Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_G22
(739 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 265 7e-71
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 264 2e-70
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 263 5e-70
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 253 4e-67
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 247 2e-65
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 240 3e-63
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 220 3e-57
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 193 4e-49
sp|P43507|CPR3_CAEEL Cathepsin B-like cysteine proteinase 3... 174 2e-43
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 173 5e-43
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 265 bits (678), Expect = 7e-71
Identities = 124/217 (57%), Positives = 153/217 (70%), Gaps = 1/217 (0%)
Frame = +1
Query: 91 PLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLNRVRL 267
PLS +L+N+VN TTWKAG +S ++K+ G ++ P KLP+R V L
Sbjct: 25 PLSDELVNFVNK-QNTTWKAGHNFYNVDLSYVKKLCGAILGGP---KLPQRDAFAADVVL 80
Query: 268 PTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLT 447
P +FDAR QWP C +I EIRDQ +CGSCWAFGAVEAI+DR CIHSNG +SAED+LT
Sbjct: 81 PESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLT 140
Query: 448 CCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTG 627
CCG CGDGCNGGFPSGAW++W GLV+GG Y +H+GC+ Y+ P C HHV G P CTG
Sbjct: 141 CCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTG 200
Query: 628 EFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQ 738
E TPKC K C+ GYS +Y EDK +G SSYSV +N++
Sbjct: 201 EGDTPKCNKTCEPGYSPSYKEDKHFGCSSYSVANNEK 237
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 264 bits (674), Expect = 2e-70
Identities = 122/221 (55%), Positives = 152/221 (68%), Gaps = 1/221 (0%)
Frame = +1
Query: 79 PIHTPLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLN 255
P PLS D+INY+N TTW+AG IS ++K+ G V+ PN LP+R
Sbjct: 21 PSSHPLSDDMINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGPN---LPERVGFSE 76
Query: 256 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 435
+ LP +FDAR QW C +I +IRDQ +CGSCWAFGAVEA++DR CIH+NG +SAE
Sbjct: 77 DINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAE 136
Query: 436 DLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYP 615
DLLTCCG +CGDGCNGG+PSGAW++W GLV+GG Y +H+GC Y P C HHV G P
Sbjct: 137 DLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRP 196
Query: 616 NCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQ 738
CTGE TPKC K C+AGYS +Y EDK YG +SYSV +++
Sbjct: 197 PCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEK 237
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 263 bits (671), Expect = 5e-70
Identities = 124/219 (56%), Positives = 151/219 (68%), Gaps = 1/219 (0%)
Frame = +1
Query: 79 PIHTPLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLN 255
P PLS DLINY+N TTW+AG IS ++K+ G V+ P KLP R
Sbjct: 21 PSFHPLSDDLINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGP---KLPGRVAFGE 76
Query: 256 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 435
+ LP TFDAR QW C +IG+IRDQ +CGSCWAFGAVEAI+DR CIH+NG +SAE
Sbjct: 77 DIDLPETFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAE 136
Query: 436 DLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYP 615
DLLTCCG +CGDGCNGG+PSGAW +W GLV+GG Y +H+GC Y P C HHV G P
Sbjct: 137 DLLTCCGIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVNGSRP 196
Query: 616 NCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSN 732
CTGE TP+C K+C+AGYS +Y EDK +G +SYSV ++
Sbjct: 197 PCTGEGDTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNS 235
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 253 bits (646), Expect = 4e-67
Identities = 116/220 (52%), Positives = 151/220 (68%)
Frame = +1
Query: 79 PIHTPLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR 258
P PLS +L+NYVN TTW+AG +S ++++ G K P+R
Sbjct: 21 PSFHPLSDELVNYVNK-RNTTWQAGHNFYNVDMSYLKRLCGTFL--GGPKPPQRVMFTED 77
Query: 259 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 438
++LP +FDAR QWP+C +I EIRDQ +CGSCWAFGAVEAI+DR CIH+N + +SAED
Sbjct: 78 LKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAED 137
Query: 439 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 618
LLTCCG CGDGCNGG+P+ AW++W GLV+GG Y +H+GC+ Y+ P C HHV G P
Sbjct: 138 LLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPP 197
Query: 619 CTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQ 738
CTGE TPKC K C+ GYS TY +DK YG +SYSV ++++
Sbjct: 198 CTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEK 237
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 247 bits (631), Expect = 2e-65
Identities = 114/222 (51%), Positives = 147/222 (66%), Gaps = 1/222 (0%)
Frame = +1
Query: 76 IPIHTPLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLN 255
IP + PLS DL+N++N + TT +AG +S ++K+ G K P+R
Sbjct: 20 IPYYPPLSSDLVNHINKL-NTTGRAGHNFHNTDMSYVKKLCGTFL--GGPKAPERVDFAE 76
Query: 256 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 435
+ LP TFD R QWP C +I EIRDQ +CGSCWAFGAVEAI+DR C+H+N + +SAE
Sbjct: 77 DMDLPDTFDTRKQWPNCPTISEIRDQGSCGSCWAFGAVEAISDRICVHTNAKVSVEVSAE 136
Query: 436 DLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYP 615
DLL+CCGF CG GCNGG+PSGAW YW GLV+GG Y +H+GC+ Y P C HHV G P
Sbjct: 137 DLLSCCGFECGMGCNGGYPSGAWRYWTERGLVSGGLYDSHVGCRAYTIPPCEHHVNGSRP 196
Query: 616 NCTGE-FPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQ 738
CTGE TP+C + C+ GYS +Y EDK YG +SY V +++
Sbjct: 197 PCTGEGGETPRCSRHCEPGYSPSYKEDKHYGITSYGVPRSEK 238
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 240 bits (612), Expect = 3e-63
Identities = 112/221 (50%), Positives = 144/221 (65%), Gaps = 5/221 (2%)
Frame = +1
Query: 91 PLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR---- 258
PLS ++I+++N WKA + RF S+ D R ++G K+ K R+P ++
Sbjct: 29 PLSDEMISFINEHPDAGWKADKSDRFHSLDDARILMGARKEDAEMKR-NRRPTVDHHDLN 87
Query: 259 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 438
V +P+ FD+R +WP CKSI +IRDQS CGSCWAFGAVEA+TDR CI S G Q+ +SA D
Sbjct: 88 VEIPSQFDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALD 147
Query: 439 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 618
L++CC CGDGC GGFP AW YWV G+VTGG H GCQ Y FPKC HH G YP
Sbjct: 148 LISCCK-DCGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPA 206
Query: 619 C-TGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQ 738
C T + TP+CK+ CQ GY Y +DK YG SY+V +N++
Sbjct: 207 CGTKIYKTPQCKQTCQKGYKTPYEQDKHYGDESYNVQNNEK 247
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 220 bits (561), Expect = 3e-57
Identities = 104/221 (47%), Positives = 139/221 (62%), Gaps = 5/221 (2%)
Frame = +1
Query: 91 PLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR---- 258
PLS D+I+Y+N W+A + RF S+ D R +G ++ + + KR+P ++
Sbjct: 28 PLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRR-KRRPTVDHNDWN 86
Query: 259 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 438
V +P+ FD+R +WP CKSI IRDQS CGSCW+FGAVEA++DR CI S G Q +SA D
Sbjct: 87 VEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVD 146
Query: 439 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 618
LLTCC CG GC GG AW YWV +G+VT H GC+ Y FPKC HH G YP
Sbjct: 147 LLTCCE-SCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPP 205
Query: 619 CTGE-FPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQ 738
C + + TP+CK+ CQ Y Y +DK GKSSY+V ++++
Sbjct: 206 CGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEK 246
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 193 bits (491), Expect = 4e-49
Identities = 106/219 (48%), Positives = 136/219 (62%), Gaps = 12/219 (5%)
Frame = +1
Query: 103 DLINYVNYIAQTTWKAGPTTRFQSI-SDIRKVLGVMKDPNNFKLP-KRKPLLNRVR---- 264
DLI+YVN Q W A RF S+ + K + N+ +L K K L++ +
Sbjct: 45 DLIDYVNE-NQNLWTAKKQRRFSSVYGENDKAKWGLMGVNHVRLSVKGKQHLSKTKDLDL 103
Query: 265 -LPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDL 441
+P +FD+R WPKC SI IRDQS+CGSCWAFGAVEA++DR CI S+G +SA+DL
Sbjct: 104 DIPESFDSRDNWPKCDSIKVIRDQSSCGSCWAFGAVEAMSDRICIASHGELQVTLSADDL 163
Query: 442 LTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHV----IGP 609
L+CC CG GCNGG P AW YWV DG+VTG Y A+ GC+ Y FP C HH P
Sbjct: 164 LSCCK-SCGFGCNGGDPLAAWRYWVKDGIVTGSNYTANNGCKPYPFPPCEHHSKKTHFDP 222
Query: 610 YPNCTGEFPTPKCKKACQAGYS-KTYAEDKQYGKSSYSV 723
P+ +PTPKC+K C + Y+ KTY+EDK +G S+Y V
Sbjct: 223 CPH--DLYPTPKCEKKCVSDYTDKTYSEDKFFGASAYGV 259
>sp|P43507|CPR3_CAEEL Cathepsin B-like cysteine proteinase 3 precursor (Cysteine
protease-related 3)
Length = 370
Score = 174 bits (442), Expect = 2e-43
Identities = 95/220 (43%), Positives = 124/220 (56%), Gaps = 10/220 (4%)
Frame = +1
Query: 106 LINYVNYIAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNRV-------- 261
L+++VN + QT+W A IS+ VM L K + + +
Sbjct: 35 LVDHVNTV-QTSWVA----EHNEISEFEMKFKVMDVKFAEPLEKDSDVASELFVRGEIVP 89
Query: 262 -RLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 438
LP TFDAR +WP C +I IR+Q+ CGSCWAFGA E I+DR CI SNGTQ P IS ED
Sbjct: 90 EPLPDTFDAREKWPDCNTIKLIRNQATCGSCWAFGAAEVISDRVCIQSNGTQQPVISVED 149
Query: 439 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 618
+L+CCG CG GC GG+ A +W + G VTGG+YG H GC Y+F C+ N
Sbjct: 150 ILSCCGTTCGYGCKGGYSIEALRFWASSGAVTGGDYGGH-GCMPYSFAPCT-------KN 201
Query: 619 CTGEFPTPKCKKACQAGY-SKTYAEDKQYGKSSYSVDSNQ 735
C E TP CK CQ+ Y ++ Y +DK YG S+Y V + +
Sbjct: 202 CP-ESTTPSCKTTCQSSYKTEEYKKDKHYGASAYKVTTTK 240
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 173 bits (438), Expect = 5e-43
Identities = 94/215 (43%), Positives = 122/215 (56%), Gaps = 9/215 (4%)
Frame = +1
Query: 106 LINYVNYIAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNRV---RLPTT 276
LI+YVN AQ W AG + K+ + D K + ++ +P
Sbjct: 32 LIDYVNS-AQKLWTAG-----HQVIPKEKITKKLMDVKYLVPHKDEDIVATEVSDAIPDH 85
Query: 277 FDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCG 456
FDAR QWP C SI IRDQS+CGSCWAF A EAI+DR CI SNG +S+EDLL+CC
Sbjct: 86 FDARDQWPNCMSINNIRDQSDCGSCWAFAAAEAISDRTCIASNGAVNTLLSSEDLLSCCT 145
Query: 457 --FRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIG-PYPNCTG 627
F CG+GC GG+P AW +WV GLVTGG Y GC+ Y+ C V G +P C
Sbjct: 146 GMFSCGNGCEGGYPIQAWKWWVKHGLVTGGSYETQFGCKPYSIAPCGETVNGVKWPACPE 205
Query: 628 EF-PTPKCKKACQA--GYSKTYAEDKQYGKSSYSV 723
+ PTPKC +C + Y+ Y +DK +G ++Y+V
Sbjct: 206 DTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAYAV 240
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,927,266
Number of Sequences: 369166
Number of extensions: 1983865
Number of successful extensions: 6438
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5965
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6284
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6631293200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)