Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_E23
(556 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P61980|HNRPK_RAT Heterogeneous nuclear ribonucleoprotein... 89 9e-18
sp|O19049|HNRPK_RABIT Heterogeneous nuclear ribonucleoprote... 89 9e-18
sp|P57722|PCBP3_MOUSE Poly(rC)-binding protein 3 (Alpha-CP3) 57 4e-08
sp|P57721|PCBP3_HUMAN Poly(rC)-binding protein 3 (Alpha-CP3) 57 4e-08
sp|P57723|PCBP4_HUMAN Poly(rC)-binding protein 4 (Alpha-CP4) 55 9e-08
sp|P60335|PCBP1_MOUSE Poly(rC)-binding protein 1 (Alpha-CP1... 52 1e-06
sp|P57724|PCBP4_MOUSE Poly(rC)-binding protein 4 (Alpha-CP4) 52 1e-06
sp|Q15366|PCBP2_HUMAN Poly(rC)-binding protein 2 (Alpha-CP2... 51 2e-06
sp|Q61990|PCBP2_MOUSE Poly(rC)-binding protein 2 (Alpha-CP2... 51 2e-06
sp|Q9UNW9|NOVA2_HUMAN RNA-binding protein Nova-2 (Neuro-onc... 49 8e-06
>sp|P61980|HNRPK_RAT Heterogeneous nuclear ribonucleoprotein K (dC stretch-binding
protein) (CSBP)
sp|P61979|HNRPK_MOUSE Heterogeneous nuclear ribonucleoprotein K
sp|P61978|HNRPK_HUMAN Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation
up-regulated nuclear protein) (TUNP)
Length = 463
Score = 88.6 bits (218), Expect = 9e-18
Identities = 45/87 (51%), Positives = 61/87 (70%)
Frame = +1
Query: 244 SMGSHSGPIEISHVSLPNKLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIIT 423
S G GPI + V++P L G+I+GKGG RI +IR E+GA I +D+ + S +RIIT
Sbjct: 379 SYGDLGGPIITTQVTIPKDLAGSIIGKGGQRIKQIRHESGASIKIDEPL--EGSEDRIIT 436
Query: 424 IQGSRDQIQNAQFLLQACVRKYGGKHF 504
I G++DQIQNAQ+LLQ V++Y GK F
Sbjct: 437 ITGTQDQIQNAQYLLQNSVKQYSGKFF 463
Score = 35.0 bits (79), Expect = 0.12
Identities = 24/88 (27%), Positives = 38/88 (43%)
Frame = +1
Query: 184 DLSQEQVYSNPTPTPLMPHLSMGSHSGPIEISHVSLPNKLIGAIMGKGGSRINEIREETG 363
D+ +EQ + T M L + L +K GA++GKGG I +R +
Sbjct: 26 DMEEEQAFKRSRNTDEMVEL------------RILLQSKNAGAVIGKGGKNIKALRTDYN 73
Query: 364 ARIDVDKTMMDNKSSERIITIQGSRDQI 447
A + V D+ ERI++I + I
Sbjct: 74 ASVSVP----DSSGPERILSISADIETI 97
>sp|O19049|HNRPK_RABIT Heterogeneous nuclear ribonucleoprotein K (hnRNP K)
Length = 463
Score = 88.6 bits (218), Expect = 9e-18
Identities = 45/87 (51%), Positives = 61/87 (70%)
Frame = +1
Query: 244 SMGSHSGPIEISHVSLPNKLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIIT 423
S G GPI + V++P L G+I+GKGG RI +IR E+GA I +D+ + S +RIIT
Sbjct: 379 SYGDLGGPIITTQVTIPKDLAGSIIGKGGQRIKQIRHESGASIKIDEPL--EGSEDRIIT 436
Query: 424 IQGSRDQIQNAQFLLQACVRKYGGKHF 504
I G++DQIQNAQ+LLQ V++Y GK F
Sbjct: 437 ITGTQDQIQNAQYLLQNSVKQYSGKFF 463
Score = 35.0 bits (79), Expect = 0.12
Identities = 24/88 (27%), Positives = 38/88 (43%)
Frame = +1
Query: 184 DLSQEQVYSNPTPTPLMPHLSMGSHSGPIEISHVSLPNKLIGAIMGKGGSRINEIREETG 363
D+ +EQ + T M L + L +K GA++GKGG I +R +
Sbjct: 26 DMEEEQAFKRSRNTDEMVEL------------RILLQSKNAGAVIGKGGKNIKALRTDYN 73
Query: 364 ARIDVDKTMMDNKSSERIITIQGSRDQI 447
A + V D+ ERI++I + I
Sbjct: 74 ASVSVP----DSSGPERILSISADIETI 97
>sp|P57722|PCBP3_MOUSE Poly(rC)-binding protein 3 (Alpha-CP3)
Length = 339
Score = 56.6 bits (135), Expect = 4e-08
Identities = 34/81 (41%), Positives = 48/81 (59%), Gaps = 5/81 (6%)
Frame = +1
Query: 247 MGSHSG-----PIEISHVSLPNKLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSE 411
MG SG P +++PN LIG I+G+ G++INEIR+ +GA+I + SSE
Sbjct: 249 MGQSSGLDASPPASTHELTIPNDLIGCIIGRQGTKINEIRQMSGAQIKIANA--TEGSSE 306
Query: 412 RIITIQGSRDQIQNAQFLLQA 474
R ITI G+ I AQ+L+ A
Sbjct: 307 RQITITGTPANISLAQYLINA 327
Score = 53.9 bits (128), Expect = 3e-07
Identities = 30/64 (46%), Positives = 42/64 (65%)
Frame = +1
Query: 289 LPNKLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNAQFLL 468
+P G+++GKGGS+I EIRE TGA++ V M+ N S+ER +TI G+ D I Q +
Sbjct: 104 VPASQCGSLIGKGGSKIKEIRESTGAQVQVAGDMLPN-STERAVTISGTPDAI--IQCVK 160
Query: 469 QACV 480
Q CV
Sbjct: 161 QICV 164
Score = 42.7 bits (99), Expect = 6e-04
Identities = 22/53 (41%), Positives = 33/53 (62%)
Frame = +1
Query: 298 KLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNA 456
K +G+I+GK G + ++REE+GARI++ + ERI+TI G D I A
Sbjct: 23 KEVGSIIGKKGETVKKMREESGARINIS----EGNCPERIVTITGPTDAIFKA 71
>sp|P57721|PCBP3_HUMAN Poly(rC)-binding protein 3 (Alpha-CP3)
Length = 339
Score = 56.6 bits (135), Expect = 4e-08
Identities = 34/81 (41%), Positives = 48/81 (59%), Gaps = 5/81 (6%)
Frame = +1
Query: 247 MGSHSG-----PIEISHVSLPNKLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSE 411
MG SG P +++PN LIG I+G+ G++INEIR+ +GA+I + SSE
Sbjct: 249 MGQSSGLDASPPASTHELTIPNDLIGCIIGRQGTKINEIRQMSGAQIKIANA--TEGSSE 306
Query: 412 RIITIQGSRDQIQNAQFLLQA 474
R ITI G+ I AQ+L+ A
Sbjct: 307 RQITITGTPANISLAQYLINA 327
Score = 53.9 bits (128), Expect = 3e-07
Identities = 30/64 (46%), Positives = 42/64 (65%)
Frame = +1
Query: 289 LPNKLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNAQFLL 468
+P G+++GKGGS+I EIRE TGA++ V M+ N S+ER +TI G+ D I Q +
Sbjct: 104 VPASQCGSLIGKGGSKIKEIRESTGAQVQVAGDMLPN-STERAVTISGTPDAI--IQCVK 160
Query: 469 QACV 480
Q CV
Sbjct: 161 QICV 164
Score = 42.7 bits (99), Expect = 6e-04
Identities = 22/53 (41%), Positives = 33/53 (62%)
Frame = +1
Query: 298 KLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNA 456
K +G+I+GK G + ++REE+GARI++ + ERI+TI G D I A
Sbjct: 23 KEVGSIIGKKGETVKKMREESGARINIS----EGNCPERIVTITGPTDAIFKA 71
>sp|P57723|PCBP4_HUMAN Poly(rC)-binding protein 4 (Alpha-CP4)
Length = 403
Score = 55.5 bits (132), Expect = 9e-08
Identities = 36/99 (36%), Positives = 56/99 (56%), Gaps = 1/99 (1%)
Frame = +1
Query: 187 LSQEQVYSNPTPTP-LMPHLSMGSHSGPIEISHVSLPNKLIGAIMGKGGSRINEIREETG 363
L Q ++ P TP ++P L G+ + E +PN LIG ++G+ GS+I+EIR+ +G
Sbjct: 216 LQQLSSHAVPFATPSVVPGLDPGTQTSSQEFL---VPNDLIGCVIGRQGSKISEIRQMSG 272
Query: 364 ARIDVDKTMMDNKSSERIITIQGSRDQIQNAQFLLQACV 480
A I + + ER +TI GS I AQ+L+ AC+
Sbjct: 273 AHIKIGN--QAEGAGERHVTITGSPVSIALAQYLITACL 309
Score = 47.4 bits (111), Expect = 2e-05
Identities = 25/66 (37%), Positives = 40/66 (60%)
Frame = +1
Query: 250 GSHSGPIEISHVSLPNKLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQ 429
G+ S P + +P G+++GK G++I EIRE TGA++ V ++ N S+ER +T+
Sbjct: 95 GNVSRPPVTLRLVIPASQCGSLIGKAGTKIKEIRETTGAQVQVAGDLLPN-STERAVTVS 153
Query: 430 GSRDQI 447
G D I
Sbjct: 154 GVPDAI 159
Score = 37.7 bits (86), Expect = 0.019
Identities = 21/53 (39%), Positives = 31/53 (58%)
Frame = +1
Query: 298 KLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNA 456
K +G+I+GK G + IRE++ ARI T+ + ERI TI GS + +A
Sbjct: 27 KEVGSIIGKKGETVKRIREQSSARI----TISEGSCPERITTITGSTAAVFHA 75
>sp|P60335|PCBP1_MOUSE Poly(rC)-binding protein 1 (Alpha-CP1) (hnRNP-E1)
sp|Q15365|PCBP1_HUMAN Poly(rC)-binding protein 1 (Alpha-CP1) (hnRNP-E1) (Nucleic
acid-binding protein SUB2.3)
sp|O19048|PCBP1_RABIT Poly(rC)-binding protein 1 (Alpha-CP1) (hnRNP-E1)
Length = 356
Score = 52.0 bits (123), Expect = 1e-06
Identities = 28/64 (43%), Positives = 42/64 (65%)
Frame = +1
Query: 283 VSLPNKLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNAQF 462
+++PN LIG I+G+ G+ INEIR+ +GA+I + + SS R +TI GS I AQ+
Sbjct: 284 LTIPNNLIGCIIGRQGANINEIRQMSGAQIKIANPV--EGSSGRQVTITGSAASISLAQY 341
Query: 463 LLQA 474
L+ A
Sbjct: 342 LINA 345
Score = 47.8 bits (112), Expect = 2e-05
Identities = 32/89 (35%), Positives = 51/89 (57%)
Frame = +1
Query: 166 ADSIMLDLSQEQVYSNPTPTPLMPHLSMGSHSGPIEISHVSLPNKLIGAIMGKGGSRINE 345
A ++++D +E + S+ T S + P+ + V +P G+++GKGG +I E
Sbjct: 71 AFAMIIDKLEEDINSSMTN-------STAASRPPVTLRLV-VPATQCGSLIGKGGCKIKE 122
Query: 346 IREETGARIDVDKTMMDNKSSERIITIQG 432
IRE TGA++ V M+ N S+ER ITI G
Sbjct: 123 IRESTGAQVQVAGDMLPN-STERAITIAG 150
Score = 41.2 bits (95), Expect = 0.002
Identities = 22/53 (41%), Positives = 32/53 (60%)
Frame = +1
Query: 298 KLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNA 456
K +G+I+GK G + IREE+GARI++ + ERIIT+ G + I A
Sbjct: 23 KEVGSIIGKKGESVKRIREESGARINIS----EGNCPERIITLTGPTNAIFKA 71
>sp|P57724|PCBP4_MOUSE Poly(rC)-binding protein 4 (Alpha-CP4)
Length = 403
Score = 51.6 bits (122), Expect = 1e-06
Identities = 27/64 (42%), Positives = 41/64 (64%)
Frame = +1
Query: 289 LPNKLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNAQFLL 468
+PN LIG ++G+ GS+I+EIR+ +GA I + + ER +TI GS I AQ+L+
Sbjct: 248 VPNDLIGCVIGRQGSKISEIRQMSGAHIKIGN--QAEGAGERHVTITGSPVSIALAQYLI 305
Query: 469 QACV 480
AC+
Sbjct: 306 TACL 309
Score = 48.5 bits (114), Expect = 1e-05
Identities = 26/66 (39%), Positives = 40/66 (60%)
Frame = +1
Query: 250 GSHSGPIEISHVSLPNKLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQ 429
GS S P + +P G+++GK G++I EIRE TGA++ V ++ N S+ER +T+
Sbjct: 95 GSVSRPPVTLRLVIPASQCGSLIGKAGTKIKEIRETTGAQVQVAGDLLPN-STERAVTVS 153
Query: 430 GSRDQI 447
G D I
Sbjct: 154 GVPDAI 159
Score = 37.7 bits (86), Expect = 0.019
Identities = 21/53 (39%), Positives = 31/53 (58%)
Frame = +1
Query: 298 KLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNA 456
K +G+I+GK G + IRE++ ARI T+ + ERI TI GS + +A
Sbjct: 27 KEVGSIIGKKGETVKRIREQSSARI----TISEGSCPERITTITGSTAAVFHA 75
>sp|Q15366|PCBP2_HUMAN Poly(rC)-binding protein 2 (Alpha-CP2) (hnRNP-E2)
Length = 365
Score = 51.2 bits (121), Expect = 2e-06
Identities = 26/62 (41%), Positives = 43/62 (69%)
Frame = +1
Query: 283 VSLPNKLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNAQF 462
+++PN LIG I+G+ G++INEIR+ +GA+I + + S++R +TI GS I AQ+
Sbjct: 292 LTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPV--EGSTDRQVTITGSAASISLAQY 349
Query: 463 LL 468
L+
Sbjct: 350 LI 351
Score = 48.9 bits (115), Expect = 8e-06
Identities = 36/105 (34%), Positives = 57/105 (54%)
Frame = +1
Query: 166 ADSIMLDLSQEQVYSNPTPTPLMPHLSMGSHSGPIEISHVSLPNKLIGAIMGKGGSRINE 345
A ++++D +E + S+ T S + P+ + V +P G+++GKGG +I E
Sbjct: 71 AFAMIIDKLEEDISSSMTN-------STAASRPPVTLRLV-VPASQCGSLIGKGGCKIKE 122
Query: 346 IREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNAQFLLQACV 480
IRE TGA++ V M+ N S+ER ITI G I + + Q CV
Sbjct: 123 IRESTGAQVQVAGDMLPN-STERAITIAGIPQSI--IECVKQICV 164
Score = 40.4 bits (93), Expect = 0.003
Identities = 21/53 (39%), Positives = 33/53 (62%)
Frame = +1
Query: 298 KLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNA 456
K +G+I+GK G + ++REE+GARI++ + ERIIT+ G + I A
Sbjct: 23 KEVGSIIGKKGESVKKMREESGARINIS----EGNCPERIITLAGPTNAIFKA 71
>sp|Q61990|PCBP2_MOUSE Poly(rC)-binding protein 2 (Alpha-CP2) (Putative heterogeneous
nuclear ribonucleoprotein X) (hnRNP X) (CTBP) (CBP)
Length = 362
Score = 51.2 bits (121), Expect = 2e-06
Identities = 26/62 (41%), Positives = 43/62 (69%)
Frame = +1
Query: 283 VSLPNKLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNAQF 462
+++PN LIG I+G+ G++INEIR+ +GA+I + + S++R +TI GS I AQ+
Sbjct: 289 LTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPV--EGSTDRQVTITGSAASISLAQY 346
Query: 463 LL 468
L+
Sbjct: 347 LI 348
Score = 48.9 bits (115), Expect = 8e-06
Identities = 36/105 (34%), Positives = 57/105 (54%)
Frame = +1
Query: 166 ADSIMLDLSQEQVYSNPTPTPLMPHLSMGSHSGPIEISHVSLPNKLIGAIMGKGGSRINE 345
A ++++D +E + S+ T S + P+ + V +P G+++GKGG +I E
Sbjct: 71 AFAMIIDKLEEDISSSMTN-------STAASRPPVTLRLV-VPASQCGSLIGKGGCKIKE 122
Query: 346 IREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNAQFLLQACV 480
IRE TGA++ V M+ N S+ER ITI G I + + Q CV
Sbjct: 123 IRESTGAQVQVAGDMLPN-STERAITIAGIPQSI--IECVKQICV 164
Score = 40.4 bits (93), Expect = 0.003
Identities = 21/53 (39%), Positives = 33/53 (62%)
Frame = +1
Query: 298 KLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNA 456
K +G+I+GK G + ++REE+GARI++ + ERIIT+ G + I A
Sbjct: 23 KEVGSIIGKKGESVKKMREESGARINIS----EGNCPERIITLAGPTNAIFKA 71
>sp|Q9UNW9|NOVA2_HUMAN RNA-binding protein Nova-2 (Neuro-oncological ventral antigen 2)
(Astrocytic NOVA1-like RNA-binding protein)
Length = 492
Score = 48.9 bits (115), Expect = 8e-06
Identities = 27/67 (40%), Positives = 40/67 (59%), Gaps = 1/67 (1%)
Frame = +1
Query: 271 EISHVSLPNKLIGAIMGKGGSRINEIREETGARIDVDKT-MMDNKSSERIITIQGSRDQI 447
E+ +++P L+GAI+GKGG + E +E TGARI + K + R +TI GS
Sbjct: 407 ELVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFLPGTRNRRVTITGSPAAT 466
Query: 448 QNAQFLL 468
Q AQ+L+
Sbjct: 467 QAAQYLI 473
Score = 43.1 bits (100), Expect = 5e-04
Identities = 17/56 (30%), Positives = 32/56 (57%)
Frame = +1
Query: 289 LPNKLIGAIMGKGGSRINEIREETGARIDVDKTMMDNKSSERIITIQGSRDQIQNA 456
+PN G I+GKGG+ + + E++GA + + + ER++T+ G +Q+ A
Sbjct: 137 VPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPEGINLQERVVTVSGEPEQVHKA 192
Score = 39.7 bits (91), Expect = 0.005
Identities = 21/69 (30%), Positives = 40/69 (57%), Gaps = 1/69 (1%)
Frame = +1
Query: 283 VSLPNKLIGAIMGKGGSRINEIREETGARIDVDKTM-MDNKSSERIITIQGSRDQIQNAQ 459
V +P+ G+I+GKGG I ++++ETGA I + K+ ++ER+ +QG+ + +
Sbjct: 37 VLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLVQGTAEALNAVH 96
Query: 460 FLLQACVRK 486
+ VR+
Sbjct: 97 SFIAEKVRE 105
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,097,353
Number of Sequences: 369166
Number of extensions: 1285342
Number of successful extensions: 3238
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3095
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3228
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3931403200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)