Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_E07
(929 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q6IQT4|CSN2_BRARE COP9 signalosome complex subunit 2 (Si... 327 3e-89
sp|P61201|CSN2_HUMAN COP9 signalosome complex subunit 2 (Si... 326 5e-89
sp|Q6IR75|CSN2_XENLA COP9 signalosome complex subunit 2 (Si... 326 5e-89
sp|Q94899|CSN2_DROME COP9 signalosome complex subunit 2 (Si... 323 3e-88
sp|O01422|CSN2_CAEEL COP9 signalosome complex subunit 2 (Si... 269 9e-72
sp|Q8W207|CSN2_ARATH COP9 signalosome complex subunit 2 (Si... 259 6e-69
sp|Q9HFR0|CSN2_SCHPO COP9 signalosome complex subunit 2 (CS... 236 9e-62
sp|Q9P7S2|RPN6_SCHPO Probable 26S proteasome regulatory sub... 81 5e-15
sp|P34481|YMJ5_CAEEL Hypothetical protein F59B2.5 in chromo... 80 8e-15
sp|Q8BG32|PSD11_MOUSE 26S proteasome non-ATPase regulatory ... 77 7e-14
>sp|Q6IQT4|CSN2_BRARE COP9 signalosome complex subunit 2 (Signalosome subunit 2)
Length = 443
Score = 327 bits (838), Expect = 3e-89
Identities = 162/239 (67%), Positives = 192/239 (80%), Gaps = 1/239 (0%)
Frame = +1
Query: 1 MYTIQRNNKKLKNLYEQSLHIKSAIPHPLIMGIIRECGGKMHLRQGEFDKAHTDFFEAFK 180
MYT Q+NNKKLK LYEQSLHIKSAIPHPLIMG+IRECGGKMHLR+GEF+KAHTDFFEAFK
Sbjct: 204 MYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFK 263
Query: 181 NYDESGSQRRTQCLKYLVLSNMLTKSAINPFDSQEIKPYRDNPEIVAMTNLVSAYQINDI 360
NYDESGS RRT CLKYLVL+NML KS INPFDSQE KPY+++PEI+AMTNLVSAYQ NDI
Sbjct: 264 NYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDI 323
Query: 361 KTFEATLTENEDTIMQDTFIREHIEELLRNIRIDVLIGLVKPYKTVRIEFLAQRLNISAN 540
FE L N IM D FIREHIEELLRNIR VLI L+KPY + I F+++ LNI
Sbjct: 324 TEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVA 383
Query: 541 EVESLLVSCIADNVIKGKIDQKSDILVID-EPRKEAKYKSLDKLISEIDKLHHNLVSRV 714
+VESLLV CI DN I G+IDQ + +L +D + R A+Y +LDK ++++ L+ +VS++
Sbjct: 384 DVESLLVQCILDNTINGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAIVSKL 442
>sp|P61201|CSN2_HUMAN COP9 signalosome complex subunit 2 (Signalosome subunit 2) (SGN2)
(JAB1-containing signalosome subunit 2) (Thyroid
receptor interacting protein 15) (Alien homolog)
sp|P61203|CSN2_RAT COP9 signalosome complex subunit 2 (Signalosome subunit 2) (SGN2)
(JAB1-containing signalosome subunit 2) (Thyroid
receptor interacting protein 15) (Alien homolog)
sp|P61202|CSN2_MOUSE COP9 signalosome complex subunit 2 (Signalosome subunit 2) (SGN2)
(JAB1-containing signalosome subunit 2) (Thyroid
receptor interacting protein 15) (Alien homolog)
Length = 443
Score = 326 bits (836), Expect = 5e-89
Identities = 162/239 (67%), Positives = 192/239 (80%), Gaps = 1/239 (0%)
Frame = +1
Query: 1 MYTIQRNNKKLKNLYEQSLHIKSAIPHPLIMGIIRECGGKMHLRQGEFDKAHTDFFEAFK 180
MYT Q+NNKKLK LYEQSLHIKSAIPHPLIMG+IRECGGKMHLR+GEF+KAHTDFFEAFK
Sbjct: 204 MYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFK 263
Query: 181 NYDESGSQRRTQCLKYLVLSNMLTKSAINPFDSQEIKPYRDNPEIVAMTNLVSAYQINDI 360
NYDESGS RRT CLKYLVL+NML KS INPFDSQE KPY+++PEI+AMTNLVSAYQ NDI
Sbjct: 264 NYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDI 323
Query: 361 KTFEATLTENEDTIMQDTFIREHIEELLRNIRIDVLIGLVKPYKTVRIEFLAQRLNISAN 540
FE L N IM D FIREHIEELLRNIR VLI L+KPY + I F+++ LNI
Sbjct: 324 TEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVA 383
Query: 541 EVESLLVSCIADNVIKGKIDQKSDILVID-EPRKEAKYKSLDKLISEIDKLHHNLVSRV 714
+VESLLV CI DN I G+IDQ + +L +D + R A+Y +LDK ++++ L+ +VS++
Sbjct: 384 DVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKL 442
>sp|Q6IR75|CSN2_XENLA COP9 signalosome complex subunit 2 (Signalosome subunit 2)
Length = 441
Score = 326 bits (836), Expect = 5e-89
Identities = 162/239 (67%), Positives = 192/239 (80%), Gaps = 1/239 (0%)
Frame = +1
Query: 1 MYTIQRNNKKLKNLYEQSLHIKSAIPHPLIMGIIRECGGKMHLRQGEFDKAHTDFFEAFK 180
MYT Q+NNKKLK LYEQSLHIKSAIPHPLIMG+IRECGGKMHLR+GEF+KAHTDFFEAFK
Sbjct: 202 MYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFK 261
Query: 181 NYDESGSQRRTQCLKYLVLSNMLTKSAINPFDSQEIKPYRDNPEIVAMTNLVSAYQINDI 360
NYDESGS RRT CLKYLVL+NML KS INPFDSQE KPY+++PEI+AMTNLVSAYQ NDI
Sbjct: 262 NYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDI 321
Query: 361 KTFEATLTENEDTIMQDTFIREHIEELLRNIRIDVLIGLVKPYKTVRIEFLAQRLNISAN 540
FE L N IM D FIREHIEELLRNIR VLI L+KPY + I F+++ LNI
Sbjct: 322 TEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVA 381
Query: 541 EVESLLVSCIADNVIKGKIDQKSDILVID-EPRKEAKYKSLDKLISEIDKLHHNLVSRV 714
+VESLLV CI DN I G+IDQ + +L +D + R A+Y +LDK ++++ L+ +VS++
Sbjct: 382 DVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKL 440
>sp|Q94899|CSN2_DROME COP9 signalosome complex subunit 2 (Signalosome subunit 2) (Dch2)
(Alien protein)
Length = 444
Score = 323 bits (829), Expect = 3e-88
Identities = 159/239 (66%), Positives = 192/239 (80%), Gaps = 1/239 (0%)
Frame = +1
Query: 1 MYTIQRNNKKLKNLYEQSLHIKSAIPHPLIMGIIRECGGKMHLRQGEFDKAHTDFFEAFK 180
MYT+Q+NNKKLK LYEQSLHIKSAIPHPLIMG+IRECGGKMHLR+GEF+KAHTDFFEAFK
Sbjct: 205 MYTVQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFK 264
Query: 181 NYDESGSQRRTQCLKYLVLSNMLTKSAINPFDSQEIKPYRDNPEIVAMTNLVSAYQINDI 360
NYDESGS RRT CLKYLVL+NML KS INPFDSQE KPY+++PEI+AMTNLV++YQ NDI
Sbjct: 265 NYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVNSYQNNDI 324
Query: 361 KTFEATLTENEDTIMQDTFIREHIEELLRNIRIDVLIGLVKPYKTVRIEFLAQRLNISAN 540
FE L ++ IM D FIREHIE+LLRNIR VLI L++PYK + I F+A LNI
Sbjct: 325 NEFETILRQHRSNIMADQFIREHIEDLLRNIRTQVLIKLIRPYKNIAIPFIANALNIEPA 384
Query: 541 EVESLLVSCIADNVIKGKIDQKSDILVIDEPRKEA-KYKSLDKLISEIDKLHHNLVSRV 714
EVESLLVSCI D+ IKG+IDQ + +L +D+ A +Y +L+K ++I L +V ++
Sbjct: 385 EVESLLVSCILDDTIKGRIDQVNQVLQLDKINSSASRYNALEKWSNQIQSLQFAVVQKM 443
>sp|O01422|CSN2_CAEEL COP9 signalosome complex subunit 2 (Signalosome subunit 2)
Length = 495
Score = 269 bits (687), Expect = 9e-72
Identities = 134/223 (60%), Positives = 169/223 (75%), Gaps = 3/223 (1%)
Frame = +1
Query: 1 MYTIQRNNKKLKNLYE---QSLHIKSAIPHPLIMGIIRECGGKMHLRQGEFDKAHTDFFE 171
MYT Q+NNK LK +YE Q++H KSAIPHPLI+G IRECGGKMHLR G F AHTDFFE
Sbjct: 201 MYTEQKNNKALKWVYELATQAIHTKSAIPHPLILGTIRECGGKMHLRDGRFLDAHTDFFE 260
Query: 172 AFKNYDESGSQRRTQCLKYLVLSNMLTKSAINPFDSQEIKPYRDNPEIVAMTNLVSAYQI 351
AFKNYDESGS RRT CLKYLVL+NML KS INPFDSQE KP+++ PEIVAMT +V AYQ
Sbjct: 261 AFKNYDESGSPRRTTCLKYLVLANMLIKSDINPFDSQEAKPFKNEPEIVAMTQMVQAYQD 320
Query: 352 NDIKTFEATLTENEDTIMQDTFIREHIEELLRNIRIDVLIGLVKPYKTVRIEFLAQRLNI 531
NDI+ FE + ++D+IM D FIREH EEL+ NIR VL+ L++PY VRI +L+Q+L +
Sbjct: 321 NDIQAFEQIMAAHQDSIMADPFIREHTEELMNNIRTQVLLRLIRPYTNVRISYLSQKLKV 380
Query: 532 SANEVESLLVSCIADNVIKGKIDQKSDILVIDEPRKEAKYKSL 660
S EV LLV I D+ ++ KI+++S ++ + + +K+ SL
Sbjct: 381 SQKEVIHLLVDAILDDGLEAKINEESGMIEMPKNKKKMMVTSL 423
>sp|Q8W207|CSN2_ARATH COP9 signalosome complex subunit 2 (Signalosome subunit 2) (FUSCA
protein 12) (FUSCA12)
Length = 439
Score = 259 bits (663), Expect = 6e-69
Identities = 129/239 (53%), Positives = 176/239 (73%), Gaps = 1/239 (0%)
Frame = +1
Query: 1 MYTIQRNNKKLKNLYEQSLHIKSAIPHPLIMGIIRECGGKMHLRQGEFDKAHTDFFEAFK 180
+YT ++NKKLK LY ++L IKSAIPHP IMGIIRECGGKMH+ + ++++A TDFFEAFK
Sbjct: 200 IYTETKDNKKLKQLYHKALAIKSAIPHPRIMGIIRECGGKMHMAERQWEEAATDFFEAFK 259
Query: 181 NYDESGSQRRTQCLKYLVLSNMLTKSAINPFDSQEIKPYRDNPEIVAMTNLVSAYQINDI 360
NYDE+G+QRR QCLKYLVL+NML +S +NPFD QE KPY+++PEI+AMTNL++AYQ N+I
Sbjct: 260 NYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPYKNDPEILAMTNLIAAYQRNEI 319
Query: 361 KTFEATLTENEDTIMQDTFIREHIEELLRNIRIDVLIGLVKPYKTVRIEFLAQRLNISAN 540
FE L N TIM D FIR ++E+LL+ +R VL+ L+KPY + I F+++ LN+
Sbjct: 320 IEFERILKSNRRTIMDDPFIRNYMEDLLKKVRTQVLLKLIKPYTKIGIPFISKELNVPET 379
Query: 541 EVESLLVSCIADNVIKGKIDQKSDILVIDEPRKEAK-YKSLDKLISEIDKLHHNLVSRV 714
+V LLVS I D+ I G ID+ + L+ + K +K++DK S++ L N+ SRV
Sbjct: 380 DVTELLVSLILDSRIDGHIDEMNRYLLRGDSGNGRKLHKAVDKWNSQLKSLSSNITSRV 438
>sp|Q9HFR0|CSN2_SCHPO COP9 signalosome complex subunit 2 (CSN complex subunit 2) (SGN2)
Length = 437
Score = 236 bits (601), Expect = 9e-62
Identities = 113/230 (49%), Positives = 164/230 (71%)
Frame = +1
Query: 1 MYTIQRNNKKLKNLYEQSLHIKSAIPHPLIMGIIRECGGKMHLRQGEFDKAHTDFFEAFK 180
MY+ +NK+LK LY+ SL +K+AIPHP IMGIIRECGGKMH+++ ++ +A T+FFE+FK
Sbjct: 206 MYSDIEDNKRLKELYQSSLRVKTAIPHPRIMGIIRECGGKMHMQENQWSEAQTNFFESFK 265
Query: 181 NYDESGSQRRTQCLKYLVLSNMLTKSAINPFDSQEIKPYRDNPEIVAMTNLVSAYQINDI 360
+YDE+GS R + LKYLVL+NML++S INPFDS E +PY+DNP I+AMT LV AYQI DI
Sbjct: 266 SYDEAGSSDRIRVLKYLVLANMLSESEINPFDSPETQPYKDNPHIIAMTKLVEAYQIRDI 325
Query: 361 KTFEATLTENEDTIMQDTFIREHIEELLRNIRIDVLIGLVKPYKTVRIEFLAQRLNISAN 540
E L + I+ D FIR++++++L +IR VLI LVKPY +V++ LA++L +S +
Sbjct: 326 TAVERILQTYQHDILDDDFIRQYVDKILYSIRSQVLIELVKPYTSVKLSLLAKKLGVSIS 385
Query: 541 EVESLLVSCIADNVIKGKIDQKSDILVIDEPRKEAKYKSLDKLISEIDKL 690
+E LV I D + GKID +++ I +P+ ++L+ ++ KL
Sbjct: 386 IIEQALVGLIIDERVNGKIDMVNEVFTISQPKNTIH----NQLVEDVQKL 431
>sp|Q9P7S2|RPN6_SCHPO Probable 26S proteasome regulatory subunit rpn6
Length = 421
Score = 80.9 bits (198), Expect = 5e-15
Identities = 55/226 (24%), Positives = 107/226 (47%), Gaps = 14/226 (6%)
Frame = +1
Query: 82 PLIMGIIRECGGKMHLRQGEFDKAHTDFFEAFKNYDESGSQRRT-QCLKYLVLSNMLTKS 258
P++ G + G +H +F A++ F+EA++ + ++ LKY++LS ++ S
Sbjct: 202 PMLQGNLDLQSGILHADDMDFKTAYSYFYEAYEGFTSLDDDKKALSSLKYMLLSQIMLNS 261
Query: 259 AINPFDSQEIKPYRDNP--------EIVAMTNLVSAYQINDIKTFEATLTENEDTIMQDT 414
E+K +I AM + A++ + FE L + + + D
Sbjct: 262 V------SEVKSLLTGKHAIRYAGRDIEAMRAIAQAHENRSLADFEKALQDYKPELASDP 315
Query: 415 FIREHIEELLRNIRIDVLIGLVKPYKTVRIEFLAQRLNISANEVESLLVSCIADNVIKGK 594
IR H+ L N+ L+ +V+P+ V + +A+ + +S +VE L I D + G
Sbjct: 316 IIRSHLSSLYDNLLEQNLLRVVEPFSRVEVSHIAELIGLSTVQVEGKLSQMILDKIFYGI 375
Query: 595 IDQKSDILVI-DEPRKEAKYKSLDKLISE----IDKLHHNLVSRVV 717
+DQ S L++ DEP+++ Y++ ++I +D L N S ++
Sbjct: 376 LDQGSGCLIVYDEPQQDKTYEAALEVIKNMGTVVDLLIENKASALL 421
>sp|P34481|YMJ5_CAEEL Hypothetical protein F59B2.5 in chromosome III
Length = 468
Score = 80.1 bits (196), Expect = 8e-15
Identities = 50/214 (23%), Positives = 108/214 (50%), Gaps = 7/214 (3%)
Frame = +1
Query: 67 SAIPHPLIMGIIRECGGKMH-LRQGEFDKAHTDFFEAFKNYDESGSQ-RRTQCLKYLVLS 240
SA P + + G ++ + ++ + + F+EAF+ + G + T LKY++L
Sbjct: 243 SAFASPQLQASVDMQSGVLYSAEERDYKTSFSYFYEAFEGFASIGDKINATSALKYMILC 302
Query: 241 NML---TKSAINPFDSQEIKPYRDNPEIVAMTNLVSAYQINDIKTFEATLTENEDTIMQD 411
++ T+ ++EI Y+ +P I+A+ ++ A++ +K F L E++ +++D
Sbjct: 303 KIMLNETEQLAGLLAAKEIVAYQKSPRIIAIRSMADAFRKRSLKDFVKALAEHKIELVED 362
Query: 412 TFIREHIEELLRNIRIDVLIGLVKPYKTVRIEFLAQRLNISANEVESLLVSCIADNVIKG 591
+ H + L RN+ + +++PY + + ++A+ + ++ VE + I D + G
Sbjct: 363 KVVAVHSQNLERNMLEKEISRVIEPYSEIELSYIARVIGMTVPPVERAIARMILDKKLMG 422
Query: 592 KIDQKSDILVIDEPRKEA--KYKSLDKLISEIDK 687
IDQ D +V+ P+ +A ++ K I E+ K
Sbjct: 423 SIDQHGDTVVV-YPKADAANQFTRSLKTIRELTK 455
>sp|Q8BG32|PSD11_MOUSE 26S proteasome non-ATPase regulatory subunit 11 (26S proteasome
regulatory subunit S9) (26S proteasome regulatory
subunit p44.5)
Length = 422
Score = 77.0 bits (188), Expect = 7e-14
Identities = 50/194 (25%), Positives = 95/194 (48%), Gaps = 3/194 (1%)
Frame = +1
Query: 139 EFDKAHTDFFEAFKNYDESGSQRRTQCLKYLVLSNML--TKSAINPFDSQEIKPYRDNPE 312
++ A++ F+EAF+ YD S + LKY++L ++ T + S ++ +
Sbjct: 224 DWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQ 283
Query: 313 IVAMTNLVSAYQINDIKTFEATLTENEDTIMQDTFIREHIEELLRNIRIDVLIGLVKPYK 492
A+ + A + + FE LT+ + D I H+ +L N+ LI +++P+
Sbjct: 284 TEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFS 343
Query: 493 TVRIEFLAQRLNISANEVESLLVSCIADNVIKGKIDQKSDILVI-DEPRKEAKYKSLDKL 669
V+IE ++ + +S +VE L I D G +DQ +L+I DEP + Y++ +
Sbjct: 344 RVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALET 403
Query: 670 ISEIDKLHHNLVSR 711
I + K+ +L S+
Sbjct: 404 IQNMSKVVDSLYSK 417
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,809,100
Number of Sequences: 369166
Number of extensions: 1782097
Number of successful extensions: 5271
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5078
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5257
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9558791870
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)