Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_M09
(782 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 237 3e-62
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 236 4e-62
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 234 2e-61
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 229 5e-60
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 226 4e-59
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 220 3e-57
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 220 4e-57
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 220 4e-57
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 218 2e-56
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 216 4e-56
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 237 bits (604), Expect = 3e-62
Identities = 128/257 (49%), Positives = 159/257 (61%), Gaps = 1/257 (0%)
Frame = +3
Query: 15 LILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKH 194
LIL+ + I + F + L +W +K R Y + RR +WE+N+K I+ H
Sbjct: 5 LILAAFCLGIASATLTF--DHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELH 62
Query: 195 NLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDW 374
N EY GKH++++ +N F DMT+EEF+ G KP +G + P P SVDW
Sbjct: 63 NQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPR-KGKVFQEPLFYEA-PRSVDW 120
Query: 375 RQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXX 554
R+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK RLIS SEQ LVDCS
Sbjct: 121 REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG 180
Query: 555 XLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAV 731
LMD AF+Y++D G++SE YPY AT+ +CK NP V TGF DI Q E L AV
Sbjct: 181 GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAV 239
Query: 732 ATVGPVSVAIDAGHASF 782
ATVGP+SVAIDAGH SF
Sbjct: 240 ATVGPISVAIDAGHESF 256
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 236 bits (603), Expect = 4e-62
Identities = 122/257 (47%), Positives = 161/257 (62%), Gaps = 1/257 (0%)
Frame = +3
Query: 15 LILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKH 194
L+L+ + I + KF N L+ +W +K T R Y + RR +WE+N+K I+ H
Sbjct: 5 LVLAAFCLGIASAVPKFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELH 62
Query: 195 NLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDW 374
N EY GKH +++ +N F DMTNEEF+ + +G + + +G + P + LP SVDW
Sbjct: 63 NGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDW 120
Query: 375 RQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXX 554
R+KGYVTPVKNQ+QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 121 RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG 180
Query: 555 XLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAV 731
M AF+Y+K+ G++SE YPY A D CK P V TGFT + E L AV
Sbjct: 181 GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV 240
Query: 732 ATVGPVSVAIDAGHASF 782
ATVGP+SVA+DAGH+SF
Sbjct: 241 ATVGPISVAMDAGHSSF 257
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 234 bits (597), Expect = 2e-61
Identities = 126/258 (48%), Positives = 157/258 (60%), Gaps = 2/258 (0%)
Frame = +3
Query: 15 LILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKH 194
L L+ + + I + KF + LN +W +K T R Y + RR +WE+N+K I+ H
Sbjct: 5 LFLTALCLGIASAAPKF--DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELH 62
Query: 195 NLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDW 374
N EY GKH +++ +N F DMTNEEF+ G K +G + P +P SVDW
Sbjct: 63 NREYSQGKHGFTMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKMFQEPL-FAEIPKSVDW 120
Query: 375 RQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXX 554
R+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 121 REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNG 180
Query: 555 XLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANA 728
LMDNAFRY+KD G++SE YPY D TC P TGF D+ Q E L A
Sbjct: 181 GLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDL-PQREKALMKA 239
Query: 729 VATVGPVSVAIDAGHASF 782
VAT+GP+SVAIDAGH SF
Sbjct: 240 VATLGPISVAIDAGHQSF 257
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 229 bits (585), Expect = 5e-60
Identities = 126/256 (49%), Positives = 154/256 (60%), Gaps = 2/256 (0%)
Frame = +3
Query: 21 LSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNL 200
L+++ + + + K N L+ W +K T R Y + RR +WE+N K I HN
Sbjct: 7 LTVLCLGVASAAPKLDPN--LDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQ 64
Query: 201 EYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQ 380
EY GKH + + +N F DMTNEEF+ G K +G + P + V P SVDW +
Sbjct: 65 EYSEGKHAFRMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKLFHEPLLVDV-PKSVDWTK 122
Query: 381 KGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXL 560
KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS L
Sbjct: 123 KGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGL 182
Query: 561 MDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVA 734
MDNAF+YIKD G++SE YPY ATD +C P TGF DI Q E L AVA
Sbjct: 183 MDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDI-PQREKALMKAVA 241
Query: 735 TVGPVSVAIDAGHASF 782
TVGP+SVAIDAGH SF
Sbjct: 242 TVGPISVAIDAGHTSF 257
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 226 bits (577), Expect = 4e-59
Identities = 124/258 (48%), Positives = 157/258 (60%), Gaps = 2/258 (0%)
Frame = +3
Query: 15 LILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKH 194
L L+ + + I + K N L+ +W +K T GR Y + RR +WE+N+K I+ H
Sbjct: 5 LFLTALCLGIASAAPKLDQN--LDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELH 62
Query: 195 NLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDW 374
N EY GKH +S+ +N F DMTNEEF+ G K +G + + V P SVDW
Sbjct: 63 NQEYSQGKHGFSMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKVFHESLVLEV-PKSVDW 120
Query: 375 RQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXX 554
R+KGYVT VKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 121 REKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG 180
Query: 555 XLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANA 728
LMDNAF+Y+KD G+++E YPY + +C P TGF DI Q E L A
Sbjct: 181 GLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDI-PQREKALMKA 239
Query: 729 VATVGPVSVAIDAGHASF 782
VATVGP+SVAIDAGH+SF
Sbjct: 240 VATVGPISVAIDAGHSSF 257
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 220 bits (561), Expect = 3e-57
Identities = 122/257 (47%), Positives = 156/257 (60%), Gaps = 1/257 (0%)
Frame = +3
Query: 12 ILILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQK 191
+L+L+++ + KF + + EW +K+T R Y + RR IWE+N++ IQ
Sbjct: 4 LLLLAVLCLGTALATPKF--DQTFSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQL 61
Query: 192 HNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVD 371
HN EY G+H +S+ +N F DMTNEEF+ G K +G + P + + P SVD
Sbjct: 62 HNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHK-KGRLFQEPLMLKI-PKSVD 119
Query: 372 WRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXX 551
WR+KG VTPVKNQ QCGSCW+FSA+G LEGQ F K +LIS SEQ LVDCS
Sbjct: 120 WREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCN 179
Query: 552 XXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANA 728
LMD AF+YIK+ G++SE YPY A DG+CK V TGF DI Q E L A
Sbjct: 180 GGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDI-PQQEKALMKA 238
Query: 729 VATVGPVSVAIDAGHAS 779
VATVGP+SVA+DA H S
Sbjct: 239 VATVGPISVAMDASHPS 255
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 220 bits (560), Expect = 4e-57
Identities = 110/248 (44%), Positives = 150/248 (60%)
Frame = +3
Query: 21 LSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNL 200
+ L ++A+ V V ++ W +K + ++Y+ D RR IWE+N+K+IQ+HNL
Sbjct: 1 MRLFILAVLTV----GVLGSNDDLWHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNL 56
Query: 201 EYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQ 380
+DLG TY+LGLNQF DMT EEFKAKYL M + N +P +DWR+
Sbjct: 57 RHDLGLVTYTLGLNQFTDMTFEEFKAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRE 116
Query: 381 KGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXL 560
GYVT VK+Q CGSCW+FS TG++EGQY + ISFSEQQLVDCS L
Sbjct: 117 SGYVTEVKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGL 176
Query: 561 MDNAFRYIKDQGIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATV 740
M+NA++Y+K G+E+E YPYTA +G C+ N V K TG+ + S +E +L N V
Sbjct: 177 MENAYQYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGAR 236
Query: 741 GPVSVAID 764
P +VA+D
Sbjct: 237 RPAAVAVD 244
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 220 bits (560), Expect = 4e-57
Identities = 120/257 (46%), Positives = 156/257 (60%), Gaps = 1/257 (0%)
Frame = +3
Query: 12 ILILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQK 191
+L+L+++ + KF + N +W +K+T R Y + RR +WE+N++ IQ
Sbjct: 4 LLLLAVLCLGTALATPKF--DQTFNAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQL 61
Query: 192 HNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVD 371
HN EY GKH +++ +N F DMTNEEF+ G K +G + P + + P +VD
Sbjct: 62 HNGEYSNGKHGFTMEMNAFGDMTNEEFRQIVNGYRHQKHK-KGRLFQEPLMLQI-PKTVD 119
Query: 372 WRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXX 551
WR+KG VTPVKNQ QCGSCW+FSA+G LEGQ F K +LIS SEQ LVDCS
Sbjct: 120 WREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCN 179
Query: 552 XXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANA 728
LMD AF+YIK+ G++SE YPY A DG+CK V TGF DI Q E L A
Sbjct: 180 GGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDI-PQQEKALMKA 238
Query: 729 VATVGPVSVAIDAGHAS 779
VATVGP+SVA+DA H S
Sbjct: 239 VATVGPISVAMDASHPS 255
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 218 bits (554), Expect = 2e-56
Identities = 121/261 (46%), Positives = 159/261 (60%), Gaps = 9/261 (3%)
Frame = +3
Query: 27 LVVVAITAVPQKFSVNSELNEEWETYKTTFGRKY-DELTDITRRLIWEQNLKYIQKHNLE 203
+ ++A+ A+ Q S + EEW TYK + Y +E+ + R I+ +N I KHN
Sbjct: 6 VALLALVALTQAISPLDLIKEEWHTYKLQHRKNYANEVEERFRMKIFNENRHKIAKHNQL 65
Query: 204 YDLGKHTYSLGLNQFADMTNEEFKAKYLG-------IMKTKPTLEGSTYMAPENIGVLPA 362
+ GK +Y LGLN++ADM + EFK G +M+ + L G+TY+ P ++ V P
Sbjct: 66 FAQGKVSYKLGLNKYADMLHHEFKETMNGYNHTLRQLMRERTGLVGATYIPPAHVTV-PK 124
Query: 363 SVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXX 542
SVDWR+ G VT VK+Q CGSCW+FS+TG+LEGQ+FRK L+S SEQ LVDCS
Sbjct: 125 SVDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNN 184
Query: 543 XXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDL 719
LMDNAFRYIKD GI++E YPY D +C N + I TGF DI +E +
Sbjct: 185 GCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKM 244
Query: 720 ANAVATVGPVSVAIDAGHASF 782
AVAT+GPVSVAIDA H SF
Sbjct: 245 KKAVATMGPVSVAIDASHESF 265
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 216 bits (551), Expect = 4e-56
Identities = 120/259 (46%), Positives = 159/259 (61%), Gaps = 4/259 (1%)
Frame = +3
Query: 18 ILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKH 194
+L L VV+ P++ L+ +WE +K T+ ++Y+ D I+RRLIWE+NLK+I H
Sbjct: 6 VLLLPVVSFALHPEEI-----LDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIH 60
Query: 195 NLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGS--TYMAPENIGVLPASV 368
NLE LG HTY L +N DMT+EE K G+ K P+ S T P+ G P S+
Sbjct: 61 NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGL-KVPPSRSHSNDTLYIPDWEGRTPDSI 119
Query: 369 DWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXX 548
D+R+KGYVTPVKNQ QCGSCW+FS+ G+LEGQ +K +L++ S Q LVDC
Sbjct: 120 DYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDC--VSENYGC 177
Query: 549 XXXLMDNAFRYI-KDQGIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLAN 725
M NAF+Y+ +++GI+SE YPY D +C NP+ KC G+ +I NE L
Sbjct: 178 GGGYMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKR 237
Query: 726 AVATVGPVSVAIDAGHASF 782
AVA VGPVSVAIDA SF
Sbjct: 238 AVARVGPVSVAIDASLTSF 256
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,870,458
Number of Sequences: 369166
Number of extensions: 1604274
Number of successful extensions: 4759
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4299
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4442
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7357347200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)