Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_C16
(656 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P60891|PRPS1_HUMAN Ribose-phosphate pyrophosphokinase I ... 150 3e-36
sp|Q9D7G0|PRPS1_MOUSE Ribose-phosphate pyrophosphokinase I ... 150 4e-36
sp|Q4R4R7|PRPS2_MACFA Ribose-phosphate pyrophosphokinase II... 147 2e-35
sp|P09330|PRPS2_RAT Ribose-phosphate pyrophosphokinase II (... 147 2e-35
sp|Q9CS42|PRPS2_MOUSE Ribose-phosphate pyrophosphokinase II... 147 2e-35
sp|P21108|PRPS3_HUMAN Ribose-phosphate pyrophosphokinase II... 143 3e-34
sp|P38689|KPR3_YEAST Ribose-phosphate pyrophosphokinase 3 (... 130 3e-30
sp|O60256|KPRB_HUMAN Phosphoribosyl pyrophosphate synthetas... 120 3e-27
sp|P46585|KPR1_CANAL Ribose-phosphate pyrophosphokinase 1 (... 120 4e-27
sp|Q8R574|KPRB_MOUSE Phosphoribosyl pyrophosphate synthetas... 119 9e-27
>sp|P60891|PRPS1_HUMAN Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I) (PPRibP)
sp|P60892|PRPS1_RAT Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I)
Length = 318
Score = 150 bits (379), Expect = 3e-36
Identities = 76/179 (42%), Positives = 118/179 (65%), Gaps = 2/179 (1%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
F++PVDNL +E + WI++NIS+W TI S + A+RV ++A+ L V F LI+ E+K
Sbjct: 138 FDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERK 197
Query: 182 EASE--QIILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERL 355
+A+E +++LVGDV R+A+++ D+ D C + + +L GA VY I THG+ S
Sbjct: 198 KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPA 257
Query: 356 MKEVDDSIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 532
+ ++++ +VVTNTI QE +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 258 ISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|Q9D7G0|PRPS1_MOUSE Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I)
Length = 318
Score = 150 bits (378), Expect = 4e-36
Identities = 76/179 (42%), Positives = 117/179 (65%), Gaps = 2/179 (1%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
F++PVDNL +E + WI++NIS+W TI S + A+RV ++A L V F LI+ E+K
Sbjct: 138 FDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIAERLNVDFALIHKERK 197
Query: 182 EASE--QIILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERL 355
+A+E +++LVGDV R+A+++ D+ D C + + +L GA VY I THG+ S
Sbjct: 198 KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPA 257
Query: 356 MKEVDDSIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 532
+ ++++ +VVTNTI QE +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 258 ISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|Q4R4R7|PRPS2_MACFA Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
sp|P11908|PRPS2_HUMAN Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II) (PPRibP)
Length = 318
Score = 147 bits (372), Expect = 2e-35
Identities = 74/179 (41%), Positives = 118/179 (65%), Gaps = 2/179 (1%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
F++PVDNL +E + WI++NI++W+ I S + A+RV ++A+ L V F LI+ E+K
Sbjct: 138 FDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERK 197
Query: 182 EASE--QIILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERL 355
+A+E +++LVGDV R+A+++ D+ D C + + +L GA VY I THG+ S
Sbjct: 198 KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPA 257
Query: 356 MKEVDDSIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 532
+ ++++ +VVTNTI QE +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 258 ISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|P09330|PRPS2_RAT Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
Length = 318
Score = 147 bits (372), Expect = 2e-35
Identities = 74/179 (41%), Positives = 117/179 (65%), Gaps = 2/179 (1%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
F++PVDNL +E + WI++NI++W I S + A+RV ++A+ L V F LI+ E+K
Sbjct: 138 FDIPVDNLYAEPAVLQWIRENITEWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERK 197
Query: 182 EASE--QIILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERL 355
+A+E +++LVGDV R+A+++ D+ D C + + +L GA VY I THG+ S
Sbjct: 198 KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPA 257
Query: 356 MKEVDDSIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 532
+ ++++ +VVTNTI QE +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 258 ISRINNAAFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|Q9CS42|PRPS2_MOUSE Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
Length = 318
Score = 147 bits (371), Expect = 2e-35
Identities = 74/179 (41%), Positives = 116/179 (64%), Gaps = 2/179 (1%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
F++PVDNL +E + WI++NI++W I S + A+RV ++A+ L V F LI+ E+K
Sbjct: 138 FDIPVDNLYAEPAVLQWIRENITEWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERK 197
Query: 182 EASE--QIILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERL 355
+A+E +++LVGDV R+A+++ D+ D C + + +L GA VY I THG+ S
Sbjct: 198 KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPA 257
Query: 356 MKEVDDSIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 532
+ ++ + +VVTNTI QE +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 258 ISRINSAAFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|P21108|PRPS3_HUMAN Ribose-phosphate pyrophosphokinase III (Phosphoribosyl
pyrophosphate synthetase III) (PRS-III) (Phosphoribosyl
pyrophosphate synthetase 1-like 1)
Length = 318
Score = 143 bits (361), Expect = 3e-34
Identities = 74/179 (41%), Positives = 116/179 (64%), Gaps = 2/179 (1%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
F++PVDNL +E + WI++NI +W+ I S + A+RV ++A+ L V F LI+ E+K
Sbjct: 138 FDIPVDNLYAEPTVLKWIRENIPEWKNCIIVSPDAGGAKRVTSIADQLNVDFALIHKERK 197
Query: 182 EASEQ--IILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERL 355
+A+E I+LVGDV R+A+++ D+ D C + + +L GA VY I THG+ S
Sbjct: 198 KANEVDCIVLVGDVNDRVAILVDDMADTCVTICLAADKLLSAGATRVYAILTHGIFSGPA 257
Query: 356 MKEVDDSIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 532
+ ++ + +VVTNTI Q++ +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 258 ISRINTACFEAVVVTNTIPQDEKMKHCSKIRVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|P38689|KPR3_YEAST Ribose-phosphate pyrophosphokinase 3 (Phosphoribosyl pyrophosphate
synthetase 3)
Length = 320
Score = 130 bits (327), Expect = 3e-30
Identities = 69/178 (38%), Positives = 116/178 (65%), Gaps = 2/178 (1%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
F+VPVDNL +E + +IK+N++ + I I S + A+R A +A+ L + F LI+ E+
Sbjct: 141 FDVPVDNLYAEPSVVRYIKENVNYMDSI-IISPDAGGAKRAATLADRLDLNFALIHKERA 199
Query: 182 EASE--QIILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERL 355
A+E +++LVGDV +I +I+ D+ D C + + + L E A V I THG+LS R
Sbjct: 200 RANEVSRMVLVGDVTDKICIIVDDMADTCGTLAKAAEILLENRAKSVIAIVTHGVLSGRA 259
Query: 356 MKEVDDSIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNN 529
++ +++S + ++V TNT+ E+ +K+ K+A +D+S + AE+IRR+H GES+S L+ N
Sbjct: 260 IENINNSKLDRVVCTNTVPFEEKIKKCPKLAVIDISSVLAESIRRLHNGESISYLFKN 317
>sp|O60256|KPRB_HUMAN Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPP
synthetase-associated protein 2) (41 kDa
phosphoribosypyrophosphate synthetase-associated
protein) (PAP41)
Length = 369
Score = 120 bits (301), Expect = 3e-27
Identities = 71/210 (33%), Positives = 115/210 (54%), Gaps = 33/210 (15%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
FN+PVDNL + + +I++ I + I + + SA+R + A L++ +I+ E +
Sbjct: 156 FNIPVDNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQ 215
Query: 182 EASEQII---------------------------------LVGDVVSRIAVILLDIIDNC 262
+A ++ +VGDV RIA+I+ DIID+
Sbjct: 216 DAESDLVDGRHSPPMVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDDV 275
Query: 263 DLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDDSIITKLVVTNTICQEKYVKQSDK 442
D +++ + LKE GA ++V+ATHG+LS + +++S I ++VVTNTI E Q K
Sbjct: 276 DSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIPHEVQKLQCPK 335
Query: 443 IACLDVSVIFAEAIRRIHYGESVSCLYNNL 532
I +D+S+I +EAIRRIH GES+S L+ N+
Sbjct: 336 IKTVDISMILSEAIRRIHNGESMSYLFRNI 365
>sp|P46585|KPR1_CANAL Ribose-phosphate pyrophosphokinase 1 (Phosphoribosyl pyrophosphate
synthetase 1)
Length = 321
Score = 120 bits (300), Expect = 4e-27
Identities = 68/178 (38%), Positives = 109/178 (61%), Gaps = 2/178 (1%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
F+VPVDNL +E + +IK+ I + E I S + A+R A +A+ L + F LI+ E+
Sbjct: 141 FDVPVDNLYAEPSVVRYIKETID-YSEAIIISSDAGGAKRAAGLADRLDLNFELIHKERA 199
Query: 182 EASE--QIILVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERL 355
A+E +++LV DV +I VI+ D+ D C + + + L + A V I THG+LS
Sbjct: 200 RANEVSRMVLVVDVTDKICVIVDDMADTCGTLAKAAEVLLDNNAKDVIAIVTHGILSGNA 259
Query: 356 MKEVDDSIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNN 529
+K +++S + K+V TNT+ E +K K+ +D+S + AE+IRR+H GES+S L+ N
Sbjct: 260 IKNINNSKLKKVVCTNTVPFEDKLKLCLKLDTIDISAVIAESIRRLHNGESISYLFKN 317
>sp|Q8R574|KPRB_MOUSE Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPP
synthetase-associated protein 2) (41 kDa
phosphoribosypyrophosphate synthetase-associated
protein) (PAP41)
Length = 369
Score = 119 bits (297), Expect = 9e-27
Identities = 71/210 (33%), Positives = 115/210 (54%), Gaps = 33/210 (15%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
FN+PVDNL + + +I++ I + I + + SA+R + A L++ +I+ E +
Sbjct: 156 FNIPVDNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQ 215
Query: 182 EASEQII---------------------------------LVGDVVSRIAVILLDIIDNC 262
+A ++ +VGDV RIA+I+ DIID+
Sbjct: 216 DAESDLVDGRHSPPMVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDDV 275
Query: 263 DLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDDSIITKLVVTNTICQEKYVKQSDK 442
D +++ + LKE GA ++V+ATHG+LS + +++S I ++VVTNTI E Q K
Sbjct: 276 DSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPK 335
Query: 443 IACLDVSVIFAEAIRRIHYGESVSCLYNNL 532
I +D+S+I +EAIRRIH GES+S L+ N+
Sbjct: 336 IKTVDISMILSEAIRRIHNGESMSYLFRNI 365
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,670,914
Number of Sequences: 369166
Number of extensions: 1365485
Number of successful extensions: 3921
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3642
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3854
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5462583840
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)