Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_H18
(473 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Pol... 86 6e-17
sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polys... 86 6e-17
sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinas... 85 7e-17
sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneu... 85 7e-17
sp|P98072|ENTK_BOVIN Enteropeptidase precursor (Enterokinas... 84 2e-16
sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-l... 83 4e-16
sp|P98074|ENTK_PIG Enteropeptidase precursor (Enterokinase)... 81 1e-15
sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Pol... 81 1e-15
sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 80 2e-15
sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contai... 80 2e-15
>sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1065
Score = 85.5 bits (210), Expect = 6e-17
Identities = 48/111 (43%), Positives = 66/111 (59%)
Frame = +1
Query: 49 GDRCEIVGWGSKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPLSTN 228
G RC I GWGS L G +++ LQKA + +LS + C + Y I R LCAG +
Sbjct: 952 GARCVITGWGS-LREGGSMARQLQKAAVRVLSEQTCRRFYPVQISSR-MLCAGFPQGGVD 1009
Query: 229 SCAGDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWI 381
SC+GD+GGPL ++ Q + G+ S+G CG P+ P V+TRVA V+ WI
Sbjct: 1010 SCSGDAGGPLACREPSGQWVLTGVTSWG-YGCGRPHFPGVYTRVAAVLGWI 1059
Score = 68.2 bits (165), Expect = 9e-12
Identities = 42/113 (37%), Positives = 57/113 (50%)
Frame = +1
Query: 46 PGDRCEIVGWGSKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPLST 225
PG +C I GWG +LQKAT+ +L C+ LY + +R +CAG
Sbjct: 324 PGKKCLISGWGYLKEDFLVKPEVLQKATVELLDQSLCSSLYGHSLTDR-MVCAGYLDGKV 382
Query: 226 NSCAGDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWIL 384
+SC GDSGGPL ++ + GI S+G C P V+TRV + WIL
Sbjct: 383 DSCQGDSGGPLVCEEPSGRFFLAGIVSWGI-GCAEARRPGVYTRVTRLRDWIL 434
Score = 65.9 bits (159), Expect = 5e-11
Identities = 40/112 (35%), Positives = 56/112 (50%)
Frame = +1
Query: 49 GDRCEIVGWGSKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPLSTN 228
G +C I GWG+ ILQKA++ I+ + C LY+ + +R LCAG +
Sbjct: 625 GRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALYNFSLTDR-MLCAGFLEGRVD 683
Query: 229 SCAGDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWIL 384
SC GDSGGPL ++ GI S+G C P V+ R+ + WIL
Sbjct: 684 SCQGDSGGPLACEETPGVFYLAGIVSWGI-GCAQAKKPGVYARITRLKDWIL 734
>sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1061
Score = 85.5 bits (210), Expect = 6e-17
Identities = 48/111 (43%), Positives = 66/111 (59%)
Frame = +1
Query: 49 GDRCEIVGWGSKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPLSTN 228
G RC I GWGS L G +++ LQKA + +LS + C + Y I R LCAG +
Sbjct: 948 GARCVITGWGS-LREGGSMARQLQKAAVRVLSEQTCRRFYPVQISSR-MLCAGFPQGGVD 1005
Query: 229 SCAGDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWI 381
SC+GD+GGPL ++ Q + G+ S+G CG P+ P V+TRVA V+ WI
Sbjct: 1006 SCSGDAGGPLACREPSGQWVLTGVTSWG-YGCGRPHFPGVYTRVAAVLGWI 1055
Score = 65.9 bits (159), Expect = 5e-11
Identities = 40/112 (35%), Positives = 56/112 (50%)
Frame = +1
Query: 49 GDRCEIVGWGSKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPLSTN 228
G +C I GWG+ ILQKA++ I+ + C LY+ + +R LCAG +
Sbjct: 625 GRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALYNFSLTDR-MLCAGFLEGRVD 683
Query: 229 SCAGDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWIL 384
SC GDSGGPL ++ GI S+G C P V+ R+ + WIL
Sbjct: 684 SCQGDSGGPLACEETPGVFYLAGIVSWGI-GCAQAKKPGVYARITRLKDWIL 734
Score = 65.1 bits (157), Expect = 8e-11
Identities = 40/113 (35%), Positives = 56/113 (49%)
Frame = +1
Query: 46 PGDRCEIVGWGSKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPLST 225
P +C I GWG +LQKAT+ +L C+ LY + +R +CAG
Sbjct: 324 PRKKCLISGWGYLKEDFLVKPEVLQKATVELLDQNLCSSLYGHSLTDR-MVCAGYLDGKV 382
Query: 226 NSCAGDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWIL 384
+SC GDSGGPL ++ + G+ S+G C P V+TRV + WIL
Sbjct: 383 DSCQGDSGGPLVCEEPSGRFFLAGVVSWGI-GCAEARRPGVYTRVTRLRDWIL 434
>sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1019
Score = 85.1 bits (209), Expect = 7e-17
Identities = 45/112 (40%), Positives = 63/112 (56%)
Frame = +1
Query: 46 PGDRCEIVGWGSKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPLST 225
PG C I GWG+ +Y G ++ILQ+A + +LSN C + I N +CAG
Sbjct: 906 PGRNCSIAGWGTVVYQGTT-ANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGI 964
Query: 226 NSCAGDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWI 381
+SC GDSGGPL ++ N+ G+ S+G + C LPN P V+ RV+ WI
Sbjct: 965 DSCQGDSGGPLMCQEN-NRWFLAGVTSFGYK-CALPNRPGVYARVSRFTEWI 1014
>sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneum chymotryptic enzyme)
(Thymopsin)
Length = 249
Score = 85.1 bits (209), Expect = 7e-17
Identities = 43/113 (38%), Positives = 62/113 (54%)
Frame = +1
Query: 46 PGDRCEIVGWGSKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPLST 225
PG C + GWG+ L + + ++S+REC K+Y ++ + LCAG T
Sbjct: 136 PGTSCTVSGWGTTTSPDVTFPSDLMCSDVKLISSRECKKVYKD-LLGKTMLCAGIPDSKT 194
Query: 226 NSCAGDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWIL 384
N+C GDSGGPL D L G+ S+G+ PCG PN P V+T+V RW++
Sbjct: 195 NTCNGDSGGPLVCNDTLQ-----GLVSWGTYPCGQPNDPGVYTQVCKYKRWVM 242
>sp|P98072|ENTK_BOVIN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1035
Score = 83.6 bits (205), Expect = 2e-16
Identities = 44/112 (39%), Positives = 63/112 (56%)
Frame = +1
Query: 46 PGDRCEIVGWGSKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPLST 225
PG C I GWG+ +Y G + +LQ+A + +LSN +C + I N +CAG
Sbjct: 922 PGRICSIAGWGALIYQGST-ADVLQEADVPLLSNEKCQQQMPEYNITENMVCAGYEAGGV 980
Query: 226 NSCAGDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWI 381
+SC GDSGGPL ++ N+ + G+ S+G + C LPN P V+ RV WI
Sbjct: 981 DSCQGDSGGPLMCQEN-NRWLLAGVTSFGYQ-CALPNRPGVYARVPRFTEWI 1030
>sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-like protein 4) (KLK-L4)
Length = 277
Score = 82.8 bits (203), Expect = 4e-16
Identities = 46/112 (41%), Positives = 60/112 (53%)
Frame = +1
Query: 46 PGDRCEIVGWGSKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPLST 225
PG C + GWG+ N LQ A + + S+ EC ++Y G I N LCAG+
Sbjct: 153 PGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYP-GKITDNMLCAGTKEGGK 211
Query: 226 NSCAGDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWI 381
+SC GDSGGPL L GI S+G PCG P+ P V+TRV+ + WI
Sbjct: 212 DSCEGDSGGPLVCNRTL-----YGIVSWGDFPCGQPDRPGVYTRVSRYVLWI 258
>sp|P98074|ENTK_PIG Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic mini chain; Enteropeptidase non-catalytic
heavy chain; Enteropeptidase catalytic light chain]
Length = 1034
Score = 81.3 bits (199), Expect = 1e-15
Identities = 45/112 (40%), Positives = 61/112 (54%)
Frame = +1
Query: 46 PGDRCEIVGWGSKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPLST 225
PG C I GWG +Y G + ILQ+A + +LSN +C + I N +CAG
Sbjct: 921 PGRICSIAGWGKVIYQGSP-ADILQEADVPLLSNEKCQQQMPEYNITENMMCAGYEEGGI 979
Query: 226 NSCAGDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWI 381
+SC GDSGGPL + N+ + G+ S+G + C LPN P V+ RV WI
Sbjct: 980 DSCQGDSGGPLMCLEN-NRWLLAGVTSFGYQ-CALPNRPGVYARVPKFTEWI 1029
>sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Polyserase-1) (Polyserase-I)
(Polyserine protease-1) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1059
Score = 80.9 bits (198), Expect = 1e-15
Identities = 46/111 (41%), Positives = 65/111 (58%)
Frame = +1
Query: 49 GDRCEIVGWGSKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPLSTN 228
G RC I GWGS + G +++ LQKA + +LS + C + Y I R LCAG +
Sbjct: 946 GTRCVITGWGS-VREGGSMARQLQKAAVRLLSEQTCRRFYPVQISSR-MLCAGFPQGGVD 1003
Query: 229 SCAGDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWI 381
SC+GD+GGPL ++ + + G+ S+G CG P+ P V+TRVA V WI
Sbjct: 1004 SCSGDAGGPLACREPSGRWVLTGVTSWG-YGCGRPHFPGVYTRVAAVRGWI 1053
Score = 67.8 bits (164), Expect = 1e-11
Identities = 39/112 (34%), Positives = 58/112 (51%)
Frame = +1
Query: 49 GDRCEIVGWGSKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPLSTN 228
G +C I GWG+ +LQKA++ I+ + C+ LY+ + +R +CAG +
Sbjct: 623 GRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFSLTDR-MICAGFLEGKVD 681
Query: 229 SCAGDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWIL 384
SC GDSGGPL ++ GI S+G C P V+TR+ + WIL
Sbjct: 682 SCQGDSGGPLACEEAPGVFYLAGIVSWGI-GCAQVKKPGVYTRITRLKGWIL 732
Score = 65.1 bits (157), Expect = 8e-11
Identities = 41/113 (36%), Positives = 55/113 (48%)
Frame = +1
Query: 46 PGDRCEIVGWGSKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPLST 225
P +C I GWG +LQKAT+ +L CA LY + +R +CAG
Sbjct: 322 PSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYGHSLTDR-MVCAGYLDGKV 380
Query: 226 NSCAGDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWIL 384
+SC GDSGGPL ++ + GI S+G C P V+ RV + WIL
Sbjct: 381 DSCQGDSGGPLVCEEPSGRFFLAGIVSWGI-GCAEARRPGVYARVTRLRDWIL 432
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 80.5 bits (197), Expect = 2e-15
Identities = 43/109 (39%), Positives = 62/109 (56%)
Frame = +1
Query: 58 CEIVGWGSKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPLSTNSCA 237
C + GWG G+ +ILQKAT+ ++ N EC K Y +I + +CAG T++C
Sbjct: 517 CWVTGWGYTKEQGET-QNILQKATIPLVPNEECQKKYRDYVINKQMICAGYKEGGTDACK 575
Query: 238 GDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWIL 384
GDSGGPL K + +GI S+G CG + P V+T+V+ + WIL
Sbjct: 576 GDSGGPLVCKHSGRWQL-VGITSWG-EGCGRKDQPGVYTKVSEYMDWIL 622
>sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1069
Score = 80.5 bits (197), Expect = 2e-15
Identities = 42/114 (36%), Positives = 66/114 (57%), Gaps = 1/114 (0%)
Frame = +1
Query: 43 VPGDRCEIVGWG-SKLYSGKNISHILQKATLIILSNRECAKLYDSGIIERNKLCAGSGPL 219
+PG C I GWG K+ +G + +L++A + ++SN +C + I + +CAG
Sbjct: 954 IPGRTCSIAGWGYDKINAGSTVD-VLKEADVPLISNEKCQQQLPEYNITESMICAGYEEG 1012
Query: 220 STNSCAGDSGGPLFFKDGLNQNIQIGINSYGSRPCGLPNVPSVFTRVAHVIRWI 381
+SC GDSGGPL ++ N+ +G+ S+G + C LPN P V+ RV+ I WI
Sbjct: 1013 GIDSCQGDSGGPLMCQEN-NRWFLVGVTSFGVQ-CALPNHPGVYVRVSQFIEWI 1064
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,374,481
Number of Sequences: 369166
Number of extensions: 1325234
Number of successful extensions: 3712
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3129
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3208
length of database: 68,354,980
effective HSP length: 101
effective length of database: 49,696,745
effective search space used: 2783017720
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)