Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_I24
(840 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinas... 138 2e-32
sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinas... 137 5e-32
sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinas... 137 5e-32
sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase kinas... 134 4e-31
sp|P23561|STE11_YEAST Serine/threonine-protein kinase STE11 131 3e-30
sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinas... 126 9e-29
sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinas... 125 1e-28
sp|O95382|M3K6_HUMAN Mitogen-activated protein kinase kinas... 124 4e-28
sp|O08648|M3K4_MOUSE Mitogen-activated protein kinase kinas... 123 6e-28
sp|Q9Y6R4|M3K4_HUMAN Mitogen-activated protein kinase kinas... 123 7e-28
>sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinase kinase 3 (Arabidospsis
NPK1-related protein kinase 3)
Length = 651
Score = 138 bits (347), Expect = 2e-32
Identities = 89/232 (38%), Positives = 124/232 (53%), Gaps = 4/232 (1%)
Frame = +3
Query: 135 QYRDNLEHDNIVKYFGAINKQWKIFIFMEFIDGGSISEKISLNNYQPLPVETIKLYTKQI 314
Q NL H NIV+Y G + + + I MEF+ GGSIS L + P I +YTKQ+
Sbjct: 123 QLLKNLSHPNIVRYLGTVRESDSLNILMEFVPGGSISSL--LEKFGSFPEPVIIMYTKQL 180
Query: 315 LCGLKFLHQSRIIHRDIKSIYLFKSSLFDFLI*IGANILITKQDCIKIVDFGWSRF---L 485
L GL++LH + I+HRDIK GANIL+ + CI++ DFG S+ L
Sbjct: 181 LLGLEYLHNNGIMHRDIK----------------GANILVDNKGCIRLADFGASKKVVEL 224
Query: 486 QTVSRQEKKKKTFCGTANYMSPEVINDEPYGFPADIWSVGATVFEMATGRPPYHSVKNEI 665
TV+ + K GT +M+PEVI + F ADIWSVG TV EMATG+PP+ +
Sbjct: 225 ATVNGAKSMK----GTPYWMAPEVILQTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQF 280
Query: 666 AVGVKIANTKQLENSKILEK-DEETKQFIDLMTKADPNERKTADQLLNYHYL 818
A + I TK + I E E K F+ +P+ R +A +LL + ++
Sbjct: 281 AAVLHIGRTK--AHPPIPEDLSPEAKDFLMKCLHKEPSLRLSATELLQHPFV 330
>sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinase kinase 2 (Arabidospsis
NPK1-related protein kinase 2)
Length = 651
Score = 137 bits (344), Expect = 5e-32
Identities = 86/228 (37%), Positives = 119/228 (52%), Gaps = 4/228 (1%)
Frame = +3
Query: 147 NLEHDNIVKYFGAINKQWKIFIFMEFIDGGSISEKISLNNYQPLPVETIKLYTKQILCGL 326
NL H NIV+Y G + + + I +EF+ GGSIS L + P ++ YT Q+L GL
Sbjct: 127 NLSHPNIVRYLGTVREDETLNILLEFVPGGSISSL--LEKFGAFPESVVRTYTNQLLLGL 184
Query: 327 KFLHQSRIIHRDIKSIYLFKSSLFDFLI*IGANILITKQDCIKIVDFGWSRF---LQTVS 497
++LH I+HRDIK GANIL+ Q CIK+ DFG S+ L T+S
Sbjct: 185 EYLHNHAIMHRDIK----------------GANILVDNQGCIKLADFGASKQVAELATIS 228
Query: 498 RQEKKKKTFCGTANYMSPEVINDEPYGFPADIWSVGATVFEMATGRPPYHSVKNEIAVGV 677
+ K GT +M+PEVI + F ADIWSVG TV EM TG+ P+ EIA
Sbjct: 229 GAKSMK----GTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEIAAIF 284
Query: 678 KIANTKQLENSKILEK-DEETKQFIDLMTKADPNERKTADQLLNYHYL 818
I TK + I + + F+ + +PN R TA +LL + ++
Sbjct: 285 HIGTTK--SHPPIPDNISSDANDFLLKCLQQEPNLRPTASELLKHPFV 330
>sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinase kinase 1 (Arabidospsis
NPK1-related protein kinase 1)
Length = 666
Score = 137 bits (344), Expect = 5e-32
Identities = 83/225 (36%), Positives = 120/225 (53%), Gaps = 1/225 (0%)
Frame = +3
Query: 147 NLEHDNIVKYFGAINKQWKIFIFMEFIDGGSISEKISLNNYQPLPVETIKLYTKQILCGL 326
NL H NIV+Y G + + + I +EF+ GGSIS L + P P ++ YT+Q+L GL
Sbjct: 128 NLSHPNIVRYLGTVREDDTLNILLEFVPGGSISSL--LEKFGPFPESVVRTYTRQLLLGL 185
Query: 327 KFLHQSRIIHRDIKSIYLFKSSLFDFLI*IGANILITKQDCIKIVDFGWSRFLQTVSRQE 506
++LH I+HRDIK GANIL+ + CIK+ DFG S+ + ++
Sbjct: 186 EYLHNHAIMHRDIK----------------GANILVDNKGCIKLADFGASKQVAELATMT 229
Query: 507 KKKKTFCGTANYMSPEVINDEPYGFPADIWSVGATVFEMATGRPPYHSVKNEIAVGVKIA 686
K + GT +M+PEVI + F ADIWSVG TV EM TG+ P+ E+A I
Sbjct: 230 GAK-SMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIG 288
Query: 687 NTKQLENSKILEK-DEETKQFIDLMTKADPNERKTADQLLNYHYL 818
TK + I + + K F+ + PN R TA +LL + ++
Sbjct: 289 TTK--SHPPIPDTLSSDAKDFLLKCLQEVPNLRPTASELLKHPFV 331
>sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (MAPK/ERK kinase
kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis
signal-regulating kinase 1) (ASK-1)
Length = 1374
Score = 134 bits (336), Expect = 4e-31
Identities = 92/231 (39%), Positives = 131/231 (56%), Gaps = 6/231 (2%)
Frame = +3
Query: 147 NLEHDNIVKYFGAINKQWKIFIFMEFIDGGSISEKISLNNYQPLP--VETIKLYTKQILC 320
+L+H NIV+Y G+ ++ I IFME + GGS+S + + + PL +TI YTKQIL
Sbjct: 731 HLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLR-SKWGPLKDNEQTIGFYTKQILE 789
Query: 321 GLKFLHQSRIIHRDIKSIYLFKSSLFDFLI*IGANILI-TKQDCIKIVDFGWSRFLQTVS 497
GLK+LH ++I+HRDIK G N+LI T +KI DFG S+ L ++
Sbjct: 790 GLKYLHDNQIVHRDIK----------------GDNVLINTYSGVLKISDFGTSKRLAGIN 833
Query: 498 RQEKKKKTFCGTANYMSPEVINDEP--YGFPADIWSVGATVFEMATGRPPYHSVKNEIAV 671
+TF GT YM+PE+I+ P YG ADIWS+G T+ EMATG+PP++ + A
Sbjct: 834 ---PCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAA 890
Query: 672 GVKIANTKQLENSKILEK-DEETKQFIDLMTKADPNERKTADQLLNYHYLK 821
K+ K + +I E E K FI + DP++R A+ LL +LK
Sbjct: 891 MFKVGMFK--VHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK 939
>sp|P23561|STE11_YEAST Serine/threonine-protein kinase STE11
Length = 738
Score = 131 bits (329), Expect = 3e-30
Identities = 83/234 (35%), Positives = 124/234 (52%)
Frame = +3
Query: 117 LEYDINQYRDNLEHDNIVKYFGAINKQWKIFIFMEFIDGGSISEKISLNNYQPLPVETIK 296
L++++N ++ L H+NIV Y+GA + + IF+E++ GGS+S LNNY P I
Sbjct: 522 LQHEMNLLKE-LHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSM--LNNYGPFEESLIT 578
Query: 297 LYTKQILCGLKFLHQSRIIHRDIKSIYLFKSSLFDFLI*IGANILITKQDCIKIVDFGWS 476
+T+QIL G+ +LH+ IIHRDIK GANILI + C+KI DFG S
Sbjct: 579 NFTRQILIGVAYLHKKNIIHRDIK----------------GANILIDIKGCVKITDFGIS 622
Query: 477 RFLQTVSRQEKKKKTFCGTANYMSPEVINDEPYGFPADIWSVGATVFEMATGRPPYHSVK 656
+ L +++++ K+ + G+ +MSPEV+ ADIWS G V EM TG+ P+
Sbjct: 623 KKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDFS 682
Query: 657 NEIAVGVKIANTKQLENSKILEKDEETKQFIDLMTKADPNERKTADQLLNYHYL 818
A+ NT S E K F+ + D R +A +LL + +L
Sbjct: 683 QMQAIFKIGTNTTPEIPS---WATSEGKNFLRKAFELDYQYRPSALELLQHPWL 733
>sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 126 bits (316), Expect = 9e-29
Identities = 83/235 (35%), Positives = 127/235 (54%), Gaps = 2/235 (0%)
Frame = +3
Query: 117 LEYDINQYRDNLEHDNIVKYFGAINKQWK--IFIFMEFIDGGSISEKISLNNYQPLPVET 290
LE +I Q NL+H+ IV+Y+G + + + + IFME++ GGS+ ++ L Y L
Sbjct: 409 LECEI-QLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQ--LKAYGALTESV 465
Query: 291 IKLYTKQILCGLKFLHQSRIIHRDIKSIYLFKSSLFDFLI*IGANILITKQDCIKIVDFG 470
+ YT+QIL G+ +LH + I+HRDIK GANIL +K+ DFG
Sbjct: 466 TRKYTRQILEGMSYLHSNMIVHRDIK----------------GANILRDSAGNVKLGDFG 509
Query: 471 WSRFLQTVSRQEKKKKTFCGTANYMSPEVINDEPYGFPADIWSVGATVFEMATGRPPYHS 650
S+ LQT+ ++ GT +MSPEVI+ E YG AD+WS+G TV EM T +PP+
Sbjct: 510 ASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAE 569
Query: 651 VKNEIAVGVKIANTKQLENSKILEKDEETKQFIDLMTKADPNERKTADQLLNYHY 815
+ A+ KIA Q N ++ E + + +R +A++LL +H+
Sbjct: 570 YEAMAAI-FKIAT--QPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHF 621
>sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 125 bits (314), Expect = 1e-28
Identities = 83/235 (35%), Positives = 127/235 (54%), Gaps = 2/235 (0%)
Frame = +3
Query: 117 LEYDINQYRDNLEHDNIVKYFGAINKQWK--IFIFMEFIDGGSISEKISLNNYQPLPVET 290
LE +I Q NL+H+ IV+Y+G + + + + IFME++ GGS+ ++ L Y L
Sbjct: 409 LECEI-QLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQ--LKAYGALTESV 465
Query: 291 IKLYTKQILCGLKFLHQSRIIHRDIKSIYLFKSSLFDFLI*IGANILITKQDCIKIVDFG 470
+ YT+QIL G+ +LH + I+HRDIK GANIL +K+ DFG
Sbjct: 466 TRKYTRQILEGMSYLHSNMIVHRDIK----------------GANILRDSAGNVKLGDFG 509
Query: 471 WSRFLQTVSRQEKKKKTFCGTANYMSPEVINDEPYGFPADIWSVGATVFEMATGRPPYHS 650
S+ LQT+ ++ GT +MSPEVI+ E YG AD+WS+G TV EM T +PP+
Sbjct: 510 ASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAE 569
Query: 651 VKNEIAVGVKIANTKQLENSKILEKDEETKQFIDLMTKADPNERKTADQLLNYHY 815
+ A+ KIA Q N ++ E + + +R +A++LL +H+
Sbjct: 570 YEAMAAI-FKIAT--QPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHF 621
>sp|O95382|M3K6_HUMAN Mitogen-activated protein kinase kinase kinase 6
Length = 1011
Score = 124 bits (310), Expect = 4e-28
Identities = 86/229 (37%), Positives = 122/229 (53%), Gaps = 5/229 (2%)
Frame = +3
Query: 150 LEHDNIVKYFGAINKQWKIFIFMEFIDGGSISEKISLNNYQPLP--VETIKLYTKQILCG 323
L H NIV+Y G+ ++ + IFME + GGS+S + + + PL TI YT+QIL G
Sbjct: 423 LRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLR-SVWGPLKDNESTISFYTRQILQG 481
Query: 324 LKFLHQSRIIHRDIKSIYLFKSSLFDFLI*IGANILI-TKQDCIKIVDFGWSRFLQTVSR 500
L +LH + I+HRDIK G N+LI T +KI DFG S+ L ++
Sbjct: 482 LGYLHDNHIVHRDIK----------------GDNVLINTFSGLLKISDFGTSKRLAGIT- 524
Query: 501 QEKKKKTFCGTANYMSPEVINDEP--YGFPADIWSVGATVFEMATGRPPYHSVKNEIAVG 674
+TF GT YM+PE+I+ P YG ADIWS+G TV EMATGRPP+H + + A
Sbjct: 525 --PCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAM 582
Query: 675 VKIANTKQLENSKILEKDEETKQFIDLMTKADPNERKTADQLLNYHYLK 821
++ K + E + F+ + DP R +A LL +L+
Sbjct: 583 FQVGMYK-VHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQ 630
>sp|O08648|M3K4_MOUSE Mitogen-activated protein kinase kinase kinase 4 (MAPK/ERK kinase
kinase 4) (MEK kinase 4) (MEKK 4)
Length = 1597
Score = 123 bits (309), Expect = 6e-28
Identities = 79/230 (34%), Positives = 118/230 (51%), Gaps = 4/230 (1%)
Frame = +3
Query: 144 DNLEHDNIVKYFGAINKQWKIFIFMEFIDGGSISEKISLNNYQPLPVETIKLYTKQILCG 323
+ ++H N+V+YFG + +++IFME+ D G++ E L L I+LYTKQI
Sbjct: 1384 EGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLG----LQEHVIRLYTKQITVA 1439
Query: 324 LKFLHQSRIIHRDIKSIYLFKSSLFDFLI*IGANILITKQDCIKIVDFGWS-RFLQTVSR 500
+ LH+ I+HRDIK GANI +T IK+ DFG S +
Sbjct: 1440 INVLHEHGIVHRDIK----------------GANIFLTSSGLIKLGDFGCSVKLKNNAQT 1483
Query: 501 QEKKKKTFCGTANYMSPEVIN---DEPYGFPADIWSVGATVFEMATGRPPYHSVKNEIAV 671
+ + GTA YM+PEVI E +G ADIWS+G V EM TG+ P+H ++ +
Sbjct: 1484 MPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQI 1543
Query: 672 GVKIANTKQLENSKILEKDEETKQFIDLMTKADPNERKTADQLLNYHYLK 821
K+ + + L E K F+ ++DP R TA QLL++ ++K
Sbjct: 1544 MYKVGMGHKPPIPERL--SPEGKAFLSHCLESDPKIRWTASQLLDHAFVK 1591
>sp|Q9Y6R4|M3K4_HUMAN Mitogen-activated protein kinase kinase kinase 4 (MAPK/ERK kinase
kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1)
Length = 1607
Score = 123 bits (308), Expect = 7e-28
Identities = 78/230 (33%), Positives = 118/230 (51%), Gaps = 4/230 (1%)
Frame = +3
Query: 144 DNLEHDNIVKYFGAINKQWKIFIFMEFIDGGSISEKISLNNYQPLPVETIKLYTKQILCG 323
+ ++H N+V+YFG + +++IFME+ D G++ E L L I+LY+KQI
Sbjct: 1394 EGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLG----LQEHVIRLYSKQITIA 1449
Query: 324 LKFLHQSRIIHRDIKSIYLFKSSLFDFLI*IGANILITKQDCIKIVDFGWS-RFLQTVSR 500
+ LH+ I+HRDIK GANI +T IK+ DFG S +
Sbjct: 1450 INVLHEHGIVHRDIK----------------GANIFLTSSGLIKLGDFGCSVKLKNNAQT 1493
Query: 501 QEKKKKTFCGTANYMSPEVIN---DEPYGFPADIWSVGATVFEMATGRPPYHSVKNEIAV 671
+ + GTA YM+PEVI E +G ADIWS+G V EM TG+ P+H ++ +
Sbjct: 1494 MPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQI 1553
Query: 672 GVKIANTKQLENSKILEKDEETKQFIDLMTKADPNERKTADQLLNYHYLK 821
K+ + + L E K F+ ++DP R TA QLL++ ++K
Sbjct: 1554 MYKVGMGHKPPIPERL--SPEGKDFLSHCLESDPKMRWTASQLLDHSFVK 1601
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,132,089
Number of Sequences: 369166
Number of extensions: 1663147
Number of successful extensions: 8961
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5845
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6163
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8197207050
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)