Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_D06
(758 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9H0M4|ZCPW1_HUMAN Zinc finger CW-type PWWP domain prote... 102 9e-22
sp|Q6IR42|ZCPW1_MOUSE Zinc finger CW-type PWWP domain prote... 99 9e-21
sp|P52701|MSH6_HUMAN DNA mismatch repair protein MSH6 (MutS... 60 5e-09
sp|P54276|MSH6_MOUSE DNA mismatch repair protein MSH6 (MutS... 60 6e-09
sp|Q8MT36|MES4_DROME Probable histone methyltransferase Mes... 46 1e-04
sp|Q96L73|NSD1_HUMAN Histone-lysine N-methyltransferase, H3... 42 0.002
sp|O88509|DNM3B_MOUSE DNA (cytosine-5)-methyltransferase 3B... 39 0.012
sp|Q9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B... 38 0.034
sp|P47405|RL29_MYCGE 50S ribosomal protein L29 36 0.098
sp|O88508|DNM3A_MOUSE DNA (cytosine-5)-methyltransferase 3A... 33 0.83
>sp|Q9H0M4|ZCPW1_HUMAN Zinc finger CW-type PWWP domain protein 1
Length = 494
Score = 102 bits (255), Expect = 9e-22
Identities = 55/160 (34%), Positives = 88/160 (55%), Gaps = 3/160 (1%)
Frame = +2
Query: 26 LNPSDIPSTWTCEMANNKSLN-CTVPEENFENSADYFINNNYTLGSVVWAKAPGFCWWPA 202
++PS +P W+C+ + N C +PEE + +Y GS++WAK G+ WWP
Sbjct: 274 IDPSVLPDNWSCDQNTDVQYNRCDIPEETWTGLESDVAYASYIPGSIIWAKQYGYPWWPG 333
Query: 203 LIDDDPDLNMFYWCYDHSNDV-SHYHVTFLDDDVSRSWITTKDVKVFRG-KADMSSMKFA 376
+I+ DPDL ++ H + + S YHVTF + VSR+WI +K F+ ++S MK
Sbjct: 334 MIESDPDLGEYFLFTSHLDSLPSKYHVTFFGETVSRAWIPVNMLKNFQELSLELSVMK-- 391
Query: 377 KSKKDYLKLLTKAAERAEECLTLSLQKRLDKYSFAVRFTG 496
K + D + L A A+E +S+Q+R++ + F RF G
Sbjct: 392 KRRNDCSQKLGVALMMAQEAEQISIQERVNLFGFWSRFNG 431
>sp|Q6IR42|ZCPW1_MOUSE Zinc finger CW-type PWWP domain protein 1 homolog
Length = 630
Score = 99.4 bits (246), Expect = 9e-21
Identities = 69/246 (28%), Positives = 114/246 (46%), Gaps = 4/246 (1%)
Frame = +2
Query: 26 LNPSDIPSTWTCEMANNKSLN-CTVPEENFENSADYFINNNYTLGSVVWAKAPGFCWWPA 202
++PS +P W+C+ + + N C +PEE++ +Y GS++WAK G+ WWP
Sbjct: 265 IDPSVLPDDWSCDQNPDPNYNRCDIPEESWAGCESDVAYASYVPGSIIWAKQYGYPWWPG 324
Query: 203 LIDDDPDLNMFYWCYDHSNDV-SHYHVTFLDDDVSRSWITTKDVKVFRGKADMSSMKFAK 379
+I+ DPDL ++ H + + S YHVTF + VSR+WI + +K F+ + + +K K
Sbjct: 325 MIEADPDLGEYFLFASHLDSLPSKYHVTFFGETVSRAWIPVRMLKNFQ-ELSLELVKKCK 383
Query: 380 SKKDYLKL--LTKAAERAEECLTLSLQKRLDKYSFAVRFTGKPNVWTSKKHTATKRKIKS 553
+K KL A RAE+ S+Q+R++ + F R+ G
Sbjct: 384 NKNPNQKLEAAIAMAHRAEQ---TSIQERVNLFGFWSRYNG------------------- 421
Query: 554 QPNNSDSDDESTGTKLTACSNKNEMKIKTERKVQDLKIAVAKIEAKTDNLVKLNQSTKYD 733
+D G LT C + N E++ +DL+ + E K D + + K
Sbjct: 422 ------ADISEEGEDLTLCESNNPESC-LEKEEKDLEEEKEEEEEKKDPTLPRPKPAKMQ 474
Query: 734 LIKKNS 751
K S
Sbjct: 475 TKKPKS 480
>sp|P52701|MSH6_HUMAN DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T
mismatch binding protein) (GTBP) (GTMBP) (p160)
Length = 1360
Score = 60.5 bits (145), Expect = 5e-09
Identities = 50/190 (26%), Positives = 82/190 (43%), Gaps = 5/190 (2%)
Frame = +2
Query: 143 NYTLGSVVWAKAPGFCWWPALIDDDPDLNMFYWCYDHSNDVSHYHVTFLDDDVSRSWITT 322
+++ G +VWAK G+ WWP L+ + P F HV F DD +R W++
Sbjct: 89 DFSPGDLVWAKMEGYPWWPCLVYNHPFDGTF---IREKGKSVRVHVQFFDDSPTRGWVSK 145
Query: 323 KDVKVFRGKADMSSMK---FAKSKKDYLKLLTKAAERAEECLTLSLQKRLDKYSFAVRFT 493
+ +K + G + K F +K + L +A +RA+E L KRL+
Sbjct: 146 RLLKPYTGSKSKEAQKGGHFYSAKPEIL----RAMQRADEALNKDKIKRLE--LAVCDEP 199
Query: 494 GKPNVWTSKKHTATKRKIKSQPNNSDSDDESTGTKLTACSNKNEMKIKTERKVQDLK--I 667
+P + T KS+ +N +E K T S ++ +IK R + D + I
Sbjct: 200 SEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPK-TQGSRRSSRQIKKRRVISDSESDI 258
Query: 668 AVAKIEAKTD 697
+ +E K D
Sbjct: 259 GGSDVEFKPD 268
>sp|P54276|MSH6_MOUSE DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T
mismatch binding protein) (GTBP) (GTMBP) (p160)
Length = 1358
Score = 60.1 bits (144), Expect = 6e-09
Identities = 48/192 (25%), Positives = 85/192 (44%), Gaps = 7/192 (3%)
Frame = +2
Query: 143 NYTLGSVVWAKAPGFCWWPALIDDDPDLNMFYWCYDHSNDVSHYHVTFLDDDVSRSWITT 322
+++ G +VWAK G+ WWP L+ + P F S V HV F DD +R W++
Sbjct: 89 DFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIRKKGKSVRV---HVQFFDDSPTRGWVSK 145
Query: 323 KDVKVFRGKADMSSMK---FAKSKKDYLKLLTKAAERAEECLTLSLQKRLDKYSFAVRFT 493
+ +K + G + K F SK + L +A +RA+E L+ +RL +
Sbjct: 146 RMLKPYTGSKSKEAQKGGHFYSSKSEIL----RAMQRADEALSKDTAERLQ-----LAVC 196
Query: 494 GKPNVWTSKKHTATKRKIKSQPNNSDSDDESTGTKLTACS--NKNEMKIKTERKVQDLK- 664
+P+ ++ T S + D+ +ES + ++ ++K R + D +
Sbjct: 197 DEPSEPEEEEETEVHEAYLSDKSEEDNYNESEEEAQPSVQGPRRSSRQVKKRRVISDSES 256
Query: 665 -IAVAKIEAKTD 697
I + +E K D
Sbjct: 257 DIGGSDVEFKPD 268
>sp|Q8MT36|MES4_DROME Probable histone methyltransferase Mes-4 (Maternal-effect sterile 4)
Length = 1427
Score = 46.2 bits (108), Expect = 1e-04
Identities = 50/231 (21%), Positives = 88/231 (38%), Gaps = 35/231 (15%)
Frame = +2
Query: 146 YTLGSVVWAKAPGFCWWPALIDDDP--------DLNMFYWCYDHSNDVSHYHVTFLDDDV 301
Y +G + W K +C+WP ++ DP + D++N HV F D+
Sbjct: 393 YQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNG 452
Query: 302 SRSWITTKDVKVFRGKADMSSM----------KFAK-----SKKDYLKLLTKAAERAEEC 436
R+WI +++ F G M K AK K+ + + +A E A+
Sbjct: 453 RRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAM 512
Query: 437 LTLSLQKRLDKYSFAVRFTGKPNVWTSKKHTATKRKIKSQP---------NNSDSDDEST 589
+ RL+K+ + NV T + + K Q +++D+
Sbjct: 513 TQIPYSDRLEKF-----YQTYENVVTLNRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQ 567
Query: 590 GTKLTACSNKNEMKIKTERKVQDLKIAVAKIEAKTDNLV---KLNQSTKYD 733
GT+L A +K ER A + +++K + KL+ T+ D
Sbjct: 568 GTQLLA--------VKRERSESPFSPAFSPVKSKNEKRAKRRKLSNGTEAD 610
Score = 32.0 bits (71), Expect = 1.9
Identities = 11/18 (61%), Positives = 13/18 (72%)
Frame = +2
Query: 155 GSVVWAKAPGFCWWPALI 208
G +VWAK F WWPA+I
Sbjct: 1050 GEIVWAKFNNFRWWPAII 1067
>sp|Q96L73|NSD1_HUMAN Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20
specific (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear
receptor binding SET domain containing protein 1)
(NR-binding SET domain containing protein) (Androgen
receptor-associated coregulator 267)
Length = 2696
Score = 41.6 bits (96), Expect = 0.002
Identities = 20/69 (28%), Positives = 31/69 (44%), Gaps = 1/69 (1%)
Frame = +2
Query: 146 YTLGSVVWAKAPGFCWWPALIDDDPDLNMF-YWCYDHSNDVSHYHVTFLDDDVSRSWITT 322
Y +G ++WAK WWP I DP +N + Y+V D R+W+
Sbjct: 321 YEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAG 380
Query: 323 KDVKVFRGK 349
K + +F G+
Sbjct: 381 KAIVMFEGR 389
Score = 32.3 bits (72), Expect = 1.4
Identities = 46/171 (26%), Positives = 66/171 (38%), Gaps = 12/171 (7%)
Frame = +2
Query: 71 NNKSLNCTVPEENFENSADYFINNNYTLGSVVWAKAPGFCWWPALIDDDPDLNMFYWCYD 250
+ + LN +PE N+ + D +VW K + WWPA I C+
Sbjct: 1730 HRECLNIDIPEGNWYCN-DCKAGKKPHYREIVWVKVGRYRWWPAEI-----------CHP 1777
Query: 251 HS---------NDVSHYHVTFLDDDVSRSWITTKDVKVF-RGKADMSSM-KFAKS-KKDY 394
+ +DV + V F S ++ T +VF + D+SS K K Y
Sbjct: 1778 RAVPSNIDKMRHDVGEFPVLFFG---SNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTY 1834
Query: 395 LKLLTKAAERAEECLTLSLQKRLDKYSFAVRFTGKPNVWTSKKHTATKRKI 547
K L +AA R EE L QK L + + KP + KH R I
Sbjct: 1835 KKALQEAAARFEE---LKAQKELRQLQEDRKNDKKPPPY---KHIKVNRPI 1879
>sp|O88509|DNM3B_MOUSE DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (DNA
methyltransferase MmuIIIB) (DNA MTase MmuIIIB)
(M.MmuIIIB)
Length = 859
Score = 39.3 bits (90), Expect = 0.012
Identities = 19/70 (27%), Positives = 35/70 (50%), Gaps = 4/70 (5%)
Frame = +2
Query: 11 DFPDILNPSDI--PSTWTCEMANNKSLNCTV--PEENFENSADYFINNNYTLGSVVWAKA 178
DF + + P + PS + + + ++ T E +S +Y + + +G +VW K
Sbjct: 181 DFMEEVTPKSVSTPSVDLSQDGDQEGMDTTQVDAESRDGDSTEYQDDKEFGIGDLVWGKI 240
Query: 179 PGFCWWPALI 208
GF WWPA++
Sbjct: 241 KGFSWWPAMV 250
>sp|Q9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (DNA
methyltransferase HsaIIIB) (DNA MTase HsaIIIB)
(M.HsaIIIB)
Length = 853
Score = 37.7 bits (86), Expect = 0.034
Identities = 12/31 (38%), Positives = 20/31 (64%)
Frame = +2
Query: 116 NSADYFINNNYTLGSVVWAKAPGFCWWPALI 208
+S++Y + +G +VW K GF WWPA++
Sbjct: 213 DSSEYQDGKEFGIGDLVWGKIKGFSWWPAMV 243
>sp|P47405|RL29_MYCGE 50S ribosomal protein L29
Length = 200
Score = 36.2 bits (82), Expect = 0.098
Identities = 37/149 (24%), Positives = 58/149 (38%), Gaps = 19/149 (12%)
Frame = +2
Query: 368 KFAKSKKDYLKLLTKAAERAEECLTLSLQKRL------DKYSFAVRFTGK--PNVWTSK- 520
K A + D L+ K + LT+ +++L DKY R T + N W K
Sbjct: 32 KLAHGELDKPHLIAKVRKLLAVVLTILTERKLNWQVEKDKYKLLSRKTNELIVNSWKQKL 91
Query: 521 ----------KHTATKRKIKSQPNNSDSDDESTGTKLTACSNKNEMKIKTERKVQDLKIA 670
K K K++S+P + ++ L + K E+K K E K LK
Sbjct: 92 STKPESKQETKKAEVKPKVESKPESKQETKKAEVKPLKQETKKVEVKPKVEPK--PLKQE 149
Query: 671 VAKIEAKTDNLVKLNQSTKYDLIKKNSTK 757
K+EA+ + K+ +KK K
Sbjct: 150 TKKVEARIETKTKVESKPLKQEVKKVEAK 178
>sp|O88508|DNM3A_MOUSE DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (DNA
methyltransferase MmuIIIA) (DNA MTase MmuIIIA)
(M.MmuIIIA)
Length = 908
Score = 33.1 bits (74), Expect = 0.83
Identities = 11/32 (34%), Positives = 17/32 (53%)
Frame = +2
Query: 113 ENSADYFINNNYTLGSVVWAKAPGFCWWPALI 208
++ +Y + +G +VW K GF WWP I
Sbjct: 275 DDEPEYEDGRGFGIGELVWGKLRGFSWWPGRI 306
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,378,718
Number of Sequences: 369166
Number of extensions: 1327256
Number of successful extensions: 4550
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4318
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4530
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6970118400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)