Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_I03
(916 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q21988|AMX1_CAEEL Amine oxidase family member 1 81 4e-15
sp|Q9XWP6|SPR5_CAEEL Suppressor of presenilin 5 (P110b homo... 59 2e-08
sp|O60341|LSD1_HUMAN Lysine-specific histone demethylase 1 ... 58 3e-08
sp|Q6ZQ88|LSD1_MOUSE Lysine-specific histone demethylase 1 ... 57 6e-08
sp|P58028|AOFB_CAVPO Amine oxidase [flavin-containing] B (M... 42 0.002
sp|Q6Q2J0|AOFA_PIG Amine oxidase [flavin-containing] A (Mon... 42 0.003
sp|P37906|PUUB_ECOLI Gamma-glutamylputrescine oxidoreductas... 41 0.004
sp|Q7YRB7|AOFB_CANFA Amine oxidase [flavin-containing] B (M... 40 0.007
sp|P21397|AOFA_HUMAN Amine oxidase [flavin-containing] A (M... 40 0.009
sp|P40974|PUO_MICRU Putrescine oxidase 40 0.009
>sp|Q21988|AMX1_CAEEL Amine oxidase family member 1
Length = 783
Score = 81.3 bits (199), Expect = 4e-15
Identities = 66/258 (25%), Positives = 116/258 (44%), Gaps = 8/258 (3%)
Frame = +1
Query: 16 EDQRIEFIRNHPASFFESIKYPVYLGTS-PYLNVYDEYSLDTVGISPIAERVNFDL---G 183
E +IE +R F +P L + Y + D Y T G+ + + G
Sbjct: 129 ESPKIERVREDSEWCFNEFGHPPLLQNNISYDLLVDHYVTRTTGMDATCQEKAALIDNGG 188
Query: 184 DPCKDFMTVFNPFSKETNTQTAAGAADPTCMDKWEYEFFPTFSSGNLRSVFLGLRNLMLL 363
+D + N F T A P M+ E FP F+ + +L +RN ++
Sbjct: 189 IEFRDTRRIMNMFYVPF-TDVIANIVHPEFMETDEKFAFPKFADDPISIYYLQVRNTIIA 247
Query: 364 LWSANPKRTVNVNLVAKCVSLRGLARVALLINSVPDLIKIYSGFGYVNFGFPDAPVNIFE 543
+W +P + V ++ + +RG AR+ + + + +++ + G VN+G D ++
Sbjct: 248 MWLKHPFVELTVKMIEPQIIVRGHARIFFIEHLIHPILEFLTIKGVVNYGAFDFRIDPL- 306
Query: 544 ENMKKDVIVVGAGLSGLSAARHLSLLGANVTVLEATDPLVSNGKRI----SLKMKAFECF 711
M+ + ++GAG+SG+S ARHL LG + + EA D G R+ SL + +
Sbjct: 307 NGMRPKIAIIGAGISGISTARHLKHLGIDAVLFEAKDRF---GGRMMDDQSLGVSVGKGA 363
Query: 712 NEVFGVINNPFSVLAHQV 765
+ G INNP ++L Q+
Sbjct: 364 QIIVGNINNPITLLCEQI 381
>sp|Q9XWP6|SPR5_CAEEL Suppressor of presenilin 5 (P110b homolog)
Length = 770
Score = 58.9 bits (141), Expect = 2e-08
Identities = 61/195 (31%), Positives = 88/195 (45%), Gaps = 14/195 (7%)
Frame = +1
Query: 223 SKETNTQTAAGAADPTCMDK---WEYEFFPT-FSSGNLRSVFLGLRNLMLLLWSANPKRT 390
S + N AA +A D+ E FFP + VFL LRN L W NP +
Sbjct: 22 SIDDNALAAAASAARLPFDRPTDHELAFFPELWEHKTAVEVFLLLRNSTLATWQYNPLK- 80
Query: 391 VNVNLVAKCVSLRGLARVALLINSVPDLIK----IYSGFGYVNFG--FPDAPVNIFEENM 552
+C +L V NS DLI+ S G +NFG ++ F
Sbjct: 81 -------ECTALDVRNNVFPPFNSDLDLIQNIVHYLSRHGLINFGRYVRSTKISRFLVRD 133
Query: 553 KKDVIVVGAGLSGLSAARHLSLLGANVTVLEATDPLVSNGKRISLKMKAFECF----NEV 720
++ VIV+GAG +G+SAA L G +V VLEA + + G+ S K K+ E + +
Sbjct: 134 RRSVIVIGAGAAGISAATQLESFGFDVIVLEARNCI--GGRIHSFKSKSGEIMETGGDTL 191
Query: 721 FGVINNPFSVLAHQV 765
+ ++P + L HQV
Sbjct: 192 RKIEDSPMATLLHQV 206
>sp|O60341|LSD1_HUMAN Lysine-specific histone demethylase 1 (Amine oxidase flavin
containing domain protein 2) (AOF2 protein) (BRAF35-HDAC
complex protein BHC110)
Length = 852
Score = 58.2 bits (139), Expect = 3e-08
Identities = 60/219 (27%), Positives = 96/219 (43%), Gaps = 7/219 (3%)
Frame = +1
Query: 274 MDKWEYEFFPTFSSG--NLRSVFLGLRNLMLLLWSANPKRTVNVNLVAKCVSLRGLARV- 444
M E FP SG + VFL +RN L LW NPK + + A L
Sbjct: 188 MTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPK--IQLTFEATLQQLEAPYNSD 245
Query: 445 ALLINSVPDLIKIYSGFGYVNFGFPDAPVNIFEENMKKDVIVVGAGLSGLSAARHLSLLG 624
+L++ V ++ + G +NFG + + K VI++G+G+SGL+AAR L G
Sbjct: 246 TVLVHRVHSYLERH---GLINFGIYKRIKPLPTKKTGK-VIIIGSGVSGLAAARQLQSFG 301
Query: 625 ANVTVLEATDPLVSNGKRISLKMKAFECFN----EVFGVINNPFSVLAHQVCGRXXXXXX 792
+VT+LEA D + G R++ K + V G+ NP +V++ QV
Sbjct: 302 MDVTLLEARDRV---GGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQV--------- 349
Query: 793 XXXXXXXINI*CNIETREISTDLSIFDEKGSIIPDDIDQ 909
N+E +I +++ G +P + D+
Sbjct: 350 ------------NMELAKIKQKCPLYEANGQAVPKEKDE 376
>sp|Q6ZQ88|LSD1_MOUSE Lysine-specific histone demethylase 1 (Amine oxidase flavin
containing domain protein 2) (AOF2 protein) (BRAF35-HDAC
complex protein BHC110)
Length = 853
Score = 57.4 bits (137), Expect = 6e-08
Identities = 60/219 (27%), Positives = 96/219 (43%), Gaps = 7/219 (3%)
Frame = +1
Query: 274 MDKWEYEFFPTFSSG--NLRSVFLGLRNLMLLLWSANPKRTVNVNLVAKCVSLRGLARV- 444
M E FP SG + VFL +RN L LW NPK + + A L
Sbjct: 189 MTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPK--IQLTFEATLQQLEAPYNSD 246
Query: 445 ALLINSVPDLIKIYSGFGYVNFGFPDAPVNIFEENMKKDVIVVGAGLSGLSAARHLSLLG 624
+L++ V ++ + G +NFG + + K VI++G+G+SGL+AAR L G
Sbjct: 247 TVLVHRVHSYLERH---GLINFGIYKRIKPLPIKKTGK-VIIIGSGVSGLAAARQLQSFG 302
Query: 625 ANVTVLEATDPLVSNGKRISLKMKAFECFN----EVFGVINNPFSVLAHQVCGRXXXXXX 792
+VT+LEA D + G R++ K + V G+ NP +V++ QV
Sbjct: 303 MDVTLLEARDRV---GGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQV--------- 350
Query: 793 XXXXXXXINI*CNIETREISTDLSIFDEKGSIIPDDIDQ 909
N+E +I +++ G +P + D+
Sbjct: 351 ------------NMELAKIKQKCPLYEANGQAVPKEKDE 377
>sp|P58028|AOFB_CAVPO Amine oxidase [flavin-containing] B (Monoamine oxidase type B)
(MAO-B)
Length = 520
Score = 42.4 bits (98), Expect = 0.002
Identities = 22/36 (61%), Positives = 26/36 (72%)
Frame = +1
Query: 547 NMKKDVIVVGAGLSGLSAARHLSLLGANVTVLEATD 654
N K DV+VVG G+SGL+AA+ L G NV VLEA D
Sbjct: 2 NSKCDVVVVGGGISGLAAAKLLHDSGLNVVVLEARD 37
>sp|Q6Q2J0|AOFA_PIG Amine oxidase [flavin-containing] A (Monoamine oxidase type A)
(MAO-A)
Length = 527
Score = 41.6 bits (96), Expect = 0.003
Identities = 20/32 (62%), Positives = 25/32 (78%)
Frame = +1
Query: 559 DVIVVGAGLSGLSAARHLSLLGANVTVLEATD 654
DV+V+G G+SGLSAA+ L+ G NV VLEA D
Sbjct: 15 DVVVIGGGISGLSAAKLLNEYGINVLVLEARD 46
>sp|P37906|PUUB_ECOLI Gamma-glutamylputrescine oxidoreductase (Gamma-glutamylputrescine
oxidase) (Gamma-Glu-Put oxidase)
Length = 426
Score = 41.2 bits (95), Expect = 0.004
Identities = 21/43 (48%), Positives = 29/43 (67%)
Frame = +1
Query: 523 APVNIFEENMKKDVIVVGAGLSGLSAARHLSLLGANVTVLEAT 651
AP + E++ DV VVG G +GLS+A HL+ G +V VLEA+
Sbjct: 17 APFDTLNESITCDVCVVGGGYTGLSSALHLAEAGFDVVVLEAS 59
>sp|Q7YRB7|AOFB_CANFA Amine oxidase [flavin-containing] B (Monoamine oxidase type B)
(MAO-B)
Length = 520
Score = 40.4 bits (93), Expect = 0.007
Identities = 20/34 (58%), Positives = 25/34 (73%)
Frame = +1
Query: 553 KKDVIVVGAGLSGLSAARHLSLLGANVTVLEATD 654
K DV+VVG G+SG++AA+ L G NV VLEA D
Sbjct: 4 KCDVVVVGGGISGMAAAKLLHDFGLNVVVLEARD 37
>sp|P21397|AOFA_HUMAN Amine oxidase [flavin-containing] A (Monoamine oxidase type A)
(MAO-A)
Length = 527
Score = 40.0 bits (92), Expect = 0.009
Identities = 19/32 (59%), Positives = 25/32 (78%)
Frame = +1
Query: 559 DVIVVGAGLSGLSAARHLSLLGANVTVLEATD 654
DV+V+G G+SGLSAA+ L+ G +V VLEA D
Sbjct: 15 DVVVIGGGISGLSAAKLLTEYGVSVLVLEARD 46
>sp|P40974|PUO_MICRU Putrescine oxidase
Length = 478
Score = 40.0 bits (92), Expect = 0.009
Identities = 21/38 (55%), Positives = 26/38 (68%)
Frame = +1
Query: 541 EENMKKDVIVVGAGLSGLSAARHLSLLGANVTVLEATD 654
E +++DV+VVGAG +GL AAR L G V VLEA D
Sbjct: 10 ETAIERDVVVVGAGPAGLMAARTLVAAGRTVAVLEARD 47
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 112,949,064
Number of Sequences: 369166
Number of extensions: 2440597
Number of successful extensions: 8769
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 8314
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 8764
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9318621220
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)