Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_E02
(644 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P45878|FKBP2_MOUSE FK506-binding protein 2 precursor (Pe... 156 5e-38
sp|P26885|FKBP2_HUMAN FK506-binding protein 2 precursor (Pe... 155 1e-37
sp|Q38935|FK21_ARATH FK506-binding protein 2-1 precursor (P... 138 1e-32
sp|P32472|FKBP2_YEAST FK506-binding protein 2 precursor (Pe... 137 2e-32
sp|Q38936|FK22_ARATH FK506-binding protein 2-2 precursor (P... 133 3e-31
sp|Q41649|FKB15_VICFA FK506-binding protein 2 precursor (Pe... 129 8e-30
sp|Q38931|FKB70_ARATH 70 kDa peptidylprolyl isomerase (Pept... 122 6e-28
sp|P20081|FKBP_YEAST FK506-binding protein 1 (FKBP) (Peptid... 112 6e-25
sp|P0A0W3|FKBP_NEIMC FK506-binding protein (Peptidyl-prolyl... 112 6e-25
sp|P0A0W2|FKBP_NEIMB FK506-binding protein (Peptidyl-prolyl... 110 2e-24
>sp|P45878|FKBP2_MOUSE FK506-binding protein 2 precursor (Peptidyl-prolyl cis-trans
isomerase) (PPIase) (Rotamase) (13 kDa FKBP) (FKBP-13)
Length = 140
Score = 156 bits (394), Expect = 5e-38
Identities = 75/114 (65%), Positives = 91/114 (79%)
Frame = +3
Query: 60 ELRIGIKKRVQDCTEKAKDGDVIHMHYTGTLYDDGTKFDSSLDRGDPLKFTLGMGQVIKG 239
+L+IG+KKRV C K++ GDV+HMHYTG L +DGT+FDSSL + P F+LG GQVIKG
Sbjct: 28 KLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL-EDGTEFDSSLPQNQPFVFSLGTGQVIKG 86
Query: 240 WDLGIQGMCVGEKRKLFIPSHMAYGDSGSPPKIPPKATLVFEVELIKIDPRSEL 401
WD G+ GMC GEKRKL IPS + YG+ G+PPKIP ATLVFEVEL+KI+ RSEL
Sbjct: 87 WDQGLLGMCEGEKRKLVIPSELGYGERGAPPKIPGGATLVFEVELLKIERRSEL 140
>sp|P26885|FKBP2_HUMAN FK506-binding protein 2 precursor (Peptidyl-prolyl cis-trans
isomerase) (PPIase) (Rotamase) (13 kDa FKBP) (FKBP-13)
Length = 142
Score = 155 bits (391), Expect = 1e-37
Identities = 74/114 (64%), Positives = 91/114 (79%)
Frame = +3
Query: 60 ELRIGIKKRVQDCTEKAKDGDVIHMHYTGTLYDDGTKFDSSLDRGDPLKFTLGMGQVIKG 239
+L+IG+KKRV C K++ GDV+HMHYTG L +DGT+FDSSL + P F+LG GQVIKG
Sbjct: 30 KLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL-EDGTEFDSSLPQNQPFVFSLGTGQVIKG 88
Query: 240 WDLGIQGMCVGEKRKLFIPSHMAYGDSGSPPKIPPKATLVFEVELIKIDPRSEL 401
WD G+ GMC GEKRKL IPS + YG+ G+PPKIP ATLVFEVEL+KI+ R+EL
Sbjct: 89 WDQGLLGMCEGEKRKLVIPSELGYGERGAPPKIPGGATLVFEVELLKIERRTEL 142
>sp|Q38935|FK21_ARATH FK506-binding protein 2-1 precursor (Peptidyl-prolyl cis-trans
isomerase) (PPIase) (Rotamase) (15 kDa FKBP) (FKBP-15-1)
Length = 153
Score = 138 bits (347), Expect = 1e-32
Identities = 68/117 (58%), Positives = 85/117 (72%), Gaps = 2/117 (1%)
Frame = +3
Query: 54 INELRIGIKKRVQDCTEKAKDGDVIHMHYTGTLYDDGTKFDSSLDRGDPLKFTLGMGQVI 233
+ EL+IG+K + Q C +A GD I +HY G L DGT FDSS +RGDP++F LG GQVI
Sbjct: 31 VTELQIGVKYKPQKCDLQAHKGDKIKVHYRGKL-TDGTVFDSSFERGDPIEFELGTGQVI 89
Query: 234 KGWDLGIQGMCVGEKRKLFIPSHMAYGDSGSPPKIPPKATLVFEVELIKI--DPRSE 398
GWD G+ G CVGEKRKL IPS + YGD+GSPPKIP ATL+F+ EL+ + +P SE
Sbjct: 90 PGWDQGLLGACVGEKRKLKIPSKLGYGDNGSPPKIPGGATLIFDTELVAVNGEPSSE 146
>sp|P32472|FKBP2_YEAST FK506-binding protein 2 precursor (Peptidyl-prolyl cis-trans
isomerase) (PPIase) (Rotamase) (FKBP-13) (FKBP-15)
Length = 135
Score = 137 bits (345), Expect = 2e-32
Identities = 66/112 (58%), Positives = 83/112 (74%), Gaps = 2/112 (1%)
Frame = +3
Query: 54 INELRIGIKKR--VQDCTEKAKDGDVIHMHYTGTLYDDGTKFDSSLDRGDPLKFTLGMGQ 227
+++L IGI KR V+DC KA GD + +HYTG+L + GT FDSS RG P+ F LG+G+
Sbjct: 20 LSDLEIGIIKRIPVEDCLIKAMPGDKVKVHYTGSLLESGTVFDSSYSRGSPIAFELGVGR 79
Query: 228 VIKGWDLGIQGMCVGEKRKLFIPSHMAYGDSGSPPKIPPKATLVFEVELIKI 383
VIKGWD G+ GMCVGEKRKL IPS +AYG+ G P IPP A LVF+VEL+ +
Sbjct: 80 VIKGWDQGVAGMCVGEKRKLQIPSSLAYGERGVPGVIPPSADLVFDVELVDV 131
>sp|Q38936|FK22_ARATH FK506-binding protein 2-2 precursor (Peptidyl-prolyl cis-trans
isomerase) (PPIase) (Rotamase) (15 kDa FKBP) (FKBP-15-2)
Length = 163
Score = 133 bits (335), Expect = 3e-31
Identities = 63/113 (55%), Positives = 82/113 (72%)
Frame = +3
Query: 54 INELRIGIKKRVQDCTEKAKDGDVIHMHYTGTLYDDGTKFDSSLDRGDPLKFTLGMGQVI 233
++EL+IG+K + + C +A GD I +HY G L DGT FDSS +RGDP +F LG GQVI
Sbjct: 31 VSELQIGVKFKPKTCEVQAHKGDTIKVHYRGKL-TDGTVFDSSFERGDPFEFKLGSGQVI 89
Query: 234 KGWDLGIQGMCVGEKRKLFIPSHMAYGDSGSPPKIPPKATLVFEVELIKIDPR 392
KGWD G+ G CVGEKRKL IP+ + YG+ GSPP IP ATL+F+ ELI ++ +
Sbjct: 90 KGWDQGLLGACVGEKRKLKIPAKLGYGEQGSPPTIPGGATLIFDTELIAVNEK 142
>sp|Q41649|FKB15_VICFA FK506-binding protein 2 precursor (Peptidyl-prolyl cis-trans
isomerase) (PPIase) (Rotamase) (15 kDa FKBP) (FKBP-15)
Length = 151
Score = 129 bits (323), Expect = 8e-30
Identities = 62/130 (47%), Positives = 85/130 (65%)
Frame = +3
Query: 6 LFQIVCSEETKSTKKPINELRIGIKKRVQDCTEKAKDGDVIHMHYTGTLYDDGTKFDSSL 185
+F I + + + EL+IG+K + C +A GD + +HY G L DGT FDSS
Sbjct: 12 IFIIASALVAAKSAADVTELQIGVKYKPASCEVQAHKGDKVKVHYRGKL-TDGTVFDSSF 70
Query: 186 DRGDPLKFTLGMGQVIKGWDLGIQGMCVGEKRKLFIPSHMAYGDSGSPPKIPPKATLVFE 365
+R P+ F LG GQVIKGWD G+ GMC+GEKRKL IP+ + YG+ GSPP IP ATL+F+
Sbjct: 71 ERNSPIDFELGGGQVIKGWDQGLLGMCLGEKRKLKIPAKLGYGEQGSPPTIPGGATLIFD 130
Query: 366 VELIKIDPRS 395
EL+ ++ +S
Sbjct: 131 TELVGVNDKS 140
>sp|Q38931|FKB70_ARATH 70 kDa peptidylprolyl isomerase (Peptidyl-prolyl cis-trans
isomerase) (PPIase) (Rotamase) (Peptidylprolyl isomerase
ROF1)
Length = 551
Score = 122 bits (307), Expect = 6e-28
Identities = 63/112 (56%), Positives = 80/112 (71%), Gaps = 3/112 (2%)
Frame = +3
Query: 60 ELRIGIKKRVQ---DCTEKAKDGDVIHMHYTGTLYDDGTKFDSSLDRGDPLKFTLGMGQV 230
E++ G+KK++ + E ++GD + +HYTGTL D GTKFDSS DR P KFTLG GQV
Sbjct: 35 EIQQGLKKKLLKEGEGYETPENGDEVEVHYTGTLLD-GTKFDSSRDRATPFKFTLGQGQV 93
Query: 231 IKGWDLGIQGMCVGEKRKLFIPSHMAYGDSGSPPKIPPKATLVFEVELIKID 386
IKGWD+GI+ M GE IP+ +AYG+SGSPP IP ATL F+VEL+K D
Sbjct: 94 IKGWDIGIKTMKKGENAVFTIPAELAYGESGSPPTIPANATLQFDVELLKWD 145
Score = 45.1 bits (105), Expect = 2e-04
Identities = 37/133 (27%), Positives = 60/133 (45%), Gaps = 8/133 (6%)
Frame = +3
Query: 24 SEETKSTKKPINELRIGIKKRVQDCTEKAKDGDVIHMHYTGTLYDDGTKFDSSLDRG--- 194
+++ K KK + E D E+ +G V+ + G L DGT F L +G
Sbjct: 268 TDDNKVVKKVLKE---------GDGYERPNEGAVVKVKLIGKL-QDGTVF---LKKGHGE 314
Query: 195 --DPLKFTLGMGQVIKGWDLGIQGMCVGEKRKLFIPSHMAYGDSGSPPK---IPPKATLV 359
+P +F QV+ G D + M GE + I A+G + S + +PP +T+
Sbjct: 315 NEEPFEFKTDEEQVVDGLDRAVMKMKKGEVALVTIDPEYAFGSNESQQELAVVPPNSTVT 374
Query: 360 FEVELIKIDPRSE 398
+EV+L+ D E
Sbjct: 375 YEVDLLTFDKERE 387
Score = 38.5 bits (88), Expect = 0.015
Identities = 30/105 (28%), Positives = 46/105 (43%), Gaps = 5/105 (4%)
Frame = +3
Query: 102 EKAKDGDVIHMHYTGTLYDDGTKFDSSLDRGDPLKFTLGMGQVIKGWDLGIQGMCVGEKR 281
E KD D + + + L +DGT S D ++FT+ G ++ M GEK
Sbjct: 168 ENPKDLDEVLVKFEAKL-EDGTVVGKS----DGVEFTVKDGHFCPALTKAVKTMKKGEKV 222
Query: 282 KLFIPSHMAYGDSGSPPK-----IPPKATLVFEVELIKIDPRSEL 401
L + +G+ G P +PP ATL +EL+ SE+
Sbjct: 223 LLTVKPQYGFGEKGKPASAGEGAVPPNATLEINLELVSWKTVSEV 267
>sp|P20081|FKBP_YEAST FK506-binding protein 1 (FKBP) (Peptidyl-prolyl cis-trans
isomerase) (PPIase) (Rapamycin-binding protein)
Length = 114
Score = 112 bits (281), Expect = 6e-25
Identities = 53/92 (57%), Positives = 70/92 (76%)
Frame = +3
Query: 111 KDGDVIHMHYTGTLYDDGTKFDSSLDRGDPLKFTLGMGQVIKGWDLGIQGMCVGEKRKLF 290
K GD++ +HYTGTL ++G KFDSS+DRG P + +G+GQVIKGWD+GI + VGEK +L
Sbjct: 24 KTGDLVTIHYTGTL-ENGQKFDSSVDRGSPFQCNIGVGQVIKGWDVGIPKLSVGEKARLT 82
Query: 291 IPSHMAYGDSGSPPKIPPKATLVFEVELIKID 386
IP AYG G P IPP +TLVF+VEL+K++
Sbjct: 83 IPGPYAYGPRGFPGLIPPNSTLVFDVELLKVN 114
>sp|P0A0W3|FKBP_NEIMC FK506-binding protein (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase)
Length = 109
Score = 112 bits (281), Expect = 6e-25
Identities = 59/94 (62%), Positives = 68/94 (72%)
Frame = +3
Query: 102 EKAKDGDVIHMHYTGTLYDDGTKFDSSLDRGDPLKFTLGMGQVIKGWDLGIQGMCVGEKR 281
++A G I +HYTG L +DGTKFDSSLDR PL TLG+GQVIKGWD G GM G KR
Sbjct: 15 KEAVKGKEITVHYTGWL-EDGTKFDSSLDRRQPLTITLGVGQVIKGWDEGFGGMKEGGKR 73
Query: 282 KLFIPSHMAYGDSGSPPKIPPKATLVFEVELIKI 383
KL IPS M YG G+ IPP ATL+FEVEL+K+
Sbjct: 74 KLTIPSEMGYGAHGAGGVIPPHATLIFEVELLKV 107
>sp|P0A0W2|FKBP_NEIMB FK506-binding protein (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase)
Length = 109
Score = 110 bits (276), Expect = 2e-24
Identities = 58/94 (61%), Positives = 68/94 (72%)
Frame = +3
Query: 102 EKAKDGDVIHMHYTGTLYDDGTKFDSSLDRGDPLKFTLGMGQVIKGWDLGIQGMCVGEKR 281
++A G I +HYTG L ++GTKFDSSLDR PL TLG+GQVIKGWD G GM G KR
Sbjct: 15 KEAVKGKEITVHYTGWL-ENGTKFDSSLDRRQPLTITLGVGQVIKGWDEGFGGMKEGGKR 73
Query: 282 KLFIPSHMAYGDSGSPPKIPPKATLVFEVELIKI 383
KL IPS M YG G+ IPP ATL+FEVEL+K+
Sbjct: 74 KLTIPSEMGYGAHGAGGVIPPHATLIFEVELLKV 107
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,843,645
Number of Sequences: 369166
Number of extensions: 1454358
Number of successful extensions: 3356
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3161
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3266
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5267491560
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)