Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_O06
(683 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 234 2e-61
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 223 4e-58
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 220 3e-57
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 216 6e-56
sp|Q9GLE3|CATK_PIG Cathepsin K precursor 214 2e-55
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 213 3e-55
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 213 3e-55
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 213 3e-55
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 213 4e-55
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 213 5e-55
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 234 bits (597), Expect = 2e-61
Identities = 115/194 (59%), Positives = 139/194 (71%), Gaps = 4/194 (2%)
Frame = +1
Query: 1 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNS--GCNGGWMNIAFEYI-SSHGI 171
SCWAFSTTGSLEGQHF K L +++EQQLVDC GCNGGWMN AF+YI +++GI
Sbjct: 130 SCWAFSTTGSLEGQHFLKTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGI 189
Query: 172 ESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGYS- 348
++E YPY+A+ G+C FD + V A C G NI S +E L AV +GPISV ID +S
Sbjct: 190 DTEAAYPYEARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSS 249
Query: 349 FQQYKQGVYYEAKCDPTIQNHAVLVVGYGVENGHKYWLVKNSWGPSWGMNGYIKMSKDRD 528
FQ Y GVYYE C P+ +HAVL VGYG E G +WLVKNSW SWG GYIKMS++R+
Sbjct: 250 FQFYSSGVYYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRN 309
Query: 529 NNCGIATTASFPIV 570
NNCGIAT AS+P+V
Sbjct: 310 NNCGIATVASYPLV 323
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 223 bits (568), Expect = 4e-58
Identities = 111/194 (57%), Positives = 135/194 (69%), Gaps = 4/194 (2%)
Frame = +1
Query: 1 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYISSHG-I 171
SCWAFS TG+LEGQHF K+ L ++SEQQLVDC T N GC GGWM AF+YI +G I
Sbjct: 129 SCWAFSATGALEGQHFLKNDELVSLSEQQLVDCSTDYGNDGCGGGWMTSAFDYIKDNGGI 188
Query: 172 ESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVG-YS 348
++E +YPY+A+ +C FD + + A C G + E+ L AV+ VGPISVAID +S
Sbjct: 189 DTESSYPYEAEDRSCRFDANSIGAICTGSVEVQH-TEEALQEAVSGVGPISVAIDASHFS 247
Query: 349 FQQYKQGVYYEAKCDPTIQNHAVLVVGYGVENGHKYWLVKNSWGPSWGMNGYIKMSKDRD 528
FQ Y GVYYE C PT +H VL VGYG E+ YWLVKNSWG SWG GYIKMS++RD
Sbjct: 248 FQFYSSGVYYEQNCSPTFLDHGVLAVGYGTESTKDYWLVKNSWGSSWGDAGYIKMSRNRD 307
Query: 529 NNCGIATTASFPIV 570
NNCGIA+ S+P V
Sbjct: 308 NNCGIASEPSYPTV 321
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 220 bits (560), Expect = 3e-57
Identities = 110/195 (56%), Positives = 144/195 (73%), Gaps = 5/195 (2%)
Frame = +1
Query: 1 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYISSHG-I 171
SCWAFS+TG+LEGQHFRK VL ++SEQ LVDC TK N+GCNGG M+ AF YI +G I
Sbjct: 147 SCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGI 206
Query: 172 ESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-S 348
++E +YPY+A +C F+K V A +GF +I +EK +A AVATVGP+SVAID + S
Sbjct: 207 DTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHES 266
Query: 349 FQQYKQGVYYEAKCDPTIQNHAVLVVGYGV-ENGHKYWLVKNSWGPSWGMNGYIKMSKDR 525
FQ Y +GVY E +CD +H VLVVG+G E+G YWLVKNSWG +WG G+IKM +++
Sbjct: 267 FQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNK 326
Query: 526 DNNCGIATTASFPIV 570
+N CGIA+ +S+P+V
Sbjct: 327 ENQCGIASASSYPLV 341
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 216 bits (549), Expect = 6e-56
Identities = 108/195 (55%), Positives = 142/195 (72%), Gaps = 5/195 (2%)
Frame = +1
Query: 1 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYISSHG-I 171
SCWAFS+TG+LEGQHFRK VL ++SEQ LVDC TK N+GCNGG M+ AF YI +G I
Sbjct: 145 SCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGI 204
Query: 172 ESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-S 348
++E +YPY+ +C F+K+ + A GF +I +E+ + AVAT+GP+SVAID + S
Sbjct: 205 DTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHES 264
Query: 349 FQQYKQGVYYEAKCDPTIQNHAVLVVGYGV-ENGHKYWLVKNSWGPSWGMNGYIKMSKDR 525
FQ Y +GVY E +CD +H VLVVGYG E+G YWLVKNSWG +WG GYIKM++++
Sbjct: 265 FQLYSEGVYNEPECDEQNLDHGVLVVGYGTDESGMDYWLVKNSWGTTWGEQGYIKMARNQ 324
Query: 526 DNNCGIATTASFPIV 570
+N CGIAT +S+P V
Sbjct: 325 NNQCGIATASSYPTV 339
>sp|Q9GLE3|CATK_PIG Cathepsin K precursor
Length = 330
Score = 214 bits (544), Expect = 2e-55
Identities = 100/190 (52%), Positives = 134/190 (70%), Gaps = 2/190 (1%)
Frame = +1
Query: 1 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYISSH-GIES 177
SCWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+ + GI+S
Sbjct: 139 SCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDS 198
Query: 178 EDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQ 354
ED YPY + NC+++ + A C+G++ I NEK L AVA VGP+SVAID SFQ
Sbjct: 199 EDAYPYVGQDENCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 258
Query: 355 QYKQGVYYEAKCDPTIQNHAVLVVGYGVENGHKYWLVKNSWGPSWGMNGYIKMSKDRDNN 534
Y +GVYY+ C+ NHAVL VGYG++ G K+W++KNSWG +WG GYI M+++++N
Sbjct: 259 FYSKGVYYDENCNSDNLNHAVLAVGYGIQKGKKHWIIKNSWGENWGNKGYILMARNKNNA 318
Query: 535 CGIATTASFP 564
CGIA ASFP
Sbjct: 319 CGIANLASFP 328
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 213 bits (543), Expect = 3e-55
Identities = 99/190 (52%), Positives = 136/190 (71%), Gaps = 2/190 (1%)
Frame = +1
Query: 1 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYISSH-GIES 177
SCWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+ + GI+S
Sbjct: 138 SCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDS 197
Query: 178 EDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQ 354
ED YPY ++ +C+++ + A C+G++ I NEK L AVA VGP+SVAID SFQ
Sbjct: 198 EDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 257
Query: 355 QYKQGVYYEAKCDPTIQNHAVLVVGYGVENGHKYWLVKNSWGPSWGMNGYIKMSKDRDNN 534
Y +GVYY+ C+ NHAVL VGYG++ G+K+W++KNSWG +WG GYI M+++++N
Sbjct: 258 FYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNA 317
Query: 535 CGIATTASFP 564
CGIA ASFP
Sbjct: 318 CGIANLASFP 327
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 213 bits (543), Expect = 3e-55
Identities = 110/198 (55%), Positives = 135/198 (68%), Gaps = 8/198 (4%)
Frame = +1
Query: 1 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYISSHG-I 171
SCWAFS TG+LEGQ FRK L ++SEQ LVDC N GCNGG+M AF+Y+ +G +
Sbjct: 137 SCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGL 196
Query: 172 ESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGYS- 348
+SE++YPY A C + VAN GF + EK L AVATVGPISVA+D G+S
Sbjct: 197 DSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSS 256
Query: 349 FQQYKQGVYYEAKCDPTIQNHAVLVVGYGVE----NGHKYWLVKNSWGPSWGMNGYIKMS 516
FQ YK G+Y+E C +H VLVVGYG E N KYWLVKNSWGP WG NGY+K++
Sbjct: 257 FQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIA 316
Query: 517 KDRDNNCGIATTASFPIV 570
KD++N+CGIAT AS+P V
Sbjct: 317 KDKNNHCGIATAASYPNV 334
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 213 bits (543), Expect = 3e-55
Identities = 99/190 (52%), Positives = 136/190 (71%), Gaps = 2/190 (1%)
Frame = +1
Query: 1 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYISSH-GIES 177
SCWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+ + GI+S
Sbjct: 138 SCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDS 197
Query: 178 EDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQ 354
ED YPY ++ +C+++ + A C+G++ I NEK L AVA VGP+SVAID SFQ
Sbjct: 198 EDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 257
Query: 355 QYKQGVYYEAKCDPTIQNHAVLVVGYGVENGHKYWLVKNSWGPSWGMNGYIKMSKDRDNN 534
Y +GVYY+ C+ NHAVL VGYG++ G+K+W++KNSWG +WG GYI M+++++N
Sbjct: 258 FYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNA 317
Query: 535 CGIATTASFP 564
CGIA ASFP
Sbjct: 318 CGIANLASFP 327
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 213 bits (542), Expect = 4e-55
Identities = 110/198 (55%), Positives = 136/198 (68%), Gaps = 8/198 (4%)
Frame = +1
Query: 1 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDC--VTKNSGCNGGWMNIAFEYISSHG-I 171
SCWAFS +G LEGQ F K L ++SEQ LVDC N GCNGG M+ AF+YI +G +
Sbjct: 137 SCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGL 196
Query: 172 ESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-S 348
+SE++YPY+AK G+C + VAN GF +I EK L AVATVGPISVA+D + S
Sbjct: 197 DSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPS 255
Query: 349 FQQYKQGVYYEAKCDPTIQNHAVLVVGYGVE----NGHKYWLVKNSWGPSWGMNGYIKMS 516
Q Y G+YYE C +H VL+VGYG E N +KYWLVKNSWG WGM GYIK++
Sbjct: 256 LQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIA 315
Query: 517 KDRDNNCGIATTASFPIV 570
KDRDN+CG+AT AS+P+V
Sbjct: 316 KDRDNHCGLATAASYPVV 333
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 213 bits (541), Expect = 5e-55
Identities = 100/190 (52%), Positives = 134/190 (70%), Gaps = 2/190 (1%)
Frame = +1
Query: 1 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYIS-SHGIES 177
SCWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+ + GI+S
Sbjct: 138 SCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGGYMTNAFQYVQRNRGIDS 197
Query: 178 EDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQ 354
ED YPY + +C+++ + A C+G++ I NEK L AVA VGP+SVAID SFQ
Sbjct: 198 EDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 257
Query: 355 QYKQGVYYEAKCDPTIQNHAVLVVGYGVENGHKYWLVKNSWGPSWGMNGYIKMSKDRDNN 534
Y +GVYY+ C NHAVL VGYG++ G+K+W++KNSWG SWG GYI M+++++N
Sbjct: 258 FYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGESWGNKGYILMARNKNNA 317
Query: 535 CGIATTASFP 564
CGIA ASFP
Sbjct: 318 CGIANLASFP 327
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,232,364
Number of Sequences: 369166
Number of extensions: 1638910
Number of successful extensions: 4597
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3923
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4094
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5830600200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)