Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_D24
(768 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P40123|CAP2_HUMAN Adenylyl cyclase-associated protein 2 ... 188 1e-47
sp|P52481|CAP2_RAT Adenylyl cyclase-associated protein 2 (C... 183 4e-46
sp|Q01518|CAP1_HUMAN Adenylyl cyclase-associated protein 1 ... 181 3e-45
sp|Q9CYT6|CAP2_MOUSE Adenylyl cyclase-associated protein 2 ... 178 1e-44
sp|P40124|CAP1_MOUSE Adenylyl cyclase-associated protein 1 ... 172 9e-43
sp|Q08163|CAP1_RAT Adenylyl cyclase-associated protein 1 (C... 172 1e-42
sp|P40122|CAP_CHLVR Adenylyl cyclase-associated protein (CAP) 147 2e-35
sp|P54654|CAP_DICDI Adenylyl cyclase-associated protein (CAP) 142 1e-33
sp|P36621|CAP_SCHPO Adenylyl cyclase-associated protein (CAP) 140 5e-33
sp|P17555|CAP_YEAST Adenylyl cyclase-associated protein (CAP) 121 2e-27
>sp|P40123|CAP2_HUMAN Adenylyl cyclase-associated protein 2 (CAP 2)
Length = 477
Score = 188 bits (478), Expect = 1e-47
Identities = 96/218 (44%), Positives = 142/218 (65%), Gaps = 4/218 (1%)
Frame = +3
Query: 21 DLENIVKRLEKVASRLETLPQLSES--GDMKSVKSSTNNVV--ISEYEKIISGELHNFLQ 188
+++ +V+RLE+ SRLE+L S G+ V V + ++K++ + FL+
Sbjct: 3 NMQGLVERLERAVSRLESLSAESHRPPGNCGEVNGVIAGVAPSVEAFDKLMDSMVAEFLK 62
Query: 189 ISDKIGGDVKTQAALVQKAFAAQLEYLKKSTSSGKPTDAVLDTLLKPMSDAIASITDYRE 368
S + GDV+T A +V AF AQ +L ++ +P + + LLKP+S+ I I +RE
Sbjct: 63 NSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPHENDVAALLKPISEKIQEIQTFRE 122
Query: 369 KNRRSEYFNHLSAVSEGIPVLGWVRVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHV 548
+NR S FNHLSAVSE IP LGW+ VSP P P++KEM DA+ FYTNRV+KDYK + HV
Sbjct: 123 RNRGSNMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHV 182
Query: 549 DWTKAWMAVFTELQSFVKKHYTTGLTWSSQCAAPVATT 662
DW K+++ +++ELQ+++K+H+TTGLTWS PVA+T
Sbjct: 183 DWVKSYLNIWSELQAYIKEHHTTGLTWSK--TGPVAST 218
>sp|P52481|CAP2_RAT Adenylyl cyclase-associated protein 2 (CAP 2)
Length = 477
Score = 183 bits (465), Expect = 4e-46
Identities = 96/219 (43%), Positives = 142/219 (64%), Gaps = 5/219 (2%)
Frame = +3
Query: 21 DLENIVKRLEKVASRLETLPQ-LSES-GDMKSVKSSTNNVV---ISEYEKIISGELHNFL 185
D+ +++RLE SRLE L L E G V S + +V + ++K+I+ + FL
Sbjct: 3 DMLGLMQRLEFAVSRLERLSSGLHEPPGGCGEVNSLSRGIVAPSVEAFDKLINSMVAEFL 62
Query: 186 QISDKIGGDVKTQAALVQKAFAAQLEYLKKSTSSGKPTDAVLDTLLKPMSDAIASITDYR 365
+ S + GDV+T A +V AF AQ +L + +P + + LLKP+S+ I I +R
Sbjct: 63 KNSRVLAGDVETHAEMVHGAFQAQRAFLLMVSQHQQPQENEVAVLLKPISEKIQEIQTFR 122
Query: 366 EKNRRSEYFNHLSAVSEGIPVLGWVRVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAH 545
E+NR S+ FNHLSAVSE I LGW+ VSP P P++KEM DA+ FYTNRV++DYK + H
Sbjct: 123 ERNRGSDMFNHLSAVSESIAALGWIAVSPKPGPYVKEMNDAATFYTNRVLRDYKHSDLRH 182
Query: 546 VDWTKAWMAVFTELQSFVKKHYTTGLTWSSQCAAPVATT 662
VDW ++++ +++ELQ+++K+H+TTGLTWS PVA+T
Sbjct: 183 VDWVRSYLKIWSELQAYIKEHHTTGLTWSK--TGPVAST 219
>sp|Q01518|CAP1_HUMAN Adenylyl cyclase-associated protein 1 (CAP 1)
Length = 475
Score = 181 bits (458), Expect = 3e-45
Identities = 88/214 (41%), Positives = 137/214 (64%), Gaps = 2/214 (0%)
Frame = +3
Query: 21 DLENIVKRLEKVASRLETLPQLSES--GDMKSVKSSTNNVVISEYEKIISGELHNFLQIS 194
D++N+V+RLE+ RLE + S+ G S + + ++ +++G + +L+IS
Sbjct: 3 DMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKAGAAPYVQAFDSLLAGPVAEYLKIS 62
Query: 195 DKIGGDVKTQAALVQKAFAAQLEYLKKSTSSGKPTDAVLDTLLKPMSDAIASITDYREKN 374
+IGGDV+ A +V + L ++ +P + L LL P+S+ I + +REKN
Sbjct: 63 KEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAENKLSDLLAPISEQIKEVITFREKN 122
Query: 375 RRSEYFNHLSAVSEGIPVLGWVRVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDW 554
R S+ FNHLSAVSE I LGWV ++P P P++KEM DA+ FYTNRV+K+YK+ + HVDW
Sbjct: 123 RGSKLFNHLSAVSESIQALGWVAMAPKPGPYVKEMNDAAMFYTNRVLKEYKDVDKKHVDW 182
Query: 555 TKAWMAVFTELQSFVKKHYTTGLTWSSQCAAPVA 656
KA+++++TELQ+++K+ +TTGL WS PVA
Sbjct: 183 VKAYLSIWTELQAYIKEFHTTGLAWSK--TGPVA 214
>sp|Q9CYT6|CAP2_MOUSE Adenylyl cyclase-associated protein 2 (CAP 2)
Length = 476
Score = 178 bits (452), Expect = 1e-44
Identities = 92/219 (42%), Positives = 138/219 (63%), Gaps = 5/219 (2%)
Frame = +3
Query: 21 DLENIVKRLEKVASRLETLPQLSES-----GDMKSVKSSTNNVVISEYEKIISGELHNFL 185
D+ +++RLE+ RLE L + G++ V V ++K+I+ + FL
Sbjct: 3 DMAGLMERLERAVIRLEQLSAGLDGPPRGCGEVNGVNGGVAPSV-EAFDKLINSMVAEFL 61
Query: 186 QISDKIGGDVKTQAALVQKAFAAQLEYLKKSTSSGKPTDAVLDTLLKPMSDAIASITDYR 365
+ S + GDV+T A +V AF AQ +L + +P + + LLKP+S+ I I +R
Sbjct: 62 KNSRVLAGDVETHAEMVHGAFQAQRAFLLMVSQYQQPQENEVAVLLKPISEKIQEIQTFR 121
Query: 366 EKNRRSEYFNHLSAVSEGIPVLGWVRVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAH 545
E+NR S FNHLSAVSE I LGW+ VSP P P++KEM DA+ FYTNRV+KDYK + H
Sbjct: 122 ERNRGSNMFNHLSAVSESIAALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRH 181
Query: 546 VDWTKAWMAVFTELQSFVKKHYTTGLTWSSQCAAPVATT 662
VDW ++++ +++ELQ+++++H+TTGLTWS PVA+T
Sbjct: 182 VDWVRSYLNIWSELQAYIREHHTTGLTWSK--TGPVAST 218
>sp|P40124|CAP1_MOUSE Adenylyl cyclase-associated protein 1 (CAP 1)
Length = 474
Score = 172 bits (436), Expect = 9e-43
Identities = 84/213 (39%), Positives = 134/213 (62%), Gaps = 1/213 (0%)
Frame = +3
Query: 21 DLENIVKRLEKVASRLETLPQLSESGDMKSVKSSTNNV-VISEYEKIISGELHNFLQISD 197
D++N+V+RLE+ RLE + S+ S V + ++ +++ + +L++S
Sbjct: 3 DMQNLVERLERAVGRLEAVSHTSDMHCGYGDSPSKGAVPYVQAFDSLLANPVAEYLKMSK 62
Query: 198 KIGGDVKTQAALVQKAFAAQLEYLKKSTSSGKPTDAVLDTLLKPMSDAIASITDYREKNR 377
+IGGDV+ A +V + L ++ +P L LL P+S+ I + +REKNR
Sbjct: 63 EIGGDVQKHAEMVHTGLKLERALLATASQCQQPAGNKLSDLLAPISEQIQEVITFREKNR 122
Query: 378 RSEYFNHLSAVSEGIPVLGWVRVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWT 557
S++FNHLSAVSE I LGWV ++ P PF+KEM DA+ FYTNRV+K+Y++ + HVDW
Sbjct: 123 GSKFFNHLSAVSESIQALGWVALAAKPGPFVKEMNDAAMFYTNRVLKEYRDVDKKHVDWV 182
Query: 558 KAWMAVFTELQSFVKKHYTTGLTWSSQCAAPVA 656
+A+++++TELQ+++K+ +TTGL WS PVA
Sbjct: 183 RAYLSIWTELQAYIKEFHTTGLAWSK--TGPVA 213
>sp|Q08163|CAP1_RAT Adenylyl cyclase-associated protein 1 (CAP 1)
Length = 474
Score = 172 bits (435), Expect = 1e-42
Identities = 84/213 (39%), Positives = 134/213 (62%), Gaps = 1/213 (0%)
Frame = +3
Query: 21 DLENIVKRLEKVASRLETLPQLSESGDMKSVKSSTNNV-VISEYEKIISGELHNFLQISD 197
D++N+V+RLE+ RLE + S+ S V + ++ +++ + +L++S
Sbjct: 3 DMQNLVERLERAVGRLEAVSHTSDMHCGYGDSPSKGAVPYVQAFDSLLANPVAEYLKMSK 62
Query: 198 KIGGDVKTQAALVQKAFAAQLEYLKKSTSSGKPTDAVLDTLLKPMSDAIASITDYREKNR 377
+IGGDV+ A +V + L ++ +P L LL P+S+ I + +REKNR
Sbjct: 63 EIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAGNKLSDLLAPISEQIQEVITFREKNR 122
Query: 378 RSEYFNHLSAVSEGIPVLGWVRVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWT 557
S++FNHLSAVSE I LGWV ++ P PF+KEM DA+ FYTNRV+K+Y++ + HVDW
Sbjct: 123 GSKFFNHLSAVSESIQALGWVALAAKPGPFVKEMNDAAMFYTNRVLKEYRDVDKKHVDWV 182
Query: 558 KAWMAVFTELQSFVKKHYTTGLTWSSQCAAPVA 656
+A+++++TELQ+++K+ +TTGL WS PVA
Sbjct: 183 RAYLSIWTELQAYIKEFHTTGLAWSK--TGPVA 213
>sp|P40122|CAP_CHLVR Adenylyl cyclase-associated protein (CAP)
Length = 481
Score = 147 bits (372), Expect = 2e-35
Identities = 69/210 (32%), Positives = 131/210 (62%), Gaps = 2/210 (0%)
Frame = +3
Query: 24 LENIVKRLEKVASRLETLPQLSESGDMKSVKSSTNN--VVISEYEKIISGELHNFLQISD 197
+E +V RLE V +RLE + + G ++K++ ++ +++ + L F+ +
Sbjct: 1 MEQLVSRLEAVTNRLEAV---ASRGGGSTIKAAVDDDPAWFDDFKVFNAKFLSGFVNDTI 57
Query: 198 KIGGDVKTQAALVQKAFAAQLEYLKKSTSSGKPTDAVLDTLLKPMSDAIASITDYREKNR 377
+GG+++ V +AF L ++ + +P+ L+ LLKP+S+AI+ + D+REKNR
Sbjct: 58 ALGGELEQMGKFVNEAFHCHLVLMEVAARHNRPSQTDLEGLLKPLSEAISKVQDFREKNR 117
Query: 378 RSEYFNHLSAVSEGIPVLGWVRVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWT 557
S+ FNHLSA+SEG+P LGWV V+P P +I++M++++QFYTN+++K+++E + +W
Sbjct: 118 SSKQFNHLSAISEGLPFLGWVGVAPKPVLYIQQMEESAQFYTNKLLKEFRESDPKQANWA 177
Query: 558 KAWMAVFTELQSFVKKHYTTGLTWSSQCAA 647
+++ + ++VK H+ GL W+ + +A
Sbjct: 178 TSFIQLLKGFAAYVKDHHQAGLMWNKEKSA 207
>sp|P54654|CAP_DICDI Adenylyl cyclase-associated protein (CAP)
Length = 464
Score = 142 bits (358), Expect = 1e-33
Identities = 75/257 (29%), Positives = 138/257 (53%), Gaps = 13/257 (5%)
Frame = +3
Query: 33 IVKRLEKVASRLETLPQLSESGDMKSVKSST--------NNVVISEYEKIISGELHNFLQ 188
++KRL++ +RLE + + SG S SS+ ++ + E++ ++ + F+
Sbjct: 9 LLKRLDQATTRLEAVEKSIASGVASSSSSSSPSSGAAGPSSASVKEFQNLVDQHITPFVA 68
Query: 189 ISDKIGGDVKTQAALVQKAFAAQLEYLKKSTSSGKPTDAVLDTLLKPMSDAIASITDYRE 368
+S K+ +V Q + KA A+ + ++ S KP+ L L+KP+++ A + R+
Sbjct: 69 LSKKLAPEVGNQVEQLVKAIDAEKALINTASQSKKPSQETLLELIKPLNNFAAEVGKIRD 128
Query: 369 KNRRSEYFNHLSAVSEGIPVLGWVRVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHV 548
NR S++FN+LSA+SE I L WV V P P P + EM+ +++FYTNR++K++K N V
Sbjct: 129 SNRSSKFFNNLSAISESIGFLSWVVVEPTPGPHVAEMRGSAEFYTNRILKEFKGVNQDQV 188
Query: 549 DWTKAWMAVFTELQSFVKKHYTTGLTWS-----SQCAAPVATTCVXXXXXXXXXXKSTAD 713
DW ++ +L+ ++K+++TTGLTW+ ++ A P + + +
Sbjct: 189 DWVSNYVNFLKDLEKYIKQYHTTGLTWNPKGGDAKSATPAPASSAPAAPVAPAVSSTPVE 248
Query: 714 DGAADKHLALFSEINKG 764
A+F E++KG
Sbjct: 249 SKKGPGLGAVFGELSKG 265
>sp|P36621|CAP_SCHPO Adenylyl cyclase-associated protein (CAP)
Length = 551
Score = 140 bits (352), Expect = 5e-33
Identities = 71/177 (40%), Positives = 111/177 (62%), Gaps = 3/177 (1%)
Frame = +3
Query: 138 ISEYEKIISGELHNFLQISDKIGGDVKTQAALVQKAFAAQLEYLKKSTSSGKPT--DAVL 311
IS Y++ S L ++++S KIGG + Q+ V+KAF + L + + KP L
Sbjct: 106 ISAYDEFCSKYLSKYMELSKKIGGLIAEQSEHVEKAFNLLRQVLSVALKAQKPDMDSPEL 165
Query: 312 DTLLKPMSDAIASITDYREKNRRSEYFNHLSAVSEGIPVLGWVRVSPAPCPFIKEMQDAS 491
LKP+ + +IT+ R+++R + FN LS V GI +LGWV V P P F+ EM+D+S
Sbjct: 166 LEFLKPIQSELLTITNIRDEHRTAPEFNQLSTVMSGISILGWVTVEPTPLSFMSEMKDSS 225
Query: 492 QFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYTTGLTWSS-QCAAPVAT 659
QFY NRV+K++K K+ ++W ++++ + TEL ++VK H+ TGLTWS+ Q A P+ T
Sbjct: 226 QFYANRVMKEFKGKDDLQIEWVRSYLTLLTELITYVKTHFKTGLTWSTKQDAVPLKT 282
>sp|P17555|CAP_YEAST Adenylyl cyclase-associated protein (CAP)
Length = 526
Score = 121 bits (304), Expect = 2e-27
Identities = 70/239 (29%), Positives = 126/239 (52%), Gaps = 30/239 (12%)
Frame = +3
Query: 3 KLNMSG-DLENIVKRLEKVASRLETLPQLSESGDMKSVKSSTNNV--------------- 134
K M G +L ++KRLE+ +RLE + E +++S NN
Sbjct: 5 KYTMQGYNLVKLLKRLEEATARLEDVTIYQEGYIQNKLEASKNNKPSDSGADANTTNEPS 64
Query: 135 ------------VISEYEKIISGELHNFLQISDKIGGDVKTQAALVQKAFAAQLEYLKKS 278
I+ ++ I + +++S KI V L++ F +QL +L+ +
Sbjct: 65 AENAPEVEQDPKCITAFQSYIGENIDPLVELSGKIDTVVLDALQLLKGGFQSQLTFLRAA 124
Query: 279 TSSGKP--TDAVLDTLLKPMSDAIASITDYREKNRRSEYFNHLSAVSEGIPVLGWVRVSP 452
S KP + L+P+++ I + +E NR+S+YF +LSA+SEG P+ WV V
Sbjct: 125 VRSRKPDYSSQTFADSLRPINENIIKLGQLKESNRQSKYFAYLSALSEGAPLFSWVAVD- 183
Query: 453 APCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYTTGLTW 629
P + + +DA+QF+TNR++K+Y+E + V+W K ++A F L++++K+++TTG++W
Sbjct: 184 TPVSMVTDFKDAAQFWTNRILKEYRESDPNAVEWVKKFLASFDNLKAYIKEYHTTGVSW 242
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,980,884
Number of Sequences: 369166
Number of extensions: 1341505
Number of successful extensions: 4149
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4023
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4137
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7115329200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)