Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_H22
(441 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P13444|METL_RAT S-adenosylmethionine synthetase alpha an... 184 7e-47
sp|Q00266|METL_HUMAN S-adenosylmethionine synthetase alpha ... 184 7e-47
sp|P18298|METK_RAT S-adenosylmethionine synthetase gamma fo... 183 1e-46
sp|P31153|METK_HUMAN S-adenosylmethionine synthetase gamma ... 181 6e-46
sp|P40320|METK_DROME S-adenosylmethionine synthetase (Methi... 173 1e-43
sp|P50305|METK_CAEEL Probable S-adenosylmethionine syntheta... 172 4e-43
sp|P50306|METL_CAEEL Probable S-adenosylmethionine syntheta... 170 1e-42
sp|P10659|METK_YEAST S-adenosylmethionine synthetase 1 (Met... 169 3e-42
sp|P19358|METL_YEAST S-adenosylmethionine synthetase 2 (Met... 168 4e-42
sp|O17680|METM_CAEEL Probable S-adenosylmethionine syntheta... 166 3e-41
>sp|P13444|METL_RAT S-adenosylmethionine synthetase alpha and beta forms (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-I/III)
Length = 397
Score = 184 bits (467), Expect = 7e-47
Identities = 91/135 (67%), Positives = 105/135 (77%), Gaps = 1/135 (0%)
Frame = +1
Query: 1 TGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYA 180
TGRKIIVDTY KDYTKVDRS AYAARWVAKSLVKAGLC+R+LVQ+SYA
Sbjct: 263 TGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYA 322
Query: 181 IGIAAPLSIFVDSYGTSSMPD-SGLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHF 357
IG+A PLSI + +YGTS + LLE++N NFDLRPG I +DLDL+KPIY++TACYGHF
Sbjct: 323 IGVAEPLSISIFTYGTSKKTERDELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHF 382
Query: 358 GRSEFTWEQPKLLKY 402
GRSEF WE PK L +
Sbjct: 383 GRSEFPWEVPKKLVF 397
>sp|Q00266|METL_HUMAN S-adenosylmethionine synthetase alpha and beta forms (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-I/III)
Length = 395
Score = 184 bits (467), Expect = 7e-47
Identities = 88/134 (65%), Positives = 105/134 (78%)
Frame = +1
Query: 1 TGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYA 180
TGRKIIVDTY KDYTKVDRS AYAARWVAKSLVKAGLC+R+LVQ+SYA
Sbjct: 262 TGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYA 321
Query: 181 IGIAAPLSIFVDSYGTSSMPDSGLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFG 360
IG+A PLSI + +YGTS + LL++++ NFDLRPG I +DLDL+KPIY++TACYGHFG
Sbjct: 322 IGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFG 381
Query: 361 RSEFTWEQPKLLKY 402
RSEF WE P+ L +
Sbjct: 382 RSEFPWEVPRKLVF 395
>sp|P18298|METK_RAT S-adenosylmethionine synthetase gamma form (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-II)
Length = 395
Score = 183 bits (465), Expect = 1e-46
Identities = 90/134 (67%), Positives = 101/134 (75%)
Frame = +1
Query: 1 TGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYA 180
TGRKIIVDTY KDYTKVDRS AYAARWVAKSLVK GLC+R+LVQ+SYA
Sbjct: 262 TGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYA 321
Query: 181 IGIAAPLSIFVDSYGTSSMPDSGLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFG 360
IG++ PLSI + YGTS + LLEI+ NNFDLRPG I +DLDL+KPIY+RTA YGHFG
Sbjct: 322 IGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVIVRDLDLKKPIYQRTAAYGHFG 381
Query: 361 RSEFTWEQPKLLKY 402
R F WE PK LKY
Sbjct: 382 RDSFPWEVPKKLKY 395
>sp|P31153|METK_HUMAN S-adenosylmethionine synthetase gamma form (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-II)
Length = 395
Score = 181 bits (459), Expect = 6e-46
Identities = 89/134 (66%), Positives = 100/134 (74%)
Frame = +1
Query: 1 TGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYA 180
TGRKIIVDTY KDYTKVDRS AYAARWVAKSLVK GLC+R+LVQ+SYA
Sbjct: 262 TGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYA 321
Query: 181 IGIAAPLSIFVDSYGTSSMPDSGLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFG 360
IG++ PLSI + YGTS + LLEI+ NFDLRPG I +DLDL+KPIY+RTA YGHFG
Sbjct: 322 IGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFG 381
Query: 361 RSEFTWEQPKLLKY 402
R F WE PK LKY
Sbjct: 382 RDSFPWEVPKKLKY 395
>sp|P40320|METK_DROME S-adenosylmethionine synthetase (Methionine adenosyltransferase)
(AdoMet synthetase)
Length = 408
Score = 173 bits (439), Expect = 1e-43
Identities = 88/133 (66%), Positives = 100/133 (75%)
Frame = +1
Query: 1 TGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYA 180
TGRKIIVDTY KD+TKVDRS AYAARWVAKSLVKAGLCKR LVQ+SYA
Sbjct: 273 TGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYA 332
Query: 181 IGIAAPLSIFVDSYGTSSMPDSGLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFG 360
IG+A PLSI V YGTS LL+II NFDLRPG I KDL+LR+PIY+RT+ YGHFG
Sbjct: 333 IGLAEPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFG 392
Query: 361 RSEFTWEQPKLLK 399
R+ F+WE+ K L+
Sbjct: 393 RAGFSWEEAKPLE 405
>sp|P50305|METK_CAEEL Probable S-adenosylmethionine synthetase C06E7.1 (Methionine
adenosyltransferase) (AdoMet synthetase)
Length = 404
Score = 172 bits (435), Expect = 4e-43
Identities = 86/133 (64%), Positives = 102/133 (76%)
Frame = +1
Query: 1 TGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYA 180
TGRKIIVDTY KD TKVDRS AYAARWVAKSLVK+GLC+R LVQ+SYA
Sbjct: 250 TGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKSGLCRRCLVQVSYA 309
Query: 181 IGIAAPLSIFVDSYGTSSMPDSGLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFG 360
IG+A PLS+ V S+GTS++ + LL+I+N+NFDLRPG I KDLDL+KPIY TA GHFG
Sbjct: 310 IGVAKPLSVMVFSFGTSALNEGELLKIVNDNFDLRPGMIIKDLDLKKPIYEPTAENGHFG 369
Query: 361 RSEFTWEQPKLLK 399
+EF WEQP+ L+
Sbjct: 370 HNEFPWEQPRHLQ 382
>sp|P50306|METL_CAEEL Probable S-adenosylmethionine synthetase C06E7.3 (Methionine
adenosyltransferase) (AdoMet synthetase)
Length = 404
Score = 170 bits (430), Expect = 1e-42
Identities = 85/133 (63%), Positives = 100/133 (75%)
Frame = +1
Query: 1 TGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYA 180
TGRKIIVDTY KD TKVDRS AYAARWVAKSLVKAGLC+R LVQ+SYA
Sbjct: 250 TGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKAGLCRRCLVQVSYA 309
Query: 181 IGIAAPLSIFVDSYGTSSMPDSGLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFG 360
IG+A PLS+ V S+GTS++ + LL I+N+NFDLRPG I K+LDL++PIY TA GHFG
Sbjct: 310 IGVAKPLSVMVFSFGTSALSEEDLLTIVNDNFDLRPGKIIKNLDLKRPIYEPTAENGHFG 369
Query: 361 RSEFTWEQPKLLK 399
+ F WEQP+ LK
Sbjct: 370 HNNFPWEQPRNLK 382
>sp|P10659|METK_YEAST S-adenosylmethionine synthetase 1 (Methionine adenosyltransferase
1) (AdoMet synthetase 1)
Length = 382
Score = 169 bits (427), Expect = 3e-42
Identities = 82/134 (61%), Positives = 98/134 (73%)
Frame = +1
Query: 1 TGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYA 180
TGRKIIVD Y KDY+KVDRS AYAARWVAKSLV AGLCKR+ VQ SYA
Sbjct: 249 TGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYA 308
Query: 181 IGIAAPLSIFVDSYGTSSMPDSGLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFG 360
IGIA PLS+ VD+YGT++ D +++II+ NFDLRPG + K+LDL +PIY TA YGHF
Sbjct: 309 IGIAEPLSLHVDTYGTATKSDEEIIDIISKNFDLRPGVLVKELDLARPIYLPTASYGHFT 368
Query: 361 RSEFTWEQPKLLKY 402
E+ WE+PK LK+
Sbjct: 369 NQEYPWEKPKTLKF 382
>sp|P19358|METL_YEAST S-adenosylmethionine synthetase 2 (Methionine adenosyltransferase
2) (AdoMet synthetase 2)
Length = 384
Score = 168 bits (426), Expect = 4e-42
Identities = 82/134 (61%), Positives = 98/134 (73%)
Frame = +1
Query: 1 TGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYA 180
TGRKIIVD Y KDY+KVDRS AYAARWVAKSLV AGLCKR+ VQ SYA
Sbjct: 251 TGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYA 310
Query: 181 IGIAAPLSIFVDSYGTSSMPDSGLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFG 360
IGIA PLS+ VD+YGT++ D ++EII NFDLRPG + K+LDL +PIY TA YGHF
Sbjct: 311 IGIAEPLSLHVDTYGTATKSDDEIIEIIKKNFDLRPGVLVKELDLARPIYLPTASYGHFT 370
Query: 361 RSEFTWEQPKLLKY 402
E++WE+PK L++
Sbjct: 371 NQEYSWEKPKKLEF 384
>sp|O17680|METM_CAEEL Probable S-adenosylmethionine synthetase C49F5.1 (Methionine
adenosyltransferase) (AdoMet synthetase)
Length = 403
Score = 166 bits (419), Expect = 3e-41
Identities = 84/133 (63%), Positives = 98/133 (73%)
Frame = +1
Query: 1 TGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYA 180
TGRKIIVDTY KD TKVDRS AYAARWVA SLVKAGL KR+LVQLSYA
Sbjct: 249 TGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVATSLVKAGLAKRVLVQLSYA 308
Query: 181 IGIAAPLSIFVDSYGTSSMPDSGLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFG 360
IGIA P+S+ V ++GTS + D L +I+ ++FDL PG I K+LDL++PIY +TA GHFG
Sbjct: 309 IGIAKPISVLVYAFGTSPLTDEELHQIVEDSFDLTPGKIIKELDLKRPIYEKTAENGHFG 368
Query: 361 RSEFTWEQPKLLK 399
SEF WEQPK LK
Sbjct: 369 HSEFPWEQPKALK 381
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,760,832
Number of Sequences: 369166
Number of extensions: 1123367
Number of successful extensions: 2716
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2603
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2663
length of database: 68,354,980
effective HSP length: 100
effective length of database: 49,881,480
effective search space used: 2294548080
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)