Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_A02
(894 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9VKJ0|HGD_DROME Homogentisate 1,2-dioxygenase (Homogent... 241 2e-63
sp|Q9Y041|HGD_CAEEL Homogentisate 1,2-dioxygenase (Homogent... 223 7e-58
sp|Q93099|HGD_HUMAN Homogentisate 1,2-dioxygenase (Homogent... 220 4e-57
sp|O09173|HGD_MOUSE Homogentisate 1,2-dioxygenase (Homogent... 218 2e-56
sp|Q9ZRA2|HGD_ARATH Homogentisate 1,2-dioxygenase (Homogent... 197 3e-50
sp|Q00667|HGD_EMENI Homogentisate 1,2-dioxygenase (Homogent... 187 3e-47
sp|Q87Z79|HGD_PSESM Homogentisate 1,2-dioxygenase (Homogent... 176 1e-43
sp|Q9S2B5|HGD_STRCO Homogentisate 1,2-dioxygenase (Homogent... 174 4e-43
sp|Q9A5B8|HGD_CAUCR Homogentisate 1,2-dioxygenase (Homogent... 171 3e-42
sp|Q9X4G0|HGD_PSEAE Homogentisate 1,2-dioxygenase (Homogent... 168 2e-41
>sp|Q9VKJ0|HGD_DROME Homogentisate 1,2-dioxygenase (Homogentisicase) (Homogentisate
oxygenase) (Homogentisic acid oxidase)
Length = 439
Score = 241 bits (615), Expect = 2e-63
Identities = 121/178 (67%), Positives = 141/178 (79%)
Frame = +3
Query: 3 NKAFFNSDWDFLLVPQEGALSVLTEFGKFIVAPGEIIVIQQGIKYSVNLLDSKSANGYIL 182
N AF+NSD DFL+VPQ+G L + TEFG+ VAP EI VI QGI+++VN+ DS S GYIL
Sbjct: 145 NSAFYNSDGDFLIVPQQGVLDITTEFGRMSVAPNEICVIPQGIRFAVNV-DSPS-RGYIL 202
Query: 183 EVCGNHFVLPNLGPIGANGLANSRDFLTCVAWFDEDAIKTNNQFTLINKYQGELFYAHQE 362
EV +HFVLP+LGPIGANGLAN RDF T VAWFD+ +K F +I+K+QG LF A Q
Sbjct: 203 EVYDDHFVLPDLGPIGANGLANPRDFETPVAWFDDRDVK---DFQVISKFQGRLFVAKQN 259
Query: 363 HTCFDVVTWSGNYAPYKYDLASFMVINSVSFDHVDPSIFTVLTCPSLKPGTALADFVI 536
HT FDVV W GNY P+KYDL+ FMVINSVSFDH DPSIFTVLTCPSL+ GTA+ADFVI
Sbjct: 260 HTVFDVVAWHGNYVPFKYDLSKFMVINSVSFDHCDPSIFTVLTCPSLRAGTAIADFVI 317
>sp|Q9Y041|HGD_CAEEL Homogentisate 1,2-dioxygenase (Homogentisicase) (Homogentisate
oxygenase) (Homogentisic acid oxidase)
Length = 437
Score = 223 bits (567), Expect = 7e-58
Identities = 113/176 (64%), Positives = 133/176 (75%)
Frame = +3
Query: 9 AFFNSDWDFLLVPQEGALSVLTEFGKFIVAPGEIIVIQQGIKYSVNLLDSKSANGYILEV 188
A +NSD DFL+VPQ+GAL + TEFG+ +V P EI VI QGI++SV + + GYILEV
Sbjct: 149 AMYNSDGDFLIVPQQGALEITTEFGRLLVNPQEIAVIPQGIRFSVAVRGP--SRGYILEV 206
Query: 189 CGNHFVLPNLGPIGANGLANSRDFLTCVAWFDEDAIKTNNQFTLINKYQGELFYAHQEHT 368
G HF LP+LGPIGANGLAN RDF VAWF++ + +FT+INKYQG F A Q H+
Sbjct: 207 YGTHFQLPDLGPIGANGLANPRDFEAPVAWFEDLDV----EFTIINKYQGSWFQAKQGHS 262
Query: 369 CFDVVTWSGNYAPYKYDLASFMVINSVSFDHVDPSIFTVLTCPSLKPGTALADFVI 536
FDVV W GNY PYKYDL FMVIN+VSFDH DPSIFTVLT PS+K GTA+ADFVI
Sbjct: 263 PFDVVGWHGNYVPYKYDLKKFMVINTVSFDHCDPSIFTVLTAPSVKHGTAIADFVI 318
>sp|Q93099|HGD_HUMAN Homogentisate 1,2-dioxygenase (Homogentisicase) (Homogentisate
oxygenase) (Homogentisic acid oxidase)
Length = 445
Score = 220 bits (561), Expect = 4e-57
Identities = 106/178 (59%), Positives = 138/178 (77%)
Frame = +3
Query: 3 NKAFFNSDWDFLLVPQEGALSVLTEFGKFIVAPGEIIVIQQGIKYSVNLLDSKSANGYIL 182
N+ F+NSD DFL+VPQ+G L + TEFGK +V P EI VIQ+G+++S+++ + GYIL
Sbjct: 144 NRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEICVIQRGMRFSIDVFEE--TRGYIL 201
Query: 183 EVCGNHFVLPNLGPIGANGLANSRDFLTCVAWFDEDAIKTNNQFTLINKYQGELFYAHQE 362
EV G HF LP+LGPIGANGLAN RDFL +AW+++ + +T+INKYQG+LF A Q+
Sbjct: 202 EVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVPGG--YTVINKYQGKLFAAKQD 259
Query: 363 HTCFDVVTWSGNYAPYKYDLASFMVINSVSFDHVDPSIFTVLTCPSLKPGTALADFVI 536
+ F+VV W GNY PYKY+L +FMVINSV+FDH DPSIFTVLT S++PG A+ADFVI
Sbjct: 260 VSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTVLTAKSVRPGVAIADFVI 317
>sp|O09173|HGD_MOUSE Homogentisate 1,2-dioxygenase (Homogentisicase) (Homogentisate
oxygenase) (Homogentisic acid oxidase)
Length = 445
Score = 218 bits (554), Expect = 2e-56
Identities = 106/178 (59%), Positives = 137/178 (76%)
Frame = +3
Query: 3 NKAFFNSDWDFLLVPQEGALSVLTEFGKFIVAPGEIIVIQQGIKYSVNLLDSKSANGYIL 182
N+ F+NSD DFL+VPQ+G L + TEFGK + P EI VIQ+G+++SV++ + GYIL
Sbjct: 144 NRCFYNSDGDFLIVPQKGKLLIYTEFGKMSLQPNEICVIQRGMRFSVDVFEE--TRGYIL 201
Query: 183 EVCGNHFVLPNLGPIGANGLANSRDFLTCVAWFDEDAIKTNNQFTLINKYQGELFYAHQE 362
EV G HF LP+LGPIGANGLAN RDFL VAW+++ + +T+INK+QG+LF Q+
Sbjct: 202 EVYGVHFELPDLGPIGANGLANPRDFLIPVAWYEDRRVPGG--YTVINKFQGKLFACKQD 259
Query: 363 HTCFDVVTWSGNYAPYKYDLASFMVINSVSFDHVDPSIFTVLTCPSLKPGTALADFVI 536
+ F+VVTW GNY PYKY+L +FMVIN+V+FDH DPSIFTVLT SL+PG A+ADFVI
Sbjct: 260 VSPFNVVTWHGNYTPYKYNLENFMVINAVAFDHADPSIFTVLTAKSLRPGVAIADFVI 317
>sp|Q9ZRA2|HGD_ARATH Homogentisate 1,2-dioxygenase (Homogentisicase) (Homogentisate
oxygenase) (Homogentisic acid oxidase)
Length = 461
Score = 197 bits (502), Expect = 3e-50
Identities = 102/178 (57%), Positives = 126/178 (70%)
Frame = +3
Query: 3 NKAFFNSDWDFLLVPQEGALSVLTEFGKFIVAPGEIIVIQQGIKYSVNLLDSKSANGYIL 182
+ AF N+D DFLLVPQ G L + TE G+ +V PGEI VI QG ++S++L D KS GY+
Sbjct: 150 DSAFCNADGDFLLVPQTGRLWIETECGRLLVTPGEIAVIPQGFRFSIDLPDGKS-RGYVA 208
Query: 183 EVCGNHFVLPNLGPIGANGLANSRDFLTCVAWFDEDAIKTNNQFTLINKYQGELFYAHQE 362
E+ G HF LP+LGPIGANGLA SRDFL AWF ED ++ ++T++ K+ GELF A Q+
Sbjct: 209 EIYGAHFQLPDLGPIGANGLAASRDFLAPTAWF-EDGLRP--EYTIVQKFGGELFTAKQD 265
Query: 363 HTCFDVVTWSGNYAPYKYDLASFMVINSVSFDHVDPSIFTVLTCPSLKPGTALADFVI 536
+ F+VV W GNY PYKYDL F N+V DH DPSI TVLT P+ KPG AL DFVI
Sbjct: 266 FSPFNVVAWHGNYVPYKYDLKKFCPYNTVLLDHGDPSINTVLTAPTDKPGVALLDFVI 323
>sp|Q00667|HGD_EMENI Homogentisate 1,2-dioxygenase (Homogentisicase) (Homogentisate
oxygenase) (Homogentisic acid oxidase)
Length = 448
Score = 187 bits (475), Expect = 3e-47
Identities = 95/177 (53%), Positives = 121/177 (68%)
Frame = +3
Query: 6 KAFFNSDWDFLLVPQEGALSVLTEFGKFIVAPGEIIVIQQGIKYSVNLLDSKSANGYILE 185
+AF+++D DFL+V Q G L + TE G+ +V P EI VI +G++Y V L D GYI E
Sbjct: 149 EAFYSADGDFLIVAQHGVLDIQTELGRLLVRPNEICVIPRGVRYRVTLPDGP-VRGYICE 207
Query: 186 VCGNHFVLPNLGPIGANGLANSRDFLTCVAWFDEDAIKTNNQFTLINKYQGELFYAHQEH 365
+ H+ LP LGPIG+NGLAN+RDF VA FD++ T ++ L +K+ LF A Q+H
Sbjct: 208 LYQGHYQLPELGPIGSNGLANARDFQAPVAAFDDEEGPT--EYRLYSKFNNHLFSARQDH 265
Query: 366 TCFDVVTWSGNYAPYKYDLASFMVINSVSFDHVDPSIFTVLTCPSLKPGTALADFVI 536
T FD+V W GNY PYKYDL F + SVSFDH DPSI+TVLT PS GTA+ADFVI
Sbjct: 266 TPFDIVAWHGNYYPYKYDLGRFNTMGSVSFDHPDPSIYTVLTGPSDHVGTAIADFVI 322
>sp|Q87Z79|HGD_PSESM Homogentisate 1,2-dioxygenase (Homogentisicase) (Homogentisate
oxygenase) (Homogentisic acid oxidase)
Length = 434
Score = 176 bits (445), Expect = 1e-43
Identities = 92/177 (51%), Positives = 117/177 (66%)
Frame = +3
Query: 6 KAFFNSDWDFLLVPQEGALSVLTEFGKFIVAPGEIIVIQQGIKYSVNLLDSKSANGYILE 185
+AFF++D ++L+VPQ+G L ++TE G + P EI V+ +G+K+SV LLD SA GY+ E
Sbjct: 143 RAFFSADGEWLIVPQQGRLRIITEMGVLDIGPLEIAVLPRGLKFSVQLLDG-SARGYLCE 201
Query: 186 VCGNHFVLPNLGPIGANGLANSRDFLTCVAWFDEDAIKTNNQFTLINKYQGELFYAHQEH 365
G LP LGPIG+NGLAN RDFLT VAWF+E + L+ K+ GEL+ +H
Sbjct: 202 NHGGVLRLPELGPIGSNGLANPRDFLTPVAWFEE----RDEPVQLVQKFLGELWTTQLQH 257
Query: 366 TCFDVVTWSGNYAPYKYDLASFMVINSVSFDHVDPSIFTVLTCPSLKPGTALADFVI 536
+ FDVV W GN PY YDL F I +VS+DH DPSIFTVLT P G A DFVI
Sbjct: 258 SPFDVVGWHGNNVPYTYDLRRFNTIGTVSYDHPDPSIFTVLTSPGAVHGQANIDFVI 314
>sp|Q9S2B5|HGD_STRCO Homogentisate 1,2-dioxygenase (Homogentisicase) (Homogentisate
oxygenase) (Homogentisic acid oxidase)
Length = 441
Score = 174 bits (440), Expect = 4e-43
Identities = 90/189 (47%), Positives = 123/189 (65%)
Frame = +3
Query: 3 NKAFFNSDWDFLLVPQEGALSVLTEFGKFIVAPGEIIVIQQGIKYSVNLLDSKSANGYIL 182
++ F ++D + L+VP+ G L + TEFG PG + +I +G+++ V LLD + A GY+
Sbjct: 147 DRVFSDADGELLIVPERGGLLLRTEFGLLHAEPGHVALIPRGVRFRVQLLD-EDARGYVC 205
Query: 183 EVCGNHFVLPNLGPIGANGLANSRDFLTCVAWFDEDAIKTNNQFTLINKYQGELFYAHQE 362
E G F LP+LGPIGANGLAN+RDF VA +++D T ++NK+ G L+ A +
Sbjct: 206 ENYGAPFQLPDLGPIGANGLANARDFRAPVAAYEDDE-STPGPVEVVNKFCGNLWTAEYD 264
Query: 363 HTCFDVVTWSGNYAPYKYDLASFMVINSVSFDHVDPSIFTVLTCPSLKPGTALADFVISS 542
H+ DVV W GN+ PY YDL F VI S+S+DH DPSIFTVLT PS PG A DFV+ +
Sbjct: 265 HSPLDVVAWHGNHVPYVYDLRRFNVIGSISYDHPDPSIFTVLTSPSDTPGLAGVDFVVFA 324
Query: 543 CRIIGGGDT 569
R + G DT
Sbjct: 325 PRWLVGEDT 333
>sp|Q9A5B8|HGD_CAUCR Homogentisate 1,2-dioxygenase (Homogentisicase) (Homogentisate
oxygenase) (Homogentisic acid oxidase)
Length = 425
Score = 171 bits (433), Expect = 3e-42
Identities = 95/189 (50%), Positives = 121/189 (64%)
Frame = +3
Query: 3 NKAFFNSDWDFLLVPQEGALSVLTEFGKFIVAPGEIIVIQQGIKYSVNLLDSKSANGYIL 182
N+ F+N+D + L+VPQ G L+++TE G PG I VI +G+++ V + A GY+
Sbjct: 137 NRVFYNADGEMLIVPQMGELTLVTEMGVLKAGPGHIAVIPRGVRFRVEV--EGPARGYVC 194
Query: 183 EVCGNHFVLPNLGPIGANGLANSRDFLTCVAWFDEDAIKTNNQFTLINKYQGELFYAHQE 362
E G F LP LGPIGANGLAN RDF VA F++ I T Q +I K+QG L+ A +
Sbjct: 195 ENYGAAFRLPELGPIGANGLANPRDFEAPVAAFED--IDTPTQ--VIQKFQGALWAATWD 250
Query: 363 HTCFDVVTWSGNYAPYKYDLASFMVINSVSFDHVDPSIFTVLTCPSLKPGTALADFVISS 542
H+ DVV W GN PY+YDL+ F IN+VS+DH DPSIFTVLT PS PGTA DFVI
Sbjct: 251 HSPLDVVAWHGNLTPYRYDLSRFNTINTVSYDHPDPSIFTVLTSPSDTPGTANCDFVIFP 310
Query: 543 CRIIGGGDT 569
R + DT
Sbjct: 311 PRWMVAEDT 319
>sp|Q9X4G0|HGD_PSEAE Homogentisate 1,2-dioxygenase (Homogentisicase) (Homogentisate
oxygenase) (Homogentisic acid oxidase)
Length = 432
Score = 168 bits (425), Expect = 2e-41
Identities = 92/177 (51%), Positives = 114/177 (64%)
Frame = +3
Query: 6 KAFFNSDWDFLLVPQEGALSVLTEFGKFIVAPGEIIVIQQGIKYSVNLLDSKSANGYILE 185
+ F+++D + LLVPQ G L + TE G V P EI VI +G+K+ V LLD + A GYI E
Sbjct: 141 RCFYDADGELLLVPQLGRLRLCTELGALQVEPLEIAVIPRGMKFRVELLDGE-ARGYIAE 199
Query: 186 VCGNHFVLPNLGPIGANGLANSRDFLTCVAWFDEDAIKTNNQFTLINKYQGELFYAHQEH 365
G LP+LGPIG+NGLAN RDFLT VA +++ + L+ KY GEL+ +H
Sbjct: 200 NHGAPLRLPDLGPIGSNGLANPRDFLTPVARYED----SRQPLQLVQKYLGELWACELDH 255
Query: 366 TCFDVVTWSGNYAPYKYDLASFMVINSVSFDHVDPSIFTVLTCPSLKPGTALADFVI 536
+ DVV W GN PYKYDL F I +VSFDH DPSIFTVLT P+ PG A DFVI
Sbjct: 256 SPLDVVAWHGNNVPYKYDLRRFNTIGTVSFDHPDPSIFTVLTSPTSVPGLANIDFVI 312
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101,007,747
Number of Sequences: 369166
Number of extensions: 2009512
Number of successful extensions: 5974
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5714
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5932
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8982382310
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)