Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_P08
(804 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UEW8|STK39_HUMAN STE20/SPS1-related proline-alanine-ri... 122 9e-28
sp|Q9Z1W9|STK39_MOUSE STE20/SPS1-related proline-alanine-ri... 115 2e-25
sp|O88506|STK39_RAT STE20/SPS1-related proline-alanine-rich... 112 9e-25
sp|Q6P9R2|OXSR1_MOUSE Serine/threonine-protein kinase OSR1 ... 85 3e-16
sp|Q863I2|OXSR1_PIG Serine/threonine-protein kinase OSR1 (O... 84 5e-16
sp|Q5R495|OXSR1_PONPY Serine/threonine-protein kinase OSR1 ... 84 5e-16
sp|O95747|OXSR1_HUMAN Serine/threonine-protein kinase OSR1 ... 83 1e-15
sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (S... 58 3e-08
sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24 58 3e-08
sp|Q99JT2|MST4_MOUSE Serine/threonine-protein kinase MST4 (... 52 2e-06
>sp|Q9UEW8|STK39_HUMAN STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20
related kinase) (Serine/threonine-protein kinase 39)
(DCHT)
Length = 547
Score = 122 bits (307), Expect = 9e-28
Identities = 86/274 (31%), Positives = 128/274 (46%), Gaps = 42/274 (15%)
Frame = +1
Query: 1 APYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRPSAKE 180
APY KY PMKVLMLTLQN+PP ++T YG +RK +CL KDP++RP+A E
Sbjct: 273 APYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAE 332
Query: 181 LLQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVR------------------------D 288
LL+ F + L+ K+L +KVR D
Sbjct: 333 LLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMD 392
Query: 289 EKQEKNPKDFSGEWNFDIKGKN----------------XXXXXXEDPPGPKTKTSTAENV 420
EK E+ FS E + +K +N + PP A +
Sbjct: 393 EKSEEGKAAFSQEKSRRVKEENPEIAVSASTIPEQIQSLSVHDSQGPPNANEDYREASSC 452
Query: 421 FYRITLRKRNPKQNNELQDISFIYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELV 600
+ LR RN ++ EL DI F + G+D+ D +++EL A L+DG D+++VA NL ++V
Sbjct: 453 AVNLVLRLRNSRK--ELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIV 510
Query: 601 AEP-TMRERVFALNSP-PASGVINEADLNGYAKV 696
+P ++ F L S S + +E L G+A++
Sbjct: 511 DDPKALKTLTFKLASGCDGSEIPDEVKLIGFAQL 544
>sp|Q9Z1W9|STK39_MOUSE STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20
related kinase) (Serine/threonine-protein kinase 39)
Length = 556
Score = 115 bits (287), Expect = 2e-25
Identities = 88/273 (32%), Positives = 129/273 (47%), Gaps = 41/273 (15%)
Frame = +1
Query: 1 APYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRPSAKE 180
APY KY PMKVLMLTLQN+PP ++T YG +RK +CL KDP++RP+A E
Sbjct: 283 APYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAE 342
Query: 181 LLQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVR------------------------D 288
LL+ F + L+ K+L +KVR D
Sbjct: 343 LLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMD 402
Query: 289 EKQEKNPKDFSGEWNFDIKGKN-----XXXXXXEDPPGPKTKTSTAE---NVFYR----- 429
EK E+ S E + +K +N E S A+ N YR
Sbjct: 403 EKSEEGKAAASQEKSRRVKEENSEISVNAGGIPEQIQSLSVHDSQAQPNANEDYREGPCA 462
Query: 430 --ITLRKRNPKQNNELQDISFIYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVA 603
+ LR RN ++ EL DI F + G+D+ D +++EL A L+DG D+++VA NL ++V
Sbjct: 463 VNLVLRLRNSRK--ELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVD 520
Query: 604 EP-TMRERVFALNSP-PASGVINEADLNGYAKV 696
+P ++ F L S S + +E L G+A++
Sbjct: 521 DPKALKTLTFKLASGCDGSEIPDEVKLIGFAQL 553
>sp|O88506|STK39_RAT STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20
related kinase) (Serine/threonine-protein kinase 39)
(Pancreatic serine/threonine-protein kinase) (PS/TK)
(PSTK1)
Length = 553
Score = 112 bits (281), Expect = 9e-25
Identities = 84/273 (30%), Positives = 129/273 (47%), Gaps = 41/273 (15%)
Frame = +1
Query: 1 APYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRPSAKE 180
APY KY PMKVLMLTLQN+PP ++T YG +RK +CL KDP++RP+A E
Sbjct: 280 APYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAE 339
Query: 181 LLQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVR------------------------D 288
LL+ F + L+ K+L +KVR D
Sbjct: 340 LLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMD 399
Query: 289 EKQEKNPKDFSGEWNFDIKGKNXXXXXXEDPPGPKTKTSTAE--------NVFYR----- 429
EK E+ S E + +K +N + ++ + N YR
Sbjct: 400 EKSEEGKAAASQEKSRRVKEENPEISVNAGGIPEQIQSLSVHDSQGQPNANEDYREGPCA 459
Query: 430 --ITLRKRNPKQNNELQDISFIYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVA 603
+ LR RN ++ EL DI F + G+D+ D +++EL A L+DG D+++VA NL ++V
Sbjct: 460 VNLVLRLRNSRK--ELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVD 517
Query: 604 EP-TMRERVFALNSP-PASGVINEADLNGYAKV 696
+P ++ F L S + + +E L G+A++
Sbjct: 518 DPKALKTLTFKLASGCDGAEIPDEVKLIGFAQL 550
>sp|Q6P9R2|OXSR1_MOUSE Serine/threonine-protein kinase OSR1 (Oxidative stress-responsive 1
protein)
Length = 527
Score = 84.7 bits (208), Expect = 3e-16
Identities = 48/122 (39%), Positives = 67/122 (54%), Gaps = 9/122 (7%)
Frame = +1
Query: 1 APYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRPSAKE 180
APY KY PMKVLMLTLQN+PP ++T YG +RK +CL KDP +RP+A E
Sbjct: 225 APYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAE 284
Query: 181 LLQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVRDEKQEKNP---------KDFSGEWN 333
LL+ F + K++++E L + +L AP R +K + P +D EW+
Sbjct: 285 LLRHKFFQ-KAKNKEFLQEKILQ----RAPTISERSKKVRRVPGSSGRLHKTEDGGWEWS 339
Query: 334 FD 339
D
Sbjct: 340 DD 341
Score = 55.8 bits (133), Expect = 1e-07
Identities = 40/117 (34%), Positives = 65/117 (55%), Gaps = 11/117 (9%)
Frame = +1
Query: 379 PPGPKTKTSTAENVFYR---------ITLRKRNPKQNNELQDISFIYVLGKDSVDVLARE 531
PP K + A++ R + LR RN K+ EL DI F + G+D+ + +++E
Sbjct: 410 PPAEPAKPAQAQSSGERSQETKIPISLVLRLRNSKK--ELNDIRFEFTPGRDTAEGVSQE 467
Query: 532 LVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNS-PPASGVINEADLNGYAKV 696
L+ A L+DG DL++VA NL ++V EP + R F L S S + ++ L G+A++
Sbjct: 468 LISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQL 524
>sp|Q863I2|OXSR1_PIG Serine/threonine-protein kinase OSR1 (Oxidative stress-responsive 1
protein)
Length = 529
Score = 84.0 bits (206), Expect = 5e-16
Identities = 46/117 (39%), Positives = 59/117 (50%), Gaps = 4/117 (3%)
Frame = +1
Query: 1 APYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRPSAKE 180
APY KY PMKVLMLTLQN+PP ++T YG +RK +CL KDP +RP+A E
Sbjct: 225 APYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAE 284
Query: 181 LLQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVR----DEKQEKNPKDFSGEWNFD 339
LL+ F + L KIL +KVR + +D EW+ D
Sbjct: 285 LLRHKFFQKAKNKEYLQEKILQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDD 341
Score = 55.8 bits (133), Expect = 1e-07
Identities = 35/91 (38%), Positives = 58/91 (63%), Gaps = 2/91 (2%)
Frame = +1
Query: 430 ITLRKRNPKQNNELQDISFIYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP 609
+ LR RN K+ EL DI F + G+D+ + +++EL+ A L+DG DL++VA NL ++V EP
Sbjct: 438 LVLRLRNSKK--ELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEP 495
Query: 610 -TMRERVFALNS-PPASGVINEADLNGYAKV 696
+ R F L S S + +++ L G+A++
Sbjct: 496 QSNRSVTFKLASGVEGSDIPDDSKLIGFAQL 526
>sp|Q5R495|OXSR1_PONPY Serine/threonine-protein kinase OSR1 (Oxidative stress-responsive 1
protein)
Length = 527
Score = 84.0 bits (206), Expect = 5e-16
Identities = 48/122 (39%), Positives = 67/122 (54%), Gaps = 9/122 (7%)
Frame = +1
Query: 1 APYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRPSAKE 180
APY KY PMKVLMLTLQN+PP ++T YG +RK +CL KDP +RP+A E
Sbjct: 225 APYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAE 284
Query: 181 LLQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVRDEKQEKNP---------KDFSGEWN 333
LL+ F + K++++E L + +L AP R +K + P +D EW+
Sbjct: 285 LLRHKFFQ-KAKNKEFLQEKILQ----RAPTISERAKKVRRVPGSSGRLHKTEDGGWEWS 339
Query: 334 FD 339
D
Sbjct: 340 DD 341
Score = 55.5 bits (132), Expect = 2e-07
Identities = 35/91 (38%), Positives = 57/91 (62%), Gaps = 2/91 (2%)
Frame = +1
Query: 430 ITLRKRNPKQNNELQDISFIYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP 609
+ LR RN K+ EL DI F + G+D+ + +++EL+ A L+DG DL++VA NL ++V EP
Sbjct: 436 LVLRLRNSKK--ELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEP 493
Query: 610 -TMRERVFALNS-PPASGVINEADLNGYAKV 696
+ R F L S S + ++ L G+A++
Sbjct: 494 QSNRSVTFKLASGVEGSDIPDDGKLIGFAQL 524
>sp|O95747|OXSR1_HUMAN Serine/threonine-protein kinase OSR1 (Oxidative stress-responsive 1
protein)
Length = 527
Score = 82.8 bits (203), Expect = 1e-15
Identities = 48/122 (39%), Positives = 66/122 (54%), Gaps = 9/122 (7%)
Frame = +1
Query: 1 APYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRPSAKE 180
APY KY PMKVLMLTLQN+PP ++T YG +RK +CL KDP +RP+A E
Sbjct: 225 APYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAE 284
Query: 181 LLQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVRDEKQEKNP---------KDFSGEWN 333
LL+ F + K++++E L + L AP R +K + P +D EW+
Sbjct: 285 LLRHKFFQ-KAKNKEFLQEKTLQ----RAPTISERAKKVRRVPGSSGRLHKTEDGGWEWS 339
Query: 334 FD 339
D
Sbjct: 340 DD 341
Score = 55.5 bits (132), Expect = 2e-07
Identities = 35/91 (38%), Positives = 57/91 (62%), Gaps = 2/91 (2%)
Frame = +1
Query: 430 ITLRKRNPKQNNELQDISFIYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP 609
+ LR RN K+ EL DI F + G+D+ + +++EL+ A L+DG DL++VA NL ++V EP
Sbjct: 436 LVLRLRNSKK--ELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEP 493
Query: 610 -TMRERVFALNS-PPASGVINEADLNGYAKV 696
+ R F L S S + ++ L G+A++
Sbjct: 494 QSNRSVTFKLASGVEGSDIPDDGKLIGFAQL 524
>sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (STE20-like kinase MST3) (MST-3)
(Mammalian STE20-like protein kinase 3)
Length = 443
Score = 58.2 bits (139), Expect = 3e-08
Identities = 37/126 (29%), Positives = 62/126 (49%), Gaps = 9/126 (7%)
Frame = +1
Query: 4 PYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRPSAKEL 183
P+++ PMKVL L +N PP ++ NY ++F + CL K+P+ RP+AKEL
Sbjct: 230 PHSELHPMKVLFLIPKNNPPTLEG---------NYSKPLKEFVEACLNKEPSFRPTAKEL 280
Query: 184 LQSPFIKSKSRDRELLSKIL---------LNCDIPPAPDRKVRDEKQEKNPKDFSGEWNF 336
L+ FI ++ L++++ + D + D + Q D SG+W F
Sbjct: 281 LKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSD-SGDWIF 339
Query: 337 DIKGKN 354
I+ K+
Sbjct: 340 TIREKD 345
>sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24
Length = 431
Score = 57.8 bits (138), Expect = 3e-08
Identities = 37/126 (29%), Positives = 63/126 (50%), Gaps = 9/126 (7%)
Frame = +1
Query: 4 PYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRPSAKEL 183
P+++ PMKVL L +N PP ++ NY ++F + CL K+P+ RP+AKEL
Sbjct: 218 PHSELHPMKVLFLIPKNNPPTLEG---------NYSKPLKEFVEACLNKEPSFRPTAKEL 268
Query: 184 LQSPFIKSKSRDRELLSKIL---------LNCDIPPAPDRKVRDEKQEKNPKDFSGEWNF 336
L+ FI ++ L++++ + + + D V + Q D SG+W F
Sbjct: 269 LKHKFIIRNAKKTSYLTELIDRYKRWKAEQSHEDSSSEDSDVETDGQASGGSD-SGDWIF 327
Query: 337 DIKGKN 354
I+ K+
Sbjct: 328 TIREKD 333
>sp|Q99JT2|MST4_MOUSE Serine/threonine-protein kinase MST4 (STE20-like kinase MST4)
(MST-4) (Mammalian STE20-like protein kinase 4)
Length = 416
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/161 (27%), Positives = 72/161 (44%), Gaps = 2/161 (1%)
Frame = +1
Query: 4 PYAKYTPMKVLMLTLQNEPPDIDTAATSSNQYTNYGHKYRKFTKVCLCKDPTQRPSAKEL 183
P + PM+VL L +N PP + T S +++F CL KDP+ RP+AKEL
Sbjct: 218 PNSDMHPMRVLFLIPKNNPPTLIGDFTKS---------FKEFIDACLNKDPSFRPTAKEL 268
Query: 184 LQSPFIKSKSRDRELLSKILLNCDIPPAPDRKVRDEKQEKNPKDFSGEWNFDIKGKNXXX 363
L+ FI S+ L++++ DR R + + + ++ D +G +
Sbjct: 269 LKHKFIVKNSKKTSYLTELI---------DRFKRWKAEGHSDEE------SDSEGSDSES 313
Query: 364 XXXEDPPGPKTKTSTAENVFYRITLRKRNPK--QNNELQDI 480
E P P+ +T +K +PK QN E QD+
Sbjct: 314 SSRESNPHPEWSFTTVR--------KKPDPKKLQNGEEQDL 346
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,373,225
Number of Sequences: 369166
Number of extensions: 1577536
Number of successful extensions: 4474
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4330
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4447
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7618580670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)