Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_E17
(565 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinas... 103 3e-22
sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinas... 102 9e-22
sp|Q13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 ... 98 2e-20
sp|Q03497|STE20_YEAST Serine/threonine-protein kinase STE20 97 2e-20
sp|P35465|PAK1_RAT Serine/threonine-protein kinase PAK 1 (p... 96 5e-20
sp|O88643|PAK1_MOUSE Serine/threonine-protein kinase PAK 1 ... 96 8e-20
sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (S... 95 1e-19
sp|Q62829|PAK3_RAT Serine/threonine-protein kinase PAK 3 (p... 95 1e-19
sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24 95 1e-19
sp|O75914|PAK3_HUMAN Serine/threonine-protein kinase PAK 3 ... 95 1e-19
>sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinase kinase 1 (Arabidospsis
NPK1-related protein kinase 1)
Length = 666
Score = 103 bits (257), Expect = 3e-22
Identities = 73/187 (39%), Positives = 100/187 (53%), Gaps = 1/187 (0%)
Frame = +2
Query: 8 DFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANWT 187
++LH+ I+HRD+KG IL+DN IKL F ++K + ++ T A+S GT W
Sbjct: 186 EYLHNHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTG----AKSMKGTPYWM 241
Query: 188 APEVINGEGYGSSADIWSFGAVMVELITGKAPLF-FLASFQAIYRLGTQKKIEFAYPLKC 364
APEVI G+ SADIWS G ++E++TGKAP AI+ +GT K
Sbjct: 242 APEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDTLS 301
Query: 365 SDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSAMEAD*FT*RVDIFSWIN*NNTYMLPK 544
SDA K F+ CL P RPT +L+KH F+ + T D+ S +N N + LP
Sbjct: 302 SDA-KDFLLKCLQEVPNLRPTASELLKHPFVMGKHKESAST---DLGSVLN-NLSTPLPL 356
Query: 545 *INNCSS 565
INN S
Sbjct: 357 QINNTKS 363
>sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinase kinase 2 (Arabidospsis
NPK1-related protein kinase 2)
Length = 651
Score = 102 bits (253), Expect = 9e-22
Identities = 67/187 (35%), Positives = 100/187 (53%), Gaps = 1/187 (0%)
Frame = +2
Query: 8 DFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANWT 187
++LH+ I+HRD+KG IL+DN IKL F ++K + ++ + A+S GT W
Sbjct: 185 EYLHNHAIMHRDIKGANILVDNQGCIKLADFGASKQVAELATISG----AKSMKGTPYWM 240
Query: 188 APEVINGEGYGSSADIWSFGAVMVELITGKAPLF-FLASFQAIYRLGTQKKIEFAYPLKC 364
APEVI G+ SADIWS G ++E++TGKAP AI+ +GT K P
Sbjct: 241 APEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEIAAIFHIGTTKS-HPPIPDNI 299
Query: 365 SDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSAMEAD*FT*RVDIFSWIN*NNTYMLPK 544
S F+ CL EP RPT +L+KH F+ + + D+ S+++ N+ LP
Sbjct: 300 SSDANDFLLKCLQQEPNLRPTASELLKHPFVTGKQKE---SASKDLTSFMD-NSCSPLPS 355
Query: 545 *INNCSS 565
+ N +S
Sbjct: 356 ELTNITS 362
>sp|Q13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1)
(PAK-1) (P65-PAK) (Alpha-PAK)
Length = 545
Score = 97.8 bits (242), Expect = 2e-20
Identities = 53/154 (34%), Positives = 82/154 (53%), Gaps = 1/154 (0%)
Frame = +2
Query: 8 DFLHSQNILHRDLKGPKILLDNNLDIKLCGF-MSAKMFPDASSETFRNHVAESNHGTANW 184
+FLHS ++HRD+K ILL + +KL F A++ P+ S + + GT W
Sbjct: 378 EFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-------TMVGTPYW 430
Query: 185 TAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKC 364
APEV+ + YG DIWS G + +E+I G+ P +A+Y + T E P K
Sbjct: 431 MAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKL 490
Query: 365 SDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSA 466
S + F++ CLD + R + K+L++H+FL A
Sbjct: 491 SAIFRDFLNRCLDMDVEKRGSAKELLQHQFLKIA 524
>sp|Q03497|STE20_YEAST Serine/threonine-protein kinase STE20
Length = 939
Score = 97.4 bits (241), Expect = 2e-20
Identities = 54/157 (34%), Positives = 81/157 (51%)
Frame = +2
Query: 8 DFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANWT 187
+FLHS+ +LHRD+K ILL DIKL F + N + GT W
Sbjct: 728 EFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINEL------NLKRTTMVGTPYWM 781
Query: 188 APEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKCS 367
APEV++ + YG DIWS G +++E+I G+ P +A+Y + T + P S
Sbjct: 782 APEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLS 841
Query: 368 DALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSAMEAD 478
+LK F+D CL EP +R + +L+ E++ EA+
Sbjct: 842 SSLKKFLDWCLCVEPEDRASATELLHDEYITEIAEAN 878
>sp|P35465|PAK1_RAT Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1)
(PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2)
Length = 544
Score = 96.3 bits (238), Expect = 5e-20
Identities = 52/154 (33%), Positives = 82/154 (53%), Gaps = 1/154 (0%)
Frame = +2
Query: 8 DFLHSQNILHRDLKGPKILLDNNLDIKLCGF-MSAKMFPDASSETFRNHVAESNHGTANW 184
+FLHS ++HRD+K ILL + +KL F A++ P+ S + + GT W
Sbjct: 377 EFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-------TMVGTPYW 429
Query: 185 TAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKC 364
APEV+ + YG DIWS G + +E+I G+ P +A+Y + T E P K
Sbjct: 430 MAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKL 489
Query: 365 SDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSA 466
S + F++ CL+ + R + K+L++H+FL A
Sbjct: 490 SAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIA 523
>sp|O88643|PAK1_MOUSE Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1)
(PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase
PAK-A)
Length = 545
Score = 95.5 bits (236), Expect = 8e-20
Identities = 52/154 (33%), Positives = 81/154 (52%), Gaps = 1/154 (0%)
Frame = +2
Query: 8 DFLHSQNILHRDLKGPKILLDNNLDIKLCGF-MSAKMFPDASSETFRNHVAESNHGTANW 184
+FLHS ++HRD+K ILL + +KL F A++ P+ S + + GT W
Sbjct: 378 EFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-------TMVGTPYW 430
Query: 185 TAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKC 364
APEV+ + YG DIWS G + +E+I G+ P +A+Y + T E P K
Sbjct: 431 MAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKL 490
Query: 365 SDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSA 466
S + F+ CL+ + R + K+L++H+FL A
Sbjct: 491 SAIFRDFLQCCLEMDVEKRGSAKELLQHQFLKIA 524
>sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (STE20-like kinase MST3) (MST-3)
(Mammalian STE20-like protein kinase 3)
Length = 443
Score = 95.1 bits (235), Expect = 1e-19
Identities = 57/152 (37%), Positives = 79/152 (51%), Gaps = 2/152 (1%)
Frame = +2
Query: 8 DFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANWT 187
D+LHS+ +HRD+K +LL + ++KL F A D + RN GT W
Sbjct: 145 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIK--RNTFV----GTPFWM 198
Query: 188 APEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRL--GTQKKIEFAYPLK 361
APEVI Y S ADIWS G +EL G+ P L + ++ + +E Y
Sbjct: 199 APEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNY--- 255
Query: 362 CSDALKSFVDPCLDPEPLNRPTVKDLMKHEFL 457
S LK FV+ CL+ EP RPT K+L+KH+F+
Sbjct: 256 -SKPLKEFVEACLNKEPSFRPTAKELLKHKFI 286
>sp|Q62829|PAK3_RAT Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3) (Beta-PAK) (p65-PAK)
Length = 544
Score = 95.1 bits (235), Expect = 1e-19
Identities = 51/154 (33%), Positives = 81/154 (52%), Gaps = 1/154 (0%)
Frame = +2
Query: 8 DFLHSQNILHRDLKGPKILLDNNLDIKLCGF-MSAKMFPDASSETFRNHVAESNHGTANW 184
DFLHS ++HRD+K ILL + +KL F A++ P+ S + + GT W
Sbjct: 376 DFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-------TMVGTPYW 428
Query: 185 TAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKC 364
APEV+ + YG DIWS G + +E++ G+ P +A+Y + T E P +
Sbjct: 429 MAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERL 488
Query: 365 SDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSA 466
S + F++ CL+ + R + K+L++H FL A
Sbjct: 489 SAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLA 522
>sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24
Length = 431
Score = 95.1 bits (235), Expect = 1e-19
Identities = 57/152 (37%), Positives = 79/152 (51%), Gaps = 2/152 (1%)
Frame = +2
Query: 8 DFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANWT 187
D+LHS+ +HRD+K +LL + ++KL F A D + RN GT W
Sbjct: 133 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIK--RNTFV----GTPFWM 186
Query: 188 APEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRL--GTQKKIEFAYPLK 361
APEVI Y S ADIWS G +EL G+ P L + ++ + +E Y
Sbjct: 187 APEVIKQSAYDSKADIWSLGITAIELAKGEPPHSELHPMKVLFLIPKNNPPTLEGNY--- 243
Query: 362 CSDALKSFVDPCLDPEPLNRPTVKDLMKHEFL 457
S LK FV+ CL+ EP RPT K+L+KH+F+
Sbjct: 244 -SKPLKEFVEACLNKEPSFRPTAKELLKHKFI 274
>sp|O75914|PAK3_HUMAN Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3) (Beta-PAK) (Oligophrenin-3)
sp|Q7YQL3|PAK3_PONPY Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3)
sp|Q7YQL4|PAK3_PANTR Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3)
Length = 559
Score = 95.1 bits (235), Expect = 1e-19
Identities = 51/154 (33%), Positives = 81/154 (52%), Gaps = 1/154 (0%)
Frame = +2
Query: 8 DFLHSQNILHRDLKGPKILLDNNLDIKLCGF-MSAKMFPDASSETFRNHVAESNHGTANW 184
DFLHS ++HRD+K ILL + +KL F A++ P+ S + + GT W
Sbjct: 391 DFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-------TMVGTPYW 443
Query: 185 TAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKC 364
APEV+ + YG DIWS G + +E++ G+ P +A+Y + T E P +
Sbjct: 444 MAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERL 503
Query: 365 SDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSA 466
S + F++ CL+ + R + K+L++H FL A
Sbjct: 504 SAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLA 537
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,666,658
Number of Sequences: 369166
Number of extensions: 1388880
Number of successful extensions: 6636
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5026
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5260
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 4078830820
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)