Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_G02
(864 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O02485|YDJ1_CAEEL Hypothetical protein ZK1073.1 in chrom... 108 3e-23
sp|Q9UGV2|NDRG3_HUMAN NDRG3 protein 105 2e-22
sp|Q9QYF9|NDRG3_MOUSE NDRG3 protein (Ndr3 protein) 103 8e-22
sp|Q9ULP0|NDRG4_HUMAN NDRG4 protein (Brain development-rela... 103 8e-22
sp|Q8BTG7|NDRG4_MOUSE NDRG4 protein 102 1e-21
sp|Q92597|NDRG1_HUMAN NDRG1 protein (N-myc downstream regul... 100 4e-21
sp|Q9Z2L9|NDRG4_RAT NDRG4 protein (Brain development-relate... 99 1e-20
sp|Q62433|NDRG1_MOUSE NDRG1 protein (N-myc downstream regul... 96 1e-19
sp|Q9QYG0|NDRG2_MOUSE NDRG2 protein (Ndr2 protein) 82 2e-15
sp|Q9UN36|NDRG2_HUMAN NDRG2 protein (Syld709613 protein) 81 4e-15
>sp|O02485|YDJ1_CAEEL Hypothetical protein ZK1073.1 in chromosome X
Length = 325
Score = 108 bits (269), Expect = 3e-23
Identities = 74/269 (27%), Positives = 127/269 (47%), Gaps = 5/269 (1%)
Frame = +2
Query: 50 IRVHVQRGKKETG----LITFHDIGTNYVSFLSFFNYPEMRVILENFTVYHVCAPGHNID 217
+ V+VQ +E G ++T HDIGTN+ SF+ F N+P M + E HVC PG +
Sbjct: 19 LHVYVQGNLEERGGKTIILTVHDIGTNHKSFVRFVNHPSMATVKEKAIFLHVCVPGQEDN 78
Query: 218 SANFNNEYSREENYRLLSSKLGSNDPNAEIFTIXXXXXXXXXXXXYPSMAELADIIADVV 397
SA+F ++ P++ + D ++ V+
Sbjct: 79 SADFFGDF--------------------------------------PTLDGIGDDLSAVL 100
Query: 398 DHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTGYYPWTRAIWSDIPYL 577
D F +K + FG G G N++ R+ + +PN+++G+ L++ TT G + + ++ L
Sbjct: 101 DKFEVKSAIAFGEGVGANIICRFAMGHPNRIMGIVLVHCTSTTAGIIEYCKEKVMNM-RL 159
Query: 578 KSGVVTDWIQNWLLDHWFGSCTERNMDLEHSYL-QLLGELNPVAVAGYIESYMNRTALGM 754
++ +++D ++LL H FG ++ + YL +L LNP ++ Y+ ++ RT L
Sbjct: 160 ENSIMSDGAWDYLLAHKFGGESKSRQE----YLEELKATLNPKNLSKYLVAFTKRTDLSS 215
Query: 755 TRPINSLDTNTSTLKVDAFLVTGEMATDL 841
T T VDA LVTG A+ L
Sbjct: 216 T-------IGTKLETVDALLVTGSKASHL 237
>sp|Q9UGV2|NDRG3_HUMAN NDRG3 protein
Length = 375
Score = 105 bits (261), Expect = 2e-22
Identities = 79/279 (28%), Positives = 129/279 (46%), Gaps = 8/279 (2%)
Frame = +2
Query: 14 EEFEIDTKVGFPIRVHVQ-----RGKKETGLITFHDIGTNYVS-FLSFFNYPEMRVILEN 175
+E +I+T G VHV +G + ++T+HDIG N+ S F +FFN+ +M+ I ++
Sbjct: 31 QEHDIETTHGV---VHVTIRGLPKGNRPV-ILTYHDIGLNHKSCFNAFFNFEDMQEITQH 86
Query: 176 FTVYHVCAPGHNIDSANFNNEYSREENYRLLSSKLGSNDPNAEIFTIXXXXXXXXXXXXY 355
F V HV APG + +F Y Y
Sbjct: 87 FAVCHVDAPGQQEGAPSFPTGYQ------------------------------------Y 110
Query: 356 PSMAELADIIADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTGY 535
P+M ELA+++ V+ H +K +G G+GAG +L+R+ L +P + GL L+N D G+
Sbjct: 111 PTMDELAEMLPPVLTHLSLKSIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKGW 170
Query: 536 YPWTRAIWSDIPYLKSGVVTDWIQNWLLDHWFGSCTERNMDLEHSY-LQLLGELNPVAVA 712
W + SG+ T+ + L H+ + N+DL +Y + + ++N +
Sbjct: 171 IDWAAS-------KLSGLTTNVVDIILAHHFGQEELQANLDLIQTYRMHIAQDINQDNLQ 223
Query: 713 GYIESYMNRTALGMTRPI-NSLDTNTSTLKVDAFLVTGE 826
++ SY R L + RPI D + TLK LV G+
Sbjct: 224 LFLNSYNGRRDLEIERPILGQNDNKSKTLKCSTLLVVGD 262
>sp|Q9QYF9|NDRG3_MOUSE NDRG3 protein (Ndr3 protein)
Length = 375
Score = 103 bits (256), Expect = 8e-22
Identities = 80/279 (28%), Positives = 127/279 (45%), Gaps = 8/279 (2%)
Frame = +2
Query: 14 EEFEIDTKVGFPIRVHVQ-----RGKKETGLITFHDIGTNYVS-FLSFFNYPEMRVILEN 175
+E +I+T G VHV +G + ++T+HDIG N+ S F +FFN+ +M+ I ++
Sbjct: 31 QEHDIETPHGM---VHVTIRGLPKGNRPV-ILTYHDIGLNHKSCFNTFFNFEDMQEITQH 86
Query: 176 FTVYHVCAPGHNIDSANFNNEYSREENYRLLSSKLGSNDPNAEIFTIXXXXXXXXXXXXY 355
F V HV APG + +F Y Y
Sbjct: 87 FAVCHVDAPGQQEAAPSFPTGYQ------------------------------------Y 110
Query: 356 PSMAELADIIADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTGY 535
P+M ELA+++ V+ H +K +G G+GAG +L+R+ L +P + GL L+N D G+
Sbjct: 111 PTMDELAEMLPPVLTHLSMKSIIGIGVGAGAYILSRFALNHPELVEGLVLINIDPCAKGW 170
Query: 536 YPWTRAIWSDIPYLKSGVVTDWIQNWLLDHWFGSCTERNMDLEHSY-LQLLGELNPVAVA 712
W + SG T+ + L H+ + N+DL +Y L + ++N +
Sbjct: 171 IDWAAS-------KLSGFTTNIVDIILAHHFGQEELQANLDLIQTYRLHIAQDINQENLQ 223
Query: 713 GYIESYMNRTALGMTRPI-NSLDTNTSTLKVDAFLVTGE 826
++ SY R L + RPI D TLK LV G+
Sbjct: 224 LFLGSYNGRRDLEIERPILGQNDNRLKTLKCSTLLVVGD 262
>sp|Q9ULP0|NDRG4_HUMAN NDRG4 protein (Brain development-related molecule 1) (Vascular
smooth muscle cell associated protein 8) (SMAP-8)
Length = 352
Score = 103 bits (256), Expect = 8e-22
Identities = 77/277 (27%), Positives = 124/277 (44%), Gaps = 5/277 (1%)
Frame = +2
Query: 17 EFEIDTKVGFPIRVHVQRGKK--ETGLITFHDIGTNY-VSFLSFFNYPEMRVILENFTVY 187
E +I+T G + V ++ K ++T+HD+G N+ + F +FFN+ +M+ I ++F V
Sbjct: 8 EHDIETPYGL-LHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVC 66
Query: 188 HVCAPGHNIDSANFNNEYSREENYRLLSSKLGSNDPNAEIFTIXXXXXXXXXXXXYPSMA 367
HV APG + ++ F Y +PSM
Sbjct: 67 HVDAPGQQVGASQFPQGYQ------------------------------------FPSME 90
Query: 368 ELADIIADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTGYYPWT 547
+LA ++ VV HF KY +G G+GAG VL ++ L++P+ + GL L+N D G+ W
Sbjct: 91 QLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDPNGKGWIDWA 150
Query: 548 RAIWSDIPYLKSGVVTDWIQNWLLDHWFG-SCTERNMDLEHSYLQLLGE-LNPVAVAGYI 721
K +T + + +L H F N +L SY Q +G +N + +
Sbjct: 151 AT--------KLSGLTSTLPDTVLSHLFSQEELVNNTELVQSYRQQIGNVVNQANLQLFW 202
Query: 722 ESYMNRTALGMTRPINSLDTNTSTLKVDAFLVTGEMA 832
Y +R L + RP N TL+ LV G+ A
Sbjct: 203 NMYNSRRDLDINRP--GTVPNAKTLRCPVMLVVGDNA 237
>sp|Q8BTG7|NDRG4_MOUSE NDRG4 protein
Length = 352
Score = 102 bits (254), Expect = 1e-21
Identities = 77/277 (27%), Positives = 123/277 (44%), Gaps = 5/277 (1%)
Frame = +2
Query: 17 EFEIDTKVGFPIRVHVQRGKK--ETGLITFHDIGTNY-VSFLSFFNYPEMRVILENFTVY 187
E +I+T G + V ++ K ++T+HD+G N+ + F +FFN+ +M+ I ++F V
Sbjct: 8 EHDIETPYGL-LHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVC 66
Query: 188 HVCAPGHNIDSANFNNEYSREENYRLLSSKLGSNDPNAEIFTIXXXXXXXXXXXXYPSMA 367
HV APG + ++ F Y +PSM
Sbjct: 67 HVDAPGQQVGASQFPQGYQ------------------------------------FPSME 90
Query: 368 ELADIIADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTGYYPWT 547
+LA ++ VV HF KY +G G+GAG VL ++ L++P+ + GL LMN D G+ W
Sbjct: 91 QLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKGWIDWA 150
Query: 548 RAIWSDIPYLKSGVVTDWIQNWLLDHWFG-SCTERNMDLEHSYLQLLGE-LNPVAVAGYI 721
K +T + + +L H F N +L SY Q + +N + +
Sbjct: 151 AT--------KLSGLTSTLPDTVLSHLFSQEELVNNTELVQSYRQQISNVVNQANLQLFW 202
Query: 722 ESYMNRTALGMTRPINSLDTNTSTLKVDAFLVTGEMA 832
Y +R L + RP N TL+ LV G+ A
Sbjct: 203 NMYNSRRDLDINRP--GTVPNAKTLRCPVMLVVGDNA 237
>sp|Q92597|NDRG1_HUMAN NDRG1 protein (N-myc downstream regulated gene 1 protein)
(Differentiation-related gene 1 protein) (DRG1)
(Reducing agents and tunicamycin-responsive protein)
(RTP) (Nickel-specific induction protein Cap43) (Rit42)
Length = 394
Score = 100 bits (250), Expect = 4e-21
Identities = 79/282 (28%), Positives = 132/282 (46%), Gaps = 7/282 (2%)
Frame = +2
Query: 2 QLSLEEFEIDTKVGFPIRVHVQRGKKETG----LITFHDIGTNYVS-FLSFFNYPEMRVI 166
+ ++E +I+T G VHV G ++T+HDIG N+ + + FNY +M+ I
Sbjct: 29 EFDVQEQDIETLHG---SVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEI 85
Query: 167 LENFTVYHVCAPGHNIDSANFNNEYSREENYRLLSSKLGSNDPNAEIFTIXXXXXXXXXX 346
++F V HV APG +A+F Y
Sbjct: 86 TQHFAVCHVDAPGQQDGAASFPAGYM---------------------------------- 111
Query: 347 XXYPSMAELADIIADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTT 526
YPSM +LA+++ V+ F +K +G G GAG +LTR+ L P + GL L+N +
Sbjct: 112 --YPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCA 169
Query: 527 TGYYPWTRAIWSDIPYLKSGVVTDWIQNWLLDHWFG-SCTERNMDLEHSYLQ-LLGELNP 700
G+ W + K T + + ++ H FG + N+++ H+Y Q ++ ++NP
Sbjct: 170 EGWMDWAAS--------KISGWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNP 221
Query: 701 VAVAGYIESYMNRTALGMTRPINSLDTNTSTLKVDAFLVTGE 826
+ +I +Y +R L + RP+ T+T TL+ A LV G+
Sbjct: 222 GNLHLFINAYNSRRDLEIERPMPG--THTVTLQCPALLVVGD 261
>sp|Q9Z2L9|NDRG4_RAT NDRG4 protein (Brain development-related molecule 1)
Length = 352
Score = 99.4 bits (246), Expect = 1e-20
Identities = 76/277 (27%), Positives = 122/277 (44%), Gaps = 5/277 (1%)
Frame = +2
Query: 17 EFEIDTKVGFPIRVHVQRGKK--ETGLITFHDIGTNY-VSFLSFFNYPEMRVILENFTVY 187
E +I+T G + V ++ K ++T+HD+G N+ + F + FN +M+ I ++F V
Sbjct: 8 EHDIETPYGL-LHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTLFNLEDMQEITKHFVVC 66
Query: 188 HVCAPGHNIDSANFNNEYSREENYRLLSSKLGSNDPNAEIFTIXXXXXXXXXXXXYPSMA 367
HV APG + ++ F Y +PSM
Sbjct: 67 HVDAPGQQVGASQFPQGYQ------------------------------------FPSME 90
Query: 368 ELADIIADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTGYYPWT 547
+LA ++ +VV HF KY +G G+GAG VL ++ L++P+ + GL LMN D G+ W
Sbjct: 91 QLATMLPNVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKGWIDWA 150
Query: 548 RAIWSDIPYLKSGVVTDWIQNWLLDHWFG-SCTERNMDLEHSYLQLLGE-LNPVAVAGYI 721
K +T + + +L H F N +L SY Q + +N + +
Sbjct: 151 AT--------KLSGLTSTLPDTVLSHLFSQEELVNNTELVQSYRQQISSVVNQANLQLFW 202
Query: 722 ESYMNRTALGMTRPINSLDTNTSTLKVDAFLVTGEMA 832
Y +R L + RP N TL+ LV G+ A
Sbjct: 203 NMYNSRRDLDINRP--GTVPNAKTLRCPVMLVVGDNA 237
>sp|Q62433|NDRG1_MOUSE NDRG1 protein (N-myc downstream regulated gene 1 protein) (Protein
Ndr1)
Length = 394
Score = 96.3 bits (238), Expect = 1e-19
Identities = 71/249 (28%), Positives = 116/249 (46%), Gaps = 3/249 (1%)
Frame = +2
Query: 89 LITFHDIGTNYVS-FLSFFNYPEMRVILENFTVYHVCAPGHNIDSANFNNEYSREENYRL 265
++T+HDIG N+ + + FN +M+ I ++F V HV APG + +F Y
Sbjct: 59 ILTYHDIGMNHKTCYNPLFNSEDMQEITQHFAVCHVDAPGQQDGAPSFPVGYM------- 111
Query: 266 LSSKLGSNDPNAEIFTIXXXXXXXXXXXXYPSMAELADIIADVVDHFHIKYFLGFGMGAG 445
YPSM +LA+++ V+ F +K +G G GAG
Sbjct: 112 -----------------------------YPSMDQLAEMLPGVLHQFGLKSVIGMGTGAG 142
Query: 446 CNVLTRYGLLYPNKLLGLFLMNPDDTTTGYYPWTRAIWSDIPYLKSGVVTDWIQNWLLDH 625
+LTR+ L P + GL LMN + G+ W + K T + + ++ H
Sbjct: 143 AYILTRFALNNPEMVEGLVLMNVNPCAEGWMDWAAS--------KISGWTQALPDMVVSH 194
Query: 626 WFG-SCTERNMDLEHSYLQ-LLGELNPVAVAGYIESYMNRTALGMTRPINSLDTNTSTLK 799
FG N+++ H+Y Q +L ++NP + +I +Y +R L + RP+ T+T TL+
Sbjct: 195 LFGKEEIHNNVEVVHTYRQHILNDMNPSNLHLFISAYNSRRDLEIERPMPG--THTVTLQ 252
Query: 800 VDAFLVTGE 826
A LV G+
Sbjct: 253 CPALLVVGD 261
>sp|Q9QYG0|NDRG2_MOUSE NDRG2 protein (Ndr2 protein)
Length = 371
Score = 82.0 bits (201), Expect = 2e-15
Identities = 69/255 (27%), Positives = 106/255 (41%), Gaps = 3/255 (1%)
Frame = +2
Query: 77 KETGLITFHDIGTNYVS-FLSFFNYPEMRVILENFTVYHVCAPGHNIDSANFNNEYSREE 253
K + T+HD+G NY S F F + +M+ I++NF HV APG
Sbjct: 61 KRPAIFTYHDVGLNYKSCFQPLFRFGDMQEIIQNFVRVHVDAPGM--------------- 105
Query: 254 NYRLLSSKLGSNDPNAEIFTIXXXXXXXXXXXXYPSMAELADIIADVVDHFHIKYFLGFG 433
+ A +F + YPS+ +LAD+I ++ + + +G G
Sbjct: 106 ------------EEGAPVFPLGYQ---------YPSLDQLADMIPCILQYLNFSTIIGVG 144
Query: 434 MGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTGYYPWTRAIWSDIPYLKSGVVTDWIQNW 613
+GAG +L+RY L +P+ + GL L+N D G+ W K +T I +
Sbjct: 145 VGAGAYILSRYALNHPDTVEGLVLINIDPNAKGWMDWAAH--------KLTGLTSSIPDM 196
Query: 614 LLDHWFG-SCTERNMDLEHSYLQLLGEL-NPVAVAGYIESYMNRTALGMTRPINSLDTNT 787
+L H F N +L Y ++ N + Y SY NR R +N
Sbjct: 197 ILGHLFSQEELSGNSELIQKYRGIIQHAPNLENIELYWNSYNNR------RDLNFERGGE 250
Query: 788 STLKVDAFLVTGEMA 832
+TLK LV G+ A
Sbjct: 251 TTLKCPVMLVVGDQA 265
>sp|Q9UN36|NDRG2_HUMAN NDRG2 protein (Syld709613 protein)
Length = 371
Score = 80.9 bits (198), Expect = 4e-15
Identities = 69/255 (27%), Positives = 104/255 (40%), Gaps = 3/255 (1%)
Frame = +2
Query: 77 KETGLITFHDIGTNYVS-FLSFFNYPEMRVILENFTVYHVCAPGHNIDSANFNNEYSREE 253
K ++T+HD+G NY S F F + +M+ I++NF HV APG
Sbjct: 61 KRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPGM--------------- 105
Query: 254 NYRLLSSKLGSNDPNAEIFTIXXXXXXXXXXXXYPSMAELADIIADVVDHFHIKYFLGFG 433
+ A +F + YPS+ +LAD+I V+ + + +G G
Sbjct: 106 ------------EEGAPVFPLGYQ---------YPSLDQLADMIPCVLQYLNFSTIIGVG 144
Query: 434 MGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTGYYPWTRAIWSDIPYLKSGVVTDWIQNW 613
+GAG +L RY L +P+ + GL L+N D G+ W K +T I
Sbjct: 145 VGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMDWAAH--------KLTGLTSSIPEM 196
Query: 614 LLDHWFG-SCTERNMDLEHSYLQLLGEL-NPVAVAGYIESYMNRTALGMTRPINSLDTNT 787
+L H F N +L Y ++ N + Y SY NR R +N
Sbjct: 197 ILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNR------RDLNFERGGD 250
Query: 788 STLKVDAFLVTGEMA 832
TL+ LV G+ A
Sbjct: 251 ITLRCPVMLVVGDQA 265
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 108,037,181
Number of Sequences: 369166
Number of extensions: 2364507
Number of successful extensions: 6176
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5771
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6160
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8582957970
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)