIDGAVGAEWLKSFKDYVENP 587
>sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X component, mitochondrial precursor
(Dihydrolipoamide dehydrogenase-binding protein of
pyruvate dehydrogenase complex) (Lipoyl-containing
pyruvate dehydrogenase complex component X)
Length = 501
Score = 164 bits (415), Expect = 3e-40
Identities = 93/245 (37%), Positives = 148/245 (60%), Gaps = 2/245 (0%)
Frame = +2
Query: 50 PVCPPTTRPAAQPEXXXXXXHVDVPLTNMRQTIARRMAASKSSIPHRYSTGEASXXXXXX 229
P+ PP + P QP ++P +N+R+ IA+R+ SKS++PH Y+T +
Sbjct: 258 PMTPPVSIPG-QPNAAGTF--TEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLK 314
Query: 230 XXXXXXDQRGLVLSVNDFIVKAASLALRLVPEINNGLNADGTIKINHNIDISVAVASESG 409
+ +SVNDFI++AA++ L+ +P +N + +G ++ ++DISVAVA++ G
Sbjct: 315 VRRDLVKD-DIKVSVNDFIIRAAAVTLKQMPGVNVTWDGEGPKQLP-SVDISVAVATDKG 372
Query: 410 LITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAII 589
LITPI+ A + I+ ++ L++KAR+ KL P+E+ GG+F+ISNLGMFGI EF A+I
Sbjct: 373 LITPIIKDAAAKGIQEIADSVKVLSKKARDGKLMPEEYQGGSFSISNLGMFGIDEFAAVI 432
Query: 590 NSPQAAILAVGAGIP--HLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKS 763
N PQA ILAVG P L D + + + T+ +D+R++D+ A+ F+ K+
Sbjct: 433 NPPQACILAVGRFRPVLKLTEDEEGNPQLQQHQLITVTMSSDSRVVDDELATRFLETFKA 492
Query: 764 YLENP 778
LENP
Sbjct: 493 NLENP 497
>sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 440
Score = 160 bits (406), Expect = 3e-39
Identities = 97/262 (37%), Positives = 145/262 (55%), Gaps = 5/262 (1%)
Frame = +2
Query: 8 EGDVLQHIDRSRLSPVCPPTTRPAAQPEXXXXXXHVDVPLTNMRQTIARRMAASKSSIPH 187
+ D+ I + + P + P A + H + L+NMR+ IARR+ SK +IPH
Sbjct: 179 KADIEAFIAEANQASSNPSVSTPEASGKITHDTPHNSIKLSNMRRVIARRLTESKQNIPH 238
Query: 188 RYSTGEASXXXXXXXXXXXXDQ---RGLVLSVNDFIVKAASLALRLVPEINNGLNADGTI 358
Y T + + + + +SVND ++KA +LAL+ P +N + D +
Sbjct: 239 IYLTVDVQMDALLKLRSELNESLAVQNIKISVNDMLIKAQALALKATPNVNVAFDGDQML 298
Query: 359 KINHNIDISVAVASESGLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTF 538
+ + DISVAV+ E GLITPI+ AD L+A+S + EL +AR +LQPQE+ GGT
Sbjct: 299 QFSQ-ADISVAVSVEGGLITPILKQADTKSLSALSVEMKELIARAREGRLQPQEYQGGTS 357
Query: 539 TISNLGMFGIKEFTAIINSPQAAILAVGAG--IPHLAHDPANPSKPKSVTKMRFTLCADA 712
+ISN+GMFGIK+F A+IN PQA+ILA+G+G P + D + ++T D
Sbjct: 358 SISNMGMFGIKQFNAVINPPQASILAIGSGERRPWVIDDAITIATVATITG-----SFDH 412
Query: 713 RIIDETSASEFVSRVKSYLENP 778
R+ID A+ F+S K +E P
Sbjct: 413 RVIDGADAAAFMSAFKHLVEKP 434
>sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 408
Score = 154 bits (388), Expect = 3e-37
Identities = 92/224 (41%), Positives = 132/224 (58%), Gaps = 4/224 (1%)
Frame = +2
Query: 119 VPLTNMRQTIARRMAASKSSIPHRYSTGEASXXXXXXXXXXXX----DQRGLVLSVNDFI 286
VP N+R+ IA+R+ SK ++PH Y + E + + + +SVNDFI
Sbjct: 184 VPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDVREDINKSFSEDKVTKISVNDFI 243
Query: 287 VKAASLALRLVPEINNGLNADGTIKINHNIDISVAVASESGLITPIVFGADKLPLAAISS 466
+ A + AL+ VP N + D I+ +N+DISVAVA E+G++TPIV A+K + +S
Sbjct: 244 ILAVAKALQEVPNANASWSEDA-IRYYNNVDISVAVAIENGIVTPIVKDANKKNIIELSR 302
Query: 467 TIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAIINSPQAAILAVGAGIPHLAH 646
+ L +KA++NKL P EF GG FTISNLGM+GIK F AIIN+PQ+ I+ VGA
Sbjct: 303 EMKTLIKKAKDNKLTPIEFQGGGFTISNLGMYGIKNFNAIINTPQSCIMGVGASTKRAI- 361
Query: 647 DPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKSYLENP 778
+ T M TL AD R+ID ++EF++ K ++ENP
Sbjct: 362 --VKNDQIIIATIMDVTLSADHRVIDGAVSAEFLASFKRFIENP 403
>sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 412
Score = 152 bits (384), Expect = 1e-36
Identities = 90/224 (40%), Positives = 129/224 (57%), Gaps = 4/224 (1%)
Frame = +2
Query: 119 VPLTNMRQTIARRMAASKSSIPHRYSTGEASXXXXXXXXXXXX----DQRGLVLSVNDFI 286
VP N+R+ IA+R+ SK ++PH Y + E + + + +SVNDFI
Sbjct: 188 VPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDIREDINKFFSEDKSTRISVNDFI 247
Query: 287 VKAASLALRLVPEINNGLNADGTIKINHNIDISVAVASESGLITPIVFGADKLPLAAISS 466
+ A + AL+ VP N D I+ +N+DISVAVA E+GL+TPIV A++ + +S
Sbjct: 248 ILAVAKALQEVPNANASWGEDA-IRYYNNVDISVAVAIENGLVTPIVKNANQKNILELSR 306
Query: 467 TIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAIINSPQAAILAVGAGIPHLAH 646
+ L +KA++NKL P+EF GG FTISNLGM+GIK F AIIN PQ+ I+ VGA
Sbjct: 307 EMKALIKKAKDNKLTPEEFQGGGFTISNLGMYGIKNFNAIINPPQSCIMGVGASAKRAI- 365
Query: 647 DPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKSYLENP 778
+ T M TL AD R++D +EF+ K ++E+P
Sbjct: 366 --VKNDQITIATIMDVTLSADHRVVDGAVGAEFLVAFKKFIESP 407
>sp|P20285|ODP2_NEUCR Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex, mitochondrial precursor (E2)
(Dihydrolipoamide acetyltransferase component of
pyruvate dehydrogenase complex) (PDC-E2) (MRP3)
Length = 458
Score = 144 bits (362), Expect = 4e-34
Identities = 89/229 (38%), Positives = 134/229 (58%), Gaps = 6/229 (2%)
Frame = +2
Query: 110 HVDVPLTNMRQTIARRMAASKSSIPHRYSTGEASXXXXXXXXXXXXDQRG--LVLSVNDF 283
+ DVP++ MR+TIA R+ S + PH + + S LSVNDF
Sbjct: 227 YTDVPISGMRKTIAARLKESVTENPHFFVSTNLSVSKLLKLRQALNSSADGRYKLSVNDF 286
Query: 284 IVKAASLALRLVPEINNGLNADGTIKINHNIDISVAVASESGLITPIVFGADKLPLAAIS 463
++KA +A + VP +N+ DG I+ +D+SVAVA+ +GLITPIV G + L +IS
Sbjct: 287 LIKAMGIASKRVPTVNSSWR-DGVIRQFETVDVSVAVATPNGLITPIVKGVEGKGLESIS 345
Query: 464 STIHELAEKARNNKLQPQEFMGGTFTISNLGMF-GIKEFTAIINSPQAAILAVGAGIPHL 640
+ + ELA+KAR+ KL+P+E+ GG+ +ISN+GM ++ FTAIIN PQAAILAVGA +
Sbjct: 346 AAVKELAKKARDGKLKPEEYQGGSISISNMGMNPAVQSFTAIINPPQAAILAVGAP-QKV 404
Query: 641 AHDPANPSKPKSVT---KMRFTLCADARIIDETSASEFVSRVKSYLENP 778
A N V+ ++ T D +++D +E++ +K +ENP
Sbjct: 405 AVPVENEDGTTGVSWDEQIIVTASFDHKVVDGAVGAEWIRELKKVIENP 453
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,214,742
Number of Sequences: 369166
Number of extensions: 1917272
Number of successful extensions: 5640
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5364
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5569
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7357347200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)