Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_L03
(828 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9QZA6|CD151_RAT Platelet endothelial tetraspan antigen ... 115 1e-25
sp|O35566|C151_MOUSE Platelet-endothelial tetraspan antigen... 113 7e-25
sp|P48509|CD151_HUMAN Platelet-endothelial tetraspan antige... 109 1e-23
sp|P28648|CD63_RAT CD63 antigen (AD1 antigen) 108 2e-23
sp|Q9XSK2|CD63_BOVIN CD63 antigen 107 3e-23
sp|P61171|CD151_MACMU Platelet-endothelial tetraspan antige... 104 3e-22
sp|O60637|TSN3_HUMAN Tetraspanin-3 (Tspan-3) (Transmembrane... 103 6e-22
sp|Q9QY33|TSN3_MOUSE Tetraspanin-3 (Tspan-3) (Transmembrane... 103 6e-22
sp|P08962|CD63_HUMAN CD63 antigen (Melanoma-associated anti... 102 1e-21
sp|P41731|CD63_MOUSE CD63 antigen 100 6e-21
>sp|Q9QZA6|CD151_RAT Platelet endothelial tetraspan antigen 3 (CD151 antigen)
Length = 253
Score = 115 bits (289), Expect = 1e-25
Identities = 62/222 (27%), Positives = 110/222 (49%), Gaps = 4/222 (1%)
Frame = +2
Query: 56 WLSGLALIVISAFFLANGTMKYVDEIINSSTNKGLLYGILAVGVIIFVIAFCGCCGAIKD 235
WL+GLA++ + + LA + Y+ ++ SST Y ++ GV++ V GCC K+
Sbjct: 28 WLAGLAVMAVGIWTLALKS-DYIS-LLASSTYLATAYILVVAGVVVMVTGVLGCCATFKE 85
Query: 236 SKMLLGIYIFLLFLVIIAEAVFGIYAIVKRPAVEEMIQNEFSKAFQKIY--GNDTTVTKT 409
+ LL +Y LL ++ + E + GI A V + ++ K Y VT
Sbjct: 86 RRNLLRLYFILLLIIFLLEIIAGILAYVYYQQLNTELKENLKDTMIKRYHQSGHEGVTNA 145
Query: 410 VDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPSSCCDPITSPCWELGYDKKAF--T 583
VD LQQ CCG+ DW S+W ++ + ++ P SCC + + C + + +
Sbjct: 146 VDKLQQEFHCCGSNNSRDWRDSEWIRSGEADSRVVPDSCCKTVVTGCGKREHASNIYKVE 205
Query: 584 DGCIPKMFSYAKTYFPLVIGITLGIAFFEIFVVVCAFCLCRN 709
GCI K+ S+ + + ++ + +GIA ++F ++ CL R+
Sbjct: 206 GGCITKLESFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRS 247
>sp|O35566|C151_MOUSE Platelet-endothelial tetraspan antigen 3 (PETA-3) (GP27) (Membrane
glycoprotein SFA-1) (CD151 antigen)
Length = 253
Score = 113 bits (282), Expect = 7e-25
Identities = 60/222 (27%), Positives = 110/222 (49%), Gaps = 4/222 (1%)
Frame = +2
Query: 56 WLSGLALIVISAFFLANGTMKYVDEIINSSTNKGLLYGILAVGVIIFVIAFCGCCGAIKD 235
WL+GLA++ + + LA + Y+ ++ SST Y ++ GV++ V GCC K+
Sbjct: 28 WLAGLAVMAVGIWTLALKS-DYIS-LLASSTYLATAYILVVAGVVVMVTGVLGCCATFKE 85
Query: 236 SKMLLGIYIFLLFLVIIAEAVFGIYAIVKRPAVEEMIQNEFSKAFQKIY--GNDTTVTKT 409
+ LL +Y LL ++ + E + GI A V + ++ K Y V+
Sbjct: 86 RRNLLRLYFILLLIIFLLEIIAGILAYVYYQQLNTELKENLKDTMVKRYHQSGHEGVSSA 145
Query: 410 VDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPSSCCDPITSPCWELGYDKKAF--T 583
VD LQQ CCG+ DW S+W ++ + ++ P SCC + + C + + +
Sbjct: 146 VDKLQQEFHCCGSNNSQDWQDSEWIRSGEADSRVVPDSCCKTMVAGCGKRDHASNIYKVE 205
Query: 584 DGCIPKMFSYAKTYFPLVIGITLGIAFFEIFVVVCAFCLCRN 709
GCI K+ ++ + + ++ + +GIA ++F ++ CL R+
Sbjct: 206 GGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRS 247
>sp|P48509|CD151_HUMAN Platelet-endothelial tetraspan antigen 3 (PETA-3) (GP27) (Membrane
glycoprotein SFA-1) (CD151 antigen) (Tetraspanin-24)
(Tspan-24)
Length = 253
Score = 109 bits (272), Expect = 1e-23
Identities = 57/222 (25%), Positives = 106/222 (47%), Gaps = 4/222 (1%)
Frame = +2
Query: 56 WLSGLALIVISAFFLANGTMKYVDEIINSSTNKGLLYGILAVGVIIFVIAFCGCCGAIKD 235
WL+GLA++ + + LA + Y+ ++ S T Y ++ G ++ V GCC K+
Sbjct: 28 WLAGLAVMAVGIWTLALKS-DYIS-LLASGTYLATAYILVVAGTVVMVTGVLGCCATFKE 85
Query: 236 SKMLLGIYIFLLFLVIIAEAVFGIYAIVKRPAVEEMIQNEFSKAFQKIY--GNDTTVTKT 409
+ LL +Y LL ++ + E + GI A + ++ + Y VT
Sbjct: 86 RRNLLRLYFILLLIIFLLEIIAGILAYAYYQQLNTELKENLKDTMTRRYHQSGHEAVTSA 145
Query: 410 VDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPSSCCDPITSPCWELGYDKKAF--T 583
VD LQQ CCG+ DW S+W ++ + + P SCC + + C + + +
Sbjct: 146 VDQLQQEFHCCGSNNSQDWRDSEWIRSQEAGGRVVPDSCCKTVVALCGQRDHASNIYKVE 205
Query: 584 DGCIPKMFSYAKTYFPLVIGITLGIAFFEIFVVVCAFCLCRN 709
GCI K+ ++ + + ++ + +GIA ++F ++ CL R+
Sbjct: 206 GGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRS 247
>sp|P28648|CD63_RAT CD63 antigen (AD1 antigen)
Length = 238
Score = 108 bits (270), Expect = 2e-23
Identities = 62/183 (33%), Positives = 96/183 (52%), Gaps = 3/183 (1%)
Frame = +2
Query: 170 ILAVGVIIFVIAFCGCCGAIKDSKMLLGIYIFLLFLVIIAEAVFGIYAIVKRPAVEEMIQ 349
I+AVG +F++AF GCCGA K++ L+ + L L+++ E I V R + ++
Sbjct: 57 IIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFR----DQVK 112
Query: 350 NEFSKAFQKIYGNDTTVTKT---VDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPS 520
+EFSK+FQK N T KT +D LQ+ +CCGA+ TDW + + P
Sbjct: 113 SEFSKSFQKQMQNYLTDNKTATILDKLQKENKCCGASNYTDWERIPGMAKDR-----VPD 167
Query: 521 SCCDPITSPCWELGYDKKAFTDGCIPKMFSYAKTYFPLVIGITLGIAFFEIFVVVCAFCL 700
SCC IT C + T GC+ + ++ + LV G LGIAF E+ ++ + CL
Sbjct: 168 SCCINITVGCGNDFKESTIHTQGCVETIAAWLRKNVLLVAGAALGIAFVEVLGIIFSCCL 227
Query: 701 CRN 709
++
Sbjct: 228 VKS 230
>sp|Q9XSK2|CD63_BOVIN CD63 antigen
Length = 237
Score = 107 bits (268), Expect = 3e-23
Identities = 61/183 (33%), Positives = 94/183 (51%), Gaps = 3/183 (1%)
Frame = +2
Query: 170 ILAVGVIIFVIAFCGCCGAIKDSKMLLGIYIFLLFLVIIAEAVFGIYAIVKRPAVEEMIQ 349
I+AVG +F++AF GCCGA K++ L+ + L L+++ E I V R + ++
Sbjct: 57 IIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFR----DKVR 112
Query: 350 NEFSKAFQ---KIYGNDTTVTKTVDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPS 520
+EF+K F+ K Y D +D +Q+ +CCGA TDW + T P
Sbjct: 113 SEFNKDFRQQMKNYPKDNQTASILDKMQKDFECCGAANYTDW------EKILAVTNKVPD 166
Query: 521 SCCDPITSPCWELGYDKKAFTDGCIPKMFSYAKTYFPLVIGITLGIAFFEIFVVVCAFCL 700
SCC IT C K T+GC+ K+ ++ + +V+ LGIAF EI +V A CL
Sbjct: 167 SCCVNITHNCGINFVVKDIHTEGCVEKIAAWLRKNVLVVVAAALGIAFVEILGIVLACCL 226
Query: 701 CRN 709
++
Sbjct: 227 VKS 229
>sp|P61171|CD151_MACMU Platelet-endothelial tetraspan antigen 3 (PETA-3) (CD151 antigen)
sp|P61170|CD151_CERAE Platelet-endothelial tetraspan antigen 3 (PETA-3) (CD151 antigen)
Length = 253
Score = 104 bits (259), Expect = 3e-22
Identities = 57/222 (25%), Positives = 105/222 (47%), Gaps = 4/222 (1%)
Frame = +2
Query: 56 WLSGLALIVISAFFLANGTMKYVDEIINSSTNKGLLYGILAVGVIIFVIAFCGCCGAIKD 235
WL+GLA++ + + LA + Y+ ++ S T Y ++ G ++ V GCC K+
Sbjct: 28 WLAGLAVMAVGIWTLALKS-DYIS-LLASGTYLATAYILVVAGAVVMVTGVLGCCATFKE 85
Query: 236 SKMLLGIYIFLLFLVIIAEAVFGIYAIVKRPAVEEMIQNEFSKAFQKIYGND--TTVTKT 409
+ LL +Y LL ++ + E + G+ A V + ++ K Y VT
Sbjct: 86 RRNLLRLYFILLLIIFLLEIIAGVLAYVYYQQLNTELKENLKDTMAKRYHQPGHEAVTSA 145
Query: 410 VDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPSSCCDPITSPCWELGYDKKAF--T 583
VD LQQ CCG+ DW S+W + + + + P SCC + + C + + +
Sbjct: 146 VDQLQQEFHCCGSNNSQDWRDSEWIRLREARGRVVPDSCCKTVVAGCGQRDHAFNIYKVE 205
Query: 584 DGCIPKMFSYAKTYFPLVIGITLGIAFFEIFVVVCAFCLCRN 709
G I K+ ++ + + ++ + GIA ++F ++ CL R+
Sbjct: 206 GGFITKLETFIQEHLRVIGAVGTGIACVQVFGMIFTCCLYRS 247
>sp|O60637|TSN3_HUMAN Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8)
(Tetraspanin TM4-A)
Length = 253
Score = 103 bits (257), Expect = 6e-22
Identities = 57/188 (30%), Positives = 93/188 (49%), Gaps = 7/188 (3%)
Frame = +2
Query: 170 ILAVGVIIFVIAFCGCCGAIKDSKMLLGIYIFLLFLVIIAEAVFGIYAIVKRPAVEEMIQ 349
I+AVG ++F+I GCC I++S+ L ++ +L LV + E V + V R VE
Sbjct: 57 IIAVGALLFIIGLIGCCATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRAKVE---- 112
Query: 350 NEFSKAFQKIY-----GNDTTVTKTVDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPF 514
NE ++ QK+Y N ++ +D +Q+ + CCG +DW +DW++ +KN Q
Sbjct: 113 NEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKN--QSV 170
Query: 515 PSSCCDPITSPC-WELGYDKKAFTDGCIPKMFSYAKTYFPLVIGITLGIAFFEIFVVVCA 691
P SCC S C L + + +GC + + VI L A ++ ++CA
Sbjct: 171 PLSCCRETASNCNGSLAHPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCA 230
Query: 692 -FCLCRNT 712
LCR +
Sbjct: 231 CIVLCRRS 238
>sp|Q9QY33|TSN3_MOUSE Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8)
(Tetraspanin TM4-A) (OSP-associated protein 1) (OAP-1)
Length = 253
Score = 103 bits (257), Expect = 6e-22
Identities = 57/188 (30%), Positives = 92/188 (48%), Gaps = 7/188 (3%)
Frame = +2
Query: 170 ILAVGVIIFVIAFCGCCGAIKDSKMLLGIYIFLLFLVIIAEAVFGIYAIVKRPAVEEMIQ 349
I+AVG ++F+I GCC I++S+ L ++F+L LV + E V + V R VE
Sbjct: 57 IIAVGALLFIIGLIGCCATIRESRCGLATFVFILLLVFVTEVVVVVLGYVYRAKVE---- 112
Query: 350 NEFSKAFQKIY-----GNDTTVTKTVDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPF 514
NE ++ QK+Y N ++ +D +Q+ + CCG +DW +DW++ +KN Q
Sbjct: 113 NEVDRSIQKVYKTYNGTNSDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKN--QSV 170
Query: 515 PSSCCDPITSPC-WELGYDKKAFTDGCIPKMFSYAKTYFPLVIGITLGIAFFEIFVVVCA 691
P SCC C L + +GC + + VI L A ++ ++CA
Sbjct: 171 PLSCCRETAKSCNGSLANPSDLYAEGCEALVVKKLQEILMHVIWAALAFAAIQLLGMLCA 230
Query: 692 -FCLCRNT 712
LCR +
Sbjct: 231 CIVLCRRS 238
>sp|P08962|CD63_HUMAN CD63 antigen (Melanoma-associated antigen ME491)
(Lysosome-associated membrane glycoprotein 3) (LAMP-3)
(Ocular melanoma-associated antigen) (OMA81H)
(Granulophysin) (Tetraspanin-30) (Tspan-30)
Length = 238
Score = 102 bits (254), Expect = 1e-21
Identities = 64/194 (32%), Positives = 97/194 (50%), Gaps = 1/194 (0%)
Frame = +2
Query: 131 IINSSTNKGLL-YGILAVGVIIFVIAFCGCCGAIKDSKMLLGIYIFLLFLVIIAEAVFGI 307
II +T LL I+AVGV +F++AF GCCGA K++ L+ + L L+++ E I
Sbjct: 43 IIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAI 102
Query: 308 YAIVKRPAVEEMIQNEFSKAFQKIYGNDTTVTKTVDSLQQAMQCCGATKMTDWLQSDWYQ 487
V R V N F + + N+ T + +D +Q +CCGA TDW +
Sbjct: 103 AGYVFRDKVMSEFNNNFRQQMENYPKNNHTAS-ILDRMQADFKCCGAANYTDWEKIP--S 159
Query: 488 NSKNKTQPFPSSCCDPITSPCWELGYDKKAFTDGCIPKMFSYAKTYFPLVIGITLGIAFF 667
SKN+ P SCC +T C +K +GC+ K+ + + +V LGIAF
Sbjct: 160 MSKNRV---PDSCCINVTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFV 216
Query: 668 EIFVVVCAFCLCRN 709
E+ +V A CL ++
Sbjct: 217 EVLGIVFACCLVKS 230
>sp|P41731|CD63_MOUSE CD63 antigen
Length = 238
Score = 100 bits (248), Expect = 6e-21
Identities = 57/183 (31%), Positives = 90/183 (49%), Gaps = 3/183 (1%)
Frame = +2
Query: 170 ILAVGVIIFVIAFCGCCGAIKDSKMLLGIYIFLLFLVIIAEAVFGIYAIVKRPAVEEMIQ 349
I+AVG +F++AF GCCGA K++ L+ + L L+++ E I V R + ++
Sbjct: 57 IIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFR----DQVK 112
Query: 350 NEFSKAFQ---KIYGNDTTVTKTVDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPS 520
+EF+K+FQ + Y D +D LQ+ CCGA+ TDW + P
Sbjct: 113 SEFNKSFQQQMQNYLKDNKTATILDKLQKENNCCGASNYTDWENIPGMAKDR-----VPD 167
Query: 521 SCCDPITSPCWELGYDKKAFTDGCIPKMFSYAKTYFPLVIGITLGIAFFEIFVVVCAFCL 700
SCC IT C + T GC+ + + + LV LGIAF E+ ++ + CL
Sbjct: 168 SCCINITVGCGNDFKESTIHTQGCVETIAIWLRKNILLVAAAALGIAFVEVLGIIFSCCL 227
Query: 701 CRN 709
++
Sbjct: 228 VKS 230
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,033,998
Number of Sequences: 369166
Number of extensions: 1881124
Number of successful extensions: 5366
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5104
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5278
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8004331590
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)