Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_H11
(949 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P11707|CP3A6_RABIT Cytochrome P450 3A6 (CYPIIIA6) (P450-3C) 149 1e-35
sp|Q64459|CP3AB_MOUSE Cytochrome P450 3A11 (CYPIIIA11) (P-4... 147 3e-35
sp|O18993|CP3AL_CALJA Cytochrome P450 3A21 (CYPIIIA21) (P45... 147 3e-35
sp|P24463|CP3AC_CANFA Cytochrome P450 3A12 (CYPIIIA12) (P45... 144 3e-34
sp|P79401|CP3AT_PIG Cytochrome P450 3A29 (CYPIIIA29) 144 3e-34
sp|P33268|CP3A8_MACFA Cytochrome P450 3A8 (CYPIIIA8) (P450-... 144 5e-34
sp|P51538|CP3A9_RAT Cytochrome P450 3A9 (CYPIIIA9) (P450-OL... 144 5e-34
sp|Q64464|CP3AD_MOUSE Cytochrome P450 3A13 (CYPIIIA13) 142 2e-33
sp|P08684|CP3A4_HUMAN Cytochrome P450 3A4 (Quinine 3-monoox... 141 2e-33
sp|P79102|CP3AS_BOVIN Cytochrome P450 3A28 (CYPIIIA28) 141 3e-33
>sp|P11707|CP3A6_RABIT Cytochrome P450 3A6 (CYPIIIA6) (P450-3C)
Length = 501
Score = 149 bits (376), Expect = 1e-35
Identities = 91/244 (37%), Positives = 137/244 (56%), Gaps = 6/244 (2%)
Frame = +3
Query: 234 TSLTKTESQTDEEKTDEEIS------DKASSKNKTNTKPLTTEEVISQANLFLFAGYETS 395
TS+ K + ++K + + +SK + K L EV++Q+ + LFAGYET+
Sbjct: 249 TSVEKIKDDRLKDKQKRRVDFLQLMINSQNSKEIDSHKALDDIEVVAQSIIILFAGYETT 308
Query: 396 STALSYILHSLAVYPEIQEILYQEIENVHKKIKNQTVGSLELYDALVKLPYLNAVIYETL 575
S+ LS+I+H LA +P++Q+ L +EI+ + + N+ L YD LVK+ YL+ V+ ETL
Sbjct: 309 SSTLSFIMHLLATHPDVQQKLQEEIDTL---LPNK---ELATYDTLVKMEYLDMVVNETL 362
Query: 576 RFYPFASTVIHRICLKSEGTYLSNGQYIKEGTNIIPNVYAIHFDKNIWTSVDPYKFSPER 755
R YP A + R+C K NG +I +GT ++ YA+H D WT +P +F PER
Sbjct: 363 RLYPIAGR-LERVCKKDVDI---NGTFIPKGTIVMMPTYALHRDPQHWT--EPDEFRPER 416
Query: 756 FLQNVGNEYEFIGPPHPFAWLPFGAGPRNCIGQRFAMMVIKATLGRFVHQFQVVKTNDTA 935
F + + +P+ + PFGAGPRNC+G RFA+M IK L R + F +T
Sbjct: 417 FSKKNKDNI------NPYIYHPFGAGPRNCLGMRFALMNIKLALVRLMQNFSFKLCKETQ 470
Query: 936 NPLK 947
PLK
Sbjct: 471 VPLK 474
>sp|Q64459|CP3AB_MOUSE Cytochrome P450 3A11 (CYPIIIA11) (P-450IIIAM1) (P-450UT)
Length = 504
Score = 147 bits (372), Expect = 3e-35
Identities = 84/215 (39%), Positives = 126/215 (58%)
Frame = +3
Query: 303 SSKNKTNTKPLTTEEVISQANLFLFAGYETSSTALSYILHSLAVYPEIQEILYQEIENVH 482
+SK+K + K L+ E+ +Q+ +F+FAGYET+S+ LS+ LHSLA +P+IQ+ L EI+
Sbjct: 281 NSKDKVSHKALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEAL 340
Query: 483 KKIKNQTVGSLELYDALVKLPYLNAVIYETLRFYPFASTVIHRICLKSEGTYLSNGQYIK 662
T YD ++++ YL+ V+ ETLR YP A+ + R+C K NG YI
Sbjct: 341 PNKAPPT------YDTVMEMEYLDMVLNETLRLYPIANR-LERVCKKDVEL---NGVYIP 390
Query: 663 EGTNIIPNVYAIHFDKNIWTSVDPYKFSPERFLQNVGNEYEFIGPPHPFAWLPFGAGPRN 842
+G+ ++ YA+H D W+ +P +F PERF + E G P+ +LPFG GPRN
Sbjct: 391 KGSTVMIPSYALHHDPQHWS--EPEEFQPERFSK------ENKGSIDPYVYLPFGNGPRN 442
Query: 843 CIGQRFAMMVIKATLGRFVHQFQVVKTNDTANPLK 947
C+G RFA+M +K L + + F +T PLK
Sbjct: 443 CLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLK 477
>sp|O18993|CP3AL_CALJA Cytochrome P450 3A21 (CYPIIIA21) (P450 CM3A-10)
Length = 503
Score = 147 bits (372), Expect = 3e-35
Identities = 97/311 (31%), Positives = 159/311 (51%), Gaps = 1/311 (0%)
Frame = +3
Query: 18 IKPLIVSLLEFFQQRPAQREELVKIRSTLIQVIEARKKCSEK-RFDLLQMLIDAEVSGTK 194
I P + +LE R+ +R ++ ++ E+R K + K R D LQ++ID++
Sbjct: 225 IFPFLTPILEALNISMFPRDSTSFLRKSIKRIKESRLKDTHKHRVDFLQLMIDSQ----- 279
Query: 195 LLDEDNLCPMNDNTSLTKTESQTDEEKTDEEISDKASSKNKTNTKPLTTEEVISQANLFL 374
+SK + K L+ E+++Q+ +F+
Sbjct: 280 ------------------------------------NSKETESDKALSDLELVAQSIIFI 303
Query: 375 FAGYETSSTALSYILHSLAVYPEIQEILYQEIENVHKKIKNQTVGSLELYDALVKLPYLN 554
FAGYET+S+ LS+I++ LA +P++Q+ L +EI+ V + N+ + YD ++++ YL+
Sbjct: 304 FAGYETTSSTLSFIMYELATHPDVQQKLQEEIDAV---LPNKAPAT---YDTVLQMEYLD 357
Query: 555 AVIYETLRFYPFASTVIHRICLKSEGTYLSNGQYIKEGTNIIPNVYAIHFDKNIWTSVDP 734
V+ ETLR +P A + R+C K NG +I +G ++ YA+H+D WT +P
Sbjct: 358 MVVNETLRLFPLAMR-LERVCKKDVEI---NGVFIPKGVVVMIPSYALHYDPKYWT--EP 411
Query: 735 YKFSPERFLQNVGNEYEFIGPPHPFAWLPFGAGPRNCIGQRFAMMVIKATLGRFVHQFQV 914
KF PERF +N + + P+ + PFG GPRNCIG RFA+M +K L R + F
Sbjct: 412 EKFLPERFSKNNKDNID------PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSF 465
Query: 915 VKTNDTANPLK 947
+T PLK
Sbjct: 466 KPCKETQIPLK 476
>sp|P24463|CP3AC_CANFA Cytochrome P450 3A12 (CYPIIIA12) (P450-PBD-1)
Length = 503
Score = 144 bits (364), Expect = 3e-34
Identities = 80/215 (37%), Positives = 128/215 (59%)
Frame = +3
Query: 303 SSKNKTNTKPLTTEEVISQANLFLFAGYETSSTALSYILHSLAVYPEIQEILYQEIENVH 482
+SK K L+ E+++Q+ +F+FAGYET+ST+LS++++ LA +P++Q+ L +EI+
Sbjct: 280 NSKEMDTHKALSDLELVAQSIIFIFAGYETTSTSLSFLMYELATHPDVQQKLQEEIDATF 339
Query: 483 KKIKNQTVGSLELYDALVKLPYLNAVIYETLRFYPFASTVIHRICLKSEGTYLSNGQYIK 662
+L YDALV++ YL+ V+ ETLR YP A + R+C K +G +I
Sbjct: 340 PN------KALPTYDALVQMEYLDMVLNETLRLYPIAGR-LERVCKKDVEI---SGVFIP 389
Query: 663 EGTNIIPNVYAIHFDKNIWTSVDPYKFSPERFLQNVGNEYEFIGPPHPFAWLPFGAGPRN 842
+GT ++ + +H D+++W +P +F PERF + + +P+ +LPFG GPRN
Sbjct: 390 KGTVVMVPTFTLHRDQSLWP--EPEEFRPERFSRKNKDSI------NPYTYLPFGTGPRN 441
Query: 843 CIGQRFAMMVIKATLGRFVHQFQVVKTNDTANPLK 947
CIG RFA+M +K L R + F +T PLK
Sbjct: 442 CIGMRFAIMNMKLALVRVLQNFSFKPCKETQIPLK 476
>sp|P79401|CP3AT_PIG Cytochrome P450 3A29 (CYPIIIA29)
Length = 503
Score = 144 bits (364), Expect = 3e-34
Identities = 88/261 (33%), Positives = 140/261 (53%), Gaps = 4/261 (1%)
Frame = +3
Query: 177 EVSGTKLLDEDNLCPMNDNTSLTKTESQTDEEKTDEEIS----DKASSKNKTNTKPLTTE 344
EV L + ++ + K TD++K ++ + +SK K L+ E
Sbjct: 234 EVLNITLFPKSSVNFFTKSVKRMKESRLTDQQKRRVDLLQLMINSQNSKEMDPHKSLSNE 293
Query: 345 EVISQANLFLFAGYETSSTALSYILHSLAVYPEIQEILYQEIENVHKKIKNQTVGSLELY 524
E+++Q +F+FAGYET+S+ALS + + LA +P++Q+ L +EIE T Y
Sbjct: 294 ELVAQGIIFIFAGYETTSSALSLLAYELATHPDVQQKLQEEIEATFPNKAPPT------Y 347
Query: 525 DALVKLPYLNAVIYETLRFYPFASTVIHRICLKSEGTYLSNGQYIKEGTNIIPNVYAIHF 704
DAL ++ YL+ V+ ETLR YP A+ + R C K + G ++ +GT ++ V+ +H
Sbjct: 348 DALAQMEYLDMVVNETLRLYPIAAR-LERACKKDVEIH---GVFVPKGTVVVVPVFVLHR 403
Query: 705 DKNIWTSVDPYKFSPERFLQNVGNEYEFIGPPHPFAWLPFGAGPRNCIGQRFAMMVIKAT 884
D ++W +P +F PERF + + +P+ +LPFG GPRNCIG RFA+M +K
Sbjct: 404 DPDLWP--EPEEFRPERFSKKHKDTI------NPYTYLPFGTGPRNCIGMRFALMNMKLA 455
Query: 885 LGRFVHQFQVVKTNDTANPLK 947
L R + F +T PLK
Sbjct: 456 LVRVLQNFSFKPCKETQIPLK 476
>sp|P33268|CP3A8_MACFA Cytochrome P450 3A8 (CYPIIIA8) (P450-MKNF2) (P-450-MK2)
Length = 503
Score = 144 bits (362), Expect = 5e-34
Identities = 96/311 (30%), Positives = 156/311 (50%), Gaps = 1/311 (0%)
Frame = +3
Query: 18 IKPLIVSLLEFFQQRPAQREELVKIRSTLIQVIEARKKCSEK-RFDLLQMLIDAEVSGTK 194
I P I+ +LE RE +R ++ ++ E+R K ++K R D LQ++ID++
Sbjct: 225 IFPFIIPILEVLNISIFpreVTSFLRKSVKRIKESRLKDTQKHRVDFLQLMIDSQ----- 279
Query: 195 LLDEDNLCPMNDNTSLTKTESQTDEEKTDEEISDKASSKNKTNTKPLTTEEVISQANLFL 374
+SK + K L+ E+++Q+ +F+
Sbjct: 280 ------------------------------------NSKETESHKALSDLELVAQSIIFI 303
Query: 375 FAGYETSSTALSYILHSLAVYPEIQEILYQEIENVHKKIKNQTVGSLELYDALVKLPYLN 554
FAGYET+S+ LS+I++ LA +P++Q+ L +EI+ V T YD ++++ YL+
Sbjct: 304 FAGYETTSSVLSFIIYELATHPDVQQKLQEEIDTVLPNKAPPT------YDTVLQMEYLD 357
Query: 555 AVIYETLRFYPFASTVIHRICLKSEGTYLSNGQYIKEGTNIIPNVYAIHFDKNIWTSVDP 734
V+ ETLR +P A + R+C K NG +I +G ++ YA+H D W +P
Sbjct: 358 MVVNETLRIFPIAMR-LERVCKKDVEI---NGIFIPKGVVVMIPSYALHHDPKYWP--EP 411
Query: 735 YKFSPERFLQNVGNEYEFIGPPHPFAWLPFGAGPRNCIGQRFAMMVIKATLGRFVHQFQV 914
KF PERF + + + P+ + PFG+GPRNCIG RFA+M +K + R + F
Sbjct: 412 EKFLPERFSKKNNDNID------PYIYTPFGSGPRNCIGMRFALMNMKLAIIRVLQNFSF 465
Query: 915 VKTNDTANPLK 947
+T PLK
Sbjct: 466 KPCKETQIPLK 476
>sp|P51538|CP3A9_RAT Cytochrome P450 3A9 (CYPIIIA9) (P450-OLF3) (Olfactive) (3AH15)
Length = 503
Score = 144 bits (362), Expect = 5e-34
Identities = 86/244 (35%), Positives = 139/244 (56%), Gaps = 6/244 (2%)
Frame = +3
Query: 234 TSLTKTESQTDEEKTDEEIS------DKASSKNKTNTKPLTTEEVISQANLFLFAGYETS 395
TS+ + + +EK + + + +SK K + K L+ E+++Q+ +F+FAGYET+
Sbjct: 251 TSVERMKENRMKEKEKQRMDFLQLMINSQNSKVKDSHKALSDVEIVAQSVIFIFAGYETT 310
Query: 396 STALSYILHSLAVYPEIQEILYQEIENVHKKIKNQTVGSLELYDALVKLPYLNAVIYETL 575
S+ALS++L+ LA++P+IQ+ L EI+ + T YD L+++ YL+ V+ ETL
Sbjct: 311 SSALSFVLYLLAIHPDIQKKLQDEIDAALPNKAHAT------YDTLLQMEYLDMVVNETL 364
Query: 576 RFYPFASTVIHRICLKSEGTYLSNGQYIKEGTNIIPNVYAIHFDKNIWTSVDPYKFSPER 755
R YP A + R+C + NG +I +GT ++ +A+H D + W +P +F PER
Sbjct: 365 RLYPIAGR-LERVC---KTDVEINGVFIPKGTVVMIPTFALHKDPHYWP--EPEEFRPER 418
Query: 756 FLQNVGNEYEFIGPPHPFAWLPFGAGPRNCIGQRFAMMVIKATLGRFVHQFQVVKTNDTA 935
F + + +P+ +LPFG GPRNCIG RFA+M +K L R + F +T
Sbjct: 419 FSKKNQDNI------NPYMYLPFGNGPRNCIGMRFALMNMKVALFRVLQNFSFQPCKETQ 472
Query: 936 NPLK 947
PLK
Sbjct: 473 IPLK 476
>sp|Q64464|CP3AD_MOUSE Cytochrome P450 3A13 (CYPIIIA13)
Length = 503
Score = 142 bits (357), Expect = 2e-33
Identities = 84/244 (34%), Positives = 140/244 (57%), Gaps = 6/244 (2%)
Frame = +3
Query: 234 TSLTKTESQTDEEKTDEEIS------DKASSKNKTNTKPLTTEEVISQANLFLFAGYETS 395
TS+ + + +EK + + + + K K + K L+ E+++Q+ +F+FAGYET+
Sbjct: 251 TSVERMKENRMKEKEKQRVDFLQLMINSQNYKTKESHKALSDVEIVAQSVIFIFAGYETT 310
Query: 396 STALSYILHSLAVYPEIQEILYQEIENVHKKIKNQTVGSLELYDALVKLPYLNAVIYETL 575
S+ALS+ L+ LA++P++Q+ L EI+ + N+ + YD L+++ YL+ V+ ETL
Sbjct: 311 SSALSFALYLLAIHPDVQKKLQDEID---AALPNKAPAT---YDTLLQMEYLDMVVNETL 364
Query: 576 RFYPFASTVIHRICLKSEGTYLSNGQYIKEGTNIIPNVYAIHFDKNIWTSVDPYKFSPER 755
R YP A + R+C + NG +I +GT ++ +A+H D W +P +F PER
Sbjct: 365 RLYPIAGR-LERVC---KTDVEINGLFIPKGTVVMIPTFALHKDPKYWP--EPEEFRPER 418
Query: 756 FLQNVGNEYEFIGPPHPFAWLPFGAGPRNCIGQRFAMMVIKATLGRFVHQFQVVKTNDTA 935
F + + +P+ +LPFG+GPRNCIG RFA++ +K L R + F V +T
Sbjct: 419 FSKKNQDSI------NPYMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETE 472
Query: 936 NPLK 947
PLK
Sbjct: 473 IPLK 476
>sp|P08684|CP3A4_HUMAN Cytochrome P450 3A4 (Quinine 3-monooxygenase) (CYPIIIA4)
(Nifedipine oxidase) (NF-25) (P450-PCN1)
Length = 503
Score = 141 bits (356), Expect = 2e-33
Identities = 81/218 (37%), Positives = 126/218 (57%)
Frame = +3
Query: 294 DKASSKNKTNTKPLTTEEVISQANLFLFAGYETSSTALSYILHSLAVYPEIQEILYQEIE 473
D +SK + K L+ E+++Q+ +F+FAGYET+S+ LS+I++ LA +P++Q+ L +EI+
Sbjct: 277 DSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEID 336
Query: 474 NVHKKIKNQTVGSLELYDALVKLPYLNAVIYETLRFYPFASTVIHRICLKSEGTYLSNGQ 653
V T YD ++++ YL+ V+ ETLR +P A + R+C K NG
Sbjct: 337 AVLPNKAPPT------YDTVLQMEYLDMVVNETLRLFPIAMR-LERVCKKDVEI---NGM 386
Query: 654 YIKEGTNIIPNVYAIHFDKNIWTSVDPYKFSPERFLQNVGNEYEFIGPPHPFAWLPFGAG 833
+I +G ++ YA+H D WT +P KF PERF + + + P+ + PFG+G
Sbjct: 387 FIPKGWVVMIPSYALHRDPKYWT--EPEKFLPERFSKKNKDNID------PYIYTPFGSG 438
Query: 834 PRNCIGQRFAMMVIKATLGRFVHQFQVVKTNDTANPLK 947
PRNCIG RFA+M +K L R + F +T PLK
Sbjct: 439 PRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK 476
>sp|P79102|CP3AS_BOVIN Cytochrome P450 3A28 (CYPIIIA28)
Length = 507
Score = 141 bits (355), Expect = 3e-33
Identities = 80/233 (34%), Positives = 130/233 (55%)
Frame = +3
Query: 249 TESQTDEEKTDEEISDKASSKNKTNTKPLTTEEVISQANLFLFAGYETSSTALSYILHSL 428
T+ Q + + + + +SK N K L+ E+++Q+ +F+F GYET+S+ LS+I++ L
Sbjct: 262 TDKQMNRVDLLQLMINSQNSKEIDNHKALSDIELVAQSTIFIFGGYETTSSTLSFIIYEL 321
Query: 429 AVYPEIQEILYQEIENVHKKIKNQTVGSLELYDALVKLPYLNAVIYETLRFYPFASTVIH 608
+P +Q+ L +EI+ T YDALV++ YL+ V+ ETLR +P A +
Sbjct: 322 TTHPHVQQKLQEEIDATFPNKAPPT------YDALVQMEYLDMVVNETLRMFPIAGR-LE 374
Query: 609 RICLKSEGTYLSNGQYIKEGTNIIPNVYAIHFDKNIWTSVDPYKFSPERFLQNVGNEYEF 788
R+C K + G I +GT ++ ++ +H + +W +P +F PERF +N +
Sbjct: 375 RVCKKDVEIH---GVTIPKGTTVLVPLFVLHNNPELWP--EPEEFRPERFSKNNKDSI-- 427
Query: 789 IGPPHPFAWLPFGAGPRNCIGQRFAMMVIKATLGRFVHQFQVVKTNDTANPLK 947
+P+ +LPFG GPRNC+G RFA+M IK L R + F +T PLK
Sbjct: 428 ----NPYVYLPFGTGPRNCLGMRFAIMNIKLALVRILQNFSFKPCKETQIPLK 476
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101,182,283
Number of Sequences: 369166
Number of extensions: 2065214
Number of successful extensions: 8295
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6924
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7297
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9846996650
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)