Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= Dr_sW_003_M14 (782 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransf... 178 2e-44 sp|O59816|ODP2_SCHPO Dihydrolipoyllysine-residue acetyltran... 176 6e-44 sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X compo... 172 9e-43 sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltran... 172 9e-43 sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltran... 167 2e-41 sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X compo... 164 3e-40 sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltran... 160 3e-39 sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltran... 154 3e-37 sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltran... 152 1e-36 sp|P20285|ODP2_NEUCR Dihydrolipoyllysine-residue acetyltran... 144 4e-34
>sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (E2) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (PDC-E2) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) Length = 555 Score = 178 bits (451), Expect = 2e-44 Identities = 109/244 (44%), Positives = 146/244 (59%), Gaps = 4/244 (1%) Frame = +2 Query: 59 PPTTRPAAQPEXXXXXXHVDVPLTNMRQTIARRMAASKSSIPHRYSTGEAS---XXXXXX 229 PP R A P +D+P++N+R+ IA+R+ SK +IPH Y + + + Sbjct: 315 PPGPRVAPTPAGVF----IDIPISNIRRVIAQRLMQSKQTIPHYYLSVDVNMGEVLLVRK 370 Query: 230 XXXXXXDQRGLVLSVNDFIVKAASLALRLVPEINNGLNADGTIKINHNIDISVAVASESG 409 + +G + SVNDFI+KA++LA VPE N+ D I+ NH +D+SVAV++ +G Sbjct: 371 ELNKMLEGKGKI-SVNDFIIKASALACLKVPEANSSW-MDTVIRQNHVVDVSVAVSTPAG 428 Query: 410 LITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAII 589 LITPIVF A L I+S + LA KAR KLQP EF GGTFTISNLGMFGIK F+AII Sbjct: 429 LITPIVFNAHIKGLETIASDVVSLASKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAII 488 Query: 590 NSPQAAILAVGAGIPHLAHDPANPSKPKSVTK-MRFTLCADARIIDETSASEFVSRVKSY 766 N PQA ILA+GA L PA+ K V M TL D R++D +++++ K Y Sbjct: 489 NPPQACILAIGASEDKLI--PADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLAEFKKY 546 Query: 767 LENP 778 LE P Sbjct: 547 LEKP 550
>sp|O59816|ODP2_SCHPO Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor (E2) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (PDC-E2) Length = 483 Score = 176 bits (446), Expect = 6e-44 Identities = 106/262 (40%), Positives = 145/262 (55%), Gaps = 12/262 (4%) Frame = +2 Query: 29 IDRSRLSPVCPP----------TTRPAAQPEXXXXXXHVDVPLTNMRQTIARRMAASKSS 178 +D PV P TT A+ + + D+PL+NMR+ IA R+A SK+ Sbjct: 218 VDIENFKPVVAPKPSNEAAAKATTPAASAADAAAPGDYEDLPLSNMRKIIASRLAESKNM 277 Query: 179 IPHRYSTGEASXXXXXXXXXXXXDQRG--LVLSVNDFIVKAASLALRLVPEINNGLNADG 352 PH Y T + LSVND ++KA + ALR VPE+N D Sbjct: 278 NPHYYVTVSVNMEKIIRLRAALNAMADGRYKLSVNDLVIKATTAALRQVPEVNAAWMGD- 336 Query: 353 TIKINHNIDISVAVASESGLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGG 532 I+ N+DIS+AVA+ SGLITP++ L LA IS+ + ++ARNNKL+P+E+ GG Sbjct: 337 FIRQYKNVDISMAVATPSGLITPVIRNTHALGLAEISTLAKDYGQRARNNKLKPEEYQGG 396 Query: 533 TFTISNLGMFGIKEFTAIINSPQAAILAVGAGIPHLAHDPANPSKPKSVTKMRFTLCADA 712 TFTISNLGMF + +FTAIIN PQA ILAVG + + D + K M+ TL +D Sbjct: 397 TFTISNLGMFPVDQFTAIINPPQACILAVGTTVDTVVPDSTSEKGFKVAPIMKCTLSSDH 456 Query: 713 RIIDETSASEFVSRVKSYLENP 778 R++D A+ F + +K LENP Sbjct: 457 RVVDGAMAARFTTALKKILENP 478
>sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X) (E3-binding protein) (E3BP) (proX) Length = 501 Score = 172 bits (436), Expect = 9e-43 Identities = 97/245 (39%), Positives = 150/245 (61%), Gaps = 2/245 (0%) Frame = +2 Query: 50 PVCPPTTRPAAQPEXXXXXXHVDVPLTNMRQTIARRMAASKSSIPHRYSTGEASXXXXXX 229 PV PP + P QP ++P +N+R+ IA+R+ SKS++PH Y+T + Sbjct: 258 PVIPPVSTPG-QPNAVGTF--TEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLK 314 Query: 230 XXXXXXDQRGLVLSVNDFIVKAASLALRLVPEINNGLNADGTIKINHNIDISVAVASESG 409 + +SVNDFI+KAA++ L+ +P++N + +G ++ IDISVAVA++ G Sbjct: 315 VRQDLVKD-DIKVSVNDFIIKAAAVTLKQMPDVNVSWDGEGPKQLPF-IDISVAVATDKG 372 Query: 410 LITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAII 589 L+TPI+ A + I+ ++ L++KAR+ KL P+E+ GG+F+ISNLGMFGI EFTA+I Sbjct: 373 LLTPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNLGMFGIDEFTAVI 432 Query: 590 NSPQAAILAVGAGIP--HLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKS 763 N PQA ILAVG P L D +K + + T+ +D+R++D+ A+ F+ K+ Sbjct: 433 NPPQACILAVGRFRPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKSFKA 492 Query: 764 YLENP 778 LENP Sbjct: 493 NLENP 497
>sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor (Pyruvate dehydrogenase complex E2 subunit) (PDCE2) (E2) (Dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex) (PDC-E2) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (M2 antigen complex 70 kDa subunit) Length = 614 Score = 172 bits (436), Expect = 9e-43 Identities = 106/245 (43%), Positives = 143/245 (58%), Gaps = 6/245 (2%) Frame = +2 Query: 62 PTTRPAAQPEXXXXXXHVDVPLTNMRQTIARRMAASKSSIPHRY-----STGEASXXXXX 226 P T P P D+P++N+R+ IA+R+ SK +IPH Y + GE Sbjct: 373 PPTGPGMAP--VPTGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSIDVNMGEVLLVRKE 430 Query: 227 XXXXXXXDQRGLVLSVNDFIVKAASLALRLVPEINNGLNADGTIKINHNIDISVAVASES 406 + +SVNDFI+KA++LA VPE N+ D I+ NH +D+SVAV++ + Sbjct: 431 LNKILEGRSK---ISVNDFIIKASALACLKVPEANSSW-MDTVIRQNHVVDVSVAVSTPA 486 Query: 407 GLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAI 586 GLITPIVF A + I++ + LA KAR KLQP EF GGTFTISNLGMFGIK F+AI Sbjct: 487 GLITPIVFNAHIKGVETIANDVVSLATKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAI 546 Query: 587 INSPQAAILAVGAGIPHLAHDPANPSKPKSV-TKMRFTLCADARIIDETSASEFVSRVKS 763 IN PQA ILA+GA L PA+ K V + M TL D R++D +++++ + Sbjct: 547 INPPQACILAIGASEDKLV--PADNEKGFDVASMMSVTLSCDHRVVDGAVGAQWLAEFRK 604 Query: 764 YLENP 778 YLE P Sbjct: 605 YLEKP 609
>sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor (E2) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (PDC-E2) Length = 592 Score = 167 bits (424), Expect = 2e-41 Identities = 100/223 (44%), Positives = 135/223 (60%), Gaps = 2/223 (0%) Frame = +2 Query: 116 DVPLTNMRQTIARRMAASKSSIPHRYSTGEASXXXXXXXXXXXXDQRGLVLSVNDFIVKA 295 D+P +N+R+ A R+ SK +IPH Y T E + +SVNDFIVKA Sbjct: 368 DIPHSNIRKVTAARLTESKQTIPHYYLTMECRVDKLLKLRSELNAMNTVKISVNDFIVKA 427 Query: 296 ASLALRLVPEINNGLNADGTIKINHNIDISVAVASESGLITPIVFGADKLPLAAISSTIH 475 + ALR P +N+ D I+ HNIDI+VAV + GL TPIV G D L +IS+++ Sbjct: 428 SLPALRDNPVVNSTWT-DQFIRRYHNIDINVAVNTPQGLFTPIVRGVDMKGLNSISTSVK 486 Query: 476 ELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAIINSPQAAILAVGAG--IPHLAHD 649 +LAEKA+N KL P EF GTFTISNLGM GIK+F A+IN PQAAILA+ + L++ Sbjct: 487 QLAEKAQNGKLHPSEFESGTFTISNLGMLGIKQFAAVINPPQAAILALVPQKLVSFLSNK 546 Query: 650 PANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKSYLENP 778 P +P ++ T + TL D R+ID +E++ K Y+ENP Sbjct: 547 PDSPY--ETATILSVTLSCDHRVIDGAVGAEWLKSFKDYVENP 587
>sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X) Length = 501 Score = 164 bits (415), Expect = 3e-40 Identities = 93/245 (37%), Positives = 148/245 (60%), Gaps = 2/245 (0%) Frame = +2 Query: 50 PVCPPTTRPAAQPEXXXXXXHVDVPLTNMRQTIARRMAASKSSIPHRYSTGEASXXXXXX 229 P+ PP + P QP ++P +N+R+ IA+R+ SKS++PH Y+T + Sbjct: 258 PMTPPVSIPG-QPNAAGTF--TEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLK 314 Query: 230 XXXXXXDQRGLVLSVNDFIVKAASLALRLVPEINNGLNADGTIKINHNIDISVAVASESG 409 + +SVNDFI++AA++ L+ +P +N + +G ++ ++DISVAVA++ G Sbjct: 315 VRRDLVKD-DIKVSVNDFIIRAAAVTLKQMPGVNVTWDGEGPKQLP-SVDISVAVATDKG 372 Query: 410 LITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAII 589 LITPI+ A + I+ ++ L++KAR+ KL P+E+ GG+F+ISNLGMFGI EF A+I Sbjct: 373 LITPIIKDAAAKGIQEIADSVKVLSKKARDGKLMPEEYQGGSFSISNLGMFGIDEFAAVI 432 Query: 590 NSPQAAILAVGAGIP--HLAHDPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKS 763 N PQA ILAVG P L D + + + T+ +D+R++D+ A+ F+ K+ Sbjct: 433 NPPQACILAVGRFRPVLKLTEDEEGNPQLQQHQLITVTMSSDSRVVDDELATRFLETFKA 492 Query: 764 YLENP 778 LENP Sbjct: 493 NLENP 497
>sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (E2) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) Length = 440 Score = 160 bits (406), Expect = 3e-39 Identities = 97/262 (37%), Positives = 145/262 (55%), Gaps = 5/262 (1%) Frame = +2 Query: 8 EGDVLQHIDRSRLSPVCPPTTRPAAQPEXXXXXXHVDVPLTNMRQTIARRMAASKSSIPH 187 + D+ I + + P + P A + H + L+NMR+ IARR+ SK +IPH Sbjct: 179 KADIEAFIAEANQASSNPSVSTPEASGKITHDTPHNSIKLSNMRRVIARRLTESKQNIPH 238 Query: 188 RYSTGEASXXXXXXXXXXXXDQ---RGLVLSVNDFIVKAASLALRLVPEINNGLNADGTI 358 Y T + + + + +SVND ++KA +LAL+ P +N + D + Sbjct: 239 IYLTVDVQMDALLKLRSELNESLAVQNIKISVNDMLIKAQALALKATPNVNVAFDGDQML 298 Query: 359 KINHNIDISVAVASESGLITPIVFGADKLPLAAISSTIHELAEKARNNKLQPQEFMGGTF 538 + + DISVAV+ E GLITPI+ AD L+A+S + EL +AR +LQPQE+ GGT Sbjct: 299 QFSQ-ADISVAVSVEGGLITPILKQADTKSLSALSVEMKELIARAREGRLQPQEYQGGTS 357 Query: 539 TISNLGMFGIKEFTAIINSPQAAILAVGAG--IPHLAHDPANPSKPKSVTKMRFTLCADA 712 +ISN+GMFGIK+F A+IN PQA+ILA+G+G P + D + ++T D Sbjct: 358 SISNMGMFGIKQFNAVINPPQASILAIGSGERRPWVIDDAITIATVATITG-----SFDH 412 Query: 713 RIIDETSASEFVSRVKSYLENP 778 R+ID A+ F+S K +E P Sbjct: 413 RVIDGADAAAFMSAFKHLVEKP 434
>sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (E2) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) Length = 408 Score = 154 bits (388), Expect = 3e-37 Identities = 92/224 (41%), Positives = 132/224 (58%), Gaps = 4/224 (1%) Frame = +2 Query: 119 VPLTNMRQTIARRMAASKSSIPHRYSTGEASXXXXXXXXXXXX----DQRGLVLSVNDFI 286 VP N+R+ IA+R+ SK ++PH Y + E + + + +SVNDFI Sbjct: 184 VPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDVREDINKSFSEDKVTKISVNDFI 243 Query: 287 VKAASLALRLVPEINNGLNADGTIKINHNIDISVAVASESGLITPIVFGADKLPLAAISS 466 + A + AL+ VP N + D I+ +N+DISVAVA E+G++TPIV A+K + +S Sbjct: 244 ILAVAKALQEVPNANASWSEDA-IRYYNNVDISVAVAIENGIVTPIVKDANKKNIIELSR 302 Query: 467 TIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAIINSPQAAILAVGAGIPHLAH 646 + L +KA++NKL P EF GG FTISNLGM+GIK F AIIN+PQ+ I+ VGA Sbjct: 303 EMKTLIKKAKDNKLTPIEFQGGGFTISNLGMYGIKNFNAIINTPQSCIMGVGASTKRAI- 361 Query: 647 DPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKSYLENP 778 + T M TL AD R+ID ++EF++ K ++ENP Sbjct: 362 --VKNDQIIIATIMDVTLSADHRVIDGAVSAEFLASFKRFIENP 403
>sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (E2) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) Length = 412 Score = 152 bits (384), Expect = 1e-36 Identities = 90/224 (40%), Positives = 129/224 (57%), Gaps = 4/224 (1%) Frame = +2 Query: 119 VPLTNMRQTIARRMAASKSSIPHRYSTGEASXXXXXXXXXXXX----DQRGLVLSVNDFI 286 VP N+R+ IA+R+ SK ++PH Y + E + + + +SVNDFI Sbjct: 188 VPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDIREDINKFFSEDKSTRISVNDFI 247 Query: 287 VKAASLALRLVPEINNGLNADGTIKINHNIDISVAVASESGLITPIVFGADKLPLAAISS 466 + A + AL+ VP N D I+ +N+DISVAVA E+GL+TPIV A++ + +S Sbjct: 248 ILAVAKALQEVPNANASWGEDA-IRYYNNVDISVAVAIENGLVTPIVKNANQKNILELSR 306 Query: 467 TIHELAEKARNNKLQPQEFMGGTFTISNLGMFGIKEFTAIINSPQAAILAVGAGIPHLAH 646 + L +KA++NKL P+EF GG FTISNLGM+GIK F AIIN PQ+ I+ VGA Sbjct: 307 EMKALIKKAKDNKLTPEEFQGGGFTISNLGMYGIKNFNAIINPPQSCIMGVGASAKRAI- 365 Query: 647 DPANPSKPKSVTKMRFTLCADARIIDETSASEFVSRVKSYLENP 778 + T M TL AD R++D +EF+ K ++E+P Sbjct: 366 --VKNDQITIATIMDVTLSADHRVVDGAVGAEFLVAFKKFIESP 407
>sp|P20285|ODP2_NEUCR Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor (E2) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (PDC-E2) (MRP3) Length = 458 Score = 144 bits (362), Expect = 4e-34 Identities = 89/229 (38%), Positives = 134/229 (58%), Gaps = 6/229 (2%) Frame = +2 Query: 110 HVDVPLTNMRQTIARRMAASKSSIPHRYSTGEASXXXXXXXXXXXXDQRG--LVLSVNDF 283 + DVP++ MR+TIA R+ S + PH + + S LSVNDF Sbjct: 227 YTDVPISGMRKTIAARLKESVTENPHFFVSTNLSVSKLLKLRQALNSSADGRYKLSVNDF 286 Query: 284 IVKAASLALRLVPEINNGLNADGTIKINHNIDISVAVASESGLITPIVFGADKLPLAAIS 463 ++KA +A + VP +N+ DG I+ +D+SVAVA+ +GLITPIV G + L +IS Sbjct: 287 LIKAMGIASKRVPTVNSSWR-DGVIRQFETVDVSVAVATPNGLITPIVKGVEGKGLESIS 345 Query: 464 STIHELAEKARNNKLQPQEFMGGTFTISNLGMF-GIKEFTAIINSPQAAILAVGAGIPHL 640 + + ELA+KAR+ KL+P+E+ GG+ +ISN+GM ++ FTAIIN PQAAILAVGA + Sbjct: 346 AAVKELAKKARDGKLKPEEYQGGSISISNMGMNPAVQSFTAIINPPQAAILAVGAP-QKV 404 Query: 641 AHDPANPSKPKSVT---KMRFTLCADARIIDETSASEFVSRVKSYLENP 778 A N V+ ++ T D +++D +E++ +K +ENP Sbjct: 405 AVPVENEDGTTGVSWDEQIIVTASFDHKVVDGAVGAEWIRELKKVIENP 453
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 92,214,742 Number of Sequences: 369166 Number of extensions: 1917272 Number of successful extensions: 5640 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 5364 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5569 length of database: 68,354,980 effective HSP length: 108 effective length of database: 48,403,600 effective search space used: 7357347200 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)