Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_J06
(649 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 233 2e-61
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 232 5e-61
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 230 2e-60
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 229 5e-60
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 228 1e-59
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 226 5e-59
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 224 1e-58
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 224 1e-58
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 223 3e-58
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 218 8e-57
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 233 bits (595), Expect = 2e-61
Identities = 113/195 (57%), Positives = 137/195 (70%), Gaps = 2/195 (1%)
Frame = +2
Query: 2 SCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-I 178
SCW+FS+TG+LEGQ+FRK+ L+S SEQ LVDCS LMDNAFRYIKD G I
Sbjct: 147 SCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGI 206
Query: 179 ESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHAS 358
++E YPY A D +C N + GFTDI +E +A AVATVGPVSVAIDA H S
Sbjct: 207 DTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHES 266
Query: 359 FQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDK 535
FQ Y G+YNE C LDHGVL VG+GT + G+ YW+VKNSW TWG+ G+IKM ++K
Sbjct: 267 FQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNK 326
Query: 536 KNQCGIATMASYPLV 580
+NQCGIA+ +SYPLV
Sbjct: 327 ENQCGIASASSYPLV 341
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 232 bits (592), Expect = 5e-61
Identities = 114/195 (58%), Positives = 134/195 (68%), Gaps = 2/195 (1%)
Frame = +2
Query: 2 SCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-I 178
SCW+FS+TG+LEGQ+FRK L+S SEQ LVDCS LMDNAFRYIKD G I
Sbjct: 145 SCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGI 204
Query: 179 ESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHAS 358
++E YPY D +C N + I TGF DI +E + AVAT+GPVSVAIDA H S
Sbjct: 205 DTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHES 264
Query: 359 FQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDK 535
FQLY G+YNE C LDHGVL VGYGT + G YW+VKNSW TWGE GYIKM++++
Sbjct: 265 FQLYSEGVYNEPECDEQNLDHGVLVVGYGTDESGMDYWLVKNSWGTTWGEQGYIKMARNQ 324
Query: 536 KNQCGIATMASYPLV 580
NQCGIAT +SYP V
Sbjct: 325 NNQCGIATASSYPTV 339
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 230 bits (587), Expect = 2e-60
Identities = 116/195 (59%), Positives = 134/195 (68%), Gaps = 2/195 (1%)
Frame = +2
Query: 2 SCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-I 178
SCW+FSATG+LEGQ FRK +L+S SEQ LVD S LMDNAF+YIK+ G +
Sbjct: 24 SCWAFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQGNQGCNGGLMDNAFQYIKENGGL 83
Query: 179 ESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHAS 358
+SE YPY ATD +C P K TGF DI Q E L AVATVGP+SVAIDAGH+S
Sbjct: 84 DSEESYPYEATDTSCNYKPEYSAAKDTGFVDIP-QREKALMKAVATVGPISVAIDAGHSS 142
Query: 359 FQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ-IGKKYWIVKNSWDVTWGESGYIKMSKDK 535
FQ YKSGIY + CS+ LDHGVL VGYG + K+WIVKNSW WG GY+KM+KD+
Sbjct: 143 FQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKFWIVKNSWGPEWGNKGYVKMAKDQ 202
Query: 536 KNQCGIATMASYPLV 580
N CGIAT ASYP V
Sbjct: 203 NNHCGIATAASYPTV 217
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 229 bits (584), Expect = 5e-60
Identities = 107/194 (55%), Positives = 140/194 (72%), Gaps = 1/194 (0%)
Frame = +2
Query: 2 SCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIK-DQGI 178
SCW+FS TGSLEGQ+F K LIS +EQQLVDCS M++AF YIK + GI
Sbjct: 130 SCWAFSTTGSLEGQHFLKTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGI 189
Query: 179 ESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHAS 358
++E YPY A DG+C+ + + + C+G T+I S +ET L AV +GP+SV IDA H+S
Sbjct: 190 DTEAAYPYEARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSS 249
Query: 359 FQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKK 538
FQ Y SG+Y E SCS + LDH VLAVGYG++ G+ +W+VKNSW +WG++GYIKMS+++
Sbjct: 250 FQFYSSGVYYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRN 309
Query: 539 NQCGIATMASYPLV 580
N CGIAT+ASYPLV
Sbjct: 310 NNCGIATVASYPLV 323
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 228 bits (580), Expect = 1e-59
Identities = 115/198 (58%), Positives = 134/198 (67%), Gaps = 5/198 (2%)
Frame = +2
Query: 2 SCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-I 178
SCW+FSATG+LEGQ FRK RLIS SEQ LVDCS LMD AF+Y++D G +
Sbjct: 137 SCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGL 196
Query: 179 ESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHAS 358
+SE YPY AT+ +CK NP V TGF DI Q E L AVATVGP+SVAIDAGH S
Sbjct: 197 DSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHES 255
Query: 359 FQLYKSGIYNEESCSTTQLDHGVLAVGYGTQI----GKKYWIVKNSWDVTWGESGYIKMS 526
F YK GIY E CS+ +DHGVL VGYG + KYW+VKNSW WG GY+KM+
Sbjct: 256 FLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMA 315
Query: 527 KDKKNQCGIATMASYPLV 580
KD++N CGIA+ ASYP V
Sbjct: 316 KDRRNHCGIASAASYPTV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 226 bits (575), Expect = 5e-59
Identities = 117/199 (58%), Positives = 133/199 (66%), Gaps = 6/199 (3%)
Frame = +2
Query: 2 SCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-I 178
SCW+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+YIKD G +
Sbjct: 137 SCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGL 196
Query: 179 ESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHA 355
+SE YPY ATD +C P TGF DI Q E L AVATVGP+SVAIDAGH
Sbjct: 197 DSEESYPYLATDTNSCNYKPECSAANDTGFVDIP-QREKALMKAVATVGPISVAIDAGHT 255
Query: 356 SFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKKYWIVKNSWDVTWGESGYIKM 523
SFQ YKSGIY + CS LDHGVL VGYG + K+WIVKNSW WG +GY+KM
Sbjct: 256 SFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKM 315
Query: 524 SKDKKNQCGIATMASYPLV 580
+KD+ N CGIAT ASYP V
Sbjct: 316 AKDQNNHCGIATAASYPTV 334
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 224 bits (572), Expect = 1e-58
Identities = 111/198 (56%), Positives = 130/198 (65%), Gaps = 5/198 (2%)
Frame = +2
Query: 2 SCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-I 178
SCW+FSATG+LEGQ FRK +L+S SEQ LVDCS M AF+Y+K+ G +
Sbjct: 137 SCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGL 196
Query: 179 ESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHAS 358
+SE YPY A D CK P V TGFT + E L AVATVGP+SVA+DAGH+S
Sbjct: 197 DSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSS 256
Query: 359 FQLYKSGIYNEESCSTTQLDHGVLAVGYG----TQIGKKYWIVKNSWDVTWGESGYIKMS 526
FQ YKSGIY E CS+ LDHGVL VGYG KYW+VKNSW WG +GY+K++
Sbjct: 257 FQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIA 316
Query: 527 KDKKNQCGIATMASYPLV 580
KDK N CGIAT ASYP V
Sbjct: 317 KDKNNHCGIATAASYPNV 334
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 224 bits (572), Expect = 1e-58
Identities = 115/198 (58%), Positives = 132/198 (66%), Gaps = 5/198 (2%)
Frame = +2
Query: 2 SCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-I 178
SCW+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAFRY+KD G +
Sbjct: 137 SCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGL 196
Query: 179 ESEGDYPYTATDG-TCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHA 355
+SE YPY D TC P TGF D+ Q E L AVAT+GP+SVAIDAGH
Sbjct: 197 DSEESYPYLGRDTETCNYKPECSAANDTGFVDLP-QREKALMKAVATLGPISVAIDAGHQ 255
Query: 356 SFQLYKSGIYNEESCSTTQLDHGVLAVGY---GTQIGKKYWIVKNSWDVTWGESGYIKMS 526
SFQ YKSGIY + CS+ LDHGVL VGY GT K+WIVKNSW WG +GY+KM+
Sbjct: 256 SFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGYVKMA 315
Query: 527 KDKKNQCGIATMASYPLV 580
KD+ N CGIAT ASYP V
Sbjct: 316 KDQNNHCGIATAASYPTV 333
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 223 bits (569), Expect = 3e-58
Identities = 109/194 (56%), Positives = 137/194 (70%), Gaps = 1/194 (0%)
Frame = +2
Query: 2 SCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-I 178
SCW+FSATG+LEGQ+F KN+ L+S SEQQLVDCS M +AF YIKD G I
Sbjct: 129 SCWAFSATGALEGQHFLKNDELVSLSEQQLVDCSTDYGNDGCGGGWMTSAFDYIKDNGGI 188
Query: 179 ESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHAS 358
++E YPY A D +C+ + + I CTG ++Q E L AV+ VGP+SVAIDA H S
Sbjct: 189 DTESSYPYEAEDRSCRFDANSIGAICTGSVEVQHTEEA-LQEAVSGVGPISVAIDASHFS 247
Query: 359 FQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKK 538
FQ Y SG+Y E++CS T LDHGVLAVGYGT+ K YW+VKNSW +WG++GYIKMS+++
Sbjct: 248 FQFYSSGVYYEQNCSPTFLDHGVLAVGYGTESTKDYWLVKNSWGSSWGDAGYIKMSRNRD 307
Query: 539 NQCGIATMASYPLV 580
N CGIA+ SYP V
Sbjct: 308 NNCGIASEPSYPTV 321
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 218 bits (556), Expect = 8e-57
Identities = 111/199 (55%), Positives = 133/199 (66%), Gaps = 6/199 (3%)
Frame = +2
Query: 2 SCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-I 178
SCW+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+Y+KD G +
Sbjct: 137 SCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQYVKDNGGL 196
Query: 179 ESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHA 355
++E YPY + +C P TGF DI Q E L AVATVGP+SVAIDAGH+
Sbjct: 197 DTEESYPYLGRETNSCTYKPECSAANDTGFVDIP-QREKALMKAVATVGPISVAIDAGHS 255
Query: 356 SFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKKYWIVKNSWDVTWGESGYIKM 523
SFQ YKSGIY + CS+ LDHGVL VGYG + K+WIVKNSW WG +GY+KM
Sbjct: 256 SFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNSSKFWIVKNSWGPEWGWNGYVKM 315
Query: 524 SKDKKNQCGIATMASYPLV 580
+KD+ N CGI+T ASYP V
Sbjct: 316 AKDQNNHCGISTAASYPTV 334
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,917,134
Number of Sequences: 369166
Number of extensions: 1336467
Number of successful extensions: 4233
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3727
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3812
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5316264630
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)