Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_F09
(876 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P48509|CD151_HUMAN Platelet-endothelial tetraspan antige... 101 2e-21
sp|Q9QZA6|CD151_RAT Platelet endothelial tetraspan antigen ... 100 5e-21
sp|O35566|C151_MOUSE Platelet-endothelial tetraspan antigen... 99 1e-20
sp|Q9QY33|TSN3_MOUSE Tetraspanin-3 (Tspan-3) (Transmembrane... 95 2e-19
sp|O60637|TSN3_HUMAN Tetraspanin-3 (Tspan-3) (Transmembrane... 95 3e-19
sp|P61171|CD151_MACMU Platelet-endothelial tetraspan antige... 94 5e-19
sp|P19075|TSN8_HUMAN Tetraspanin-8 (Tspan-8) (Transmembrane... 91 5e-18
sp|P28648|CD63_RAT CD63 antigen (AD1 antigen) 81 4e-15
sp|Q28709|CD63_RABIT CD63 antigen 81 4e-15
sp|P41731|CD63_MOUSE CD63 antigen 79 2e-14
>sp|P48509|CD151_HUMAN Platelet-endothelial tetraspan antigen 3 (PETA-3) (GP27) (Membrane
glycoprotein SFA-1) (CD151 antigen) (Tetraspanin-24)
(Tspan-24)
Length = 253
Score = 101 bits (252), Expect = 2e-21
Identities = 65/233 (27%), Positives = 105/233 (45%), Gaps = 9/233 (3%)
Frame = +1
Query: 76 KIILFILNFGFWLIGLFLIVIS--SIFLRNDAWKF--SDETVTNKYVIIGILVTGTIMFL 243
K +LF N FWL GL ++ + ++ L++D S + Y+++ V GT++ +
Sbjct: 17 KYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASGTYLATAYILV---VAGTVVMV 73
Query: 244 IAFAGCCGAIKESRFLLRXXXXXXXXXXXXXXXXXXXXXXKKQKIDKVLRKEMKYMFLVQ 423
GCC KE R LLR Q+++ L++ +K +
Sbjct: 74 TGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYAYYQQLNTELKENLKDTMTRR 133
Query: 424 YGTTPE--VTQSVDDLQQKLKCCGLQNASDWLHSSWYTKSNKTGQTVPESCCRNKTEKCW 597
Y + VT +VD LQQ+ CCG N+ DW S W G+ VP+SCC+ C
Sbjct: 134 YHQSGHEAVTSAVDQLQQEFHCCGSNNSQDWRDSEWIRSQEAGGRVVPDSCCKTVVALCG 193
Query: 598 KLG-GENVFNI--GCQTALIELVNKTLLIILLVAFGTIFFEMFLVICALCIYR 747
+ N++ + GC T L + + L +I V G ++F +I C+YR
Sbjct: 194 QRDHASNIYKVEGGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYR 246
>sp|Q9QZA6|CD151_RAT Platelet endothelial tetraspan antigen 3 (CD151 antigen)
Length = 253
Score = 100 bits (249), Expect = 5e-21
Identities = 64/233 (27%), Positives = 104/233 (44%), Gaps = 9/233 (3%)
Frame = +1
Query: 76 KIILFILNFGFWLIGLFLIVIS--SIFLRNDAWKF--SDETVTNKYVIIGILVTGTIMFL 243
K +LF N FWL GL ++ + ++ L++D S + Y+++ V G ++ +
Sbjct: 17 KYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASSTYLATAYILV---VAGVVVMV 73
Query: 244 IAFAGCCGAIKESRFLLRXXXXXXXXXXXXXXXXXXXXXXKKQKIDKVLRKEMKYMFLVQ 423
GCC KE R LLR Q+++ L++ +K + +
Sbjct: 74 TGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYVYYQQLNTELKENLKDTMIKR 133
Query: 424 YGTTPE--VTQSVDDLQQKLKCCGLQNASDWLHSSWYTKSNKTGQTVPESCCRNKTEKCW 597
Y + VT +VD LQQ+ CCG N+ DW S W + VP+SCC+ C
Sbjct: 134 YHQSGHEGVTNAVDKLQQEFHCCGSNNSRDWRDSEWIRSGEADSRVVPDSCCKTVVTGCG 193
Query: 598 KL-GGENVFNI--GCQTALIELVNKTLLIILLVAFGTIFFEMFLVICALCIYR 747
K N++ + GC T L + + L +I V G ++F +I C+YR
Sbjct: 194 KREHASNIYKVEGGCITKLESFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYR 246
>sp|O35566|C151_MOUSE Platelet-endothelial tetraspan antigen 3 (PETA-3) (GP27) (Membrane
glycoprotein SFA-1) (CD151 antigen)
Length = 253
Score = 99.4 bits (246), Expect = 1e-20
Identities = 63/233 (27%), Positives = 104/233 (44%), Gaps = 9/233 (3%)
Frame = +1
Query: 76 KIILFILNFGFWLIGLFLIVIS--SIFLRNDAWKF--SDETVTNKYVIIGILVTGTIMFL 243
K +LF N FWL GL ++ + ++ L++D S + Y+++ V G ++ +
Sbjct: 17 KYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASSTYLATAYILV---VAGVVVMV 73
Query: 244 IAFAGCCGAIKESRFLLRXXXXXXXXXXXXXXXXXXXXXXKKQKIDKVLRKEMKYMFLVQ 423
GCC KE R LLR Q+++ L++ +K + +
Sbjct: 74 TGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYVYYQQLNTELKENLKDTMVKR 133
Query: 424 YGTTPE--VTQSVDDLQQKLKCCGLQNASDWLHSSWYTKSNKTGQTVPESCCRNKTEKCW 597
Y + V+ +VD LQQ+ CCG N+ DW S W + VP+SCC+ C
Sbjct: 134 YHQSGHEGVSSAVDKLQQEFHCCGSNNSQDWQDSEWIRSGEADSRVVPDSCCKTMVAGCG 193
Query: 598 KLG-GENVFNI--GCQTALIELVNKTLLIILLVAFGTIFFEMFLVICALCIYR 747
K N++ + GC T L + + L +I V G ++F +I C+YR
Sbjct: 194 KRDHASNIYKVEGGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYR 246
>sp|Q9QY33|TSN3_MOUSE Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8)
(Tetraspanin TM4-A) (OSP-associated protein 1) (OAP-1)
Length = 253
Score = 95.1 bits (235), Expect = 2e-19
Identities = 53/237 (22%), Positives = 111/237 (46%), Gaps = 4/237 (1%)
Frame = +1
Query: 73 AKIILFILNFGFW-LIGLFLIVISSIFLRNDAWKFSDETVTNKYVIIGILVTGTIMFLIA 249
+K +L LN FW G+ V + +F+ D + E V + + I+ G ++F+I
Sbjct: 9 SKTVLVFLNLIFWGAAGILCYVGAYVFITYDDYDHFFEDVYTLFPAVVIIAVGALLFIIG 68
Query: 250 FAGCCGAIKESRFLLRXXXXXXXXXXXXXXXXXXXXXXKKQKIDKVLRKEMKYMFLVQYG 429
GCC I+ESR L + K++ + + ++ ++ G
Sbjct: 69 LIGCCATIRESRCGLATFVFILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQKVYKTYNG 128
Query: 430 TTPE-VTQSVDDLQQKLKCCGLQNASDWLHSSWYTKSNKTGQTVPESCCRNKTEKC--WK 600
T + ++++D +Q++L CCG+ N SDW ++ W+ ++ Q+VP SCCR + C
Sbjct: 129 TNSDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETK--NQSVPLSCCRETAKSCNGSL 186
Query: 601 LGGENVFNIGCQTALIELVNKTLLIILLVAFGTIFFEMFLVICALCIYRHKNMSGGY 771
+++ GC+ +++ + + L+ ++ A ++ ++CA + ++ Y
Sbjct: 187 ANPSDLYAEGCEALVVKKLQEILMHVIWAALAFAAIQLLGMLCACIVLCRRSRDPAY 243
>sp|O60637|TSN3_HUMAN Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8)
(Tetraspanin TM4-A)
Length = 253
Score = 94.7 bits (234), Expect = 3e-19
Identities = 53/237 (22%), Positives = 110/237 (46%), Gaps = 4/237 (1%)
Frame = +1
Query: 73 AKIILFILNFGFW-LIGLFLIVISSIFLRNDAWKFSDETVTNKYVIIGILVTGTIMFLIA 249
+K +L LN FW G+ V + +F+ D + E V + I+ G ++F+I
Sbjct: 9 SKTVLVFLNLIFWGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIG 68
Query: 250 FAGCCGAIKESRFLLRXXXXXXXXXXXXXXXXXXXXXXKKQKIDKVLRKEMKYMFLVQYG 429
GCC I+ESR L + K++ + + ++ ++ G
Sbjct: 69 LIGCCATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQKVYKTYNG 128
Query: 430 TTPE-VTQSVDDLQQKLKCCGLQNASDWLHSSWYTKSNKTGQTVPESCCRNKTEKC--WK 600
T P+ ++++D +Q++L CCG+ N SDW ++ W+ ++ Q+VP SCCR C
Sbjct: 129 TNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETK--NQSVPLSCCRETASNCNGSL 186
Query: 601 LGGENVFNIGCQTALIELVNKTLLIILLVAFGTIFFEMFLVICALCIYRHKNMSGGY 771
+++ GC+ +++ + + ++ ++ A ++ ++CA + ++ Y
Sbjct: 187 AHPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVLCRRSRDPAY 243
>sp|P61171|CD151_MACMU Platelet-endothelial tetraspan antigen 3 (PETA-3) (CD151 antigen)
sp|P61170|CD151_CERAE Platelet-endothelial tetraspan antigen 3 (PETA-3) (CD151 antigen)
Length = 253
Score = 94.0 bits (232), Expect = 5e-19
Identities = 65/235 (27%), Positives = 103/235 (43%), Gaps = 11/235 (4%)
Frame = +1
Query: 76 KIILFILNFGFWLIGLFLIVIS--SIFLRNDAWKF--SDETVTNKYVIIGILVTGTIMFL 243
K +LF N FWL GL ++ + ++ L++D S + Y+++ V G ++ +
Sbjct: 17 KYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASGTYLATAYILV---VAGAVVMV 73
Query: 244 IAFAGCCGAIKESRFLLRXXXXXXXXXXXXXXXXXXXXXXKKQKIDKVLRKEMKYMFLVQ 423
GCC KE R LLR Q+++ L++ +K +
Sbjct: 74 TGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGVLAYVYYQQLNTELKENLKDTMAKR 133
Query: 424 YGTTPE--VTQSVDDLQQKLKCCGLQNASDWLHSSWYTKSNKTGQTVPESCCRNKTEKCW 597
Y VT +VD LQQ+ CCG N+ DW S W G+ VP+SCC+ C
Sbjct: 134 YHQPGHEAVTSAVDQLQQEFHCCGSNNSQDWRDSEWIRLREARGRVVPDSCCKTVVAGCG 193
Query: 598 KLGGENVFNI-----GCQTALIELVNKTLLIILLVAFGTIFFEMFLVICALCIYR 747
+ ++ FNI G T L + + L +I V G ++F +I C+YR
Sbjct: 194 Q--RDHAFNIYKVEGGFITKLETFIQEHLRVIGAVGTGIACVQVFGMIFTCCLYR 246
>sp|P19075|TSN8_HUMAN Tetraspanin-8 (Tspan-8) (Transmembrane 4 superfamily member 3)
(Tumor-associated antigen CO-029)
Length = 237
Score = 90.5 bits (223), Expect = 5e-18
Identities = 60/232 (25%), Positives = 110/232 (47%), Gaps = 9/232 (3%)
Frame = +1
Query: 76 KIILFILNFGFWLIGLFLIVISS-IFLRNDAWKF--SDETVTNKYVIIGILVT-GTIMFL 243
K +F NF FWL G+ ++ ++ + + ND+ S++ ++ YV + IL+ G I+ +
Sbjct: 9 KYSMFTFNFLFWLCGILILALAIWVRVSNDSQAIFGSEDVGSSSYVAVDILIAVGAIIMI 68
Query: 244 IAFAGCCGAIKESRFLLRXXXXXXXXXXXXXXXXXXXXXXKKQKIDKVLRK---EMKYMF 414
+ F GCCGAIKESR +L K K D+++ + E +
Sbjct: 69 LGFLGCCGAIKESRCMLLLFFIGLLLILLLQVATGILGAVFKSKSDRIVNETLYENTKLL 128
Query: 415 LVQYGTTPEVTQSVDDLQQKLKCCGLQN-ASDWLHSSWYTKSNKTGQTVPESC-CRNKTE 588
+ + +++ Q++ KCCGL N A+DW Q PE C C +K
Sbjct: 129 SATGESEKQFQEAIIVFQEEFKCCGLVNGAADW---------GNNFQHYPELCACLDKQR 179
Query: 589 KCWKLGGENVFNIGCQTALIELVNKTLLIILLVAFGTIFFEMFLVICALCIY 744
C G+ V+ C + + + + K L+I++ ++FG E+ ++ ++ +Y
Sbjct: 180 PCQSYNGKQVYKETCISFIKDFLAKNLIIVIGISFGLAVIEILGLVFSMVLY 231
>sp|P28648|CD63_RAT CD63 antigen (AD1 antigen)
Length = 238
Score = 80.9 bits (198), Expect = 4e-15
Identities = 59/233 (25%), Positives = 95/233 (40%), Gaps = 1/233 (0%)
Frame = +1
Query: 76 KIILFILNFGFWLIGLFLIVISSIFLRNDAWKFSDETVTNKYVIIGILVTGTIMFLIAFA 255
K +L++L F + LI I + ET + + I+ G +FL+AF
Sbjct: 11 KFLLYVLLLAFCACAVGLIAIGVAVQVVLKQAITHETTAGSLLPVVIIAVGAFLFLVAFV 70
Query: 256 GCCGAIKESRFLLRXXXXXXXXXXXXXXXXXXXXXXKKQKIDKVLRKEMKYMFLVQYGTT 435
GCCGA KE+ L+ + ++ K + + Y T
Sbjct: 71 GCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEFSKSFQKQ-MQNYLTD 129
Query: 436 PEVTQSVDDLQQKLKCCGLQNASDWLHSSWYTKSNKTGQTVPESCCRNKTEKCWKLGGEN 615
+ +D LQ++ KCCG N +DW K VP+SCC N T C E+
Sbjct: 130 NKTATILDKLQKENKCCGASNYTDWERIPGMAKDR-----VPDSCCINITVGCGNDFKES 184
Query: 616 VFNI-GCQTALIELVNKTLLIILLVAFGTIFFEMFLVICALCIYRHKNMSGGY 771
+ GC + + K +L++ A G F E+ +I + C+ K++ GY
Sbjct: 185 TIHTQGCVETIAAWLRKNVLLVAGAALGIAFVEVLGIIFSCCLV--KSIRSGY 235
>sp|Q28709|CD63_RABIT CD63 antigen
Length = 238
Score = 80.9 bits (198), Expect = 4e-15
Identities = 58/238 (24%), Positives = 99/238 (41%), Gaps = 6/238 (2%)
Frame = +1
Query: 76 KIILFILNFGFWLIGLFLIVISSIFLRNDAWKFSDETVTN-----KYVIIGILVTGTIMF 240
K +L++L F + LI + A +T+T+ + + I+ G +F
Sbjct: 11 KFLLYVLLLAFCACAVGLIAVGV-----GAQLVLSQTITHGATPGSLLPVVIIAVGAFLF 65
Query: 241 LIAFAGCCGAIKESRFLLRXXXXXXXXXXXXXXXXXXXXXXKKQKIDKVLRKEMKYMFLV 420
L+AF GCCG KE+ L+ + K+ K+ + +
Sbjct: 66 LVAFVGCCGTCKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNKDFRQQ-MQ 124
Query: 421 QYGTTPEVTQSVDDLQQKLKCCGLQNASDWLHSSWYTKSNKTGQTVPESCCRNKTEKCW- 597
Y T + +D +Q+ CCG N +DW T T VP+SCC N T C
Sbjct: 125 NYSTDNQTALILDRMQKDFTCCGAANYTDWA-----TIPGMTRDRVPDSCCVNVTSGCGV 179
Query: 598 KLGGENVFNIGCQTALIELVNKTLLIILLVAFGTIFFEMFLVICALCIYRHKNMSGGY 771
K ++++ GC + + K +L++ A G F E+ ++ A C+ K++ GY
Sbjct: 180 KFNVKDIYVEGCVEKIGLWLRKNVLVVAAAALGIAFVEVLGIVFACCLV--KSIRSGY 235
>sp|P41731|CD63_MOUSE CD63 antigen
Length = 238
Score = 78.6 bits (192), Expect = 2e-14
Identities = 57/233 (24%), Positives = 94/233 (40%), Gaps = 1/233 (0%)
Frame = +1
Query: 76 KIILFILNFGFWLIGLFLIVISSIFLRNDAWKFSDETVTNKYVIIGILVTGTIMFLIAFA 255
K +L++L F + LI I + ET + + I+ G +FL+AF
Sbjct: 11 KFLLYVLLLAFCACAVGLIAIGVAVQVVLKQAITHETTAGSLLPVVIIAVGAFLFLVAFV 70
Query: 256 GCCGAIKESRFLLRXXXXXXXXXXXXXXXXXXXXXXKKQKIDKVLRKEMKYMFLVQYGTT 435
GCCGA KE+ L+ + ++ K + + Y
Sbjct: 71 GCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEFNKSFQQQ-MQNYLKD 129
Query: 436 PEVTQSVDDLQQKLKCCGLQNASDWLHSSWYTKSNKTGQTVPESCCRNKTEKCWKLGGEN 615
+ +D LQ++ CCG N +DW + K VP+SCC N T C E+
Sbjct: 130 NKTATILDKLQKENNCCGASNYTDWENIPGMAKDR-----VPDSCCINITVGCGNDFKES 184
Query: 616 VFNI-GCQTALIELVNKTLLIILLVAFGTIFFEMFLVICALCIYRHKNMSGGY 771
+ GC + + K +L++ A G F E+ +I + C+ K++ GY
Sbjct: 185 TIHTQGCVETIAIWLRKNILLVAAAALGIAFVEVLGIIFSCCLV--KSIRSGY 235
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,911,398
Number of Sequences: 369166
Number of extensions: 1664329
Number of successful extensions: 5046
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4785
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4952
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8694177530
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)