Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_G23
(724 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O00560|SDCB1_HUMAN Syntenin-1 (Syndecan binding protein ... 247 2e-65
sp|Q9JI92|SDCB1_RAT Syntenin-1 (Syndecan binding protein 1) 246 6e-65
sp|O08992|SDCB1_MOUSE Syntenin-1 (Syndecan binding protein ... 243 4e-64
sp|Q99JZ0|SDCB2_MOUSE Syntenin-2 (Syndecan binding protein 2) 219 6e-57
sp|Q9H190|SDCB2_HUMAN Syntenin-2 (Syndecan binding protein 2) 210 4e-54
sp|O35430|APBA1_RAT Amyloid beta A4 precursor protein-bindi... 57 7e-08
sp|Q02410|APBA1_HUMAN Amyloid beta A4 precursor protein-bin... 56 1e-07
sp|Q99767|APBA2_HUMAN Amyloid beta A4 precursor protein-bin... 52 2e-06
sp|Q5RD33|APBA2_PONPY Amyloid beta A4 precursor protein-bin... 52 2e-06
sp|P98084|APBA2_MOUSE Amyloid beta A4 precursor protein-bin... 52 2e-06
>sp|O00560|SDCB1_HUMAN Syntenin-1 (Syndecan binding protein 1) (Melanoma
differentiation-associated protein 9) (MDA-9) (Scaffold
protein Pbp1) (Pro-TGF-alpha cytoplasmic
domain-interacting protein 18) (TACIP18)
Length = 298
Score = 247 bits (631), Expect = 2e-65
Identities = 134/257 (52%), Positives = 171/257 (66%), Gaps = 18/257 (7%)
Frame = +2
Query: 5 LYPTLEDLKVDELKSVQHNFINTVVNEPAGSQGS------------LYPALDDYLGLDMR 148
LYP+LEDLKVD++ Q F N S+ S LYP L Y+GL +
Sbjct: 3 LYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPIPHDGNLYPRLYPELSQYMGLSLN 62
Query: 149 AAQ---NQMVQSYGNSVVGYGWRQNTSV---VAPVTKNDVGISRAEIKQGLRRAVLCKDS 310
+ N V S G + G + +S+ VAPVT NDVGI RAEIKQG+R +LCKD
Sbjct: 63 EEEIRANVAVVS-GAPLQGQLVARPSSINYMVAPVTGNDVGIRRAEIKQGIREVILCKDQ 121
Query: 311 KGIIGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA 490
G IGLR+++++ GIFV V NSPAS+ GLRFGDQ+L++N + AGW+++K HK K A
Sbjct: 122 DGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQA 181
Query: 491 GSNNITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEI 670
IT+ +RDRPFERTITM+KDS G++GF+FKNG IT +VKDSSAARNGLL +H + EI
Sbjct: 182 FGEKITMTIRDRPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICEI 241
Query: 671 NGQNVIGLKDKEIQKII 721
NGQNVIGLKD +I I+
Sbjct: 242 NGQNVIGLKDSQIADIL 258
>sp|Q9JI92|SDCB1_RAT Syntenin-1 (Syndecan binding protein 1)
Length = 300
Score = 246 bits (627), Expect = 6e-65
Identities = 134/259 (51%), Positives = 173/259 (66%), Gaps = 20/259 (7%)
Frame = +2
Query: 5 LYPTLEDLKVDELKSVQH-------------NFINTVVNEPAGS-QGSLYPALDDYLGLD 142
LYP+LEDLKVD++ Q N +++ P G+ LYP L Y+GL
Sbjct: 3 LYPSLEDLKVDKVIQAQTASSANPASQAFFLNVVDSAAFPPGGNLYPKLYPELSQYMGLS 62
Query: 143 MRAAQ---NQMVQSYGNSVVGYGWRQNTSV---VAPVTKNDVGISRAEIKQGLRRAVLCK 304
+ A+ N V S G G + +SV VAPVT ND GI RAEIKQG+R +LCK
Sbjct: 63 LSEAEICENMPVVS-GAPTQGQLVARPSSVNYMVAPVTGNDAGIRRAEIKQGIREVILCK 121
Query: 305 DSKGIIGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFK 484
D G IGLR+++V+ GIFV V NSPAS+ GLRFGDQ+L++N + AGW+++K HK K
Sbjct: 122 DQDGKIGLRLKSVDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLK 181
Query: 485 AAGSNNITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLI 664
A IT+ +RDRPFERT+TM+KDS+G++GF+FK+G IT +VKDSSAARNGLL DH +
Sbjct: 182 QAFGEKITMTIRDRPFERTVTMHKDSSGHVGFIFKSGKITSIVKDSSAARNGLLTDHHIC 241
Query: 665 EINGQNVIGLKDKEIQKII 721
EINGQNVIGLKD +I I+
Sbjct: 242 EINGQNVIGLKDAQIADIL 260
>sp|O08992|SDCB1_MOUSE Syntenin-1 (Syndecan binding protein 1) (Scaffold protein Pbp1)
Length = 299
Score = 243 bits (620), Expect = 4e-64
Identities = 130/257 (50%), Positives = 170/257 (66%), Gaps = 18/257 (7%)
Frame = +2
Query: 5 LYPTLEDLKVDELKSVQHNFINTVVNE------------PAGS-QGSLYPALDDYLGLDM 145
LYP+LEDLKVD++ Q + ++ P G+ LYP L Y+GL +
Sbjct: 3 LYPSLEDLKVDKVIQAQTAYSANPASQAFVLVDASAALPPDGNLYPKLYPELSQYMGLSL 62
Query: 146 RAAQ--NQMVQSYGNSVVGYGWRQNTSV---VAPVTKNDVGISRAEIKQGLRRAVLCKDS 310
A+ M G G + +SV VAPVT ND GI RAEIKQG+R +LCKD
Sbjct: 63 NEAEICESMPMVSGAPAQGQLVARPSSVNYMVAPVTGNDAGIRRAEIKQGIREVILCKDQ 122
Query: 311 KGIIGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA 490
G IGLR+++++ GIFV V NSPAS+ GLRFGDQ+L++N + AGW+++K HK K A
Sbjct: 123 DGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQA 182
Query: 491 GSNNITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEI 670
IT+ +RDRPFERT+TM+KDS+G++GF+FK+G IT +VKDSSAARNGLL DH + EI
Sbjct: 183 FGEKITMTIRDRPFERTVTMHKDSSGHVGFIFKSGKITSIVKDSSAARNGLLTDHHICEI 242
Query: 671 NGQNVIGLKDKEIQKII 721
NGQNVIGLKD +I I+
Sbjct: 243 NGQNVIGLKDAQIADIL 259
>sp|Q99JZ0|SDCB2_MOUSE Syntenin-2 (Syndecan binding protein 2)
Length = 292
Score = 219 bits (558), Expect = 6e-57
Identities = 123/254 (48%), Positives = 163/254 (64%), Gaps = 15/254 (5%)
Frame = +2
Query: 5 LYPTLEDLKVDELKSVQHNFINTVVNEPAGSQGS-----LYP---ALDDYLGLDMRAAQN 160
LYP+LEDLKV ++ Q T+ PA + LYP L+ Y+GL + + +
Sbjct: 4 LYPSLEDLKVGQVIQAQGRASPTMPTLPAPMASAPPLSELYPNLAELESYMGLSLSSQEV 63
Query: 161 Q----MVQSYGNSVV---GYGWRQNTSVVAPVTKNDVGISRAEIKQGLRRAVLCKDSKGI 319
Q + N VV G G VVAPV+ N++GI RAEIK G+R LCKD +G
Sbjct: 64 QKNLTQIPDSDNMVVTSPGPG-----QVVAPVSGNNLGILRAEIKPGVREIHLCKDERGK 118
Query: 320 IGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAAGSN 499
GLR+QAV+KG+FV V N+PAS+ GLRFGDQIL+++ AGW T K HK K A +
Sbjct: 119 TGLRLQAVDKGLFVQLVQANTPASLVGLRFGDQILQIDGCDCAGWNTHKAHKVLKKASAE 178
Query: 500 NITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQ 679
I + +RDRPF+RT+TM+KDS+G +GF K G I +VK SSAARNGLL +H + E+NGQ
Sbjct: 179 KIVMVIRDRPFQRTVTMHKDSSGQVGFSIKKGKIVSVVKGSSAARNGLLTNHYVCEVNGQ 238
Query: 680 NVIGLKDKEIQKII 721
NVIGLKDK++ +I+
Sbjct: 239 NVIGLKDKKVTEIL 252
>sp|Q9H190|SDCB2_HUMAN Syntenin-2 (Syndecan binding protein 2)
Length = 292
Score = 210 bits (534), Expect = 4e-54
Identities = 116/252 (46%), Positives = 163/252 (64%), Gaps = 13/252 (5%)
Frame = +2
Query: 5 LYPTLEDLKVDELKSVQHNFINTVVNEPAGSQGS-----LYP---ALDDYLGLDMRAAQN 160
LYP+LEDLKVD+ Q + P + LYP L++Y+GL + + +
Sbjct: 4 LYPSLEDLKVDQAIQAQVRASPKMPALPVQATAISPPPVLYPNLAELENYMGLSLSSQEV 63
Query: 161 Q-----MVQSYGNSVVGYGWRQNTSVVAPVTKNDVGISRAEIKQGLRRAVLCKDSKGIIG 325
Q + + +V G G Q +VAPVT +G+ RAEIK G+R LCKD +G G
Sbjct: 64 QESLLQIPEGDSTAVSGPGPGQ---MVAPVTGYSLGVRRAEIKPGVREIHLCKDERGKTG 120
Query: 326 LRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAAGSNNI 505
LR++ V++G+FV V N+PAS+ GLRFGDQ+L+++ + AGW++ K H+ K A + I
Sbjct: 121 LRLRKVDQGLFVQLVQANTPASLVGLRFGDQLLQIDGRDCAGWSSHKAHQVVKKASGDKI 180
Query: 506 TVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNV 685
V +RDRPF+RT+TM+KDS G++GFV K G I LVK SSAARNGLL +H + E++GQNV
Sbjct: 181 VVVVRDRPFQRTVTMHKDSMGHVGFVIKKGKIVSLVKGSSAARNGLLTNHYVCEVDGQNV 240
Query: 686 IGLKDKEIQKII 721
IGLKDK+I +I+
Sbjct: 241 IGLKDKKIMEIL 252
>sp|O35430|APBA1_RAT Amyloid beta A4 precursor protein-binding family A member 1
(Neuron-specific X11 protein) (Neuronal
Munc18-1-interacting protein 1) (Mint-1) (Adapter protein
X11alpha)
Length = 839
Score = 56.6 bits (135), Expect = 7e-08
Identities = 35/127 (27%), Positives = 62/127 (48%), Gaps = 4/127 (3%)
Frame = +2
Query: 353 IFVSFVNENSPASMAG-LRFGDQILEVNNQVVAGW---TTEKVHKFFKAAGSNNITVALR 520
+ ++ + PA +G L GDQI+ +N + G T + + K K + + +R
Sbjct: 685 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNI-VR 743
Query: 521 DRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKD 700
P + D +GF +NG I L++ A R G+ + H++IEINGQ+V+
Sbjct: 744 CPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPH 803
Query: 701 KEIQKII 721
++I I+
Sbjct: 804 EKIVHIL 810
>sp|Q02410|APBA1_HUMAN Amyloid beta A4 precursor protein-binding family A member 1
(Neuron-specific X11 protein) (Neuronal
Munc18-1-interacting protein 1) (Mint-1) (Adapter protein
X11alpha)
Length = 837
Score = 55.8 bits (133), Expect = 1e-07
Identities = 36/127 (28%), Positives = 58/127 (45%), Gaps = 4/127 (3%)
Frame = +2
Query: 353 IFVSFVNENSPASMAG-LRFGDQILEVNNQVVAGWTTEKVHKFFKAAGSNNITVAL---R 520
+ ++ + PA +G L GDQI+ +N + G K N V L R
Sbjct: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGL-ENQSRVKLNIVR 741
Query: 521 DRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKD 700
P + D +GF +NG I L++ A R G+ + H++IEINGQ+V+
Sbjct: 742 CPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPH 801
Query: 701 KEIQKII 721
++I I+
Sbjct: 802 EKIVHIL 808
>sp|Q99767|APBA2_HUMAN Amyloid beta A4 precursor protein-binding family A member 2
(Neuron-specific X11L protein) (Neuronal
Munc18-1-interacting protein 2) (Mint-2) (Adapter
protein X11beta)
Length = 749
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/121 (26%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Frame = +2
Query: 353 IFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA-GSNNITVALRDRP 529
I + +N A L GDQI+ +N + G K + + + P
Sbjct: 596 ILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCP 655
Query: 530 FERTITMNKDSNGY-IGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKDKE 706
T+ + + Y +GF +NG I L++ A R G+ + H++IEINGQ+V+ ++
Sbjct: 656 PVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEK 715
Query: 707 I 709
I
Sbjct: 716 I 716
>sp|Q5RD33|APBA2_PONPY Amyloid beta A4 precursor protein-binding family A member 2
Length = 749
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/121 (26%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Frame = +2
Query: 353 IFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA-GSNNITVALRDRP 529
I + +N A L GDQI+ +N + G K + + + P
Sbjct: 596 ILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCP 655
Query: 530 FERTITMNKDSNGY-IGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKDKE 706
T+ + + Y +GF +NG I L++ A R G+ + H++IEINGQ+V+ ++
Sbjct: 656 PVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEK 715
Query: 707 I 709
I
Sbjct: 716 I 716
>sp|P98084|APBA2_MOUSE Amyloid beta A4 precursor protein-binding family A member 2
(Neuron-specific X11L protein) (Neuronal
Munc18-1-interacting protein 2) (Mint-2) (Adapter
protein X11beta)
Length = 750
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/121 (26%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Frame = +2
Query: 353 IFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA-GSNNITVALRDRP 529
I + +N A L GDQI+ +N + G K + + + P
Sbjct: 597 ILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCP 656
Query: 530 FERTITMNKDSNGY-IGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKDKE 706
T+ + + Y +GF +NG I L++ A R G+ + H++IEINGQ+V+ ++
Sbjct: 657 PVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEK 716
Query: 707 I 709
I
Sbjct: 717 I 717
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,115,365
Number of Sequences: 369166
Number of extensions: 1786052
Number of successful extensions: 5062
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4765
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5031
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6462248555
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)