Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_A21
(805 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor... 114 4e-25
sp|P79287|MMP20_PIG Matrix metalloproteinase-20 precursor (... 112 2e-24
sp|O18767|MMP20_BOVIN Matrix metalloproteinase-20 precursor... 111 2e-24
sp|O60882|MMP20_HUMAN Matrix metalloproteinase-20 precursor... 110 6e-24
sp|P33435|MMP13_MOUSE Collagenase 3 precursor (Matrix metal... 109 1e-23
sp|P57748|MMP20_MOUSE Matrix metalloproteinase-20 precursor... 107 3e-23
sp|P22757|HE_PARLI Hatching enzyme precursor (HE) (HEZ) (En... 106 8e-23
sp|O18927|MMP13_HORSE Collagenase 3 precursor (Matrix metal... 106 8e-23
sp|O62806|MMP13_RABIT Collagenase 3 precursor (Matrix metal... 105 1e-22
sp|P53690|MMP14_MOUSE Matrix metalloproteinase-14 precursor... 104 2e-22
>sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor (MMP-19) (Matrix
metalloproteinase RASI)
Length = 527
Score = 114 bits (284), Expect = 4e-25
Identities = 85/268 (31%), Positives = 122/268 (45%), Gaps = 15/268 (5%)
Frame = +2
Query: 35 PTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSYKQGSMFSLSFADAEHVQYDVHNNFVES 214
P+T++L ++ AL YWS+ + F +V + LSF + + N F
Sbjct: 118 PSTLSLPRVRAALHQAFKYWSSVAPLTFREVKAGWADI-RLSFHGRQSLYCS--NTF--- 171
Query: 215 RDPYPLDNVPGGVLAHAFFPRNGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHS 394
+ PG VLAHA P G++HFD E WTEG G+NLR++AAHE+GHA+GL HS
Sbjct: 172 -------DGPGKVLAHADIPELGSIHFDKDELWTEGTYQGVNLRIIAAHEVGHALGLGHS 224
Query: 395 NDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKN---------------GKVFVRS 529
ALMAP Y GY + FKL DD G +YG ++ V +
Sbjct: 225 RYTQALMAPVYAGY--QPFFKLHPDDVAGIQALYGKRSPETRDEEEETEMLTVSPVTAKP 282
Query: 530 NKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTLQL 709
+ E + + + + D ++ VTD F++ A ++ L
Sbjct: 283 GPMPNPCSGEVDAMVLGPRGKTYAFKGDYVWTVTDSG-------PGPLFQISALWE--GL 333
Query: 710 PNQLFDSDALFYDYSGRRFVFFKGNRVF 793
P L DA Y RR FFKGN+V+
Sbjct: 334 PGNL---DAAVYSPRTRRTHFFKGNKVW 358
>sp|P79287|MMP20_PIG Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 483
Score = 112 bits (279), Expect = 2e-24
Identities = 89/274 (32%), Positives = 126/274 (45%), Gaps = 6/274 (2%)
Frame = +2
Query: 2 TYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSYKQGSMFSLSFADAEHV 181
TYR ++ +MT E+ +A+ + L WS+A + F +V+ + + +SF +H
Sbjct: 123 TYRI----SKYTPSMTPAEVDKAMEMALQAWSSAVPLSFVRVNAGEADIM-ISFETGDH- 176
Query: 182 QYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLV 352
D YP D P G LAHAF P G + HFD+AE+WT G +G NL V
Sbjct: 177 -----------GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGM-NGFNLFTV 223
Query: 353 AAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYG---TKNGKVFV 523
AAHE GHA+GL HS DP+ALM P Y Y + F LP DD +G +YG T GK V
Sbjct: 224 AAHEFGHALGLAHSTDPSALMYPTY-KYQNPYGFHLPKDDVKGIQALYGPRKTFTGKPTV 282
Query: 524 RSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTL 703
S ++C+ ++ A + D+ R +H + R S T
Sbjct: 283 PHGPPHNPSL--PDICDSSSSFDAVTMLGKELLFFRDRIFWRRQVHLMSGIR--PSTITS 338
Query: 704 QLPNQLFDSDALFYDYSGRRFVFFKGNRVFSANG 805
P + + DA + FFKG + G
Sbjct: 339 SFPQLMSNVDAAYEVADRGMAYFFKGPHYWITRG 372
>sp|O18767|MMP20_BOVIN Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 481
Score = 111 bits (278), Expect = 2e-24
Identities = 88/274 (32%), Positives = 126/274 (45%), Gaps = 6/274 (2%)
Frame = +2
Query: 2 TYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSYKQGSMFSLSFADAEHV 181
TYR ++ +MT E+ RA+ + L WS+A + F +++ + + +SF +H
Sbjct: 121 TYRI----SKYTPSMTPAEVDRAMEMALRAWSSAVPLNFVRINAGEADIM-ISFETGDH- 174
Query: 182 QYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLV 352
D YP D P G LAHAF P G + HFD+AE+WT G +G NL V
Sbjct: 175 -----------GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-NGFNLFTV 221
Query: 353 AAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTK---NGKVFV 523
AAHE GHA+GL HS DP+ALM P Y Y + F+LP DD +G +YG + +GK
Sbjct: 222 AAHEFGHALGLAHSTDPSALMFPTY-KYQNPYGFRLPKDDVKGIQALYGPRRAFSGKPTA 280
Query: 524 RSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTL 703
S +LC+ A + + D+ R +H + R S T
Sbjct: 281 PHGPPHNPSI--PDLCDSNLSFDAVTMLGKELLLFRDRIFWRRQVHLMSGIR--PSTITS 336
Query: 704 QLPNQLFDSDALFYDYSGRRFVFFKGNRVFSANG 805
P + + DA + FFKG + G
Sbjct: 337 SFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRG 370
>sp|O60882|MMP20_HUMAN Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 483
Score = 110 bits (274), Expect = 6e-24
Identities = 86/274 (31%), Positives = 128/274 (46%), Gaps = 6/274 (2%)
Frame = +2
Query: 2 TYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSYKQGSMFSLSFADAEHV 181
TYR ++ +M+ E+ +A+ + L WS+A + F +++ + + +SF + +H
Sbjct: 123 TYRI----SKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIM-ISFENGDH- 176
Query: 182 QYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLV 352
D YP D P G LAHAF P G + HFD+AE+WT G +G NL V
Sbjct: 177 -----------GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-NGFNLFTV 223
Query: 353 AAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRS- 529
AAHE GHA+GL HS DP+ALM P Y Y + F LP DD +G +YG + KVF+
Sbjct: 224 AAHEFGHALGLAHSTDPSALMYPTY-KYKNPYGFHLPKDDVKGIQALYGPR--KVFLGKP 280
Query: 530 --NKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTL 703
+ +LC+ ++ A + + D+ R +H R S T
Sbjct: 281 TLPHAPHHKPSIPDLCDSSSSFDAVTMLGKELLLFKDRIFWRRQVHLRTGIR--PSTITS 338
Query: 704 QLPNQLFDSDALFYDYSGRRFVFFKGNRVFSANG 805
P + + DA + FFKG + G
Sbjct: 339 SFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRG 372
>sp|P33435|MMP13_MOUSE Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 472
Score = 109 bits (272), Expect = 1e-23
Identities = 83/258 (32%), Positives = 120/258 (46%), Gaps = 4/258 (1%)
Frame = +2
Query: 44 MTLGEIQRALMIGLSYWSTAGDIYFAKVSYKQGSMFSLSFADAEHVQYDVHNNFVESRDP 223
M+ E+++A WS + F ++ Y + +SF EH +
Sbjct: 130 MSHSEVEKAFRKAFKVWSDVTPLNFTRI-YDGTADIMISFGTKEHGDF------------ 176
Query: 224 YPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHS 394
YP D P G+LAHAF P G+ HFD E WT + G NL +VAAHE+GH++GL HS
Sbjct: 177 YPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK-GYNLFIVAAHELGHSLGLDHS 234
Query: 395 NDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRSNKKREQSANEKELCN 574
DP ALM P Y Y ++ F LPDDD QG F+YG + + K E+ L
Sbjct: 235 KDPGALMFPIY-TYTGKSHFMLPDDDVQGIQFLYGPGDEDPNPKHPKTPEKCDPALSLDA 293
Query: 575 ITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTLQLPNQLFDSDALFYDYS 754
IT++ D + +V + SF +LPN + DA Y++
Sbjct: 294 ITSLRGETMIFKDRFFWRLHPQQVEAELFLTKSF-------WPELPNHV---DAA-YEHP 342
Query: 755 GRRFVF-FKGNRVFSANG 805
R +F F+G + ++ NG
Sbjct: 343 SRDLMFIFRGRKFWALNG 360
>sp|P57748|MMP20_MOUSE Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 482
Score = 107 bits (268), Expect = 3e-23
Identities = 87/274 (31%), Positives = 126/274 (45%), Gaps = 6/274 (2%)
Frame = +2
Query: 2 TYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSYKQGSMFSLSFADAEHV 181
TYR ++ +M+ E+ +A+ + L WSTA + F +++ + + +SF +H
Sbjct: 122 TYRI----SKYTPSMSPTEVDKAIQMALHAWSTAVPLNFVRINSGEADIM-ISFETGDH- 175
Query: 182 QYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLV 352
D YP D P G LAHAF P G + HFD+AE+WT G +G NL V
Sbjct: 176 -----------GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-NGFNLFTV 222
Query: 353 AAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKN---GKVFV 523
AAHE GHA+GL HS DP+ALM P Y Y + F LP DD +G +YG + GK +
Sbjct: 223 AAHEFGHALGLGHSTDPSALMYPTY-KYQNPYRFHLPKDDVKGIQALYGPRKIFPGKPTM 281
Query: 524 RSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTL 703
+ S +LC+ ++ A + D+ R +H R S T
Sbjct: 282 PHIPPHKPSI--PDLCDSSSSFDAVTMLGKELLFFKDRIFWRRQVHLPTGIR--PSTITS 337
Query: 704 QLPNQLFDSDALFYDYSGRRFVFFKGNRVFSANG 805
P + + DA + FFKG + G
Sbjct: 338 SFPQLMSNVDAAYEVAERGIAFFFKGPHYWVTRG 371
>sp|P22757|HE_PARLI Hatching enzyme precursor (HE) (HEZ) (Envelysin)
(Sea-urchin-hatching proteinase) [Contains: Hatching
enzyme 18 kDa form]
Length = 587
Score = 106 bits (264), Expect = 8e-23
Identities = 49/89 (55%), Positives = 63/89 (70%)
Frame = +2
Query: 245 GGVLAHAFFPRNGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHSNDPNALMAPW 424
GGVLAHAF PRNG+ HFD +E WTEG G NL VAAHE GH++GL+HS +ALM P+
Sbjct: 245 GGVLAHAFLPRNGDAHFDDSETWTEGTRSGTNLFQVAAHEFGHSLGLYHSTVRSALMYPY 304
Query: 425 YGGYISENDFKLPDDDSQGAAFIYGTKNG 511
Y GY+ +F+L +DD G +YG+ +G
Sbjct: 305 YQGYVP--NFRLDNDDIAGIRSLYGSNSG 331
>sp|O18927|MMP13_HORSE Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 472
Score = 106 bits (264), Expect = 8e-23
Identities = 81/258 (31%), Positives = 119/258 (46%), Gaps = 4/258 (1%)
Frame = +2
Query: 44 MTLGEIQRALMIGLSYWSTAGDIYFAKVSYKQGSMFSLSFADAEHVQYDVHNNFVESRDP 223
+T E+++A WS + F ++ Y + +SF EH +
Sbjct: 130 LTHSEVEKAFKKAFKVWSDVTPLNFTRL-YNGTADIMISFGTKEHGDF------------ 176
Query: 224 YPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHS 394
YP D P G+LAHAF P G+ HFD E WT + G NL LVAAHE GH++GL HS
Sbjct: 177 YPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK-GYNLFLVAAHEFGHSLGLDHS 234
Query: 395 NDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRSNKKREQSANEKELCN 574
DP ALM P Y Y ++ F LPDDD QG ++YG + + K ++ L
Sbjct: 235 KDPGALMFPIY-TYTGKSHFVLPDDDVQGIQYLYGPGDEDPNPKHPKTPDKCDPSLSLDA 293
Query: 575 ITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTLQLPNQLFDSDALFYDYS 754
IT++ D + V + SF +LPN++ DA Y++
Sbjct: 294 ITSLRGETMVFKDRFFWRLHPQLVDAELFLTKSF-------WPELPNRI---DAA-YEHP 342
Query: 755 GRRFVF-FKGNRVFSANG 805
+ +F F+G + ++ NG
Sbjct: 343 SKDLIFIFRGRKFWALNG 360
>sp|O62806|MMP13_RABIT Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 471
Score = 105 bits (263), Expect = 1e-22
Identities = 81/258 (31%), Positives = 118/258 (45%), Gaps = 4/258 (1%)
Frame = +2
Query: 44 MTLGEIQRALMIGLSYWSTAGDIYFAKVSYKQGSMFSLSFADAEHVQYDVHNNFVESRDP 223
+T E+++A WS + F ++ + +SF EH +
Sbjct: 129 LTHSEVEKAFKKAFKVWSDVTPLNFTRIHNGTADIM-ISFGTKEHGDF------------ 175
Query: 224 YPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHS 394
YP D P G+LAHAF P G+ HFD E WT + G NL LVAAHE GH++GL HS
Sbjct: 176 YPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK-GYNLFLVAAHEFGHSLGLDHS 233
Query: 395 NDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRSNKKREQSANEKELCN 574
DP ALM P Y Y ++ F LPDDD QG +YG + + K ++ L
Sbjct: 234 KDPGALMFPIY-TYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDA 292
Query: 575 ITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTLQLPNQLFDSDALFYDYS 754
IT++ D + +V + SF +LPN++ DA Y++
Sbjct: 293 ITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSF-------WPELPNRI---DAA-YEHP 341
Query: 755 GRRFVF-FKGNRVFSANG 805
R +F F+G + ++ NG
Sbjct: 342 ARDLIFIFRGKKFWAPNG 359
>sp|P53690|MMP14_MOUSE Matrix metalloproteinase-14 precursor (MMP-14) (Membrane-type
matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1)
(Membrane-type-1 matrix metalloproteinase) (MT1-MMP)
(MT1MMP) (MMP-X1) (MT-MMP)
Length = 582
Score = 104 bits (260), Expect = 2e-22
Identities = 64/147 (43%), Positives = 84/147 (57%), Gaps = 7/147 (4%)
Frame = +2
Query: 92 WSTAGDIYFAKVSYKQGSMFSLSFADAEHVQYDVHNNFVES--RDPYPLDNVPGGVLAHA 265
W +A + F +V Y + Q D+ F E D P D GG LAHA
Sbjct: 151 WESATPLRFREVPYAY-------IREGHEKQADIMILFAEGFHGDSTPFDG-EGGFLAHA 202
Query: 266 FFPR---NGNLHFDSAEEWTEGKED--GINLRLVAAHEMGHAIGLFHSNDPNALMAPWYG 430
+FP G+ HFDSAE WT ED G ++ LVA HE+GHA+GL HSNDP+A+M+P+Y
Sbjct: 203 YFPGPNIGGDTHFDSAEPWTVQNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMSPFYQ 262
Query: 431 GYISENDFKLPDDDSQGAAFIYGTKNG 511
+EN F LPDDD +G +YG+K+G
Sbjct: 263 WMDTEN-FVLPDDDRRGIQQLYGSKSG 288
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,240,931
Number of Sequences: 369166
Number of extensions: 1918781
Number of successful extensions: 5872
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5450
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5714
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7618580670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)