Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_L14
(795 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q13042|CDC16_HUMAN Cell division cycle protein 16 homolo... 185 1e-46
sp|Q8R349|CDC16_MOUSE Cell division cycle protein 16 homolo... 182 9e-46
sp|P41889|CUT9_SCHPO 20S cyclosome/APC complex protein cut9... 126 8e-29
sp|P09798|CDC16_YEAST Anaphase promoting complex subunit CD... 124 2e-28
sp|P38042|CDC27_YEAST Anaphase promoting complex subunit CD... 55 2e-07
sp|P30260|CDC27_HUMAN Cell division cycle protein 27 homolo... 48 3e-05
sp|P17885|BIMA_EMENI Protein bimA 48 4e-05
sp|O94556|CUT23_SCHPO 20S cyclosome/APC complex protein cut... 48 4e-05
sp|P16522|CDC23_YEAST Anaphase promoting complex subunit CD... 46 1e-04
sp|Q9UJX2|CDC23_HUMAN Cell division cycle protein 23 homolo... 45 2e-04
>sp|Q13042|CDC16_HUMAN Cell division cycle protein 16 homolog (CDC16Hs) (Anaphase
promoting complex subunit 6) (APC6) (Cyclosome subunit
6)
Length = 620
Score = 185 bits (470), Expect = 1e-46
Identities = 94/263 (35%), Positives = 162/263 (61%), Gaps = 1/263 (0%)
Frame = +3
Query: 9 LHSGNMLSANEAQIFLSSLDYSEIGNEKIAQLIKARYEDMFNIECETGKEHKLPMVDNIL 188
L S +ML+A E + L SL S++ NE+ +L++ +E+ + E +P + L
Sbjct: 170 LTSHHMLTAQEEKELLESLPLSKLCNEE-QELLRFLFENKLK-KYNKPSETVIPESVDGL 227
Query: 189 DEHYSNILNSATRYYNNAKFKKAYELTKSILKDDPHNPNCITLHVAILTELKLNNELFSF 368
E+ +++ A R+Y N FK Y+LT +++ DP + +C+ +H+ L EL NELF
Sbjct: 228 QENLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYL 287
Query: 369 ASGLIDNYPDKKESWYAIGCYSLVTGNYNLALQQFI-KATEIEKFFGYAWLAIGHTYSIQ 545
+ L+D YP SW+A+GCY L+ G+ N ++++ KAT +EK +G AW+A GH+++++
Sbjct: 288 SHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVE 347
Query: 546 KKSDQARAAYCSANQAIRGSHIPLLYIALEYSLDNNTCLSINYLQEAMKVGSHDPYFWNE 725
+ DQA AAY +A Q ++G H+P+LYI LEY L NN+ L+ + +A+ + DP+ +E
Sbjct: 348 SEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHE 407
Query: 726 KGYLSFKHKNYSDSLKFFLNAYE 794
G ++F++ + + K+FL+A E
Sbjct: 408 VGVVAFQNGEWKTAEKWFLDALE 430
>sp|Q8R349|CDC16_MOUSE Cell division cycle protein 16 homolog (Anaphase promoting complex
subunit 6) (APC6) (Cyclosome subunit 6)
Length = 620
Score = 182 bits (462), Expect = 9e-46
Identities = 93/263 (35%), Positives = 162/263 (61%), Gaps = 1/263 (0%)
Frame = +3
Query: 9 LHSGNMLSANEAQIFLSSLDYSEIGNEKIAQLIKARYEDMFNIECETGKEHKLPMVDNIL 188
L S +ML+A E + L SL +++ E+ +L++ +E+ + E +P + L
Sbjct: 170 LTSHHMLTAQEEKELLDSLPLNKLCAEE-QELLRFVFENKLK-KYNKPSETVIPESVDGL 227
Query: 189 DEHYSNILNSATRYYNNAKFKKAYELTKSILKDDPHNPNCITLHVAILTELKLNNELFSF 368
E+ +++ A R+Y N FK Y+LT ++++ DP + NC+ +H+ L EL NELF
Sbjct: 228 QENLDVVVSLAERHYYNCDFKMCYKLTSTVMEKDPFHANCLPVHIGTLVELNKANELFYL 287
Query: 369 ASGLIDNYPDKKESWYAIGCYSLVTGNYNLALQQFI-KATEIEKFFGYAWLAIGHTYSIQ 545
+ L+D YP SW+A+GCY L+ G+ N ++++ KAT +EK +G AW+A GH+++++
Sbjct: 288 SHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVE 347
Query: 546 KKSDQARAAYCSANQAIRGSHIPLLYIALEYSLDNNTCLSINYLQEAMKVGSHDPYFWNE 725
+ DQA AAY +A Q ++G H+P+LYI LEY L NN+ L+ + +A+ + DP+ +E
Sbjct: 348 SEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHE 407
Query: 726 KGYLSFKHKNYSDSLKFFLNAYE 794
G ++F++ + + K+FL+A E
Sbjct: 408 VGVVAFQNGEWKTAEKWFLDALE 430
>sp|P41889|CUT9_SCHPO 20S cyclosome/APC complex protein cut9 (Cell untimely torn protein 9)
Length = 671
Score = 126 bits (316), Expect = 8e-29
Identities = 75/267 (28%), Positives = 140/267 (52%), Gaps = 6/267 (2%)
Frame = +3
Query: 6 KLHSGNMLSANEAQIFLSSLDYSEIGNEKIAQLIKARYEDMFNIECETGKEHKLPMVD-- 179
+L S ++L+A+E + L+YS E A +++ Y N +T E +L +
Sbjct: 239 QLVSNHLLTADEEWDLVLKLNYSTYSKEDAA-FLRSLYMLKLN---KTSHEDELRRAEDY 294
Query: 180 ----NILDEHYSNILNSATRYYNNAKFKKAYELTKSILKDDPHNPNCITLHVAILTELKL 347
N L++ +L A + ++F +T IL+ DP+N + LH+A L E
Sbjct: 295 LSSINGLEKSSDLLLCKADTLFVRSRFIDVLAITTKILEIDPYNLDVYPLHLASLHESGE 354
Query: 348 NNELFSFASGLIDNYPDKKESWYAIGCYSLVTGNYNLALQQFIKATEIEKFFGYAWLAIG 527
N+L+ ++ L+D +P+K +W A+G Y L + A + F K++ ++ FG AW+
Sbjct: 355 KNKLYLISNDLVDRHPEKAVTWLAVGIYYLCVNKISEARRYFSKSSTMDPQFGPAWIGFA 414
Query: 528 HTYSIQKKSDQARAAYCSANQAIRGSHIPLLYIALEYSLDNNTCLSINYLQEAMKVGSHD 707
H+++I+ + DQA +AY +A + +G+H+P L++ +++ N L+ YLQ + + +D
Sbjct: 415 HSFAIEGEHDQAISAYTTAARLFQGTHLPYLFLGMQHMQLGNILLANEYLQSSYALFQYD 474
Query: 708 PYFWNEKGYLSFKHKNYSDSLKFFLNA 788
P NE G ++F + ++ F NA
Sbjct: 475 PLLLNELGVVAFNKSDMQTAINHFQNA 501
>sp|P09798|CDC16_YEAST Anaphase promoting complex subunit CDC16 (Cell division control
protein 16)
Length = 840
Score = 124 bits (312), Expect = 2e-28
Identities = 71/266 (26%), Positives = 131/266 (49%), Gaps = 2/266 (0%)
Frame = +3
Query: 3 QKLHSGNMLSANEAQIFLSSLDYSEIGNEK--IAQLIKARYEDMFNIECETGKEHKLPMV 176
+ L S N+L+ E SLD+ E G +K + L K N E T K +++
Sbjct: 397 EMLLSKNLLTPQEEWDLFDSLDFKEFGEDKEIMKNLYKINLSKYINTEDIT-KSNEILAK 455
Query: 177 DNILDEHYSNILNSATRYYNNAKFKKAYELTKSILKDDPHNPNCITLHVAILTELKLNNE 356
D L ++ + + Y KF + EL +++L++D N N + ++ L EL N+
Sbjct: 456 DYKLADNVDVVRSKVDICYTQCKFNECLELCETVLENDEFNTNILPAYIGCLYELSNKNK 515
Query: 357 LFSFASGLIDNYPDKKESWYAIGCYSLVTGNYNLALQQFIKATEIEKFFGYAWLAIGHTY 536
LF + L + +P +W+++ Y + + A + + K++ ++ F AWL HTY
Sbjct: 516 LFLLSHRLAETFPKSAITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTY 575
Query: 537 SIQKKSDQARAAYCSANQAIRGSHIPLLYIALEYSLDNNTCLSINYLQEAMKVGSHDPYF 716
+++ + DQA AY +A++ G H+P L++ +++ N+ L+ +Y A + +DP
Sbjct: 576 ALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFMAMNSLNLAESYFVLAYDICPNDPLV 635
Query: 717 WNEKGYLSFKHKNYSDSLKFFLNAYE 794
NE G + FK + + K+ A E
Sbjct: 636 LNEMGVMYFKKNEFVKAKKYLKKALE 661
>sp|P38042|CDC27_YEAST Anaphase promoting complex subunit CDC27 (Cell division control
protein 27) (Anaphase promoting complex subunit 3)
Length = 758
Score = 55.1 bits (131), Expect = 2e-07
Identities = 26/74 (35%), Positives = 43/74 (58%)
Frame = +3
Query: 363 SFASGLIDNYPDKKESWYAIGCYSLVTGNYNLALQQFIKATEIEKFFGYAWLAIGHTYSI 542
+ A+GL+D P+K E+W IG + +++ A++ F KAT+++ F YA+ GH +S
Sbjct: 527 NLANGLMDTMPNKPETWCCIGNLLSLQKDHDAAIKAFEKATQLDPNFAYAYTLQGHEHSS 586
Query: 543 QKKSDQARAAYCSA 584
SD A+ Y A
Sbjct: 587 NDSSDSAKTCYRKA 600
>sp|P30260|CDC27_HUMAN Cell division cycle protein 27 homolog (CDC27Hs) (H-NUC)
Length = 824
Score = 48.1 bits (113), Expect = 3e-05
Identities = 43/217 (19%), Positives = 98/217 (45%), Gaps = 24/217 (11%)
Frame = +3
Query: 6 KLHSGNMLSAN-EAQIFLSSLDYSEIGNEKIA---------QLIKARYEDMFNIECETGK 155
K + G + N + ++ LD S I KI+ L KA E + ++ E GK
Sbjct: 412 KTNKGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGK 471
Query: 156 ----------EHKLPMVDNILDEHYSN---ILNSATRYYNNAKFKKAYELTKSILKDDPH 296
+ + ++ ++ HY+ + Y+ +++ +A + + + + +
Sbjct: 472 GYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENY 531
Query: 297 NPNCITLHVAILTELKLNNELFSFASGLIDNYPDKKESWYAIG-CYSLVTGNYNLALQQF 473
+ ++ L L+ + L + L D + E+W A G C+SL +++A++ F
Sbjct: 532 RVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQR-EHDIAIKFF 590
Query: 474 IKATEIEKFFGYAWLAIGHTYSIQKKSDQARAAYCSA 584
+A +++ + YA+ +GH + + ++ D+A A + +A
Sbjct: 591 QRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNA 627
>sp|P17885|BIMA_EMENI Protein bimA
Length = 806
Score = 47.8 bits (112), Expect = 4e-05
Identities = 33/122 (27%), Positives = 57/122 (46%)
Frame = +3
Query: 228 YYNNAKFKKAYELTKSILKDDPHNPNCITLHVAILTELKLNNELFSFASGLIDNYPDKKE 407
YY A + +A + + P + ++ +L LK + EL A L+D E
Sbjct: 523 YYEQAMYTEAEKYFVRVKAMAPSRLEDMEIYSTVLWHLKNDVELAYLAHELMDVDRLSPE 582
Query: 408 SWYAIGCYSLVTGNYNLALQQFIKATEIEKFFGYAWLAIGHTYSIQKKSDQARAAYCSAN 587
+W A+G +++ AL+ F +AT+++ F Y + GH Y ++ D+A AY S
Sbjct: 583 AWCAVGNSFSHQRDHDQALKCFKRATQLDPHFAYGFTLQGHEYVANEEYDKALDAYRSGI 642
Query: 588 QA 593
A
Sbjct: 643 NA 644
>sp|O94556|CUT23_SCHPO 20S cyclosome/APC complex protein cut23 (Anaphase promoting factor
component 8) (Cell untimely torn protein 23)
Length = 565
Score = 47.8 bits (112), Expect = 4e-05
Identities = 41/188 (21%), Positives = 82/188 (43%), Gaps = 2/188 (1%)
Frame = +3
Query: 231 YNNAKFKKAYELTKSILKDDPHNPNCITLHVAILTELKLNNELFSFA--SGLIDNYPDKK 404
Y++ F +A L ++IL +DP+ + + + +L L+ ++L A + ID + +
Sbjct: 281 YDSRDFDEAESLFENILTNDPYRLDDMDTYSNVLFVLENKSKLGFLAQVASSIDKF--RP 338
Query: 405 ESWYAIGCYSLVTGNYNLALQQFIKATEIEKFFGYAWLAIGHTYSIQKKSDQARAAYCSA 584
E+ IG Y + + A+ F +A ++ + + AW +GH Y K + A +Y A
Sbjct: 339 ETCSIIGNYYSLLSEHEKAVTYFKRALQLNRNYLSAWTLMGHEYVELKNTHAAIESYRLA 398
Query: 585 NQAIRGSHIPLLYIALEYSLDNNTCLSINYLQEAMKVGSHDPYFWNEKGYLSFKHKNYSD 764
R + + Y + + ++ Y Q A + +D W G K +
Sbjct: 399 VDVNRKDYRAWYGLGQTYEVLDMHFYALYYFQRATALRPYDQRMWQALGNCYEKIDRPQE 458
Query: 765 SLKFFLNA 788
++K + A
Sbjct: 459 AIKSYKRA 466
>sp|P16522|CDC23_YEAST Anaphase promoting complex subunit CDC23 (Cell division control
protein 23)
Length = 626
Score = 46.2 bits (108), Expect = 1e-04
Identities = 42/188 (22%), Positives = 73/188 (38%)
Frame = +3
Query: 216 SATRYYNNAKFKKAYELTKSILKDDPHNPNCITLHVAILTELKLNNELFSFASGLIDNYP 395
+AT YNN + A I+K DP+ N + + IL ++ N++L A +
Sbjct: 335 NATISYNNLDYVTAESRFDDIVKQDPYRLNDLETYSNILYVMQKNSKLAYLAQFVSQIDR 394
Query: 396 DKKESWYAIGCYSLVTGNYNLALQQFIKATEIEKFFGYAWLAIGHTYSIQKKSDQARAAY 575
+ E+ I Y + ++ F +A ++K AW +GH + S A Y
Sbjct: 395 FRPETCCIIANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECY 454
Query: 576 CSANQAIRGSHIPLLYIALEYSLDNNTCLSINYLQEAMKVGSHDPYFWNEKGYLSFKHKN 755
A + Y+L + S+ Y Q+A + D W G K N
Sbjct: 455 RRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGN 514
Query: 756 YSDSLKFF 779
+++K +
Sbjct: 515 KVEAIKCY 522
>sp|Q9UJX2|CDC23_HUMAN Cell division cycle protein 23 homolog (Anaphase promoting complex
subunit 8) (APC8) (Cyclosome subunit 8)
Length = 591
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/216 (20%), Positives = 80/216 (37%), Gaps = 4/216 (1%)
Frame = +3
Query: 156 EHKLPMVDNILDEHYSN----ILNSATRYYNNAKFKKAYELTKSILKDDPHNPNCITLHV 323
E L N++D +S + A Y+N KA + + K DP+ +
Sbjct: 239 EEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFS 298
Query: 324 AILTELKLNNELFSFASGLIDNYPDKKESWYAIGCYSLVTGNYNLALQQFIKATEIEKFF 503
+L + +EL A L + + E+ IG Y + + A F +A ++ +
Sbjct: 299 NLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRY 358
Query: 504 GYAWLAIGHTYSIQKKSDQARAAYCSANQAIRGSHIPLLYIALEYSLDNNTCLSINYLQE 683
AW +GH Y K + A AY A + + + + Y + + Y +
Sbjct: 359 LGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRR 418
Query: 684 AMKVGSHDPYFWNEKGYLSFKHKNYSDSLKFFLNAY 791
A ++ +D G K ++ K + AY
Sbjct: 419 AHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAY 454
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,538,096
Number of Sequences: 369166
Number of extensions: 1623575
Number of successful extensions: 4237
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4074
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4221
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7473924075
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)