Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_K04
(901 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q7Z4W1|DCXR_HUMAN L-xylulose reductase (XR) (Dicarbonyl/... 212 1e-54
sp|Q91XV4|DCXR_MESAU L-xylulose reductase (XR) (Dicarbonyl/... 208 2e-53
sp|Q91X52|DCXR_MOUSE L-xylulose reductase (XR) (Dicarbonyl/... 206 7e-53
sp|Q920P0|DCXR_RAT L-xylulose reductase (XR) (Dicarbonyl/L-... 205 2e-52
sp|Q8JIS3|DER_CHICK D-erythrulose reductase 199 9e-51
sp|Q920N9|DCXR_CAVPO L-xylulose reductase (XR) (Dicarbonyl/... 197 3e-50
sp|Q21929|CBR2_CAEEL Probable carbonyl reductase [NADPH] (N... 184 4e-46
sp|P08074|CBR2_MOUSE Lung carbonyl reductase [NADPH] (NADPH... 181 3e-45
sp|Q29529|CBR2_PIG Lung carbonyl reductase [NADPH] (NADPH-d... 176 6e-44
sp|Q8CPI3|FABG_STAES 3-oxoacyl-[acyl-carrier-protein] reduc... 120 4e-27
>sp|Q7Z4W1|DCXR_HUMAN L-xylulose reductase (XR) (Dicarbonyl/L-xylulose reductase) (Kidney
dicarbonyl reductase) (kiDCR) (Carbonyl reductase II)
(Sperm surface protein P34H)
Length = 244
Score = 212 bits (539), Expect = 1e-54
Identities = 109/239 (45%), Positives = 154/239 (64%)
Frame = +3
Query: 90 GKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEVKCDISKWD 269
G+ VLVTG KGIG+ VQ L +GARV+++SR+ S+ E IE V D+ W+
Sbjct: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC-PGIEPVCVDLGDWE 65
Query: 270 EVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVASDWKTR 449
+ S+ PVD LVNNAA+ L F E+ + D F N++A+I +SQ+VA R
Sbjct: 66 ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIAR 125
Query: 450 HIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNPTAILTD 629
+ G IVNVSSQ SQRAV + YC+ K A+D +T+ MALELGP IRVN+VNPT ++T
Sbjct: 126 GVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTS 185
Query: 630 MGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIIFLLTNCCTLVTGSTIPIDGGCWSC 806
MG+ WS+P + + +R+PL + EV VV+ I+FLL++ + TGST+P++GG W+C
Sbjct: 186 MGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFWAC 244
>sp|Q91XV4|DCXR_MESAU L-xylulose reductase (XR) (Dicarbonyl/L-xylulose reductase) (Sperm
antigen P26h)
Length = 244
Score = 208 bits (529), Expect = 2e-53
Identities = 107/241 (44%), Positives = 152/241 (63%)
Frame = +3
Query: 72 LNYNFTGKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEVKC 251
++ G+ LVTG KGIG+ V L +GA V+++SR+ S+ SE +E V
Sbjct: 1 MDLGLAGRRALVTGAGKGIGRSTVLALQAAGAHVVAVSRTQADLDSLVSEC-PGVETVCV 59
Query: 252 DISKWDEVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVA 431
D++ W+ + S+ PVD LVNNAA+ L F E+ + D FN N++A+I +SQ+VA
Sbjct: 60 DLADWEATEQALSSVGPVDLLVNNAAVALLQPFLEVTKEAFDMSFNVNLRAVIQVSQIVA 119
Query: 432 SDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNP 611
R G IVNVSSQASQRA+ + YC+ K A+D +T+ MALELGP IRVN+VNP
Sbjct: 120 RGMIARGAPGAIVNVSSQASQRALANHSVYCSTKGALDMLTKMMALELGPHKIRVNAVNP 179
Query: 612 TAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIIFLLTNCCTLVTGSTIPIDG 791
T ++T MG+ WS+P + + R+PL + EV VVD I+FLL++ + TGST+P+DG
Sbjct: 180 TVVMTSMGRTNWSDPHKAKVMLDRIPLGKFAEVENVVDAILFLLSHRSNMTTGSTLPVDG 239
Query: 792 G 794
G
Sbjct: 240 G 240
>sp|Q91X52|DCXR_MOUSE L-xylulose reductase (XR) (Dicarbonyl/L-xylulose reductase)
Length = 244
Score = 206 bits (524), Expect = 7e-53
Identities = 105/241 (43%), Positives = 152/241 (63%)
Frame = +3
Query: 72 LNYNFTGKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEVKC 251
++ G+ LVTG KGIG+ V L +GA+V+++SR+ + E +E V
Sbjct: 1 MDLGLAGRRALVTGAGKGIGRSTVLALKAAGAQVVAVSRTREDLDDLVREC-PGVEPVCV 59
Query: 252 DISKWDEVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVA 431
D++ W+ + ++ PVD LVNNAA+ L F E+ + D FN N++A+I +SQ+VA
Sbjct: 60 DLADWEATEQALSNVGPVDLLVNNAAVALLQPFLEVTKEACDTSFNVNLRAVIQVSQIVA 119
Query: 432 SDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNP 611
R + G IVNVSSQASQRA+ + YC+ K A+D +T+ MALELGP IRVN+VNP
Sbjct: 120 KGMIARGVPGAIVNVSSQASQRALTNHTVYCSTKGALDMLTKMMALELGPHKIRVNAVNP 179
Query: 612 TAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIIFLLTNCCTLVTGSTIPIDG 791
T ++T MG+ WS+P + + R+PL + EV VVD I+FLL+N + TGST+P+DG
Sbjct: 180 TVVMTPMGRTNWSDPHKAKAMLDRIPLGKFAEVENVVDTILFLLSNRSGMTTGSTLPVDG 239
Query: 792 G 794
G
Sbjct: 240 G 240
>sp|Q920P0|DCXR_RAT L-xylulose reductase (XR) (Dicarbonyl/L-xylulose reductase)
Length = 244
Score = 205 bits (521), Expect = 2e-52
Identities = 104/241 (43%), Positives = 152/241 (63%)
Frame = +3
Query: 72 LNYNFTGKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEVKC 251
++ G+ LVTG KGIG+ V L +GA+V+++SR+ S+ E +E V
Sbjct: 1 MDLGLAGRRALVTGAGKGIGRSTVLALQAAGAQVVAVSRTREDLDSLVREC-PGVEPVCV 59
Query: 252 DISKWDEVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVA 431
D++ W+ + ++ PVD LVNNAA+ L F E+ + D FN N +A++ +SQ+VA
Sbjct: 60 DLADWEATEQALSNVGPVDLLVNNAAVATLQPFLEVTKEACDTSFNVNFRAVVQVSQIVA 119
Query: 432 SDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNP 611
R + G IVNVSSQASQRA+ + YC+ K A+D +T+ MALELGP IRVN+VNP
Sbjct: 120 RGMIARGVPGAIVNVSSQASQRALTNHTVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179
Query: 612 TAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIIFLLTNCCTLVTGSTIPIDG 791
T ++T MG+ WS+P + + R+PL + EV VVD I+FLL+N ++ TGS +P+DG
Sbjct: 180 TVVMTPMGRANWSDPHKAKVMLDRIPLGKFAEVENVVDTILFLLSNRSSMTTGSALPVDG 239
Query: 792 G 794
G
Sbjct: 240 G 240
>sp|Q8JIS3|DER_CHICK D-erythrulose reductase
Length = 246
Score = 199 bits (506), Expect = 9e-51
Identities = 100/243 (41%), Positives = 158/243 (65%)
Frame = +3
Query: 66 MTLNYNFTGKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEV 245
M + +F G+ LVTG KGIG+ + L ++GARV +LSR+ S+ E IE +
Sbjct: 1 MEPDLSFRGRRALVTGAGKGIGRAVAVALCKAGARVTALSRTAADLESLVREC-PGIEPL 59
Query: 246 KCDISKWDEVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQV 425
D++ WD + V + P + LVNNAA+ L F ++ ++ F+ N +A++++SQ+
Sbjct: 60 CLDLADWDATEAAVGAAGPFELLVNNAAVAMLQPFLQVTREAVERSFDVNFRAVLHVSQI 119
Query: 426 VASDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSV 605
VA + + G IVNVSSQASQRA+ D YC+ K+A+D +++ MA+ELGP IRVN+V
Sbjct: 120 VARQMIAQGLPGAIVNVSSQASQRALRDHAVYCSTKSALDMLSKVMAMELGPHKIRVNTV 179
Query: 606 NPTAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIIFLLTNCCTLVTGSTIPI 785
NPT ++TDMG++ WS+P + +R+PL + EV++VV+ I+FLL++ + TGS++ +
Sbjct: 180 NPTVVMTDMGRINWSDPQKSAAMINRIPLGKFAEVDDVVNSILFLLSDKSAMTTGSSLMV 239
Query: 786 DGG 794
DGG
Sbjct: 240 DGG 242
>sp|Q920N9|DCXR_CAVPO L-xylulose reductase (XR) (Dicarbonyl/L-xylulose reductase)
(Protein P26h)
Length = 244
Score = 197 bits (502), Expect = 3e-50
Identities = 102/241 (42%), Positives = 149/241 (61%)
Frame = +3
Query: 72 LNYNFTGKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEVKC 251
++ G+ LVTG KGIG+ V L +GA+V+++SR+ + E +E V
Sbjct: 1 MDLGLAGRRALVTGAGKGIGRSTVLALKAAGAQVVAVSRTREDLDDLVREC-PGVEPVCV 59
Query: 252 DISKWDEVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVA 431
D++ W+ + ++ P D LVNNAA+ L F E+ + FN N++A+I +SQ+VA
Sbjct: 60 DLADWEATEQALSNVGPADLLVNNAAVALLQPFLEVTKEACVTSFNVNLRAVIQVSQIVA 119
Query: 432 SDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNP 611
R + G IVNVSSQASQRA+ + YC+ K A+ +T+ MALELGP IRVN+VNP
Sbjct: 120 KGMIARGVPGAIVNVSSQASQRALTNHTVYCSTKGALYMLTKMMALELGPHKIRVNAVNP 179
Query: 612 TAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIIFLLTNCCTLVTGSTIPIDG 791
T ++T MG+ WS+P + + R+PL + EV VVD I+FLL+N + TGST+P+DG
Sbjct: 180 TVVMTPMGRTNWSDPHKAKAMLDRIPLGKFAEVENVVDTILFLLSNRSGMTTGSTLPVDG 239
Query: 792 G 794
G
Sbjct: 240 G 240
>sp|Q21929|CBR2_CAEEL Probable carbonyl reductase [NADPH] (NADPH-dependent carbonyl
reductase)
Length = 251
Score = 184 bits (466), Expect = 4e-46
Identities = 100/228 (43%), Positives = 149/228 (65%), Gaps = 4/228 (1%)
Frame = +3
Query: 123 GIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVS---NIEEVKCDISKWDEVN-SIVK 290
GIGK + LA++GA+VI+ +R+ S+ E S I + D+S +EV ++
Sbjct: 20 GIGKEICLSLAKAGAQVIAFARNEANLLSLVKETTSLRYTIIPIVGDVSANEEVLFKLIV 79
Query: 291 SLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVASDWKTRHIEGVIV 470
P+ LVNNA I + G+I + ID F NV+ I I+Q+VA ++ R I+G IV
Sbjct: 80 PHFPIHGLVNNAGIATNHAIGQITQQSIDRTFAVNVRGPILIAQLVARNFVDRQIKGSIV 139
Query: 471 NVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNPTAILTDMGKLYWS 650
N+SSQA+ R + + YCA+KAA+D +TR +A ELG IRVNSVNPT ++TDMG+ WS
Sbjct: 140 NISSQAAIRPLDNHTVYCASKAALDMVTRCLANELGSQNIRVNSVNPTVVMTDMGRDNWS 199
Query: 651 EPSNKEKLTSRMPLRRLGEVNEVVDVIIFLLTNCCTLVTGSTIPIDGG 794
+P K+K+ RMP++R EV+EVV+ ++FLL++ ++ TGST+P+DGG
Sbjct: 200 DPDKKKKMLDRMPIKRFAEVDEVVNAVLFLLSDNASMTTGSTLPVDGG 247
>sp|P08074|CBR2_MOUSE Lung carbonyl reductase [NADPH] (NADPH-dependent carbonyl
reductase) (LCR) (Adipocyte P27 protein) (AP27)
Length = 244
Score = 181 bits (458), Expect = 3e-45
Identities = 98/241 (40%), Positives = 144/241 (59%)
Frame = +3
Query: 72 LNYNFTGKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEVKC 251
+ NF+G LVTG KGIG+ V+ L SGA+V++++R+ S+ E IE V
Sbjct: 1 MKLNFSGLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDLVSLAKEC-PGIEPVCV 59
Query: 252 DISKWDEVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVA 431
D+ WD + + PVD LVNNAA++ + F E+ + D F+ N++++ +SQ+VA
Sbjct: 60 DLGDWDATEKALGGIGPVDLLVNNAALVIMQPFLEVTKEAFDRSFSVNLRSVFQVSQMVA 119
Query: 432 SDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNP 611
D R + G IVNVSS + + +TY + K A+ +T+ MA+ELGP IRVNSVNP
Sbjct: 120 RDMINRGVPGSIVNVSSMVAHVTFPNLITYSSTKGAMTMLTKAMAMELGPHKIRVNSVNP 179
Query: 612 TAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIIFLLTNCCTLVTGSTIPIDG 791
T +LTDMGK ++P KL R PLR+ EV +VV+ I+FLL++ +G I +D
Sbjct: 180 TVVLTDMGKKVSADPEFARKLKERHPLRKFAEVEDVVNSILFLLSDRSASTSGGGILVDA 239
Query: 792 G 794
G
Sbjct: 240 G 240
>sp|Q29529|CBR2_PIG Lung carbonyl reductase [NADPH] (NADPH-dependent carbonyl
reductase) (LCR)
Length = 244
Score = 176 bits (447), Expect = 6e-44
Identities = 97/241 (40%), Positives = 141/241 (58%)
Frame = +3
Query: 72 LNYNFTGKTVLVTGGSKGIGKYLVQELAESGARVISLSRSIGTSFSIKSEAVSNIEEVKC 251
+ NF+G LVTG KGIG+ V+ L SGARV++++R+ G S+ E IE V
Sbjct: 1 MQMNFSGLRALVTGAGKGIGRDTVKALHVSGARVVAVTRTNGDLVSLSQEC-PGIEPVCV 59
Query: 252 DISKWDEVNSIVKSLLPVDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQVVA 431
D+ W+ + + PVD LVNNAA+ + F + + D FN N++++ +SQ+VA
Sbjct: 60 DLGDWEATERALGGVGPVDLLVNNAAVALMQPFLDTTKEVFDRSFNVNLRSVFQVSQIVA 119
Query: 432 SDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSVNP 611
R + G IVNVSS S Y + K A+ +T++MA+ELGP IRVNSVNP
Sbjct: 120 RSMIERGVPGSIVNVSSMVSHVTYPGLAAYSSTKGAMTMLTKSMAMELGPHKIRVNSVNP 179
Query: 612 TAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIIFLLTNCCTLVTGSTIPIDG 791
T +LT MG+ S+P KL R P+R+ EV +VV+ I+FLL++ +GS+I +D
Sbjct: 180 TVVLTAMGRSVTSDPELARKLKERHPMRKFAEVEDVVNSILFLLSDRSASTSGSSIFVDA 239
Query: 792 G 794
G
Sbjct: 240 G 240
>sp|Q8CPI3|FABG_STAES 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
Length = 244
Score = 120 bits (302), Expect = 4e-27
Identities = 80/245 (32%), Positives = 128/245 (52%), Gaps = 9/245 (3%)
Frame = +3
Query: 93 KTVLVTGGSKGIGKYLVQELAESGARVI-----SLSRSIGTSFSIKSEAVSNIEEVKCDI 257
K+ LVTG S+GIG+ + +LAE G V S ++ IK++ V + ++ ++
Sbjct: 3 KSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKDKAEAVVEEIKAKGVESFA-IQANV 61
Query: 258 SKWDEVNSIVKSLLP----VDYLVNNAAILKLNKFGEIGEVEIDEVFNTNVKAIINISQV 425
+K DEV ++K ++ VD LVNNA I K N + E E D+V +TN+K + N Q
Sbjct: 62 AKGDEVKEMIKEVVSQFGSVDVLVNNAGITKDNLLMRMKEQEWDDVIDTNLKGVFNCIQK 121
Query: 426 VASDWKTRHIEGVIVNVSSQASQRAVVDFMTYCAAKAAVDAITRNMALELGPFGIRVNSV 605
V R G I+N++S Y A KA V +T+ A EL GI VN+V
Sbjct: 122 VTPQ-MLRQRSGAIINLTSIVGAMGNPGQANYVATKAGVIGLTKTAARELASRGITVNAV 180
Query: 606 NPTAILTDMGKLYWSEPSNKEKLTSRMPLRRLGEVNEVVDVIIFLLTNCCTLVTGSTIPI 785
P I++DM K+++ ++PL+R GE ++ + + FL ++ +TG TI +
Sbjct: 181 APGFIVSDMTNAL--SDDLKDQMLEQIPLKRFGEDTDIANTVAFLASDKAKYITGQTIHV 238
Query: 786 DGGCW 800
+GG +
Sbjct: 239 NGGMY 243
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,639,767
Number of Sequences: 369166
Number of extensions: 1894496
Number of successful extensions: 6250
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5630
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5835
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9078450570
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)