Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_H16
(564 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8WNV7|DHRS4_PIG Dehydrogenase/reductase SDR family memb... 147 1e-35
sp|Q9GKX2|DHRS4_RABIT Dehydrogenase/reductase SDR family me... 145 9e-35
sp|Q99LB2|DHRS4_MOUSE Dehydrogenase/reductase SDR family me... 144 1e-34
sp|Q8SPU8|DHRS4_BOVIN Dehydrogenase/reductase SDR family me... 144 2e-34
sp|Q9BTZ2|DHRS4_HUMAN Dehydrogenase/reductase SDR family me... 143 3e-34
sp|Q13268|DHS2_HUMAN Dehydrogenase/reductase SDR family mem... 141 1e-33
sp|Q8VID1|DHRS4_RAT Dehydrogenase/reductase SDR family memb... 137 2e-32
sp|Q8CPI3|FABG_STAES 3-oxoacyl-[acyl-carrier-protein] reduc... 95 1e-19
sp|P99093|FABG_STAAN 3-oxoacyl-[acyl-carrier-protein] reduc... 92 1e-18
sp|P38004|FABG_CHLTR 3-oxoacyl-[acyl-carrier-protein] reduc... 92 1e-18
>sp|Q8WNV7|DHRS4_PIG Dehydrogenase/reductase SDR family member 4 (NADPH-dependent
carbonyl reductase/NADP-retinol dehydrogenase) (CR)
(PHCR) (Peroxisomal short-chain alcohol dehydrogenase)
(NADPH-dependent retinol dehydrogenase/reductase) (NDRD)
Length = 260
Score = 147 bits (372), Expect = 1e-35
Identities = 76/161 (47%), Positives = 109/161 (67%), Gaps = 2/161 (1%)
Frame = +1
Query: 1 NIHFGSVIECSEETWDKMFDTNLKSTFFLVKEALPYFNERG--SIIVNSSICGYNSMPML 174
N FG++I+ +EE WDK+ N+K+T + K +P +RG S+++ SS+ Y+ P L
Sbjct: 102 NPFFGNIIDATEEVWDKILHVNVKATVLMTKAVVPEMEKRGGGSVLIVSSVGAYHPFPNL 161
Query: 175 GIYSITKTALIGMVKVLSQELANSPLAIRVNGIAPGIIKTKFSQTIHNNDILCDEVMKQL 354
G Y+++KTAL+G+ K L+ ELA P IRVN +APG+IKT FSQ + + + + + L
Sbjct: 162 GPYNVSKTALLGLTKNLAVELA--PRNIRVNCLAPGLIKTNFSQVLWMDKARKEYMKESL 219
Query: 355 HLKRLGLGEDCAGLAAFLASEDASYITGEIIVVAGGLPSRL 477
++RLG EDCAG+ +FL SEDASYITGE +VV GG SRL
Sbjct: 220 RIRRLGNPEDCAGIVSFLCSEDASYITGETVVVGGGTASRL 260
>sp|Q9GKX2|DHRS4_RABIT Dehydrogenase/reductase SDR family member 4 (NADPH-dependent
carbonyl reductase/NADP-retinol dehydrogenase) (CR)
(PHCR) (Peroxisomal short-chain alcohol dehydrogenase)
(NADPH-dependent retinol dehydrogenase/reductase) (NDRD)
(rabNRDR)
Length = 260
Score = 145 bits (365), Expect = 9e-35
Identities = 73/161 (45%), Positives = 110/161 (68%), Gaps = 2/161 (1%)
Frame = +1
Query: 1 NIHFGSVIECSEETWDKMFDTNLKSTFFLVKEALPYFNERG--SIIVNSSICGYNSMPML 174
N FG +++ +EE WDK+ D N+K+ + K +P +RG S+++ +SI +N L
Sbjct: 102 NPFFGKLMDVTEEVWDKILDINVKAMALMTKAVVPEMEKRGGGSVVIVASIAAFNPFSGL 161
Query: 175 GIYSITKTALIGMVKVLSQELANSPLAIRVNGIAPGIIKTKFSQTIHNNDILCDEVMKQL 354
G Y+++KTAL+G+ K L+ ELA IRVN +APG+IKT FS+ + + + ++++L
Sbjct: 162 GPYNVSKTALVGLTKNLALELAAQN--IRVNCLAPGLIKTSFSKALWEDKAQEENIIQKL 219
Query: 355 HLKRLGLGEDCAGLAAFLASEDASYITGEIIVVAGGLPSRL 477
++RLG E+CAG+ +FL SEDASYITGE +VVAGG PSRL
Sbjct: 220 RIRRLGKPEECAGIVSFLCSEDASYITGETVVVAGGAPSRL 260
>sp|Q99LB2|DHRS4_MOUSE Dehydrogenase/reductase SDR family member 4 (NADPH-dependent
carbonyl reductase/NADP-retinol dehydrogenase) (CR)
(PHCR) (Peroxisomal short-chain alcohol dehydrogenase)
(NADPH-dependent retinol dehydrogenase/reductase) (NDRD)
(mouNRDR)
Length = 260
Score = 144 bits (364), Expect = 1e-34
Identities = 71/161 (44%), Positives = 106/161 (65%), Gaps = 2/161 (1%)
Frame = +1
Query: 1 NIHFGSVIECSEETWDKMFDTNLKSTFFLVKEALPYFNERG--SIIVNSSICGYNSMPML 174
N FG++++ +EE WDK+ N+ +T ++K +P +RG S+++ S+ G+ P L
Sbjct: 102 NPFFGNLMDVTEEVWDKVLSINVTATAMMIKAVVPEMEKRGGGSVVIVGSVAGFTRFPSL 161
Query: 175 GIYSITKTALIGMVKVLSQELANSPLAIRVNGIAPGIIKTKFSQTIHNNDILCDEVMKQL 354
G Y+++KTAL+G+ K + ELA P IRVN +APG+IKT+FS + D + + +
Sbjct: 162 GPYNVSKTALLGLTKNFAAELA--PKNIRVNCLAPGLIKTRFSSVLWEEKAREDFIKEAM 219
Query: 355 HLKRLGLGEDCAGLAAFLASEDASYITGEIIVVAGGLPSRL 477
++RLG EDCAG+ +FL SEDASYI GE +VV GG PSRL
Sbjct: 220 QIRRLGKPEDCAGIVSFLCSEDASYINGETVVVGGGTPSRL 260
>sp|Q8SPU8|DHRS4_BOVIN Dehydrogenase/reductase SDR family member 4 (NADPH-dependent
carbonyl reductase/NADP-retinol dehydrogenase) (CR)
(PHCR) (Peroxisomal short-chain alcohol dehydrogenase)
(NADPH-dependent retinol dehydrogenase/reductase) (NDRD)
Length = 260
Score = 144 bits (362), Expect = 2e-34
Identities = 74/158 (46%), Positives = 106/158 (67%), Gaps = 2/158 (1%)
Frame = +1
Query: 10 FGSVIECSEETWDKMFDTNLKSTFFLVKEALPYFNERG--SIIVNSSICGYNSMPMLGIY 183
FGS+++ EE WDK+ D N+K+T L K +P +RG SI++ SSI Y+ P LG Y
Sbjct: 105 FGSLMDVPEEVWDKILDVNVKATALLTKAVVPEMAKRGGGSIVIVSSIAAYSPFPSLGPY 164
Query: 184 SITKTALIGMVKVLSQELANSPLAIRVNGIAPGIIKTKFSQTIHNNDILCDEVMKQLHLK 363
+++KTAL+G+ K L+ ELA S +RVN +APG+I+T FS+ + + + + +K
Sbjct: 165 NVSKTALLGLTKNLALELAESN--VRVNCLAPGLIRTSFSRVLWEDPARQESIKATFQIK 222
Query: 364 RLGLGEDCAGLAAFLASEDASYITGEIIVVAGGLPSRL 477
R+G E+CAG+ +FL SEDASYITGE +VVAGG S L
Sbjct: 223 RIGKPEECAGIVSFLCSEDASYITGETVVVAGGSLSHL 260
>sp|Q9BTZ2|DHRS4_HUMAN Dehydrogenase/reductase SDR family member 4 (NADPH-dependent
carbonyl reductase/NADP-retinol dehydrogenase) (CR)
(PHCR) (Peroxisomal short-chain alcohol dehydrogenase)
(NADPH-dependent retinol dehydrogenase/reductase) (NDRD)
(SCAD-SRL) (humNRDR) (PSCD)
Length = 260
Score = 143 bits (360), Expect = 3e-34
Identities = 74/161 (45%), Positives = 107/161 (66%), Gaps = 2/161 (1%)
Frame = +1
Query: 1 NIHFGSVIECSEETWDKMFDTNLKSTFFLVKEALPYFNERG--SIIVNSSICGYNSMPML 174
N FGS+++ +EE WDK D N+K+ + K +P +RG S+++ SSI ++ P
Sbjct: 102 NPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGF 161
Query: 175 GIYSITKTALIGMVKVLSQELANSPLAIRVNGIAPGIIKTKFSQTIHNNDILCDEVMKQL 354
Y+++KTAL+G+ K L+ ELA P IRVN +APG+IKT FS+ + + + + + L
Sbjct: 162 SPYNVSKTALLGLTKTLAIELA--PRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETL 219
Query: 355 HLKRLGLGEDCAGLAAFLASEDASYITGEIIVVAGGLPSRL 477
++RLG EDCAG+ +FL SEDASYITGE +VV GG PSRL
Sbjct: 220 RIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL 260
>sp|Q13268|DHS2_HUMAN Dehydrogenase/reductase SDR family member 2 (HEP27 protein)
(Protein D)
Length = 258
Score = 141 bits (355), Expect = 1e-33
Identities = 72/150 (48%), Positives = 99/150 (66%), Gaps = 1/150 (0%)
Frame = +1
Query: 13 GSVIECSEETWDKMFDTNLKSTFFLVKEALPYF-NERGSIIVNSSICGYNSMPMLGIYSI 189
GS + SE+ WDK+ N+KS L+ + LPY N RG++I+ SSI YN + LG+Y++
Sbjct: 106 GSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNV 165
Query: 190 TKTALIGMVKVLSQELANSPLAIRVNGIAPGIIKTKFSQTIHNNDILCDEVMKQLHLKRL 369
+KTAL+G+ + L+ ELA P IRVN + PGIIKT FS+ H N+ L + L+R+
Sbjct: 166 SKTALLGLTRTLALELA--PKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRI 223
Query: 370 GLGEDCAGLAAFLASEDASYITGEIIVVAG 459
G EDCAG+ +FL S DASY+ GE I VAG
Sbjct: 224 GESEDCAGIVSFLCSPDASYVNGENIAVAG 253
>sp|Q8VID1|DHRS4_RAT Dehydrogenase/reductase SDR family member 4 (NADPH-dependent
carbonyl reductase/NADP-retinol dehydrogenase) (CR)
(PHCR) (Peroxisomal short-chain alcohol dehydrogenase)
(NADPH-dependent retinol dehydrogenase/reductase) (NDRD)
Length = 260
Score = 137 bits (345), Expect = 2e-32
Identities = 68/161 (42%), Positives = 105/161 (65%), Gaps = 2/161 (1%)
Frame = +1
Query: 1 NIHFGSVIECSEETWDKMFDTNLKSTFFLVKEALPYFNERG--SIIVNSSICGYNSMPML 174
N FG++++ +EE W+K+ N+ ++ ++K +P +RG S+++ SS+ G+ P L
Sbjct: 102 NPFFGNLMDVTEEVWNKVLSINVTASAMMIKAVVPAMEKRGGGSVVIVSSVAGFVLFPSL 161
Query: 175 GIYSITKTALIGMVKVLSQELANSPLAIRVNGIAPGIIKTKFSQTIHNNDILCDEVMKQL 354
G Y+++KTAL+G+ K + ELA P IRVN +APG+IKT FS + + + + +
Sbjct: 162 GPYNVSKTALLGLTKNFAAELA--PKNIRVNCLAPGLIKTHFSSVLWKEKAREEMIKETM 219
Query: 355 HLKRLGLGEDCAGLAAFLASEDASYITGEIIVVAGGLPSRL 477
++RLG EDC G+ +FL SEDASYI GE +VV GG PSRL
Sbjct: 220 QIRRLGKPEDCVGIVSFLCSEDASYINGETVVVGGGTPSRL 260
>sp|Q8CPI3|FABG_STAES 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
Length = 244
Score = 94.7 bits (234), Expect = 1e-19
Identities = 57/151 (37%), Positives = 84/151 (55%), Gaps = 2/151 (1%)
Frame = +1
Query: 19 VIECSEETWDKMFDTNLKSTFFLVKEALPYF--NERGSIIVNSSICGYNSMPMLGIYSIT 192
++ E+ WD + DTNLK F +++ P G+II +SI G P Y T
Sbjct: 96 LMRMKEQEWDDVIDTNLKGVFNCIQKVTPQMLRQRSGAIINLTSIVGAMGNPGQANYVAT 155
Query: 193 KTALIGMVKVLSQELANSPLAIRVNGIAPGIIKTKFSQTIHNNDILCDEVMKQLHLKRLG 372
K +IG+ K ++ELA+ I VN +APG I + + + +D L D++++Q+ LKR G
Sbjct: 156 KAGVIGLTKTAARELASR--GITVNAVAPGFIVSDMTNAL--SDDLKDQMLEQIPLKRFG 211
Query: 373 LGEDCAGLAAFLASEDASYITGEIIVVAGGL 465
D A AFLAS+ A YITG+ I V GG+
Sbjct: 212 EDTDIANTVAFLASDKAKYITGQTIHVNGGM 242
>sp|P99093|FABG_STAAN 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
sp|P0A0I0|FABG_STAAW 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
sp|P0A0H9|FABG_STAAM 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
sp|Q6GHK4|FABG_STAAR 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
sp|Q6G9Y2|FABG_STAAS 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
Length = 246
Score = 91.7 bits (226), Expect = 1e-18
Identities = 56/151 (37%), Positives = 83/151 (54%), Gaps = 2/151 (1%)
Frame = +1
Query: 19 VIECSEETWDKMFDTNLKSTFFLVKEALPYF--NERGSIIVNSSICGYNSMPMLGIYSIT 192
++ E+ WD + DTNLK F +++A P G+II SS+ G P Y T
Sbjct: 98 LMRMKEQEWDDVIDTNLKGVFNCIQKATPQMLRQRSGAIINLSSVVGAVGNPGQANYVAT 157
Query: 193 KTALIGMVKVLSQELANSPLAIRVNGIAPGIIKTKFSQTIHNNDILCDEVMKQLHLKRLG 372
K +IG+ K ++ELA+ I VN +APG I + + + +D L ++++ Q+ L R G
Sbjct: 158 KAGVIGLTKSAARELASR--GITVNAVAPGFIVSDMTDAL--SDELKEQMLTQIPLARFG 213
Query: 373 LGEDCAGLAAFLASEDASYITGEIIVVAGGL 465
D A AFLAS+ A YITG+ I V GG+
Sbjct: 214 QDTDIANTVAFLASDKAKYITGQTIHVNGGM 244
>sp|P38004|FABG_CHLTR 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
Length = 248
Score = 91.7 bits (226), Expect = 1e-18
Identities = 58/151 (38%), Positives = 87/151 (57%), Gaps = 2/151 (1%)
Frame = +1
Query: 19 VIECSEETWDKMFDTNLKSTFFLVKEAL-PYFNERGSIIVN-SSICGYNSMPMLGIYSIT 192
++ SEE W + +TNL S + + + P R I+N SSI G P Y+
Sbjct: 101 LMRMSEEEWSSVINTNLGSIYNVCSAVIRPMIKARSGAIINISSIVGLRGSPGQTNYAAA 160
Query: 193 KTALIGMVKVLSQELANSPLAIRVNGIAPGIIKTKFSQTIHNNDILCDEVMKQLHLKRLG 372
K +IG K LS+E+ + IRVN IAPG I T ++++ ND L +E +K + L R+G
Sbjct: 161 KAGIIGFSKALSKEVGSKN--IRVNCIAPGFIDTDMTKSL--NDNLKNEWLKGVPLGRVG 216
Query: 373 LGEDCAGLAAFLASEDASYITGEIIVVAGGL 465
+ E+ A A FLAS+ +SYITG+++ V GG+
Sbjct: 217 MPEEIAKAALFLASDGSSYITGQVLSVDGGM 247
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,694,225
Number of Sequences: 369166
Number of extensions: 1065550
Number of successful extensions: 2926
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2699
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2730
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 4078830820
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)