Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_J10
(631 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q99873|ANM1_HUMAN Protein arginine N-methyltransferase 1... 209 5e-54
sp|Q63009|ANM1_RAT Protein arginine N-methyltransferase 1 207 1e-53
sp|Q9JIF0|ANM1_MOUSE Protein arginine N-methyltransferase 1 207 1e-53
sp|Q9NR22|ANM4_HUMAN Protein arginine N-methyltransferase 4... 205 7e-53
sp|Q6PAK3|ANM4_MOUSE Protein arginine N-methyltransferase 4... 205 7e-53
sp|Q9URX7|ANM1_SCHPO Probable protein arginine N-methyltran... 150 3e-36
sp|P38074|HMT1_YEAST HNRNP arginine N-methyltransferase (OD... 124 2e-28
sp|O60678|ANM3_HUMAN Protein arginine N-methyltransferase 3... 117 2e-26
sp|O70467|ANM3_RAT Protein arginine N-methyltransferase 3 (... 115 7e-26
sp|Q922H1|ANM3_MOUSE Protein arginine N-methyltransferase 3... 109 5e-24
>sp|Q99873|ANM1_HUMAN Protein arginine N-methyltransferase 1 (Interferon receptor 1-bound
protein 4)
Length = 361
Score = 209 bits (532), Expect = 5e-54
Identities = 94/141 (66%), Positives = 119/141 (84%)
Frame = +1
Query: 1 VLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVYGFDMSCIRKVAVSEPL 180
VL+ARDKWL G+I PD+ATL++ AIEDRQYKD KI+WWENVYGFDMSCI+ VA+ EPL
Sbjct: 167 VLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPL 226
Query: 181 VDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDYIHALVAFFNIDFTSSH 360
VDVV+P Q+V+N C++KEV++Y +KVEDL+F+SPF L V++NDY+HALVA+FNI+FT H
Sbjct: 227 VDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCH 286
Query: 361 KHIGFSTGPSDRRGTHWKQTL 423
K GFST P + THWKQT+
Sbjct: 287 KRTGFSTSP-ESPYTHWKQTV 306
Score = 55.1 bits (131), Expect = 1e-07
Identities = 22/47 (46%), Positives = 35/47 (74%)
Frame = +3
Query: 420 VNNGEEVTGMFSLKPNARNNRDLDISIDVKFRGKISQMEETFNYRMR 560
V GEE+ G ++PNA+NNRDLD +ID+ F+G++ ++ + +YRMR
Sbjct: 315 VKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR 361
>sp|Q63009|ANM1_RAT Protein arginine N-methyltransferase 1
Length = 353
Score = 207 bits (528), Expect = 1e-53
Identities = 94/141 (66%), Positives = 118/141 (83%)
Frame = +1
Query: 1 VLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVYGFDMSCIRKVAVSEPL 180
VL ARDKWL G+I PD+ATL++ AIEDRQYKD KI+WWENVYGFDMSCI+ VA+ EPL
Sbjct: 159 VLHARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPL 218
Query: 181 VDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDYIHALVAFFNIDFTSSH 360
VDVV+P Q+V+N C++KEV++Y +KVEDL+F+SPF L V++NDY+HALVA+FNI+FT H
Sbjct: 219 VDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCH 278
Query: 361 KHIGFSTGPSDRRGTHWKQTL 423
K GFST P + THWKQT+
Sbjct: 279 KRTGFSTSP-ESPYTHWKQTV 298
Score = 55.1 bits (131), Expect = 1e-07
Identities = 22/47 (46%), Positives = 35/47 (74%)
Frame = +3
Query: 420 VNNGEEVTGMFSLKPNARNNRDLDISIDVKFRGKISQMEETFNYRMR 560
V GEE+ G ++PNA+NNRDLD +ID+ F+G++ ++ + +YRMR
Sbjct: 307 VKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR 353
>sp|Q9JIF0|ANM1_MOUSE Protein arginine N-methyltransferase 1
Length = 371
Score = 207 bits (528), Expect = 1e-53
Identities = 94/141 (66%), Positives = 118/141 (83%)
Frame = +1
Query: 1 VLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVYGFDMSCIRKVAVSEPL 180
VL ARDKWL G+I PD+ATL++ AIEDRQYKD KI+WWENVYGFDMSCI+ VA+ EPL
Sbjct: 177 VLHARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPL 236
Query: 181 VDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDYIHALVAFFNIDFTSSH 360
VDVV+P Q+V+N C++KEV++Y +KVEDL+F+SPF L V++NDY+HALVA+FNI+FT H
Sbjct: 237 VDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCH 296
Query: 361 KHIGFSTGPSDRRGTHWKQTL 423
K GFST P + THWKQT+
Sbjct: 297 KRTGFSTSP-ESPYTHWKQTV 316
Score = 55.1 bits (131), Expect = 1e-07
Identities = 22/47 (46%), Positives = 35/47 (74%)
Frame = +3
Query: 420 VNNGEEVTGMFSLKPNARNNRDLDISIDVKFRGKISQMEETFNYRMR 560
V GEE+ G ++PNA+NNRDLD +ID+ F+G++ ++ + +YRMR
Sbjct: 325 VKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR 371
>sp|Q9NR22|ANM4_HUMAN Protein arginine N-methyltransferase 4 (Heterogeneous nuclear
ribonucleoprotein methyltransferase-like protein 4)
Length = 334
Score = 205 bits (522), Expect = 7e-53
Identities = 90/141 (63%), Positives = 118/141 (83%)
Frame = +1
Query: 1 VLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVYGFDMSCIRKVAVSEPL 180
V+FARDKWLK GG++ PD+A L++ AIEDRQYKD KI+WWENVYGFDM+CIR VA+ EPL
Sbjct: 140 VIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPL 199
Query: 181 VDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDYIHALVAFFNIDFTSSH 360
VD+V+P Q+V+N C++KEV++Y +K E+LSF+S F L +++NDY+HALV +FNI+FT H
Sbjct: 200 VDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCH 259
Query: 361 KHIGFSTGPSDRRGTHWKQTL 423
K +GFST P D THWKQT+
Sbjct: 260 KKMGFSTAP-DAPYTHWKQTV 279
Score = 52.0 bits (123), Expect = 1e-06
Identities = 21/47 (44%), Positives = 34/47 (72%)
Frame = +3
Query: 420 VNNGEEVTGMFSLKPNARNNRDLDISIDVKFRGKISQMEETFNYRMR 560
V GEE+ G S+KPNA+N RDLD ++D+ F+G++ + + +Y+MR
Sbjct: 288 VRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR 334
>sp|Q6PAK3|ANM4_MOUSE Protein arginine N-methyltransferase 4 (Heterogeneous nuclear
ribonucleoprotein methyltransferase-like protein 4)
Length = 394
Score = 205 bits (522), Expect = 7e-53
Identities = 90/141 (63%), Positives = 118/141 (83%)
Frame = +1
Query: 1 VLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVYGFDMSCIRKVAVSEPL 180
V+FARDKWLK GG++ PD+A L++ AIEDRQYKD KI+WWENVYGFDM+CIR VA+ EPL
Sbjct: 200 VIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPL 259
Query: 181 VDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDYIHALVAFFNIDFTSSH 360
VD+V+P Q+V+N C++KEV++Y +K E+LSF+S F L +++NDY+HALV +FNI+FT H
Sbjct: 260 VDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCH 319
Query: 361 KHIGFSTGPSDRRGTHWKQTL 423
K +GFST P D THWKQT+
Sbjct: 320 KKMGFSTAP-DAPYTHWKQTV 339
Score = 52.0 bits (123), Expect = 1e-06
Identities = 21/47 (44%), Positives = 34/47 (72%)
Frame = +3
Query: 420 VNNGEEVTGMFSLKPNARNNRDLDISIDVKFRGKISQMEETFNYRMR 560
V GEE+ G S+KPNA+N RDLD ++D+ F+G++ + + +Y+MR
Sbjct: 348 VRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR 394
>sp|Q9URX7|ANM1_SCHPO Probable protein arginine N-methyltransferase
Length = 339
Score = 150 bits (379), Expect = 3e-36
Identities = 70/146 (47%), Positives = 102/146 (69%)
Frame = +1
Query: 1 VLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVYGFDMSCIRKVAVSEPL 180
VL ARD++L G++ PD+A + L AIED YK EKI +W++VYGFD S I+K EPL
Sbjct: 143 VLVARDRYLAPDGLLFPDRAQIQLAAIEDADYKSEKIGFWDDVYGFDFSPIKKDVWKEPL 202
Query: 181 VDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDYIHALVAFFNIDFTSSH 360
VD V+ + +N C++ ++++ +K EDL+FSSPF + +ND++HA +A+F+I+F++ H
Sbjct: 203 VDTVDRIAVNTNSCVILDLDLKTVKKEDLAFSSPFEITATRNDFVHAFLAWFDIEFSACH 262
Query: 361 KHIGFSTGPSDRRGTHWKQTLITGRK 438
K I FSTGP R THWKQT+ K
Sbjct: 263 KPIKFSTGPFSRY-THWKQTVFYTHK 287
Score = 31.6 bits (70), Expect = 1.7
Identities = 18/52 (34%), Positives = 25/52 (48%), Gaps = 3/52 (5%)
Frame = +3
Query: 411 ETNVNNGEEVTGMFSLKPNARNNRDLDISIDVKFRGKISQME---ETFNYRM 557
+ V GE + G + KP N+R+LDI I F + E E +YRM
Sbjct: 288 DLTVKAGEYIRGTITCKPAEGNHRELDIDISYTFNprePNREPVSEDLSYRM 339
>sp|P38074|HMT1_YEAST HNRNP arginine N-methyltransferase (ODP1 protein)
Length = 348
Score = 124 bits (312), Expect = 2e-28
Identities = 61/143 (42%), Positives = 92/143 (64%), Gaps = 2/143 (1%)
Frame = +1
Query: 1 VLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVYGFDMSCIRKVAVSEPL 180
VL+ARD +L GG+I PDK ++HL +ED QYKDEK+N+W++VYGFD S + + EP+
Sbjct: 147 VLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPI 206
Query: 181 VDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDYIHALVAFFNIDFTS-- 354
VD V N + + + E ++ +K+ DL+F S F L ++ D I+ +V +F+I F +
Sbjct: 207 VDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPK 266
Query: 355 SHKHIGFSTGPSDRRGTHWKQTL 423
+ + FSTGP THWKQT+
Sbjct: 267 GKRPVEFSTGP-HAPYTHWKQTI 288
Score = 32.3 bits (72), Expect = 1.0
Identities = 13/34 (38%), Positives = 19/34 (55%)
Frame = +3
Query: 411 ETNVNNGEEVTGMFSLKPNARNNRDLDISIDVKF 512
+ + G+ + G PN +NNRDL+I I KF
Sbjct: 294 DLDAETGDTIEGELVCSPNEKNNRDLNIKISYKF 327
>sp|O60678|ANM3_HUMAN Protein arginine N-methyltransferase 3 (Heterogeneous nuclear
ribonucleoprotein methyltransferase-like protein 3)
Length = 531
Score = 117 bits (294), Expect = 2e-26
Identities = 54/142 (38%), Positives = 89/142 (62%), Gaps = 1/142 (0%)
Frame = +1
Query: 1 VLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVYGFDMSCIRKVAVSEPL 180
VL+A++K+L GG + PD T+ L A+ D ++I +W++VYGF MSC++K + E +
Sbjct: 344 VLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAV 403
Query: 181 VDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDYIHALVAFFNIDFTSS- 357
V+V++P ++S C +K ++ + + DL FSS FTL + + A+ +F+I F +
Sbjct: 404 VEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNC 463
Query: 358 HKHIGFSTGPSDRRGTHWKQTL 423
H + FSTGP + THWKQT+
Sbjct: 464 HNRVVFSTGPQSTK-THWKQTV 484
>sp|O70467|ANM3_RAT Protein arginine N-methyltransferase 3 (Heterogeneous nuclear
ribonucleoprotein methyltransferase-like protein 3)
Length = 528
Score = 115 bits (289), Expect = 7e-26
Identities = 55/142 (38%), Positives = 88/142 (61%), Gaps = 1/142 (0%)
Frame = +1
Query: 1 VLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVYGFDMSCIRKVAVSEPL 180
VL+A+ K+L GG + PD T+ L A+ D ++I +W++VYGF+MSC++K + E +
Sbjct: 341 VLYAKSKYLAKGGSVYPDICTISLVAVSDVSKHADRIAFWDDVYGFNMSCMKKAVIPEAV 400
Query: 181 VDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDYIHALVAFFNIDFTSS- 357
V+VV+ ++S+ C +K ++ + + DL FSS FTL K A+ +F+I F +
Sbjct: 401 VEVVDHKTLISDPCDIKHIDCHTTSISDLEFSSDFTLRTTKTAMCTAVAGYFDIYFEKNC 460
Query: 358 HKHIGFSTGPSDRRGTHWKQTL 423
H + FSTGP + THWKQT+
Sbjct: 461 HNRVVFSTGPQSTK-THWKQTI 481
>sp|Q922H1|ANM3_MOUSE Protein arginine N-methyltransferase 3 (Heterogeneous nuclear
ribonucleoprotein methyltransferase-like protein 3)
Length = 532
Score = 109 bits (273), Expect = 5e-24
Identities = 55/146 (37%), Positives = 88/146 (60%), Gaps = 5/146 (3%)
Frame = +1
Query: 1 VLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVYGFDMSCIRKVAVSEPL 180
VL+A+ K+L GG + PD T+ L A+ D ++I +W++VYGF+MSC++K + E +
Sbjct: 341 VLYAKSKYLAKGGSVYPDICTISLVAVSDVSKHADRIAFWDDVYGFNMSCMKKAVIPEAV 400
Query: 181 VDVVNPNQIVSNFCIV----KEVNMYEIKVEDLSFSSPFTLAVRKNDYIHALVAFFNIDF 348
V+VV+ ++S+ C + K ++ + + DL FSS FTL K A+ +F+I F
Sbjct: 401 VEVVDHKTLISDPCDIKMDGKHIDCHTTSISDLEFSSDFTLRTTKTAMCTAVAGYFDIYF 460
Query: 349 TSS-HKHIGFSTGPSDRRGTHWKQTL 423
+ H + FSTGP + THWKQT+
Sbjct: 461 EKNCHNRVVFSTGPQSTK-THWKQTV 485
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,138,767
Number of Sequences: 369166
Number of extensions: 1306308
Number of successful extensions: 3190
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3112
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3183
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5023626210
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)