Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_L02
(459 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q60597|ODO1_MOUSE 2-oxoglutarate dehydrogenase E1 compon... 109 3e-24
sp|Q5RCB8|ODO1_PONPY 2-oxoglutarate dehydrogenase E1 compon... 105 5e-23
sp|Q60HE2|ODO1_MACFA 2-oxoglutarate dehydrogenase E1 compon... 105 5e-23
sp|Q02218|ODO1_HUMAN 2-oxoglutarate dehydrogenase E1 compon... 100 3e-21
sp|P20967|ODO1_YEAST 2-oxoglutarate dehydrogenase E1 compon... 79 5e-15
sp|P51056|ODO1_COXBU 2-oxoglutarate dehydrogenase E1 compon... 79 6e-15
sp|Q9ZDY3|ODO1_RICPR 2-oxoglutarate dehydrogenase E1 compon... 72 5e-13
sp|Q59106|ODO1_RALEU 2-oxoglutarate dehydrogenase E1 compon... 70 2e-12
sp|Q8K9N3|ODO1_BUCAP 2-oxoglutarate dehydrogenase E1 compon... 70 2e-12
sp|Q92J42|ODO1_RICCN 2-oxoglutarate dehydrogenase E1 compon... 69 4e-12
>sp|Q60597|ODO1_MOUSE 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor
(Alpha-ketoglutarate dehydrogenase)
Length = 1019
Score = 109 bits (273), Expect = 3e-24
Identities = 53/118 (44%), Positives = 75/118 (63%)
Frame = +3
Query: 3 KVYYELMKERERRSLQDRIAIVRLEQISPFPYDLLFEELTKFSEAGVQWVQEEHKNMGAW 182
KVYY+L +ER+ R++++ +AI R+EQ+SPFP+DLL +E K+ A + W QEEHKN G +
Sbjct: 903 KVYYDLTRERKARNMEEEVAITRIEQLSPFPFDLLLKEAQKYPNAELAWCQEEHKNQGYY 962
Query: 183 FYVEPRVNNLIKVKLPNHRKPKISYVGRPPSAAAAAGNKFIHLMEISQFMRQAISTRA 356
YV+PR+ I R + Y GR P+AA A GNK HL E+ +F+ A A
Sbjct: 963 DYVKPRLRTTI------DRAKPVWYAGRDPAAAPATGNKKTHLTELQRFLDTAFDLDA 1014
>sp|Q5RCB8|ODO1_PONPY 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor
(Alpha-ketoglutarate dehydrogenase)
Length = 1023
Score = 105 bits (262), Expect = 5e-23
Identities = 51/113 (45%), Positives = 72/113 (63%)
Frame = +3
Query: 3 KVYYELMKERERRSLQDRIAIVRLEQISPFPYDLLFEELTKFSEAGVQWVQEEHKNMGAW 182
KVYY+L +ER+ R + ++AI R+EQ+SPFP+DLL +E+ K+ A + W QEEHKN G +
Sbjct: 907 KVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPSAELAWCQEEHKNQGYY 966
Query: 183 FYVEPRVNNLIKVKLPNHRKPKISYVGRPPSAAAAAGNKFIHLMEISQFMRQA 341
YV+PR+ I R + Y GR P+AA A GNK HL E+ + + A
Sbjct: 967 DYVKPRLRTTIS------RAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTA 1013
>sp|Q60HE2|ODO1_MACFA 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor
(Alpha-ketoglutarate dehydrogenase)
Length = 1023
Score = 105 bits (262), Expect = 5e-23
Identities = 51/113 (45%), Positives = 72/113 (63%)
Frame = +3
Query: 3 KVYYELMKERERRSLQDRIAIVRLEQISPFPYDLLFEELTKFSEAGVQWVQEEHKNMGAW 182
KVYY+L +ER+ R + ++AI R+EQ+SPFP+DLL +E+ K+ A + W QEEHKN G +
Sbjct: 907 KVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAELAWCQEEHKNQGYY 966
Query: 183 FYVEPRVNNLIKVKLPNHRKPKISYVGRPPSAAAAAGNKFIHLMEISQFMRQA 341
YV+PR+ I R + Y GR P+AA A GNK HL E+ + + A
Sbjct: 967 DYVKPRLRTTIS------RAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTA 1013
>sp|Q02218|ODO1_HUMAN 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor
(Alpha-ketoglutarate dehydrogenase)
Length = 1002
Score = 99.8 bits (247), Expect = 3e-21
Identities = 48/102 (47%), Positives = 66/102 (64%)
Frame = +3
Query: 3 KVYYELMKERERRSLQDRIAIVRLEQISPFPYDLLFEELTKFSEAGVQWVQEEHKNMGAW 182
KVYY+L +ER+ R + ++AI R+EQ+SPFP+DLL +E+ K+ A + W QEEHKN G +
Sbjct: 907 KVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAELAWCQEEHKNQGYY 966
Query: 183 FYVEPRVNNLIKVKLPNHRKPKISYVGRPPSAAAAAGNKFIH 308
YV+PR+ I R + Y GR P+AA A GNK H
Sbjct: 967 DYVKPRLRTTIS------RAKPVWYAGRNPAAAPATGNKKTH 1002
>sp|P20967|ODO1_YEAST 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor
(Alpha-ketoglutarate dehydrogenase)
Length = 1014
Score = 79.0 bits (193), Expect = 5e-15
Identities = 45/113 (39%), Positives = 67/113 (59%), Gaps = 2/113 (1%)
Frame = +3
Query: 3 KVYYELMKERERRSLQDRI-AIVRLEQISPFPYDLLFEELTKFSEAG-VQWVQEEHKNMG 176
+VY L K RE SL D+ A +++EQ+ PFP+ L + L + + W QEE NMG
Sbjct: 899 QVYTALHKRRE--SLGDKTTAFLKIEQLHPFPFAQLRDSLNSYPNLEEIVWCQEEPLNMG 956
Query: 177 AWFYVEPRVNNLIKVKLPNHRKPKISYVGRPPSAAAAAGNKFIHLMEISQFMR 335
+W Y EPR++ +K + ++ K+ Y GR PS A AAG+K +HL E F++
Sbjct: 957 SWAYTEPRLHTTLK-ETDKYKDFKVRYCGRNPSGAVAAGSKSLHLAEEDAFLK 1008
>sp|P51056|ODO1_COXBU 2-oxoglutarate dehydrogenase E1 component (Alpha-ketoglutarate
dehydrogenase)
Length = 934
Score = 78.6 bits (192), Expect = 6e-15
Identities = 50/116 (43%), Positives = 66/116 (56%), Gaps = 2/116 (1%)
Frame = +3
Query: 3 KVYYELM-KERERRSLQDRIAIVRLEQISPFPYDLLFEELTKFSEA-GVQWVQEEHKNMG 176
KVYY+L+ K RE + + IA++R+EQ+ PFPYD L EL K+ A V W QEE KN G
Sbjct: 823 KVYYDLLAKRREHKGKLNHIAMIRIEQLYPFPYDELKAELEKYPNAKQVIWCQEEPKNQG 882
Query: 177 AWFYVEPRVNNLIKVKLPNHRKPKISYVGRPPSAAAAAGNKFIHLMEISQFMRQAI 344
AWF R LIK + + YVGR AA AAG +++ Q + QA+
Sbjct: 883 AWFCTRHR---LIKCMRDDQ---TLEYVGRSAFAAPAAGYSALYVKLQEQLVNQAL 932
>sp|Q9ZDY3|ODO1_RICPR 2-oxoglutarate dehydrogenase E1 component (Alpha-ketoglutarate
dehydrogenase)
Length = 936
Score = 72.4 bits (176), Expect = 5e-13
Identities = 43/115 (37%), Positives = 64/115 (55%), Gaps = 1/115 (0%)
Frame = +3
Query: 3 KVYYELMKERERRSLQDRIAIVRLEQISPFPYDLLFEELTKFSEA-GVQWVQEEHKNMGA 179
KVYY+L R S I I+RLEQ+ PF L+ L K+++A W QEE KNMGA
Sbjct: 818 KVYYDLFAMRTNNS---NIVIIRLEQLYPFEKKLVASLLKKYNKAQAFIWCQEEPKNMGA 874
Query: 180 WFYVEPRVNNLIKVKLPNHRKPKISYVGRPPSAAAAAGNKFIHLMEISQFMRQAI 344
W Y+ +N+ +K N+ + YVGR SA+ A G+ +H + + + +A+
Sbjct: 875 WHYIATHLNDALKEAEINN---EFKYVGREESASPAVGSLQVHNKQQEKLLMEAL 926
>sp|Q59106|ODO1_RALEU 2-oxoglutarate dehydrogenase E1 component (Alpha-ketoglutarate
dehydrogenase)
Length = 950
Score = 70.5 bits (171), Expect = 2e-12
Identities = 39/98 (39%), Positives = 59/98 (60%), Gaps = 1/98 (1%)
Frame = +3
Query: 3 KVYYELMKERERRSLQDRIAIVRLEQISPFPYDLLFEELTKFSEA-GVQWVQEEHKNMGA 179
KVYY+L+ R+ R D A++RLEQ+ PFP+ + EL K+ A + W Q+E +N GA
Sbjct: 833 KVYYDLVNTRKEREANDT-AVIRLEQLYPFPHKAVAAELKKYPNATEIVWCQDEPQNQGA 891
Query: 180 WFYVEPRVNNLIKVKLPNHRKPKISYVGRPPSAAAAAG 293
WF+V+ + I + + + K+ Y GRP SA+ A G
Sbjct: 892 WFFVQ----HYIMENMTDGQ--KLGYAGRPASASPAVG 923
>sp|Q8K9N3|ODO1_BUCAP 2-oxoglutarate dehydrogenase E1 component (Alpha-ketoglutarate
dehydrogenase)
Length = 923
Score = 70.5 bits (171), Expect = 2e-12
Identities = 39/116 (33%), Positives = 67/116 (57%), Gaps = 1/116 (0%)
Frame = +3
Query: 3 KVYYELMKERERRSLQDRIAIVRLEQISPFPYDLLFEELTKFSEA-GVQWVQEEHKNMGA 179
K+YY+L++ R + + + + ++R+EQ+ PFP D + L +S W QEE N GA
Sbjct: 811 KIYYDLLEYRNKCDINN-VLLIRIEQLYPFPKDEILTILKSYSYVQDFIWCQEEPHNQGA 869
Query: 180 WFYVEPRVNNLIKVKLPNHRKPKISYVGRPPSAAAAAGNKFIHLMEISQFMRQAIS 347
WFY++ ++ L+ L +H ++YV RP +A+ AAG+ IH E + + A +
Sbjct: 870 WFYIKDLLSTLL--PLNSH----LNYVSRPSAASPAAGHILIHRKEQEKLINNAFN 919
>sp|Q92J42|ODO1_RICCN 2-oxoglutarate dehydrogenase E1 component (Alpha-ketoglutarate
dehydrogenase)
Length = 928
Score = 69.3 bits (168), Expect = 4e-12
Identities = 43/115 (37%), Positives = 62/115 (53%), Gaps = 1/115 (0%)
Frame = +3
Query: 3 KVYYELMKERERRSLQDRIAIVRLEQISPFPYDLLFEELTKFSEAG-VQWVQEEHKNMGA 179
KVYY+L + R S IAI+RLEQ+ PF L+ L K++ W QEE KNMG
Sbjct: 818 KVYYDLFEMRGNNS---NIAIIRLEQLYPFEKKLVASLLKKYNRTQEFIWCQEEPKNMGT 874
Query: 180 WFYVEPRVNNLIKVKLPNHRKPKISYVGRPPSAAAAAGNKFIHLMEISQFMRQAI 344
W Y+ +N+ +K K + YVGR SA+ A G+ +H + + +R A+
Sbjct: 875 WCYIVSHLNDALK---EAGIKNEFKYVGREESASPAVGSLQVHNKQQEKLLRTAL 926
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,950,502
Number of Sequences: 369166
Number of extensions: 1037736
Number of successful extensions: 2284
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2230
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2259
length of database: 68,354,980
effective HSP length: 101
effective length of database: 49,696,745
effective search space used: 2534533995
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)